Intracerebroventricular injection of neosurugatoxin induces a prolonged blockade of brain nicotinic acetylcholine receptors.

abstract：:In addition to its well-known interaction with ionotropic and metabotropic receptors, glutamate may, at high concentrations, interfere with a cystine-glutamate antiport designated as Xc- and lead to a significant decrease in cystine uptake and intracellular glutathione level. These effects, in turn, may induce death i...

journal_title：European journal of pharmacology

authors： Froissard P,Monrocq H,Duval D

更新日期：1997-05-12 00:00:00

abstract：:Barbiturates derived by minor structural changes to the butenyl sidechain of the convulsant 5-ethyl-5-(3'-methyl-but-2'-enyl)-barbituric acid are almost devoid of convulsant activity, but all have anaesthetic and anticonvulsant effects. Anticonvulsant activity is also observed in the convulsant barbiturate. Increased ...

journal_title：European journal of pharmacology

authors： Andrews PR,Jones GP,Lodge D

更新日期：1979-04-15 00:00:00

abstract：:We used in vitro autoradiography to identify the endothelin-1 receptor subtype(s) in the superficial gray layer of the superior colliculus of rats. These studies showed dense binding of (3-[125I]iodotyrosyl13)-[Ala11,15]Ac-endothelin-1-(6-2 1) (BQ3020) (for endothelin ETB receptors), while tissues incubated with [125I...

journal_title：European journal of pharmacology

authors： D'Amico M,Di Filippo C,Rossi F

更新日期：1998-04-17 00:00:00

abstract：:The effects of several slow channel blockers were compared on the normal fast action potentials (APs) and the slow APs of guinea pig Purkinje fibers. In spontaneously-firing Purkinje fibers perfused with normal Tyrode solution, mesudipine (analog of nifedipine) at 10(-7) and 10(-6) M, had no significant effect on the ...

journal_title：European journal of pharmacology

authors： Molyvdas PA,Sperelakis N

更新日期：1983-03-25 00:00:00

abstract：:The effects of GABA and diazepam on the spontaneous and potassium-evoked release of 3H-5-HT from rat hippocampal synaptosomes, preloaded by incubation with 3H-5-HT, have been investigated. Both GABA and diazepam independently increased the spontaneous release of 5-HT whereas they blocked the calcium-dependent, potassi...

journal_title：European journal of pharmacology

authors： Balfour DJ

更新日期：1980-11-07 00:00:00

abstract：:A study was undertaken to ascertain why in the mouse vas deferens excitatory junction potentials facilitate whereas contractions depress during low frequency stimulation. In a set of contraction studies, where a conditioning stimulus was followed 2 s later by a test stimulus, depression in the first phase of contracti...

journal_title：European journal of pharmacology

authors： Karunanithi S,Lavidis NA,Bennett MR

更新日期：1994-08-11 00:00:00

abstract：:Some antidepressants, as well as antiepileptics, are effective for treating pain of varying etiology. The present study was designed to characterize the antinociceptive effects of imipramine, a tricyclic antidepressant, fluvoxamine, a selective serotonin reuptake inhibitor, milnacipran, a serotonin noradrenaline reupt...

journal_title：European journal of pharmacology

authors： Aoki M,Tsuji M,Takeda H,Harada Y,Nohara J,Matsumiya T,Chiba H

更新日期：2006-11-21 00:00:00

abstract：:To test the hypothesis that serotonergic modulation of the effects of phencyclidine (PCP) are due to circuit- rather than receptor-based interactions between glutamatergic and serotonergic systems, multivariate profiles of rat behavior were assessed after treatments with the 5-hydroxytryptamine (5-HT) 5-HT2 receptor a...

journal_title：European journal of pharmacology

authors： Krebs-Thomson K,Lehmann-Masten V,Naiem S,Paulus MP,Geyer MA

更新日期：1998-02-19 00:00:00

abstract：:The endocannabinoid system appears to have an important role in specific aspects of learning and memory, yet there has been no systematic study of the role of cannabinoid receptors in contextual fear conditioning. The present study examined the effects of cannabinoid CB(1) receptor blockade on the acquisition, consoli...

journal_title：European journal of pharmacology

authors： Arenos JD,Musty RE,Bucci DJ

更新日期：2006-06-13 00:00:00

abstract：:Precipitated withdrawal in rats chronically exposed to delta 9-tetrahydrocannabinol, the major psychoactive principle of the marijuana plant, was unequivocally demonstrated for the first time using a selective antagonist, SR 141716A (N-(piperidin-1-yl)-5-(4-chlorophenyl)-1(2,4- dichloro-phenyl)-4-methyl-1H-pyrazole ca...

