"It Takes Two to Tango": Role of Neglected Macrophage Manipulators Coronin 1 and Protein Kinase G in Mycobacterial Pathogenesis.

abstract：:The formation of biofilms by Staphylococcus aureus and Staphylococcus epidermidis is an important aspect of many staphylococcal infections, most notably endocarditis, osteomyelitis and infections associated with indwelling medical devices. The major constituents of staphylococcal biofilms are polysaccharides, such as ...

journal_title：Frontiers in cellular and infection microbiology

authors： Cue D,Lei MG,Lee CY

更新日期：2012-03-26 00:00:00

abstract：:Sepsis is a life-threatening health condition caused by infectious pathogens of the respiratory tract, and accounts for 28-50% of annual deaths in the US alone. Current treatment regimen advocates the use of corticosteroids as adjunct treatment with antibiotics, for their broad inhibitory effect on the activity and pr...

journal_title：Frontiers in cellular and infection microbiology

authors： Ngo Ndjom CG,Kantor LV,Jones HP

更新日期：2017-06-22 00:00:00

abstract：:Cold shock-domain family proteins (Csps) are highly conserved nucleic acid binding proteins regulating the expression of various genes including those involved in stress resistance and virulence in bacteria. We show here that Csps are involved in virulence, cell aggregation and flagella-based extracellular motility of...

journal_title：Frontiers in cellular and infection microbiology

authors： Eshwar AK,Guldimann C,Oevermann A,Tasara T

更新日期：2017-10-26 00:00:00

abstract：:Shiga toxin (Stx)-producing Escherichia coli (STEC) O157:H7 is an enteric pathogen that causes life-threatening disease in humans, with cattle being major natural reservoirs. A group of STEC O157:H7 with a dramatic combination of high virulence potentials and super-shedder bovine origin have been isolated. Here, an ST...

journal_title：Frontiers in cellular and infection microbiology

authors： Teng L,Lee S,Park D,Jeong KC

更新日期：2020-06-05 00:00:00

abstract：:Emerging antibiotic resistance in pathogenic bacteria like Mycobacterium sp., poses a threat to human health and therefore calls for the development of novel antibacterial strategies. We have recently discovered that bacterial membrane peptides, such as KdpF, possess anti-virulence properties when overproduced in path...

journal_title：Frontiers in cellular and infection microbiology

authors： Rosas Olvera M,Vivès E,Molle V,Blanc-Potard AB,Gannoun-Zaki L

更新日期：2017-04-06 00:00:00

abstract：:Cell death can be critical for host defense against intracellular pathogens because it eliminates a crucial replicative niche, and pro-inflammatory cell death can alert neighboring cells to the presence of pathogenic organisms and enhance downstream immune responses. Pyroptosis is a pro-inflammatory form of cell death...

journal_title：Frontiers in cellular and infection microbiology

authors： Casson CN,Shin S

更新日期：2013-12-27 00:00:00

abstract：:Pertussis is a respiratory infectious disease that has been resurged during the last decades. The change from the traditional multi-antigen whole-cell pertussis (wP) vaccines to acellular pertussis (aP) vaccines that consist of a few antigens formulated with alum, appears to be a key factor in the resurgence of pertus...

journal_title：Frontiers in cellular and infection microbiology

authors： Zurita ME,Wilk MM,Carriquiriborde F,Bartel E,Moreno G,Misiak A,Mills KHG,Hozbor D

更新日期：2019-04-26 00:00:00

abstract：Background:Disseminated histoplasmosis remains a major killer of immunocompromised patients in Latin America. Cytological and histological methods are usually present in most hospitals and may represent a precious diagnostic method. We report 15 years of experience of the department of pathology of the Centre Hospitali...

journal_title：Frontiers in cellular and infection microbiology

authors： Drak Alsibai K,Couppié P,Blanchet D,Adenis A,Epelboin L,Blaizot R,Louvel D,Djossou F,Demar M,Nacher M

更新日期：2020-10-29 00:00:00

abstract：:Microsporidia are a group of intracellular pathogens causing self-limited and severe diseases in immunocompetent and immunocompromised individuals, respectively. A cellular type 1 adaptive response, mediated by IL-12, IFNγ, CD4+, and CD8+ T cells has been shown to be essential for host resistance, and dendritic cells ...

journal_title：Frontiers in cellular and infection microbiology

authors： Bernal CE,Zorro MM,Sierra J,Gilchrist K,Botero JH,Baena A,Ramirez-Pineda JR

更新日期：2016-02-02 00:00:00

abstract：:Burkholderia cenocepacia is an opportunistic respiratory pathogen of individuals with cystic fibrosis (CF). Some strains of B. cenocepacia are highly transmissible and resistant to almost all antibiotics. Approximately one-third of B. cenocepacia infected CF patients go on to develop fatal "cepacia syndrome." During t...

