Curcumin Blocks Cytotoxicity of Enteroaggregative and Enteropathogenic Escherichia coli by Blocking Pet and EspC Proteolytic Release From Bacterial Outer Membrane.

abstract：:Additional research on soft ticks in the family Argasidae is needed to bridge the knowledge gap relative to hard ticks of the family Ixodidae; especially, the molecular mechanisms of Ornithodoros biology. Ornithodoros species are vectors of human and animal pathogens that include tick-borne relapsing fever spirochetes...

journal_title：Frontiers in cellular and infection microbiology

authors： Armstrong BA,Kneubehl AR,Mitchell RD 3rd,Krishnavajhala A,Teel PD,Pérez de León AA,Lopez JE

更新日期：2020-05-05 00:00:00

abstract：:Streptococcus pyogenes (Group A Streptococcus or GAS) is a hemolytic human pathogen associated with a wide variety of infections ranging from minor skin and throat infections to life-threatening invasive diseases. The cell wall of GAS consists of peptidoglycan sacculus decorated with a carbohydrate comprising a polyrh...

journal_title：Frontiers in cellular and infection microbiology

authors： Edgar RJ,Chen J,Kant S,Rechkina E,Rush JS,Forsberg LS,Jaehrig B,Azadi P,Tchesnokova V,Sokurenko EV,Zhu H,Korotkov KV,Pancholi V,Korotkova N

更新日期：2016-10-13 00:00:00

abstract：:Herpes simplex virus-1 (HSV-1) is a significant human pathogen. Upon infection, HSV-1 expresses its immediate early (IE) genes, and the IE transcription factor ICP4 (infectious cell protein-4) plays a pivotal role in initiating the downstream gene-expression cascade. Using live-cell time-lapse fluorescence microscopy,...

journal_title：Frontiers in cellular and infection microbiology

authors： Chaturvedi S,Engel R,Weinberger L

更新日期：2020-06-24 00:00:00

abstract：:The Toxoplasma gondii parasitophorous vacuole membrane (PVM) offers protection from the host immune system but is also a barrier for uptake of nutrients from the host. Previously, we showed that GRA17 mediates the tachyzoite PVM permeability to small molecules. During the conversion from tachyzoites to encysted bradyz...

journal_title：Frontiers in cellular and infection microbiology

authors： Paredes-Santos T,Wang Y,Waldman B,Lourido S,Saeij JP

更新日期：2019-09-12 00:00:00

abstract：:Despite decades of dedicated research, there remains a dire need for new drugs against tuberculosis (TB). Current therapies are generations old and problematic. Resistance to these existing therapies results in an ever-increasing burden of patients with disease that is difficult or impossible to treat. Novel chemical ...

journal_title：Frontiers in cellular and infection microbiology

authors： Butman HS,Kotzé TJ,Dowd CS,Strauss E

更新日期：2020-12-15 00:00:00

abstract：:Candida albicans is a common human fungal pathogen capable of causing serious systemic infections that can progress to become lethal. Current therapeutic approaches have limited effectiveness, especially once a systemic infection is established, in part due to the lack of an effective immune response. Boosting the imm...

journal_title：Frontiers in cellular and infection microbiology

authors： Carpino N,Naseem S,Frank DM,Konopka JB

更新日期：2017-11-21 00:00:00

abstract：:The ability of the opportunistic pathogen, Staphylococcus aureus, to form biofilms is increasingly being viewed as an important contributor to chronic infections. In vitro methods for analyzing S. aureus biofilm formation have focused on bacterial attachment and accumulation on abiotic surfaces, such as in microtiter ...

journal_title：Frontiers in cellular and infection microbiology

authors： Walker JN,Horswill AR

更新日期：2012-03-27 00:00:00

abstract：:Deposition of Burkholderia pseudomallei within either the lungs or nasal passages of the Balb/c murine model resulted in different infection kinetics. The infection resulting from the inhalation of B. pseudomallei within a 12 μm particle aerosol was prolonged compared to a 1 μm particle aerosol with a mean time-to-dea...

journal_title：Frontiers in cellular and infection microbiology

authors： Thomas RJ,Davies C,Nunez A,Hibbs S,Eastaugh L,Harding S,Jordan J,Barnes K,Oyston P,Eley S

更新日期：2012-07-23 00:00:00

abstract：:Antifolate resistance is significant in Kenya and presumed to result from extensive use and cross-resistance between antifolate antimalarials and antibiotics, including cotrimoxazole/Bactrim used for HIV-1 chemotherapy. However, little is known about antifolate-resistant malaria in the context of newly diagnosed HIV-1...

journal_title：Frontiers in cellular and infection microbiology

authors： Torrevillas BK,Garrison SM,McKeeken AJ,Patel D,Van Leuven JT,Dizon NI,Rivas KI,Hathaway NJ,Bailey JA,Waitumbi JN,Kifude CM,Oyieko J,Stewart VA,Luckhart S

更新日期：2020-11-26 00:00:00

abstract：:Burkholderia pseudomallei is the causative agent of melioidosis, a rare disease of biodefense concern with high mortality and extreme difficulty in treatment. No human vaccines are available that protect against B. pseudomallei infection, and with the current limitations of antibiotic treatment, the development of new...

