Cellular Aspects of Shigella Pathogenesis: Focus on the Manipulation of Host Cell Processes.

abstract：:A cohort study was conducted to evaluate oral microbial diversity among toddlers aged 12-24 months, and to describe the dynamic processes of colonization, development, and stabilization of the oral microflora during tooth eruption using high-throughput sequencing technology. A total of 20 healthy toddlers aged 12 mont...

journal_title：Frontiers in cellular and infection microbiology

authors： Li F,Tao D,Feng X,Wong MCM,Lu H

更新日期：2018-12-04 00:00:00

abstract：:Natural killer (NK) cells are critical for targeting and killing tumor, virus-infected and stressed cells as a member of the innate immune system. Recently, NK cells have also emerged as key regulators of adaptive immunity and have become a prominent therapeutic target for cancer immunotherapy and infection control. N...

journal_title：Frontiers in cellular and infection microbiology

authors： Pierce S,Geanes ES,Bradley T

更新日期：2020-05-19 00:00:00

abstract：:Cold shock-domain family proteins (Csps) are highly conserved nucleic acid binding proteins regulating the expression of various genes including those involved in stress resistance and virulence in bacteria. We show here that Csps are involved in virulence, cell aggregation and flagella-based extracellular motility of...

journal_title：Frontiers in cellular and infection microbiology

authors： Eshwar AK,Guldimann C,Oevermann A,Tasara T

更新日期：2017-10-26 00:00:00

abstract：:Cell death can be critical for host defense against intracellular pathogens because it eliminates a crucial replicative niche, and pro-inflammatory cell death can alert neighboring cells to the presence of pathogenic organisms and enhance downstream immune responses. Pyroptosis is a pro-inflammatory form of cell death...

journal_title：Frontiers in cellular and infection microbiology

authors： Casson CN,Shin S

更新日期：2013-12-27 00:00:00

abstract：:Pet and EspC are toxins secreted by enteroaggregative (EAEC) and enteropathogenic (EPEC) diarrheagenic Escherichia coli pathotypes, respectively. Both toxins are members of the Serine Protease Autotransporters of Enterobacteriaceae (SPATEs) family. Pet and EspC are important virulence factors that produce cytotoxic an...

journal_title：Frontiers in cellular and infection microbiology

authors： Sanchez-Villamil JI,Navarro-Garcia F,Castillo-Romero A,Gutierrez-Gutierrez F,Tapia D,Tapia-Pastrana G

更新日期：2019-09-25 00:00:00

abstract：:Pathogenic species of Leptospira cause leptospirosis, a bacterial zoonotic disease with a global distribution affecting over one million people annually. Reservoir hosts of leptospirosis, including rodents, dogs, and cattle, exhibit little to no signs of disease but shed large numbers of organisms in their urine. Tran...

journal_title：Frontiers in cellular and infection microbiology

authors： Nally JE,Grassmann AA,Planchon S,Sergeant K,Renaut J,Seshu J,McBride AJ,Caimano MJ

更新日期：2017-08-09 00:00:00

abstract：:The cell envelope of pathogenic bacteria is a barrier against host environmental conditions and immunity molecules, as well as the site where many virulence factors are assembled. Extracytoplasmic stress responses (ESRs) have evolved to help maintain its integrity in conditions where it might be compromised. These ESR...

journal_title：Frontiers in cellular and infection microbiology

authors： Flores-Kim J,Darwin AJ

更新日期：2012-10-10 00:00:00

abstract：:Non-typeable Haemophilus influenzae (NTHI) is an opportunistic bacterial pathogen of the human respiratory tract and is a leading cause of respiratory infections in children and adults. NTHI is considered to be an extracellular pathogen, but has consistently been observed within and between human respiratory epithelia...

journal_title：Frontiers in cellular and infection microbiology

authors： Clementi CF,Murphy TF

更新日期：2011-11-18 00:00:00

abstract：:The Toxoplasma gondii parasitophorous vacuole membrane (PVM) offers protection from the host immune system but is also a barrier for uptake of nutrients from the host. Previously, we showed that GRA17 mediates the tachyzoite PVM permeability to small molecules. During the conversion from tachyzoites to encysted bradyz...

journal_title：Frontiers in cellular and infection microbiology

authors： Paredes-Santos T,Wang Y,Waldman B,Lourido S,Saeij JP

更新日期：2019-09-12 00:00:00

abstract：:Thyroxine metabolism is an important topic of pathogenesis research and treatment schedule of subclinical hypothyroidism (SCH). L-Thyroxine replacement therapy (LRT) is usually recommended for severe SCH patients only. Our previous studies reported that disordered serum lipid of mild SCH people could also benefit from...