journal_title：Frontiers in cellular and infection microbiology

authors： Ganesan S,Sajjan US

更新日期：2012-01-11 00:00:00

abstract：:Streptococcus mutans is an oral species closely associated with dental caries. As an early oral colonizer, S. mutans utilizes interspecies coaggregation to promote the colonization of subsequent species and affect polymicrobial pathogenesis. Previous studies have confirmed several adhering partner species of S. mutans...

journal_title：Frontiers in cellular and infection microbiology

authors： Liu T,Liu J,Liu J,Yang R,Lu X,He X,Shi W,Guo L

更新日期：2020-07-07 00:00:00

abstract：:Mycobacterium avium subspecies paratuberculosis (MAP) causes Johne's disease, a chronic granulomatous enteritis in ruminants. Furthermore, infections of humans with MAP have been reported and a possible association with Crohn's disease and diabetes type I is currently discussed. MAP owns large sequence polymorphisms (...

journal_title：Frontiers in cellular and infection microbiology

authors： Meißner T,Eckelt E,Basler T,Meens J,Heinzmann J,Suwandi A,Oelemann WM,Trenkamp S,Holst O,Weiss S,Bunk B,Spröer C,Gerlach GF,Goethe R

更新日期：2014-08-14 00:00:00

abstract：:Colorectal adenocarcinoma (CRC) is a common tumor with high mortality rates. Interestingly, CRC was found to be colonized by the oral anaerobic bacteria Fusobacterium nucleatum, which accelerates tumor progression and enables immune evasion. The CRC-specific colonization by fusobacteria is mediated through the recogni...

journal_title：Frontiers in cellular and infection microbiology

authors： Abed J,Maalouf N,Parhi L,Chaushu S,Mandelboim O,Bachrach G

更新日期：2017-06-30 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fcimb.2018.00102.]. ...

journal_title：Frontiers in cellular and infection microbiology

authors： Yin Y,Zhou D

更新日期：2018-07-27 00:00:00

abstract：:An attenuated vaccinia virus-MVTTEAB-was constructed by deletion of non-essential gene segments related to the immunomodulatory and virulence functions of the vaccinia virus Tiantan strain (VVTT). The shuttle plasmids pTC-EGFP, pTE-EGFP, pTA35-EGFP, pTB-EGFP, and pTA66-EGFP were constructed and combined with the early...

journal_title：Frontiers in cellular and infection microbiology

authors： Li Y,Zhu Y,Chen S,Li W,Yin X,Li S,Xiao P,Han J,Li X,Sun L,Jin N

更新日期：2017-10-31 00:00:00

abstract：:Syf1 is a tetratricopeptide repeat (TPR) protein implicated in transcription elongation, spliceosome conformation, mRNA nuclear-cytoplasmic export and transcription-coupled DNA repair. Recently, we identified the spliceosomal components of the human parasite Entamoeba histolytica, among them is EhSyf. Molecular predic...

journal_title：Frontiers in cellular and infection microbiology

authors： Torres-Cifuentes DM,Galindo-Rosales JM,Saucedo-Cárdenas O,Valdés J

更新日期：2018-07-09 00:00:00

abstract：:Genital tract infections with Chlamydia trachomatis (C. trachomatis) are the most frequent sexually transmitted disease worldwide. Severe clinical sequelae such as pelvic inflammatory disease (PID), tubal occlusion, and tubal infertility are linked to inflammatory processes of chronically infected tissues. The oxygen ...

journal_title：Frontiers in cellular and infection microbiology

authors： Jerchel S,Kaufhold I,Schuchardt L,Shima K,Rupp J

更新日期：2014-04-16 00:00:00

abstract：:The worldwide increase in antibiotic-resistant pathogens means that identification of alternative antibacterial drug targets and the subsequent development of new treatment strategies are urgently required. One such new target is the quorum sensing (QS) system. Coral microbial consortia harbor an enormous diversity of...

journal_title：Frontiers in cellular and infection microbiology

authors： Ma ZP,Song Y,Cai ZH,Lin ZJ,Lin GH,Wang Y,Zhou J

更新日期：2018-05-08 00:00:00

abstract：:Enterobacteriaceae cause different types of community- and hospital-acquired infections. Moreover, the spread of multidrug-resistant Enterobacteriaceae is a public health problem and the World Health Organization pointed them among the pathogens in which the search of new antibiotics is critical. The objective of this...

journal_title：Frontiers in cellular and infection microbiology

authors： Cebrero-Cangueiro T,Álvarez-Marín R,Labrador-Herrera G,Smani Y,Cordero-Matía E,Pachón J,Pachón-Ibáñez ME

更新日期：2018-10-18 00:00:00

abstract：:Thyroxine metabolism is an important topic of pathogenesis research and treatment schedule of subclinical hypothyroidism (SCH). L-Thyroxine replacement therapy (LRT) is usually recommended for severe SCH patients only. Our previous studies reported that disordered serum lipid of mild SCH people could also benefit from...

