The HSV-1 ICP4 Transcriptional Auto-Repression Circuit Functions as a Transcriptional "Accelerator" Circuit.

abstract：:Toxoplasma gondii is an exceptionally successful parasite that infects a very broad host range, including humans, across the globe. The outcome of infection differs remarkably between hosts, ranging from acute death to sterile infection. These differential disease patterns are strongly influenced by both host- and par...

journal_title：Frontiers in cellular and infection microbiology

authors： Mukhopadhyay D,Arranz-Solís D,Saeij JPJ

更新日期：2020-10-15 00:00:00

abstract：:Macrophages being the connecting link between innate and adaptive immune system plays a crucial role in microbial antigen presentation and orchestrates the subsequent clearance of microorganisms. Microbial invasion of macrophages trigger a plethora of signaling cascades, which interact among them to generate a dynamic...

journal_title：Frontiers in cellular and infection microbiology

authors： Saha S,Das P,BoseDasgupta S

更新日期：2020-10-20 00:00:00

abstract：:Intracellular bacterial pathogens have evolved distinct lifestyles inside eukaryotic cells. Some pathogens coexist with the infected cell in an obligate intracellular state, whereas others transit between the extracellular and intracellular environment. Adaptation to these intracellular lifestyles is regulated in both...

journal_title：Frontiers in cellular and infection microbiology

authors： Ortega AD,Quereda JJ,Pucciarelli MG,García-del Portillo F

更新日期：2014-11-12 00:00:00

abstract：:Entamoeba histolytica is a protozoan parasite and a major cause of dysentery and diarrheal disease in developing countries. Disease transmission from one host to another occurs via cysts which can survive in environmental extremes and are transmitted through contaminated food and water. Recent studies in our lab ident...

journal_title：Frontiers in cellular and infection microbiology

authors： Manna D,Lozano-Amado D,Ehrenkaufer G,Singh U

更新日期：2020-07-17 00:00:00

abstract：:Acute pancreatitis (AP) is considered a cascade of immune responses triggered by acinar cell necrosis. AP involves two main processes of systemic inflammatory response syndrome and subsequent compensatory anti-inflammatory response syndrome. Although great efforts have been made regarding AP therapy, the mortality rat...

journal_title：Frontiers in cellular and infection microbiology

authors： Ding L,Yang Y,Li H,Wang H,Gao P

更新日期：2020-03-31 00:00:00

abstract：:Lung microbiome ecosystem homeostasis in idiopathic pulmonary fibrosis (IPF) remains uncharacterized. The aims of this study were to identify unique microbial signatures of the lung microbiome and analyze microbial gene function in IPF patients. DNA isolated from BALF samples was obtained for high-throughput gene sequ...

journal_title：Frontiers in cellular and infection microbiology

authors： Tong X,Su F,Xu X,Xu H,Yang T,Xu Q,Dai H,Huang K,Zou L,Zhang W,Pei S,Xiao F,Li Y,Wang C

更新日期：2019-05-21 00:00:00

abstract：:Objective:Streptococcus pneumoniae colonizes the nasopharynx of children, and from nasopharynx it could migrate to the middle ear and causes acute otitis media (AOM). During colonization and AOM, the pneumococcus forms biofilms. In vitro biofilm formation requires a functional LuxS/AI-2 quorum-sensing system. We inves...

journal_title：Frontiers in cellular and infection microbiology

authors： Yadav MK,Vidal JE,Go YY,Kim SH,Chae SW,Song JJ

更新日期：2018-05-04 00:00:00

abstract：:Brucella is a facultative intracellular pathogen that causes zoonotic infection known as brucellosis which results in abortion and infertility in natural host. Humans, especially in low income countries, can acquire infection by direct contact with infected animal or by consumption of animal products and show high mor...

journal_title：Frontiers in cellular and infection microbiology

authors： Ahmed W,Zheng K,Liu ZF

更新日期：2016-03-15 00:00:00

abstract：:Amoeba-associated microorganisms (AAMs) are frequently isolated from water networks. In this paper, we report the isolation and characterization of Protochlamydia massiliensis, an obligate intracellular Gram-negative bacterium belonging to the Parachlamydiaceae family in the Chlamydiales order, from a cooling water to...

journal_title：Frontiers in cellular and infection microbiology

authors： Benamar S,Bou Khalil JY,Blanc-Tailleur C,Bilen M,Barrassi L,La Scola B

更新日期：2017-08-31 00:00:00

abstract：:Intracellular bacterial pathogens (IBPs) invade and replicate in different cell types including immune cells, in particular of the innate immune system (IIS) during infection in the acute phase. However, immune cells primarily function as essential players in the highly effective and integrated host defense systems co...

journal_title：Frontiers in cellular and infection microbiology

authors： Eisenreich W,Rudel T,Heesemann J,Goebel W

更新日期：2017-07-13 00:00:00

abstract：:Ocular toxoplasmosis is one of the most common complications caused by the infection with the parasite Toxoplasma gondii. The risk of developing eye lesions and impaired vision is considered higher in Brazil than other countries. The clinical diagnosis is difficult and the use of sensitive and specific laboratorial me...