journal_title：Frontiers in cellular and infection microbiology

authors： Yao Z,Zhao M,Gong Y,Chen W,Wang Q,Fu Y,Guo T,Zhao J,Gao L,Bo T

更新日期：2020-09-18 00:00:00

abstract：:Sortases function as cysteine transpeptidases that catalyze the covalent attachment of virulence-associated surface proteins into the cell wall peptidoglycan in Gram-positive bacteria. The substrate proteins targeted by sortase enzymes have a cell wall sorting signal (CWSS) located at the C-terminus. Up to date, it is...

journal_title：Frontiers in cellular and infection microbiology

authors： Yin JC,Fei CH,Lo YC,Hsiao YY,Chang JC,Nix JC,Chang YY,Yang LW,Huang IH,Wang S

更新日期：2016-11-22 00:00:00

abstract：:Despite decades of dedicated research, there remains a dire need for new drugs against tuberculosis (TB). Current therapies are generations old and problematic. Resistance to these existing therapies results in an ever-increasing burden of patients with disease that is difficult or impossible to treat. Novel chemical ...

journal_title：Frontiers in cellular and infection microbiology

authors： Butman HS,Kotzé TJ,Dowd CS,Strauss E

更新日期：2020-12-15 00:00:00

abstract：:Ticks are vectors of pathogens affecting human and animal health worldwide. Nevertheless, the ecological and evolutionary interactions between ticks, hosts, and pathogens are largely unknown. Here, we integrated a framework to evaluate the associations of the tick Ixodes ricinus with its hosts and environmental niches...

journal_title：Frontiers in cellular and infection microbiology

authors： Estrada-Peña A,de la Fuente J,Cabezas-Cruz A

更新日期：2017-05-31 00:00:00

abstract：:Chronic HCV infection is characterized by several immunological alterations, such as the accumulation of suppressor cells and of hyperactivated T lymphocytes. However, it is unclear whether direct-acting antiviral (DAA)-mediated HCV clearance restores immune dysfunctions. We performed a phenotypic characterization by ...

journal_title：Frontiers in cellular and infection microbiology

authors： Telatin V,Nicoli F,Frasson C,Menegotto N,Barbaro F,Castelli E,Erne E,Palù G,Caputo A

更新日期：2019-06-14 00:00:00

abstract：:Dermatophytoses account for nearly a quarter of all fungal infections worldwide. These difficult to treat infections of the skin, hair, and nails, are growing more resistant to conventional antifungal treatments, and when treatable, often require prolonged therapeutic regimens. For centuries, essential oils have been ...

journal_title：Frontiers in cellular and infection microbiology

authors： Parrish N,Fisher SL,Gartling A,Craig D,Boire N,Khuvis J,Riedel S,Zhang S

更新日期：2020-10-16 00:00:00

abstract：:Studying how arthropod-borne viruses interact with their arthropod vectors is critical to understanding how these viruses replicate and are transmitted. Until recently, these types of studies were limited in scale because of the lack of classical tools available to study virus-host interaction for non-model viruses an...

journal_title：Frontiers in cellular and infection microbiology

authors： Petit MJ,Shah PS

更新日期：2019-01-07 00:00:00

abstract：:Programmed cell death (PCD) can play a crucial role in tuning the immune response to microbial infection. Although PCD can occur in different forms, all are mediated by a family of proteases called caspases. Caspase-2 is the most conserved caspase, however, its function in cell death is ill-defined. Previously we demo...

journal_title：Frontiers in cellular and infection microbiology

authors： Bronner DN,O'Riordan MX,He Y

更新日期：2013-11-27 00:00:00

abstract：:The endosymbiotic origin of eukaryotes brought together two disparate genomes in the cell. Additionally, eukaryotic natural history has included other endosymbiotic events, phagotrophic consumption of organisms, and intimate interactions with viruses and endoparasites. These phenomena facilitated large-scale lateral g...

journal_title：Frontiers in cellular and infection microbiology

authors： Aravind L,Anantharaman V,Zhang D,de Souza RF,Iyer LM

更新日期：2012-06-29 00:00:00

abstract：:Background: Increasing evidence has shown that Helicobacter pylori is associated with coronary heart disease (CHD); however, the underlying mechanism remains unclear. Methods: The expression of miR-25 and mRNAs was measured using qRT-PCR. Protein levels were detected using western blotting and exosomes were assessed w...

journal_title：Frontiers in cellular and infection microbiology

authors： Li N,Liu SF,Dong K,Zhang GC,Huang J,Wang ZH,Wang TJ

更新日期：2019-10-29 00:00:00

abstract：:Periodontal microorganisms not only colonize subgingival pockets, but also are detected on various mucous membranes in patients with periodontitis. The object of this pilot study was, using the next-generation sequencing of 16S RNA gene, to characterize the microbiota in two oral habitats (buccal mucosas and subgingiv...

journal_title：Frontiers in cellular and infection microbiology

authors： Wei Y,Shi M,Zhen M,Wang C,Hu W,Nie Y,Wu X

更新日期：2019-03-11 00:00:00

abstract：:MiRNAs are important post-transcriptional regulators of gene expression. MiRNA expression is a crucial part of host responses to bacterial infection, however there is limited knowledge of their impact on the outcome of infections. We investigated the influence of miR-21 on macrophage responses during infection with Li...

