Chronic Toxoplasma gondii Infection Exacerbates Secondary Polymicrobial Sepsis.

abstract：:Due to the importance of a rapid determination of patients infected by multidrug resistant bacteria, we evaluated two rapid diagnostic tests for the detection of third-generation cephalosporins (3GC)-resistant Enterobacterales directly from positive blood cultures within 1 h: BL-REDTM (electrochemical method) and β-LA...

journal_title：Frontiers in cellular and infection microbiology

authors： Durand C,Boudet A,Lavigne JP,Pantel A

更新日期：2020-09-11 00:00:00

abstract：:The plasma membrane of mammalian cells is susceptible to disruption by mechanical and biochemical damages that frequently occur within tissues. Therefore, efficient and rapid repair of the plasma membrane is essential for maintaining cellular homeostasis and survival. Excessive damage of the plasma membrane and defect...

journal_title：Frontiers in cellular and infection microbiology

authors： Pathak-Sharma S,Zhang X,Lam JGT,Weisleder N,Seveau SM

更新日期：2017-07-14 00:00:00

abstract：:Burkholderia pseudomallei is the causative agent of melioidosis, a rare disease of biodefense concern with high mortality and extreme difficulty in treatment. No human vaccines are available that protect against B. pseudomallei infection, and with the current limitations of antibiotic treatment, the development of new...

journal_title：Frontiers in cellular and infection microbiology

authors： Van Zandt KE,Tuanyok A,Keim PS,Warren RL,Gelhaus HC

更新日期：2012-09-26 00:00:00

abstract：:Dengue fever is an Aedes mosquito-borne illness caused by any one of the four different dengue virus (DENV) serotypes (1-4) and manifests in the form of symptoms ranging from mild or asymptomatic to severe disease with vascular leakage, leading to shock, and viral hemorrhagic syndrome. Increased risk of severe disease...

journal_title：Frontiers in cellular and infection microbiology

authors： Narayan R,Tripathi S

更新日期：2020-10-02 00:00:00

abstract：:Mycobacterium avium subspecies paratuberculosis (MAP) causes Johne's disease, a chronic granulomatous enteritis in ruminants. Furthermore, infections of humans with MAP have been reported and a possible association with Crohn's disease and diabetes type I is currently discussed. MAP owns large sequence polymorphisms (...

journal_title：Frontiers in cellular and infection microbiology

authors： Meißner T,Eckelt E,Basler T,Meens J,Heinzmann J,Suwandi A,Oelemann WM,Trenkamp S,Holst O,Weiss S,Bunk B,Spröer C,Gerlach GF,Goethe R

更新日期：2014-08-14 00:00:00

abstract：:Different species inhabit different sensory worlds and thus have evolved diverse means of processing information, learning and memory. In the escalated arms race with host defense, each pathogenic bacterium not only has evolved its individual cellular sensing and behavior, but also collective sensing, interbacterial c...

journal_title：Frontiers in cellular and infection microbiology

authors： Steinert M

更新日期：2014-01-31 00:00:00

abstract：:Pathogenic fungi have developed many strategies to evade the host immune system. Multiple escape mechanisms appear to function together to inhibit attack by the various stages of both the adaptive and the innate immune response. Thus, after entering the host, such pathogens fight to overcome the immune system to allow...

journal_title：Frontiers in cellular and infection microbiology

authors： Marcos CM,de Oliveira HC,de Melo WC,da Silva JF,Assato PA,Scorzoni L,Rossi SA,de Paula E Silva AC,Mendes-Giannini MJ,Fusco-Almeida AM

更新日期：2016-11-15 00:00:00

abstract：:Vaccination has had a major impact on the control of infectious diseases. However, there are still many infectious diseases for which the development of an effective vaccine has been elusive. In many cases the failure to devise vaccines is a consequence of the inability of vaccine candidates to evoke appropriate immun...

journal_title：Frontiers in cellular and infection microbiology

authors： Gregory AE,Titball R,Williamson D

更新日期：2013-03-25 00:00:00

abstract：:Pediculus humanus is an obligate bloodsucking ectoparasite of human that includes two ecotypes, head louse and body louse, which differ slightly in morphology and biology, but have distinct ecologies. Phylogenetically, they are classified on six mitochondrial clades (A, B, C, D, E, and F), head louse encompasses the f...

journal_title：Frontiers in cellular and infection microbiology

authors： Amanzougaghene N,Fenollar F,Raoult D,Mediannikov O

更新日期：2020-01-21 00:00:00

abstract：:The type VI secretion system (T6SS) secretes numerous toxins for bacteria-bacteria competition. TplE is a newly identified trans-kingdom toxin secreted by the T6SS in Pseudomonas aeruginosa, while TplEi neutralizes the toxic effect of TplE to protect bacteria autointoxication. Blocking the interaction of TplE-TplEi co...