journal_title：Frontiers in cellular and infection microbiology

authors： Murata FHA,Previato M,Frederico FB,Barbosa AP,Nakashima F,de Faria GM Jr,Silveira Carvalho AP,Meira Strejevitch CDS,Pereira-Chioccola VL,Castiglioni L,de Mattos LC,Siqueira RC,Brandão de Mattos CC

更新日期：2020-02-07 00:00:00

abstract：:Deposition of Burkholderia pseudomallei within either the lungs or nasal passages of the Balb/c murine model resulted in different infection kinetics. The infection resulting from the inhalation of B. pseudomallei within a 12 μm particle aerosol was prolonged compared to a 1 μm particle aerosol with a mean time-to-dea...

journal_title：Frontiers in cellular and infection microbiology

authors： Thomas RJ,Davies C,Nunez A,Hibbs S,Eastaugh L,Harding S,Jordan J,Barnes K,Oyston P,Eley S

更新日期：2012-07-23 00:00:00

abstract：:The ability of the opportunistic pathogen, Staphylococcus aureus, to form biofilms is increasingly being viewed as an important contributor to chronic infections. In vitro methods for analyzing S. aureus biofilm formation have focused on bacterial attachment and accumulation on abiotic surfaces, such as in microtiter ...

journal_title：Frontiers in cellular and infection microbiology

authors： Walker JN,Horswill AR

更新日期：2012-03-27 00:00:00

abstract：:Cytokinesis, or the division of the cytoplasm, following the end of mitosis or meiosis, is accomplished in animal cells, fungi, and amoebae, by the constriction of an actomyosin contractile ring, comprising filamentous actin, myosin II, and associated proteins. However, despite this being the best-studied mode of cyto...

journal_title：Frontiers in cellular and infection microbiology

authors： Hammarton TC

更新日期：2019-11-21 00:00:00

abstract：:Platycodin D, extract from the root of Platycodon grandiflorum, is one of the most important monomers of the Qinbaiqingfei pellets (Qinbai) that has already been approved as the first Traditional Chinese Medicine for clinic use as an anti-M. pneumoniae agent. Qinbai constituents Scutellaria baicalensis and Platycodon ...

journal_title：Frontiers in cellular and infection microbiology

authors： Meng Y,Yang Y,Lu W,Wang Y,Qian F,Wang X,Zhang Z,Wang W

更新日期：2015-01-13 00:00:00

abstract：:For centuries, hydrogen sulfide (H2S) was considered primarily as a poisonous gas and environmental hazard. However, with the discovery of prokaryotic and eukaryotic enzymes for H2S production, breakdown, and utilization, H2S has emerged as an important signaling molecule in a wide range of physiological and pathologi...

journal_title：Frontiers in cellular and infection microbiology

authors： Rahman MA,Glasgow JN,Nadeem S,Reddy VP,Sevalkar RR,Lancaster JR Jr,Steyn AJC

更新日期：2020-11-10 00:00:00

abstract：:Gram-positive and Gram-negative pathogens exist as planktonic cells only at limited times during their life cycle. In response to environmental signals such as temperature, pH, osmolality, and nutrient availability, pathogenic bacteria can adopt varied cellular fates, which involves the activation of virulence gene pr...

journal_title：Frontiers in cellular and infection microbiology

authors： Desai SK,Kenney LJ

更新日期：2019-12-11 00:00:00

abstract：:Cytolethal distending toxin (CDT) produced by Campylobacter jejuni contains three subunits: CdtA, CdtB, and CdtC. Among these three toxin subunits, CdtB is the toxic moiety of CDT with DNase I activity, resulting in DNA double-strand breaks (DSB) and, consequently, cell cycle arrest at the G2/M stage and apoptosis. Ra...

journal_title：Frontiers in cellular and infection microbiology

authors： Lin HJ,Liu HH,Lin CD,Kao MC,Chen YA,Chiang-Ni C,Jiang ZP,Huang MZ,Lin CJ,Lo UG,Lin LC,Lai CK,Lin H,Hsieh JT,Chiu CH,Lai CH

更新日期：2017-06-08 00:00:00

abstract：:Infections with parasites of the genus Leishmania lead to a rapid, but transient activation of natural killer (NK) cells. In mice activation of NK cells requires a toll-like-receptor 9-dependent stimulation of dendritic cells (DC) which is followed by the production of IL-12. Although NK cells appear to be non-essenti...

journal_title：Frontiers in cellular and infection microbiology

authors： Bogdan C

更新日期：2012-05-29 00:00:00

abstract：:Chlamydiae are obligate intracellular pathogens of eukaryotes. The bacteria grow in an intracellular vesicle called an inclusion, the membrane of which is heavily modified by chlamydial proteins called Incs (Inclusion membrane proteins). Incs represent 7-10% of the genomes of Chlamydia and, given their localization at...

journal_title：Frontiers in cellular and infection microbiology

authors： Gauliard E,Ouellette SP,Rueden KJ,Ladant D

更新日期：2015-02-11 00:00:00

abstract：:The ability to efficiently scavenge nutrients in the host is essential for the viability of any pathogen. All catabolic pathways must begin with the transport of substrate from the environment through the cytoplasmic membrane, a role executed by membrane transporters. Although several classes of cytoplasmic membrane t...