journal_title：Frontiers in cellular and infection microbiology

authors： Van Zandt KE,Tuanyok A,Keim PS,Warren RL,Gelhaus HC

更新日期：2012-09-26 00:00:00

abstract：:To investigate the parameters associated with post-treatment recurrence of bacterial vaginosis (BV), clinical factors and vaginal microbiota were examined and analyzed for BV patients who received standard metronidazole therapy. The variables associated with BV recurrence included clinical factors of past BV history, ...

journal_title：Frontiers in cellular and infection microbiology

authors： Xiao B,Wu C,Song W,Niu X,Qin N,Liu Z,Xu Q

更新日期：2019-06-11 00:00:00

abstract：:The fungal pathogen Cryptococcus neoformans can cause life-threatening infections in immune compromised individuals. This pathogen is typically acquired via inhalation, and enters the respiratory tract. Innate immune cells such as macrophages and dendritic cells (DCs) are the first host cells that encounter C. neoform...

journal_title：Frontiers in cellular and infection microbiology

authors： Nelson BN,Hawkins AN,Wozniak KL

更新日期：2020-02-11 00:00:00

abstract：:We have previously demonstrated that Candida albicans induces differentiation of hematopoietic stem and progenitor cells (HSPCs) toward the myeloid lineage both in vitro and in vivo in a TLR2- and Dectin-1-dependent manner, giving rise to functional macrophages. In this work, we used an ex vivo model to investigate th...

journal_title：Frontiers in cellular and infection microbiology

authors： Martínez A,Bono C,Megías J,Yáñez A,Gozalbo D,Gil ML

更新日期：2018-09-03 00:00:00

abstract：:Shigella spp. are highly adapted human pathogens that cause bacillary dysentery (shigellosis). Via the type III secretion system (T3SS), Shigella deliver a subset of virulence proteins (effectors) that are responsible for pathogenesis, with functions including pyroptosis, invasion of the epithelial cells, intracellula...

journal_title：Frontiers in cellular and infection microbiology

authors： Ashida H,Sasakawa C

更新日期：2016-01-06 00:00:00

abstract：:The worldwide increase in antibiotic-resistant pathogens means that identification of alternative antibacterial drug targets and the subsequent development of new treatment strategies are urgently required. One such new target is the quorum sensing (QS) system. Coral microbial consortia harbor an enormous diversity of...

journal_title：Frontiers in cellular and infection microbiology

authors： Ma ZP,Song Y,Cai ZH,Lin ZJ,Lin GH,Wang Y,Zhou J

更新日期：2018-05-08 00:00:00

abstract：:Fusarium is an important genus of plant pathogenic fungi, and is widely distributed in soil and associated with plants worldwide. The diversity of mycoviruses in Fusarium is increasing continuously due to the development and extensive use of state-of-the-art RNA deep sequencing techniques. To date, fully-sequenced myc...

journal_title：Frontiers in cellular and infection microbiology

authors： Li P,Bhattacharjee P,Wang S,Zhang L,Ahmed I,Guo L

更新日期：2019-07-18 00:00:00

abstract：:Intracellular bacterial pathogens (IBPs) invade and replicate in different cell types including immune cells, in particular of the innate immune system (IIS) during infection in the acute phase. However, immune cells primarily function as essential players in the highly effective and integrated host defense systems co...

journal_title：Frontiers in cellular and infection microbiology

authors： Eisenreich W,Rudel T,Heesemann J,Goebel W

更新日期：2017-07-13 00:00:00

abstract：:Histoplasmosis is one of the most frequent systemic mycosis in HIV patients. In these patients, histoplasmosis has high rates of morbidity/mortality if diagnosis and treatment are delayed. Despite its relevance, there is a paucity of information concerning the interaction between Histoplasma capsulatum and the human h...

journal_title：Frontiers in cellular and infection microbiology

authors： Almeida MA,Almeida-Paes R,Guimarães AJ,Valente RH,Soares CMA,Zancopé-Oliveira RM

更新日期：2020-10-29 00:00:00

abstract：:Bacteria comprise the earliest form of independent life on this planet. Bacterial development has included co-operative symbiosis with plants (e.g., Leguminosae family and nitrogen fixing bacteria in soil) and animals (e.g., the gut microbiome). A fusion event of two prokaryotes evolutionarily gave rise to the eukaryo...

journal_title：Frontiers in cellular and infection microbiology

authors： Vitetta L,Hall S,Linnane AW

更新日期：2014-10-15 00:00:00

abstract：:Brucella is a facultative intracellular pathogen that causes zoonotic infection known as brucellosis which results in abortion and infertility in natural host. Humans, especially in low income countries, can acquire infection by direct contact with infected animal or by consumption of animal products and show high mor...

journal_title：Frontiers in cellular and infection microbiology

authors： Ahmed W,Zheng K,Liu ZF

更新日期：2016-03-15 00:00:00

abstract：:Tularemia is an endemic zoonotic disease in many parts of the world including Asia. A cross-sectional study was conducted to determine genome-based prevalence of Francisella tularensis (Ft) in soil, assess an association between its occurrence in soil and likely predictors i.e., macro and micro-nutrients and several c...