journal_title：Frontiers in cellular and infection microbiology

authors： Gao X,Mu Z,Qin B,Sun Y,Cui S

更新日期：2017-09-20 00:00:00

abstract：:The cell surface mucin MUC1 is an important host factor limiting Helicobacter pylori (H. pylori) pathogenesis in both humans and mice by providing a protective barrier and modulating mucosal epithelial and leukocyte responses. The aim of this study was to establish the time-course of molecular events in MUC1-modulated...

journal_title：Frontiers in cellular and infection microbiology

authors： Sheng YH,Ng GZ,Summers KM,Every AL,Price G,Hasnain SZ,Sutton P,McGuckin MA

更新日期：2020-07-24 00:00:00

abstract：:Intestinal microbes are an important system in the human body, with significant effects on behavior. An increasing body of research indicates that intestinal microbes affect brain function and neurogenesis, including sensitivity to stress. To investigate the effects of microbial colonization on behavior, we examined b...

journal_title：Frontiers in cellular and infection microbiology

authors： Huo R,Zeng B,Zeng L,Cheng K,Li B,Luo Y,Wang H,Zhou C,Fang L,Li W,Niu R,Wei H,Xie P

更新日期：2017-11-30 00:00:00

abstract：:Streptococcus pneumoniae is a leading cause of bacterial pneumonia worldwide. Given the critical role of dendritic cells (DCs) in regulating and modulating the immune response to pathogens, we investigated here the role of DCs in S. pneumoniae lung infections. Using a well-established transgenic mouse line which allow...

journal_title：Frontiers in cellular and infection microbiology

authors： Rosendahl A,Bergmann S,Hammerschmidt S,Goldmann O,Medina E

更新日期：2013-06-21 00:00:00

abstract：:Enterohemorrhagic Escherichia coli (EHEC) O157:H7 EspF is an important multifunctional protein that destroys the tight junctions of intestinal epithelial cells and promotes host cell apoptosis. However, its molecular mechanism remains elusive. We knocked out the espF sequence (747 bp, ΔespF), N-terminal sequence (219 ...

journal_title：Frontiers in cellular and infection microbiology

authors： Wang X,Du Y,Hua Y,Fu M,Niu C,Zhang B,Zhao W,Zhang Q,Wan C

更新日期：2017-09-21 00:00:00

abstract：:Toxoplasma gondii has been found to infect almost all warm-blooded animals, including humans. In this study, a total of 3,275 human serum samples were collected from hospitals in five provinces of China. About 5.13% (168/3,275) (95% CI, 4.42-5.94) of the serum samples tested positive for T. gondii IgG antibody by a mo...

journal_title：Frontiers in cellular and infection microbiology

authors： Xin S,Su R,Jiang N,Zhang L,Yang Y

更新日期：2020-06-23 00:00:00

abstract：:Transition metal ions are essential micronutrients for all living organisms. In mammals, these ions are often protein-bound and sequestered within cells, limiting their availability to microbes. Moreover, in response to infection, mammalian hosts further reduce the availability of metal nutrients by activating epithel...

journal_title：Frontiers in cellular and infection microbiology

authors： Diaz-Ochoa VE,Jellbauer S,Klaus S,Raffatellu M

更新日期：2014-01-24 00:00:00

abstract：:Shigella is a Gram-negative bacterium that is responsible for shigellosis. Over the years, the study of Shigella has provided a greater understanding of how the host responds to bacterial infection, and how bacteria have evolved to effectively counter the host defenses. In this review, we provide an update on some of ...

journal_title：Frontiers in cellular and infection microbiology

authors： Killackey SA,Sorbara MT,Girardin SE

更新日期：2016-03-31 00:00:00

abstract：:The major Mycobacterium tuberculosis virulence factor ESAT-6 exported by the ESX-1 secretion system has been described as a pro-apoptotic factor by several independent groups in recent years, sustaining a role for apoptosis in M. tuberculosis pathogenesis. This role has been supported by independent studies in which a...

journal_title：Frontiers in cellular and infection microbiology

authors： Aguiló N,Marinova D,Martín C,Pardo J

更新日期：2013-12-04 00:00:00

abstract：:The frequent emergence of azole-resistant strains has increasingly led azoles to fail in treating candidiasis. Combination with other drugs is a good option to effectively reduce or retard its incidence of resistance. Natural products are a promising synergist source to assist azoles in treating resistant candidiasis....

journal_title：Frontiers in cellular and infection microbiology

authors： Xu J,Liu R,Sun F,An L,Shang Z,Kong L,Yang M

更新日期：2019-06-20 00:00:00

abstract：:The emerging relapsing fever spirochete Borrelia (B.) miyamotoi is transmitted by ixodid ticks and causes the so-called hard tick-borne relapsing fever or B. miyamotoi disease (BMD). More recently, we identified a surface-exposed molecule, CbiA exhibiting complement binding and inhibitory capacity and rendering spiroc...

journal_title：Frontiers in cellular and infection microbiology

authors： Nguyen NTT,Röttgerding F,Devraj G,Lin YP,Koenigs A,Kraiczy P

更新日期：2018-02-02 00:00:00

abstract：:Relapsing fever still remains a neglected disease and little is known on its reservoir, tick vector and physiopathology in the vertebrate host. The disease occurs in temperate as well as tropical countries. Relapsing fever borreliae are spirochaetes, members of the Borreliaceae family which also contain Lyme disease s...

