The Gut Microbiome Signatures Discriminate Healthy From Pulmonary Tuberculosis Patients.

abstract：:In the last decade it has become clear that, similarly to nucleated cells, enucleated red blood cells (RBCs) are susceptible to programmed apoptotic cell death. Erythrocytic apoptosis seems to play a role in physiological clearance of aged RBCs, but it may also be implicated in anemia of different etiological sources ...

journal_title：Frontiers in cellular and infection microbiology

authors： Totino PR,Daniel-Ribeiro CT,Ferreira-da-Cruz MF

更新日期：2016-12-09 00:00:00

abstract：:Fusarium is an important genus of plant pathogenic fungi, and is widely distributed in soil and associated with plants worldwide. The diversity of mycoviruses in Fusarium is increasing continuously due to the development and extensive use of state-of-the-art RNA deep sequencing techniques. To date, fully-sequenced myc...

journal_title：Frontiers in cellular and infection microbiology

authors： Li P,Bhattacharjee P,Wang S,Zhang L,Ahmed I,Guo L

更新日期：2019-07-18 00:00:00

abstract：:The cell surface mucin MUC1 is an important host factor limiting Helicobacter pylori (H. pylori) pathogenesis in both humans and mice by providing a protective barrier and modulating mucosal epithelial and leukocyte responses. The aim of this study was to establish the time-course of molecular events in MUC1-modulated...

journal_title：Frontiers in cellular and infection microbiology

authors： Sheng YH,Ng GZ,Summers KM,Every AL,Price G,Hasnain SZ,Sutton P,McGuckin MA

更新日期：2020-07-24 00:00:00

abstract：:Programmed cell death plays crucial roles in organismal development and host defense. Recent studies have highlighted mechanistic overlaps and extensive, multifaceted crosstalk between pyroptosis, apoptosis, and necroptosis, three programmed cell death pathways traditionally considered autonomous. The growing body of ...

journal_title：Frontiers in cellular and infection microbiology

authors： Christgen S,Zheng M,Kesavardhana S,Karki R,Malireddi RKS,Banoth B,Place DE,Briard B,Sharma BR,Tuladhar S,Samir P,Burton A,Kanneganti TD

更新日期：2020-05-29 00:00:00

abstract：:Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis (TB), which leads to an estimated 1. 5 million deaths worldwide each year. Although the immune correlates of protection against Mtb infection and TB disease have not been well-defined, natural killer (NK) cells are increasingly recognized as a key...

journal_title：Frontiers in cellular and infection microbiology

authors： Harris LD,Khayumbi J,Ongalo J,Sasser LE,Tonui J,Campbell A,Odhiambo FH,Ouma SG,Alter G,Gandhi NR,Day CL

更新日期：2020-03-24 00:00:00

abstract：:Human coronaviruses, which can cause a range of infectious diseases, have been studied for nearly 60 years. The field has gained renewed interest from researchers around the world due to the COVID-19 outbreak in late 2019. Despite a large amount of research, little is known about the knowledge structure and developing...

journal_title：Frontiers in cellular and infection microbiology

authors： Deng Z,Chen J,Wang T

更新日期：2020-09-23 00:00:00

abstract：:Previous studies demonstrated that oral antibiotic (ABX) treatment prior to and during influenza A virus (IAV) infection of adult mice profoundly altered gut microbiota (GM) and was associated with increased susceptibility and impaired immunity to IAV. We examined the impact of ABX during critical times relevant to th...

journal_title：Frontiers in cellular and infection microbiology

authors： Fuglsang E,Pizzolla A,Krych L,Nielsen DS,Brooks AG,Frøkiær H,Reading PC

更新日期：2018-09-12 00:00:00

abstract：:In 2019, the United States Food and Drug Administration accorded restricted approval to Sanofi Pasteur's Dengvaxia, a live attenuated vaccine (LAV) for dengue fever, a mosquito-borne viral disease, caused by four antigenically distinct dengue virus serotypes (DENV 1-4). The reason for this limited approval is the conc...

journal_title：Frontiers in cellular and infection microbiology

authors： Shukla R,Ramasamy V,Shanmugam RK,Ahuja R,Khanna N

更新日期：2020-10-22 00:00:00

abstract：:Cleavage and activation of hemagglutinin (HA) by trypsin-like proteases in influenza A virus (IAV) are essential prerequisites for its successful infection and spread. In host cells, some transmembrane serine proteases such as TMPRSS2, TMPRSS4 and HAT, along with plasmin in the bloodstream, have been reported to cleav...

journal_title：Frontiers in cellular and infection microbiology

authors： Hayashi H,Kubo Y,Izumida M,Takahashi E,Kido H,Sato K,Yamaya M,Nishimura H,Nakayama K,Matsuyama T

更新日期：2018-03-23 00:00:00

abstract：:Vibrio parahaemolyticus, autochthonous to estuarine, marine, and coastal environments throughout the world, is the causative agent of food-borne gastroenteritis. More than 80 serotypes have been described worldwide, based on antigenic properties of the somatic (O) and capsular (K) antigens. Serovar O3:K6 emerged in In...

