Circulating Lymphocyte Subsets Induce Secondary Infection in Acute Pancreatitis.

abstract：:Enterobacteriaceae cause different types of community- and hospital-acquired infections. Moreover, the spread of multidrug-resistant Enterobacteriaceae is a public health problem and the World Health Organization pointed them among the pathogens in which the search of new antibiotics is critical. The objective of this...

journal_title：Frontiers in cellular and infection microbiology

authors： Cebrero-Cangueiro T,Álvarez-Marín R,Labrador-Herrera G,Smani Y,Cordero-Matía E,Pachón J,Pachón-Ibáñez ME

更新日期：2018-10-18 00:00:00

abstract：:Intracellular bacterial pathogens have evolved distinct lifestyles inside eukaryotic cells. Some pathogens coexist with the infected cell in an obligate intracellular state, whereas others transit between the extracellular and intracellular environment. Adaptation to these intracellular lifestyles is regulated in both...

journal_title：Frontiers in cellular and infection microbiology

authors： Ortega AD,Quereda JJ,Pucciarelli MG,García-del Portillo F

更新日期：2014-11-12 00:00:00

abstract：:Non-encapsulated Streptococcus pneumoniae often possess two genes, aliB-like ORF 1 and aliB-like ORF 2, in place of capsule genes. AliB-like ORF 1 is thought to encode a substrate binding protein of an ABC transporter which binds peptide SETTFGRDFN, found in 50S ribosomal subunit protein L4 of Enterobacteriaceae. Here...

journal_title：Frontiers in cellular and infection microbiology

authors： Nasher F,Kwun MJ,Croucher NJ,Heller M,Hathaway LJ

更新日期：2019-09-10 00:00:00

abstract：:Gut microbiota serves as a critical indicator for gut health during treatment of pathogenic bacterial infection. Both Pulsatilla Decoction (abbreviated to PD, a traditional Chinese medicine compound) and Levofloxacin Hydrochloride (LVX) were known to have therapeutic effects to intestinal infectious disease. However, ...

journal_title：Frontiers in cellular and infection microbiology

authors： Liu X,He S,Li Q,Mu X,Hu G,Dong H

更新日期：2020-06-30 00:00:00

abstract：:Enterohemorrhagic Escherichia coli (EHEC) is a significant cause of serious human gastrointestinal disease worldwide. EHEC strains contain a pathogenicity island called the locus of enterocyte effacement (LEE), which encodes virulence factors responsible for damaging the gut mucosa. The Cpx envelope stress response of...

journal_title：Frontiers in cellular and infection microbiology

authors： De la Cruz MA,Morgan JK,Ares MA,Yáñez-Santos JA,Riordan JT,Girón JA

更新日期：2016-02-05 00:00:00

abstract：:Despite decades of dedicated research, there remains a dire need for new drugs against tuberculosis (TB). Current therapies are generations old and problematic. Resistance to these existing therapies results in an ever-increasing burden of patients with disease that is difficult or impossible to treat. Novel chemical ...

journal_title：Frontiers in cellular and infection microbiology

authors： Butman HS,Kotzé TJ,Dowd CS,Strauss E

更新日期：2020-12-15 00:00:00

abstract：:The hemorrhagic septicemic disease vibriosis caused by Vibrio anguillarum shows noticeable similarities to invasive septicemia in humans, and in this case, the V. anguillarum-host system has the potential to serve as a model for understanding native eukaryotic host-pathogen interactions. Iron acquisition, as a fierce ...

journal_title：Frontiers in cellular and infection microbiology

authors： Li Y,Ma Q

更新日期：2017-07-25 00:00:00

abstract：:Sepsis is a severe syndrome that arises when the host response to an insult is exacerbated, leading to organ failure and frequently to death. How a chronic infection that causes a prolonged Th1 expansion affects the course of sepsis is unknown. In this study, we showed that mice chronically infected with Toxoplasma go...

journal_title：Frontiers in cellular and infection microbiology

authors： Souza MC,Fonseca DM,Kanashiro A,Benevides L,Medina TS,Dias MS,Andrade WA,Bonfá G,Silva MAB,Gozzi A,Borges MC,Gazzinelli RT,Alves-Filho JC,Cunha FQ,Silva JS

更新日期：2017-04-07 00:00:00

abstract：:Objectives: To evaluate metagenomic next-generation sequencing (mNGS) as a diagnostic tool in detecting pathogens from osteoarticular infection (OAI) samples. Methods: 130 samples of joint fluid, sonicate fluid, and tissue were prospectively collected from 92 patients with OAI. The performance of mNGS and microbiology...

journal_title：Frontiers in cellular and infection microbiology

authors： Huang ZD,Zhang ZJ,Yang B,Li WB,Zhang CJ,Fang XY,Zhang CF,Zhang WM,Lin JH

更新日期：2020-09-17 00:00:00

abstract：:Stress granules (SGs) are sites of mRNA storage that are formed in response to various conditions of stress, including viral infections. Porcine reproductive and respiratory syndrome virus (PRRSV) is an Arterivirus that has been devastating the swine industry worldwide since the late 1980s. In this study, we found tha...

