Abstract:
:In the last decade it has become clear that, similarly to nucleated cells, enucleated red blood cells (RBCs) are susceptible to programmed apoptotic cell death. Erythrocytic apoptosis seems to play a role in physiological clearance of aged RBCs, but it may also be implicated in anemia of different etiological sources including drug therapy and infectious diseases. In malaria, severe anemia is a common complication leading to death of children and pregnant women living in malaria-endemic regions of Africa. The pathogenesis of malarial anemia is multifactorial and involves both ineffective production of RBCs by the bone marrow and premature elimination of non-parasitized RBCs, phenomena potentially associated with apoptosis. In the present overview, we discuss evidences associating erythrocytic apoptosis with the pathogenesis of severe malarial anemia, as well as with regulation of parasite clearance in malaria. Efforts to understand the role of erythrocytic apoptosis in malarial anemia can help to identify potential targets for therapeutic intervention based on apoptotic pathways and consequently, mitigate the harmful impact of malaria in global public health.
journal_name
Front Cell Infect Microbioljournal_title
Frontiers in cellular and infection microbiologyauthors
Totino PR,Daniel-Ribeiro CT,Ferreira-da-Cruz MFdoi
10.3389/fcimb.2016.00176subject
Has Abstractpub_date
2016-12-09 00:00:00pages
176issn
2235-2988journal_volume
6pub_type
杂志文章,评审abstract::Transition metal ions are essential micronutrients for all living organisms. In mammals, these ions are often protein-bound and sequestered within cells, limiting their availability to microbes. Moreover, in response to infection, mammalian hosts further reduce the availability of metal nutrients by activating epithel...
journal_title:Frontiers in cellular and infection microbiology
pub_type: 杂志文章,评审
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abstract::Radiation enteritis (RE) is a common complication in cancer patients receiving radiotherapy. Although studies have shown the changes of this disease at clinical, pathological and other levels, the dynamic characteristics of local microbiome and metabolomics are hitherto unknown. We aimed to examine the multi-omics fea...
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journal_title:Frontiers in cellular and infection microbiology
pub_type: 杂志文章,评审
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journal_title:Frontiers in cellular and infection microbiology
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journal_title:Frontiers in cellular and infection microbiology
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abstract::An attenuated vaccinia virus-MVTTEAB-was constructed by deletion of non-essential gene segments related to the immunomodulatory and virulence functions of the vaccinia virus Tiantan strain (VVTT). The shuttle plasmids pTC-EGFP, pTE-EGFP, pTA35-EGFP, pTB-EGFP, and pTA66-EGFP were constructed and combined with the early...
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Frontiers in cellular and infection microbiology
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journal_title:Frontiers in cellular and infection microbiology
pub_type: 杂志文章
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journal_title:Frontiers in cellular and infection microbiology
pub_type: 杂志文章
doi:10.3389/fcimb.2018.00107
更新日期:2018-04-05 00:00:00
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journal_title:Frontiers in cellular and infection microbiology
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journal_title:Frontiers in cellular and infection microbiology
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abstract::The major Mycobacterium tuberculosis virulence factor ESAT-6 exported by the ESX-1 secretion system has been described as a pro-apoptotic factor by several independent groups in recent years, sustaining a role for apoptosis in M. tuberculosis pathogenesis. This role has been supported by independent studies in which a...
journal_title:Frontiers in cellular and infection microbiology
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