journal_title：Frontiers in cellular and infection microbiology

authors： Muhammad J,Rabbani M,Shabbir MZ,Muhammad K,Ghori MT,Chaudhry HR,Ul Hassnain Z,Jamil T,Abbas T,Chaudhry MH,Haisem-Ur-Rasool M,Ali MA,Nisar M,Kirimanjeswara GS,Jayarao BM

更新日期：2019-04-05 00:00:00

abstract：:Prompt and effective elicitation of protective immunity is highly relevant for cases of rapidly deteriorating fatal diseases, such as plague, which is caused by Yersinia pestis. Here, we assessed the potential of a live vaccine to induce rapid protection against this infection. We demonstrated that the Y. pestis EV76 ...

journal_title：Frontiers in cellular and infection microbiology

authors： Zauberman A,Vagima Y,Tidhar A,Aftalion M,Gur D,Rotem S,Chitlaru T,Levy Y,Mamroud E

更新日期：2017-06-21 00:00:00

abstract：:Toxoplasma gondii is a prevalent parasite of mammals and birds including up to 30% of humans world-wide. Primary infection of immunocompetent hosts leads to a robust cell-mediated immune response, which controls but does not clear the infection, thus enabling long-term parasite persistence in brain and muscle tissues....

journal_title：Frontiers in cellular and infection microbiology

authors： Ehmen HG,Lüder CGK

更新日期：2019-06-28 00:00:00

abstract：:Lipids are essential players in parasites pathogenesis. In particular, the highly phagocytic trophozoites of Entamoeba histolytica, the causative agent of amoebiasis, exhibit a dynamic membrane fusion and fission, in which lipids strongly participate; particularly during the overstated motility of the parasite to reac...

journal_title：Frontiers in cellular and infection microbiology

authors： Castellanos-Castro S,Bolaños J,Orozco E

更新日期：2020-03-10 00:00:00

abstract：:Cross talk occurs between the human gut and the lung through a gut-lung axis involving the gut microbiota. However, the signatures of the human gut microbiota after active Mycobacterium tuberculosis infection have not been fully understood. Here, we investigated changes in the gut microbiota in tuberculosis (TB) patie...

journal_title：Frontiers in cellular and infection microbiology

authors： Hu Y,Feng Y,Wu J,Liu F,Zhang Z,Hao Y,Liang S,Li B,Li J,Lv N,Xu Y,Zhu B,Sun Z

更新日期：2019-04-03 00:00:00

abstract：:Streptococcus dentisani 7746, isolated from dental plaque of caries-free individuals, has been shown to have several beneficial effects in vitro which could contribute to promote oral health, including an antimicrobial activity against oral pathogens by the production of bacteriocins and a pH buffering capacity throug...

journal_title：Frontiers in cellular and infection microbiology

authors： Ferrer MD,López-López A,Nicolescu T,Perez-Vilaplana S,Boix-Amorós A,Dzidic M,Garcia S,Artacho A,Llena C,Mira A

更新日期：2020-08-31 00:00:00

abstract：:Thyroxine metabolism is an important topic of pathogenesis research and treatment schedule of subclinical hypothyroidism (SCH). L-Thyroxine replacement therapy (LRT) is usually recommended for severe SCH patients only. Our previous studies reported that disordered serum lipid of mild SCH people could also benefit from...

journal_title：Frontiers in cellular and infection microbiology

authors： Yao Z,Zhao M,Gong Y,Chen W,Wang Q,Fu Y,Guo T,Zhao J,Gao L,Bo T

更新日期：2020-09-18 00:00:00

abstract：:The endosymbiotic origin of eukaryotes brought together two disparate genomes in the cell. Additionally, eukaryotic natural history has included other endosymbiotic events, phagotrophic consumption of organisms, and intimate interactions with viruses and endoparasites. These phenomena facilitated large-scale lateral g...

journal_title：Frontiers in cellular and infection microbiology

authors： Aravind L,Anantharaman V,Zhang D,de Souza RF,Iyer LM

更新日期：2012-06-29 00:00:00

abstract：:The Mycobacterium fortuitum complex comprises several closely related species, causing pulmonary and extra-pulmonary infections. However, there is very limited knowledge about the disease pathogenesis involved in M. fortuitum infections, particularly due to the lack of suitable animal models. Using the zebrafish model...

journal_title：Frontiers in cellular and infection microbiology

authors： Johansen MD,Kremer L

更新日期：2020-07-17 00:00:00

abstract：:Transition metal ions are essential micronutrients for all living organisms. In mammals, these ions are often protein-bound and sequestered within cells, limiting their availability to microbes. Moreover, in response to infection, mammalian hosts further reduce the availability of metal nutrients by activating epithel...

journal_title：Frontiers in cellular and infection microbiology

authors： Diaz-Ochoa VE,Jellbauer S,Klaus S,Raffatellu M

更新日期：2014-01-24 00:00:00