journal_title：Frontiers in cellular and infection microbiology

authors： Talagrand-Reboul E,Boyer PH,Bergström S,Vial L,Boulanger N

更新日期：2018-04-04 00:00:00

abstract：:More than a decade ago a short tandem repeat-based typing method was developed for the fungus Aspergillus fumigatus. This STRAf assay is based on the analysis of nine short tandem repeat markers. Interpretation of this STRAf assay is complicated when there are only one or two differences in tandem repeat markers betwe...

journal_title：Frontiers in cellular and infection microbiology

authors： de Groot T,Meis JF

更新日期：2019-03-29 00:00:00

abstract：:Visceral leishmaniasis is a neglected tropical disease caused by Leishmania (L.) donovani parasite in the Indian subcontinent. Macrophages (mϕ) are the harboring cells for parasite and their interactions dictate the pathogenesis of this disease. Polyunsaturated fatty acids are an integral part of the mϕ cell membrane ...

journal_title：Frontiers in cellular and infection microbiology

authors： Saini S,Rai AK

更新日期：2020-08-07 00:00:00

abstract：:The development of new effective vaccines strongly depends on adjuvants and formulations able to stimulate not only strong humoral responses against a certain pathogen but also effector as well as memory CD4+ and CD8+ T cells (Dubensky et al., 2013). However, the majority of vaccines licensed for human use or currentl...

journal_title：Frontiers in cellular and infection microbiology

authors： Ebensen T,Delandre S,Prochnow B,Guzmán CA,Schulze K

更新日期：2019-02-19 00:00:00

abstract：:During intestinal invasion, Entamoeba histolytica opens tight junctions (TJs) reflected by transepithelial electrical resistance (TEER) dropping. To explore the molecular mechanisms underlying this, we studied in vitro and in vivo the damage produced by the recombinant E. histolytica cysteine protease (rEhCP112) on TJ...

journal_title：Frontiers in cellular and infection microbiology

authors： Cuellar P,Hernández-Nava E,García-Rivera G,Chávez-Munguía B,Schnoor M,Betanzos A,Orozco E

更新日期：2017-08-16 00:00:00

abstract：:Cerebral malaria is characterized by permanent cognitive impairments in Plasmodium-infected children. Antimalarial therapies show little effectiveness to avoid neurological deficits and brain tissue alterations elicited by severe malaria. Melatonin is a well-recognized endogenous hormone involved in the control of bra...

journal_title：Frontiers in cellular and infection microbiology

authors： Ataide BJA,Kauffmann N,Mendes NSF,Torres MLM,Dos Anjos LM,Passos ADCF,de Moraes SAS,Batista EJO,Herculano AM,Oliveira KRHM

更新日期：2020-09-30 00:00:00

abstract：:Mycoplasma bovis is an important cause of bovine respiratory disease worldwide. To understand its virulence mechanisms, we sequenced three attenuated M. bovis strains, P115, P150, and P180, which were passaged in vitro 115, 150, and 180 times, respectively, and exhibited progressively decreasing virulence. Comparative...

journal_title：Frontiers in cellular and infection microbiology

authors： Rasheed MA,Qi J,Zhu X,Chenfei H,Menghwar H,Khan FA,Zhao G,Zubair M,Hu C,Chen Y,Chen H,Guo A

更新日期：2017-05-11 00:00:00

abstract：:Enterobacteriaceae cause different types of community- and hospital-acquired infections. Moreover, the spread of multidrug-resistant Enterobacteriaceae is a public health problem and the World Health Organization pointed them among the pathogens in which the search of new antibiotics is critical. The objective of this...

journal_title：Frontiers in cellular and infection microbiology

authors： Cebrero-Cangueiro T,Álvarez-Marín R,Labrador-Herrera G,Smani Y,Cordero-Matía E,Pachón J,Pachón-Ibáñez ME

更新日期：2018-10-18 00:00:00

abstract：:Culture-independent metagenomic methodologies have enabled detection and identification of microorganisms in various biological systems and often revealed complex and unknown microbiomes. In many organisms, the microbiome outnumbers the host cells and greatly affects the host biology and fitness. Ticks are hematophago...

journal_title：Frontiers in cellular and infection microbiology

authors： Guizzo MG,Neupane S,Kucera M,Perner J,Frantová H,da Silva Vaz I,de Oliveira PL,Kopacek P,Zurek L

更新日期：2020-05-08 00:00:00

abstract：:The phenylacetic acid (PA) degradative pathway is the central pathway by which various aromatic compounds (e.g., styrene) are degraded. Upper pathways for different aromatic compounds converge at common intermediate phenylacetyl-CoA (PA-CoA), which is then metabolized to succinyl-CoA and acetyl-CoA. We previously made...

journal_title：Frontiers in cellular and infection microbiology

authors： Imolorhe IA,Cardona ST

更新日期：2011-12-14 00:00:00