journal_title：Frontiers in cellular and infection microbiology

authors： Rosa LT,Bianconi ME,Thomas GH,Kelly DJ

更新日期：2018-02-12 00:00:00

abstract：:Transition metal ions are essential micronutrients for all living organisms. In mammals, these ions are often protein-bound and sequestered within cells, limiting their availability to microbes. Moreover, in response to infection, mammalian hosts further reduce the availability of metal nutrients by activating epithel...

journal_title：Frontiers in cellular and infection microbiology

authors： Diaz-Ochoa VE,Jellbauer S,Klaus S,Raffatellu M

更新日期：2014-01-24 00:00:00

abstract：:An attenuated vaccinia virus-MVTTEAB-was constructed by deletion of non-essential gene segments related to the immunomodulatory and virulence functions of the vaccinia virus Tiantan strain (VVTT). The shuttle plasmids pTC-EGFP, pTE-EGFP, pTA35-EGFP, pTB-EGFP, and pTA66-EGFP were constructed and combined with the early...

journal_title：Frontiers in cellular and infection microbiology

authors： Li Y,Zhu Y,Chen S,Li W,Yin X,Li S,Xiao P,Han J,Li X,Sun L,Jin N

更新日期：2017-10-31 00:00:00

abstract：:Solid-state fermentation of feedstuffs by Bacillus subtilis MA139 can reduce insoluble dietary fiber content in vitro and improve growth performance in pigs. This study was conducted to investigate the effects of dietary corn bran (CB) fermented by B. subtilis on growth performance and gut microbiota composition in fi...

journal_title：Frontiers in cellular and infection microbiology

authors： Liu P,Zhao J,Guo P,Lu W,Geng Z,Levesque CL,Johnston LJ,Wang C,Liu L,Zhang J,Ma N,Qiao S,Ma X

更新日期：2017-12-22 00:00:00

abstract：:Compounds with novel modes of action are urgently needed to develop effective combination therapies for the treatment of tuberculosis. In this study, a series of compounds was evaluated for activity against replicating Mycobacterium tuberculosis and Vero cell line toxicity. Fourteen of the compounds with in vitro acti...

journal_title：Frontiers in cellular and infection microbiology

authors： Chengalroyen MD,Jordaan A,Seldon R,Ioerger T,Franzblau SG,Nasr M,Warner DF,Mizrahi V

更新日期：2020-11-13 00:00:00

abstract：:During intestinal invasion, Entamoeba histolytica opens tight junctions (TJs) reflected by transepithelial electrical resistance (TEER) dropping. To explore the molecular mechanisms underlying this, we studied in vitro and in vivo the damage produced by the recombinant E. histolytica cysteine protease (rEhCP112) on TJ...

journal_title：Frontiers in cellular and infection microbiology

authors： Cuellar P,Hernández-Nava E,García-Rivera G,Chávez-Munguía B,Schnoor M,Betanzos A,Orozco E

更新日期：2017-08-16 00:00:00

abstract：:Iron is an absolute requirement for both the host and most pathogens alike and is needed for normal cellular growth. The acquisition of iron by biological systems is regulated to circumvent toxicity of iron overload, as well as the growth deficits imposed by iron deficiency. In addition, hosts, such as humans, need to...

journal_title：Frontiers in cellular and infection microbiology

authors： Fourie R,Kuloyo OO,Mochochoko BM,Albertyn J,Pohl CH

更新日期：2018-06-05 00:00:00

abstract：:Hundred-thousands of fungal species are present in our environment, including normal colonizers that constitute part of the human microbiota. The homeostasis of host-fungus interactions encompasses efficient fungal sensing, tolerance at mucosal surfaces, as well as antifungal defenses. Decrease in host immune fitness ...

journal_title：Frontiers in cellular and infection microbiology

authors： Bourgeois C,Kuchler K

更新日期：2012-11-22 00:00:00

abstract：:Pathogenic species of Leptospira cause leptospirosis, a bacterial zoonotic disease with a global distribution affecting over one million people annually. Reservoir hosts of leptospirosis, including rodents, dogs, and cattle, exhibit little to no signs of disease but shed large numbers of organisms in their urine. Tran...

journal_title：Frontiers in cellular and infection microbiology

authors： Nally JE,Grassmann AA,Planchon S,Sergeant K,Renaut J,Seshu J,McBride AJ,Caimano MJ

更新日期：2017-08-09 00:00:00

abstract：:The natural history of genital Chlamydia trachomatis infections can vary widely; infections can spontaneously resolve but can also last from months to years, potentially progressing to cause significant pathology. The host and bacterial factors underlying this wide variation are not completely understood, but emphasiz...

journal_title：Frontiers in cellular and infection microbiology

authors： Aiyar A,Quayle AJ,Buckner LR,Sherchand SP,Chang TL,Zea AH,Martin DH,Belland RJ

更新日期：2014-06-03 00:00:00