journal_title：Frontiers in cellular and infection microbiology

authors： Yao Z,Zhao M,Gong Y,Chen W,Wang Q,Fu Y,Guo T,Zhao J,Gao L,Bo T

更新日期：2020-09-18 00:00:00

abstract：:Quorum Sensing (QS) mediated by Acyl Homoserine Lactone (AHL) molecules are probably the most widespread and studied among Gram-negative bacteria. Canonical AHL systems are composed by a synthase (LuxI family) and a regulator element (LuxR family), whose genes are usually adjacent in the genome. However, incomplete AH...

journal_title：Frontiers in cellular and infection microbiology

authors： Martínez P,Huedo P,Martinez-Servat S,Planell R,Ferrer-Navarro M,Daura X,Yero D,Gibert I

更新日期：2015-05-15 00:00:00

abstract：:Shigella is a Gram-negative bacterium that is responsible for shigellosis. Over the years, the study of Shigella has provided a greater understanding of how the host responds to bacterial infection, and how bacteria have evolved to effectively counter the host defenses. In this review, we provide an update on some of ...

journal_title：Frontiers in cellular and infection microbiology

authors： Killackey SA,Sorbara MT,Girardin SE

更新日期：2016-03-31 00:00:00

abstract：:Vibrio parahaemolyticus elicits gastroenteritis by deploying Type III Secretion Systems (TTSS) to deliver effector proteins into epithelial cells of the human intestinal tract. The bacteria must adhere to the human cells to allow colonization and operation of the TTSS translocation apparatus bridging the bacterium and...

journal_title：Frontiers in cellular and infection microbiology

authors： O'Boyle N,Boyd A

更新日期：2014-01-10 00:00:00

abstract：:Cerebral malaria is among the major causes of malaria-associated mortality and effective adjunctive therapeutic strategies are currently lacking. Central pathophysiological processes involved in the development of cerebral malaria include an imbalance of pro- and anti-inflammatory responses to Plasmodium infection, en...

journal_title：Frontiers in cellular and infection microbiology

authors： Dunst J,Kamena F,Matuschewski K

更新日期：2017-07-20 00:00:00

abstract：:With major advances in experimental techniques to track antigen-specific immune responses many basic questions on the kinetics of virus-specific immunity in humans remain unanswered. To gain insights into kinetics of T and B cell responses in human volunteers we combined mathematical models and experimental data from ...

journal_title：Frontiers in cellular and infection microbiology

authors： Le D,Miller JD,Ganusov VV

更新日期：2015-01-09 00:00:00

abstract：:Gut microbiota serves as a critical indicator for gut health during treatment of pathogenic bacterial infection. Both Pulsatilla Decoction (abbreviated to PD, a traditional Chinese medicine compound) and Levofloxacin Hydrochloride (LVX) were known to have therapeutic effects to intestinal infectious disease. However, ...

journal_title：Frontiers in cellular and infection microbiology

authors： Liu X,He S,Li Q,Mu X,Hu G,Dong H

更新日期：2020-06-30 00:00:00

abstract：:To investigate the parameters associated with post-treatment recurrence of bacterial vaginosis (BV), clinical factors and vaginal microbiota were examined and analyzed for BV patients who received standard metronidazole therapy. The variables associated with BV recurrence included clinical factors of past BV history, ...

journal_title：Frontiers in cellular and infection microbiology

authors： Xiao B,Wu C,Song W,Niu X,Qin N,Liu Z,Xu Q

更新日期：2019-06-11 00:00:00

abstract：:Bacillus anthracis, the causative agent of anthrax, has been a focus of study in host-pathogen dynamics since the nineteenth century. While the interaction between anthrax and host macrophages has been extensively modeled, comparatively little is known about the effect of anthrax on the immune function of neutrophils,...

journal_title：Frontiers in cellular and infection microbiology

authors： Liu JZ,Ali SR,Bier E,Nizet V

更新日期：2018-01-22 00:00:00

abstract：:Given the increasing prevalence of antibiotic resistance among bacterial strains and the side effects caused by synthetic drugs, it is increasingly important to investigate potential herbal alternatives. In the present study, antimicrobial, cell cytotoxicity, and cleaning tests were performed to evaluate the potential...

journal_title：Frontiers in cellular and infection microbiology

authors： Shi Y,Deng Z,Yang Y,Cui L,Chen T,Hu M,Xie L,Yang J

更新日期：2019-05-10 00:00:00

abstract：:Gram-positive and Gram-negative pathogens exist as planktonic cells only at limited times during their life cycle. In response to environmental signals such as temperature, pH, osmolality, and nutrient availability, pathogenic bacteria can adopt varied cellular fates, which involves the activation of virulence gene pr...

journal_title：Frontiers in cellular and infection microbiology

authors： Desai SK,Kenney LJ

更新日期：2019-12-11 00:00:00