journal_title：Frontiers in cellular and infection microbiology

authors： Ceccarelli D,Hasan NA,Huq A,Colwell RR

更新日期：2013-12-11 00:00:00

abstract：:Bacteria comprise the earliest form of independent life on this planet. Bacterial development has included co-operative symbiosis with plants (e.g., Leguminosae family and nitrogen fixing bacteria in soil) and animals (e.g., the gut microbiome). A fusion event of two prokaryotes evolutionarily gave rise to the eukaryo...

journal_title：Frontiers in cellular and infection microbiology

authors： Vitetta L,Hall S,Linnane AW

更新日期：2014-10-15 00:00:00

abstract：:Pertussis is a respiratory infectious disease that has been resurged during the last decades. The change from the traditional multi-antigen whole-cell pertussis (wP) vaccines to acellular pertussis (aP) vaccines that consist of a few antigens formulated with alum, appears to be a key factor in the resurgence of pertus...

journal_title：Frontiers in cellular and infection microbiology

authors： Zurita ME,Wilk MM,Carriquiriborde F,Bartel E,Moreno G,Misiak A,Mills KHG,Hozbor D

更新日期：2019-04-26 00:00:00

abstract：:The natural history of genital Chlamydia trachomatis infections can vary widely; infections can spontaneously resolve but can also last from months to years, potentially progressing to cause significant pathology. The host and bacterial factors underlying this wide variation are not completely understood, but emphasiz...

journal_title：Frontiers in cellular and infection microbiology

authors： Aiyar A,Quayle AJ,Buckner LR,Sherchand SP,Chang TL,Zea AH,Martin DH,Belland RJ

更新日期：2014-06-03 00:00:00

abstract：:Protein secretion systems are vital for prokaryotic life, as they enable bacteria to acquire nutrients, communicate with other species, defend against biological and chemical agents, and facilitate disease through the delivery of virulence factors. In this review, we will focus on the recently discovered type IX secre...

journal_title：Frontiers in cellular and infection microbiology

authors： Lasica AM,Ksiazek M,Madej M,Potempa J

更新日期：2017-05-26 00:00:00

abstract：:With major advances in experimental techniques to track antigen-specific immune responses many basic questions on the kinetics of virus-specific immunity in humans remain unanswered. To gain insights into kinetics of T and B cell responses in human volunteers we combined mathematical models and experimental data from ...

journal_title：Frontiers in cellular and infection microbiology

authors： Le D,Miller JD,Ganusov VV

更新日期：2015-01-09 00:00:00

abstract：:Extracellular vesicles (EVs) have garnered much interest in the cell biology and biomedical research fields. Many studies have reported the existence of EVs in all types of living cells, including in fifteen different fungal genera. EVs play diverse biological roles, from the regulation of physiological events and res...

journal_title：Frontiers in cellular and infection microbiology

authors： Rizzo J,Rodrigues ML,Janbon G

更新日期：2020-07-15 00:00:00

abstract：:Pathogenic fungi have developed many strategies to evade the host immune system. Multiple escape mechanisms appear to function together to inhibit attack by the various stages of both the adaptive and the innate immune response. Thus, after entering the host, such pathogens fight to overcome the immune system to allow...

journal_title：Frontiers in cellular and infection microbiology

authors： Marcos CM,de Oliveira HC,de Melo WC,da Silva JF,Assato PA,Scorzoni L,Rossi SA,de Paula E Silva AC,Mendes-Giannini MJ,Fusco-Almeida AM

更新日期：2016-11-15 00:00:00

abstract：:Cytolethal distending toxin (CDT) produced by Campylobacter jejuni contains three subunits: CdtA, CdtB, and CdtC. Among these three toxin subunits, CdtB is the toxic moiety of CDT with DNase I activity, resulting in DNA double-strand breaks (DSB) and, consequently, cell cycle arrest at the G2/M stage and apoptosis. Ra...

journal_title：Frontiers in cellular and infection microbiology

authors： Lin HJ,Liu HH,Lin CD,Kao MC,Chen YA,Chiang-Ni C,Jiang ZP,Huang MZ,Lin CJ,Lo UG,Lin LC,Lai CK,Lin H,Hsieh JT,Chiu CH,Lai CH

更新日期：2017-06-08 00:00:00

abstract：:Natural killer (NK) cells are critical for targeting and killing tumor, virus-infected and stressed cells as a member of the innate immune system. Recently, NK cells have also emerged as key regulators of adaptive immunity and have become a prominent therapeutic target for cancer immunotherapy and infection control. N...

journal_title：Frontiers in cellular and infection microbiology

authors： Pierce S,Geanes ES,Bradley T

更新日期：2020-05-19 00:00:00

abstract：:The protozoan Trypanosoma cruzi is the etiological agent of Chagas disease. In immunosuppressed individuals, as it occurs in the coinfection with human immunodeficiency virus (HIV), the central nervous system may be affected. In this regard, reactivation of Chagas disease is severe and often lethal, and it accounts fo...