journal_title：Frontiers in cellular and infection microbiology

authors： Johnston DGW,Kearney J,Zasłona Z,Williams MA,O'Neill LAJ,Corr SC

更新日期：2017-05-23 00:00:00

abstract：:Probiotics have been used to treat a variety of diseases for decades; however, what is the rationale for their application? Such a treatment was first proposed in the early nineteenth century based on observations of decreased bifidobacterial populations in children suffering from diarrhea, suggesting that oral intake...

journal_title：Frontiers in cellular and infection microbiology

authors： Wieërs G,Belkhir L,Enaud R,Leclercq S,Philippart de Foy JM,Dequenne I,de Timary P,Cani PD

更新日期：2020-01-15 00:00:00

abstract：:Total parenteral nutrition (TPN), a commonly used treatment for patients who cannot receive enteral nutrition, is associated with significant septic complications due in part to a loss of epithelial barrier function (EBF). While the underlying mechanisms of TPN-related epithelial changes are poorly understood, a mouse...

journal_title：Frontiers in cellular and infection microbiology

authors： Demehri FR,Barrett M,Ralls MW,Miyasaka EA,Feng Y,Teitelbaum DH

更新日期：2013-12-23 00:00:00

abstract：:The natural history of genital Chlamydia trachomatis infections can vary widely; infections can spontaneously resolve but can also last from months to years, potentially progressing to cause significant pathology. The host and bacterial factors underlying this wide variation are not completely understood, but emphasiz...

journal_title：Frontiers in cellular and infection microbiology

authors： Aiyar A,Quayle AJ,Buckner LR,Sherchand SP,Chang TL,Zea AH,Martin DH,Belland RJ

更新日期：2014-06-03 00:00:00

abstract：:Dengue fever is an Aedes mosquito-borne illness caused by any one of the four different dengue virus (DENV) serotypes (1-4) and manifests in the form of symptoms ranging from mild or asymptomatic to severe disease with vascular leakage, leading to shock, and viral hemorrhagic syndrome. Increased risk of severe disease...

journal_title：Frontiers in cellular and infection microbiology

authors： Narayan R,Tripathi S

更新日期：2020-10-02 00:00:00

abstract：:Caprine parainfluenza virus type 3 (CPIV3) is a newly emerging pathogenic respiratory agent infecting both young and adult goats, and it was identified in eastern China in 2013. Cellular microRNAs (miRNAs) have been reported to be important modulators of the intricate virus-host interactions. In order to elucidate the...

journal_title：Frontiers in cellular and infection microbiology

authors： Li J,Mao L,Li W,Hao F,Zhong C,Zhu X,Ji X,Yang L,Zhang W,Liu M,Jiang J

更新日期：2018-03-29 00:00:00

abstract：:The SaeRS two-component system plays important roles in regulation of key virulence factors and pathogenicity. In this study, however, we found that the deletion mutation of saeRS enhanced bacterial survival in human blood, whereas complementation of the mutant with SaeRS returned survival to wild-type levels. Moreove...

journal_title：Frontiers in cellular and infection microbiology

authors： Guo H,Hall JW,Yang J,Ji Y

更新日期：2017-05-29 00:00:00

abstract：:Campylobacter jejuni (CJ) is the most prevalent zoonotic pathogen of chicken meat and related products, which may lead to gastroenteritis and autoimmune diseases in humans. Although controlling this bacterium is important, CJ strains resistance against traditional antibiotic therapy has been increased. Vegetable oils ...

journal_title：Frontiers in cellular and infection microbiology

authors： Ribeiro LNM,de Paula E,Rossi DA,Martins FA,de Melo RT,Monteiro GP,Breitkreitz MC,Goulart LR,Fonseca BB

更新日期：2021-01-08 00:00:00

abstract：:Rheumatoid Arthritis (RA) has been increasingly associated with perturbations to the microbial communities that reside in and on the body (the microbiome), in both human and animal studies. To date, such studies have mainly focused on the microbial communities that inhabit the gut and oral cavity. Mounting evidence su...

journal_title：Frontiers in cellular and infection microbiology

authors： Hammad DBM,Hider SL,Liyanapathirana VC,Tonge DP

更新日期：2020-01-22 00:00:00

abstract：:Bacteria comprise the earliest form of independent life on this planet. Bacterial development has included co-operative symbiosis with plants (e.g., Leguminosae family and nitrogen fixing bacteria in soil) and animals (e.g., the gut microbiome). A fusion event of two prokaryotes evolutionarily gave rise to the eukaryo...

journal_title：Frontiers in cellular and infection microbiology

authors： Vitetta L,Hall S,Linnane AW

更新日期：2014-10-15 00:00:00