journal_title：Frontiers in cellular and infection microbiology

authors： Zhou Y,Fang L,Wang D,Cai K,Chen H,Xiao S

更新日期：2017-04-04 00:00:00

abstract：:In 2019, the United States Food and Drug Administration accorded restricted approval to Sanofi Pasteur's Dengvaxia, a live attenuated vaccine (LAV) for dengue fever, a mosquito-borne viral disease, caused by four antigenically distinct dengue virus serotypes (DENV 1-4). The reason for this limited approval is the conc...

journal_title：Frontiers in cellular and infection microbiology

authors： Shukla R,Ramasamy V,Shanmugam RK,Ahuja R,Khanna N

更新日期：2020-10-22 00:00:00

abstract：:Programmed cell death (PCD) can play a crucial role in tuning the immune response to microbial infection. Although PCD can occur in different forms, all are mediated by a family of proteases called caspases. Caspase-2 is the most conserved caspase, however, its function in cell death is ill-defined. Previously we demo...

journal_title：Frontiers in cellular and infection microbiology

authors： Bronner DN,O'Riordan MX,He Y

更新日期：2013-11-27 00:00:00

abstract：:The fungal pathogen Cryptococcus neoformans can cause life-threatening infections in immune compromised individuals. This pathogen is typically acquired via inhalation, and enters the respiratory tract. Innate immune cells such as macrophages and dendritic cells (DCs) are the first host cells that encounter C. neoform...

journal_title：Frontiers in cellular and infection microbiology

authors： Nelson BN,Hawkins AN,Wozniak KL

更新日期：2020-02-11 00:00:00

abstract：:Brucella spp. are intracellular vacuolar pathogens that causes brucellosis, a worldwide zoonosis of profound importance. We previously demonstrated that the activity of host unfolded protein response (UPR) sensor IRE1α (inositol-requiring enzyme 1) and ER-associated autophagy confer susceptibility to Brucella melitens...

journal_title：Frontiers in cellular and infection microbiology

authors： Pandey A,Lin F,Cabello AL,da Costa LF,Feng X,Feng HQ,Zhang MZ,Iwawaki T,Rice-Ficht A,Ficht TA,de Figueiredo P,Qin QM

更新日期：2018-04-20 00:00:00

abstract：:In the last decade it has become clear that, similarly to nucleated cells, enucleated red blood cells (RBCs) are susceptible to programmed apoptotic cell death. Erythrocytic apoptosis seems to play a role in physiological clearance of aged RBCs, but it may also be implicated in anemia of different etiological sources ...

journal_title：Frontiers in cellular and infection microbiology

authors： Totino PR,Daniel-Ribeiro CT,Ferreira-da-Cruz MF

更新日期：2016-12-09 00:00:00

abstract：:Cerebral malaria is characterized by permanent cognitive impairments in Plasmodium-infected children. Antimalarial therapies show little effectiveness to avoid neurological deficits and brain tissue alterations elicited by severe malaria. Melatonin is a well-recognized endogenous hormone involved in the control of bra...

journal_title：Frontiers in cellular and infection microbiology

authors： Ataide BJA,Kauffmann N,Mendes NSF,Torres MLM,Dos Anjos LM,Passos ADCF,de Moraes SAS,Batista EJO,Herculano AM,Oliveira KRHM

更新日期：2020-09-30 00:00:00

abstract：:Streptococcus pneumoniae is a leading cause of bacterial pneumonia worldwide. Given the critical role of dendritic cells (DCs) in regulating and modulating the immune response to pathogens, we investigated here the role of DCs in S. pneumoniae lung infections. Using a well-established transgenic mouse line which allow...

journal_title：Frontiers in cellular and infection microbiology

authors： Rosendahl A,Bergmann S,Hammerschmidt S,Goldmann O,Medina E

更新日期：2013-06-21 00:00:00

abstract：:We have previously demonstrated that Candida albicans induces differentiation of hematopoietic stem and progenitor cells (HSPCs) toward the myeloid lineage both in vitro and in vivo in a TLR2- and Dectin-1-dependent manner, giving rise to functional macrophages. In this work, we used an ex vivo model to investigate th...

journal_title：Frontiers in cellular and infection microbiology

authors： Martínez A,Bono C,Megías J,Yáñez A,Gozalbo D,Gil ML

更新日期：2018-09-03 00:00:00

abstract：:The type VI secretion system (T6SS) secretes numerous toxins for bacteria-bacteria competition. TplE is a newly identified trans-kingdom toxin secreted by the T6SS in Pseudomonas aeruginosa, while TplEi neutralizes the toxic effect of TplE to protect bacteria autointoxication. Blocking the interaction of TplE-TplEi co...

journal_title：Frontiers in cellular and infection microbiology

authors： Gao X,Mu Z,Qin B,Sun Y,Cui S

更新日期：2017-09-20 00:00:00

abstract：:The SaeRS two-component system plays important roles in regulation of key virulence factors and pathogenicity. In this study, however, we found that the deletion mutation of saeRS enhanced bacterial survival in human blood, whereas complementation of the mutant with SaeRS returned survival to wild-type levels. Moreove...