journal_title：Frontiers in cellular and infection microbiology

authors： Urquiza JM,Burgos JM,Ojeda DS,Pascuale CA,Leguizamón MS,Quarleri JF

更新日期：2017-08-02 00:00:00

abstract：:Shigella spp. are highly adapted human pathogens that cause bacillary dysentery (shigellosis). Via the type III secretion system (T3SS), Shigella deliver a subset of virulence proteins (effectors) that are responsible for pathogenesis, with functions including pyroptosis, invasion of the epithelial cells, intracellula...

journal_title：Frontiers in cellular and infection microbiology

authors： Ashida H,Sasakawa C

更新日期：2016-01-06 00:00:00

abstract：:Escherichia coli O157:H7 and other pathogenic E. coli strains are enteric pathogens associated with food safety threats and which remain a significant cause of morbidity and mortality worldwide. In the current study, we investigated whether enterohemorrhagic E. coli (EHEC), Shiga toxin-producing E. coli (STEC), and en...

journal_title：Frontiers in cellular and infection microbiology

authors： Botkin DJ,Galli L,Sankarapani V,Soler M,Rivas M,Torres AG

更新日期：2012-02-14 00:00:00

abstract：:Stress granules (SGs) are sites of mRNA storage that are formed in response to various conditions of stress, including viral infections. Porcine reproductive and respiratory syndrome virus (PRRSV) is an Arterivirus that has been devastating the swine industry worldwide since the late 1980s. In this study, we found tha...

journal_title：Frontiers in cellular and infection microbiology

authors： Zhou Y,Fang L,Wang D,Cai K,Chen H,Xiao S

更新日期：2017-04-04 00:00:00

abstract：:Pneumonia and meningitis continue to present an enormous public health burden and pose a major threat to young children. Among the causative organisms of pneumonia and meningitis, bacteria are the most common causes of serious disease and deaths. It is challenging to accurately and rapidly identify these agents. To so...

journal_title：Frontiers in cellular and infection microbiology

authors： Zhang C,Xiu L,Xiao Y,Xie Z,Ren L,Peng J

更新日期：2018-04-05 00:00:00

abstract：:The spread of microorganisms in hospitals is an important public health threat, and yet few studies have assessed how human microbial communities (microbiota) evolve in the hospital setting. Studies conducted so far have mainly focused on a limited number of bacterial species, mostly pathogenic ones and primarily duri...

journal_title：Frontiers in cellular and infection microbiology

authors： Lazarevic V,Gaïa N,Emonet S,Girard M,Renzi G,Despres L,Wozniak H,Yugueros Marcos J,Veyrieras JB,Chatellier S,van Belkum A,Pugin J,Schrenzel J

更新日期：2014-05-23 00:00:00

abstract：:Chronic otitis media with effusion (COME) is a common childhood disease characterized by an accumulation of fluid behind the eardrum. COME often requires surgical intervention and can also lead to significant hearing loss and subsequent learning disabilities. Recent characterization of the middle ear fluid (MEF) micro...

journal_title：Frontiers in cellular and infection microbiology

authors： Kolbe AR,Castro-Nallar E,Preciado D,Pérez-Losada M

更新日期：2019-10-04 00:00:00

abstract：:The formation of biofilms by Staphylococcus aureus and Staphylococcus epidermidis is an important aspect of many staphylococcal infections, most notably endocarditis, osteomyelitis and infections associated with indwelling medical devices. The major constituents of staphylococcal biofilms are polysaccharides, such as ...

journal_title：Frontiers in cellular and infection microbiology

authors： Cue D,Lei MG,Lee CY

更新日期：2012-03-26 00:00:00

abstract：:Burkholderia cenocepacia is an opportunistic respiratory pathogen of individuals with cystic fibrosis (CF). Some strains of B. cenocepacia are highly transmissible and resistant to almost all antibiotics. Approximately one-third of B. cenocepacia infected CF patients go on to develop fatal "cepacia syndrome." During t...

journal_title：Frontiers in cellular and infection microbiology

authors： Ganesan S,Sajjan US

更新日期：2012-01-11 00:00:00

abstract：:Francisella tularensis can bypass and suppress host immune responses, even to the point of manipulating immune cell phenotypes and intercellular inflammatory networks. Strengthening these responses such that immune cells more readily identify and destroy the bacteria is likely to become a viable (and perhaps necessary...

journal_title：Frontiers in cellular and infection microbiology

authors： Gillette DD,Tridandapani S,Butchar JP

更新日期：2014-02-21 00:00:00

abstract：:Anopheles female mosquitoes can transmit Plasmodium, the malaria parasite. During their aquatic life, wild Anopheles mosquito larvae are exposed to a huge diversity of microbes present in their breeding sites. Later, adult females often take successive blood meals that might also carry different micro-organisms, inclu...

journal_title：Frontiers in cellular and infection microbiology

authors： Dieme C,Rotureau B,Mitri C

更新日期：2017-12-07 00:00:00