journal_title：Frontiers in cellular and infection microbiology

authors： Guo H,Hall JW,Yang J,Ji Y

更新日期：2017-05-29 00:00:00

abstract：:Chlamydia trachomatis is the leading cause of preventable blindness and the most common bacterial sexually transmitted infection. Different strains are associated with ocular or urogenital infections, and a proposed mechanism that may explain this tissue tropism is the active tryptophan biosynthesis pathway encoded by...

journal_title：Frontiers in cellular and infection microbiology

authors： O'Neill CE,Skilton RJ,Pearson SA,Filardo S,Andersson P,Clarke IN

更新日期：2018-12-14 00:00:00

abstract：:Toxoplasma gondii is a prevalent parasite of mammals and birds including up to 30% of humans world-wide. Primary infection of immunocompetent hosts leads to a robust cell-mediated immune response, which controls but does not clear the infection, thus enabling long-term parasite persistence in brain and muscle tissues....

journal_title：Frontiers in cellular and infection microbiology

authors： Ehmen HG,Lüder CGK

更新日期：2019-06-28 00:00:00

abstract：:Hundred-thousands of fungal species are present in our environment, including normal colonizers that constitute part of the human microbiota. The homeostasis of host-fungus interactions encompasses efficient fungal sensing, tolerance at mucosal surfaces, as well as antifungal defenses. Decrease in host immune fitness ...

journal_title：Frontiers in cellular and infection microbiology

authors： Bourgeois C,Kuchler K

更新日期：2012-11-22 00:00:00

abstract：:The frequent emergence of azole-resistant strains has increasingly led azoles to fail in treating candidiasis. Combination with other drugs is a good option to effectively reduce or retard its incidence of resistance. Natural products are a promising synergist source to assist azoles in treating resistant candidiasis....

journal_title：Frontiers in cellular and infection microbiology

authors： Xu J,Liu R,Sun F,An L,Shang Z,Kong L,Yang M

更新日期：2019-06-20 00:00:00

abstract：:The phenylacetic acid (PA) degradative pathway is the central pathway by which various aromatic compounds (e.g., styrene) are degraded. Upper pathways for different aromatic compounds converge at common intermediate phenylacetyl-CoA (PA-CoA), which is then metabolized to succinyl-CoA and acetyl-CoA. We previously made...

journal_title：Frontiers in cellular and infection microbiology

authors： Imolorhe IA,Cardona ST

更新日期：2011-12-14 00:00:00

abstract：:Preservation of health from infectious diseases depends upon both mucosal and systemic immunity via the collaborative effort of innate and adaptive immune responses. The proficiency of host immunity stems from robust defense mechanisms--physical barriers and specialized immune cells--and a failure of these mechanisms ...

journal_title：Frontiers in cellular and infection microbiology

authors： Denny JE,Powell WL,Schmidt NW

更新日期：2016-04-11 00:00:00

abstract：:Compounds with novel modes of action are urgently needed to develop effective combination therapies for the treatment of tuberculosis. In this study, a series of compounds was evaluated for activity against replicating Mycobacterium tuberculosis and Vero cell line toxicity. Fourteen of the compounds with in vitro acti...

journal_title：Frontiers in cellular and infection microbiology

authors： Chengalroyen MD,Jordaan A,Seldon R,Ioerger T,Franzblau SG,Nasr M,Warner DF,Mizrahi V

更新日期：2020-11-13 00:00:00

abstract：:During intestinal invasion, Entamoeba histolytica opens tight junctions (TJs) reflected by transepithelial electrical resistance (TEER) dropping. To explore the molecular mechanisms underlying this, we studied in vitro and in vivo the damage produced by the recombinant E. histolytica cysteine protease (rEhCP112) on TJ...

journal_title：Frontiers in cellular and infection microbiology

authors： Cuellar P,Hernández-Nava E,García-Rivera G,Chávez-Munguía B,Schnoor M,Betanzos A,Orozco E

更新日期：2017-08-16 00:00:00

abstract：:Programmed cell death plays crucial roles in organismal development and host defense. Recent studies have highlighted mechanistic overlaps and extensive, multifaceted crosstalk between pyroptosis, apoptosis, and necroptosis, three programmed cell death pathways traditionally considered autonomous. The growing body of ...

journal_title：Frontiers in cellular and infection microbiology

authors： Christgen S,Zheng M,Kesavardhana S,Karki R,Malireddi RKS,Banoth B,Place DE,Briard B,Sharma BR,Tuladhar S,Samir P,Burton A,Kanneganti TD

更新日期：2020-05-29 00:00:00

abstract：:The black yeast Exophiala dermatitidis is a widespread polyextremophile and human pathogen, that is found in extreme natural habitats and man-made environments such as dishwashers. It can cause various diseases ranging from phaeohyphomycosis and systemic infections, with fatality rates reaching 40%. While the number o...

journal_title：Frontiers in cellular and infection microbiology

authors： Poyntner C,Blasi B,Arcalis E,Mirastschijski U,Sterflinger K,Tafer H

更新日期：2016-10-24 00:00:00