journal_title：European journal of pharmacology

authors： Aceto MD,Scates SM,Lowe JA,Martin BR

更新日期：1995-08-25 00:00:00

abstract：:Nitric oxide (10 ppm) inhaled by pigs before or during endotoxin shock induced by an infusion of E. coli lipopolysaccharide. Nitric oxide inhalation selectively attenuated pulmonary hypertension during endotoxin infusion without influencing mean arterial blood pressure and cardiac output. Upon cessation of nitric oxid...

journal_title：European journal of pharmacology

authors： Weitzberg E,Rudehill A,Lundberg JM

更新日期：1993-03-16 00:00:00

abstract：:The effects of the serotonin (5-HT) precursor L-tryptophan on MDMA (3,4-methylenedioxymethamphetamine)-induced inhibition of dorsal raphe neuronal firing were characterized using extracellular single-unit recording and microdialysis techniques in the in vitro midbrain slice preparation. Pretreatment with L-tryptophan ...

journal_title：European journal of pharmacology

authors： Sprouse JS,Bradberry CW,Roth RH,Aghajanian GK

更新日期：1990-03-27 00:00:00

abstract：:Binding of the radioligand [125I]iodoclonazepam to three different areas of rat brain (cerebellum, hippocampus and striatum) has been characterised. In all three regions binding is rapid, saturable and of high affinity (cerebellum Bmax = 1.49 +/- 0.3 pmol/mg of protein, Kd = 0.39 +/- 0.06 nM; hippocampus Bmax = 1.5 +/...

journal_title：European journal of pharmacology

authors： Gillard NP,Quirk K,Ragan CI,McKernan RM

更新日期：1991-04-03 00:00:00

abstract：:We have made extracellular recordings from locus coeruleus neurones contained in a pontine slice preparation. The in vitro technique permits application of known concentrations of drugs in the perfusion medium. Substance P excites locus coeruleus neurones in a concentration-dependent manner. The activity of substance ...

journal_title：European journal of pharmacology

authors： Cheeseman HJ,Pinnock RD,Henderson G

更新日期：1983-10-14 00:00:00

abstract：:(+/-)3,4-Methylenedioxymethamphetamine (MDMA) was administered to rats as a single 40 mg/kg injection s.c. or 40 mg/kg s.c. every second day for 4 injections. Sixteen days following the last injection rats were killed. MDMA produced significant depletions of 5-HT and its metabolite 5-HIAA in the hippocampus and the fr...

journal_title：European journal of pharmacology

authors： Mokler DJ,Robinson SE,Rosecrans JA

更新日期：1987-06-19 00:00:00

abstract：:The effects of baicalein, a flavonoid, and alpha-tocopherol (vitamin E) on lipid peroxidation in rat forebrain homogenates, on free radical scavenging action against diphenyl-p-picrylhydrazyl (DPPH), and on 12-O-tetradecanoylphorbol acetate (TPA)-induced ear edema in mice were studied. Baicalein inhibited lipid peroxi...

journal_title：European journal of pharmacology

authors： Hara H,Sukamoto T,Ohtaka H,Abe K,Tatumi Y,Saito Y,Suzuki A,Tsukamoto G

更新日期：1992-10-20 00:00:00

abstract：:Intracellular Ca2+ overload induced by hypoxia-reoxygenation alters Ca2+ homeostasis, which plays an important role in myocardial cell injury. Even though propofol is known as a radical scavenger with Ca2+ channel blocking properties, little is known about cardioprotective effect associated with Ca2+ homeostasis in ca...

journal_title：European journal of pharmacology

authors： Kim HS,Chang WC,Hwang KC,Choi IG,Park WK

更新日期：2008-10-10 00:00:00

abstract：:Natural purines like ATP, ADP and adenosine have crucial roles in platelet physiology. This knowledge has been significant in drug development and today ADP receptor antagonists are widely used for prevention of thrombotic events following myocardial infarction and ischaemic stroke. Recent studies have shown that a pu...

journal_title：European journal of pharmacology

authors： Kardeby C,Paramel GV,Pournara D,Fotopoulou T,Sirsjö A,Koufaki M,Fransén K,Grenegård M

更新日期：2019-08-15 00:00:00

abstract：:The influence of CGS 21680, an adenosine A2A receptor agonist, on striatal glutamate extracellular levels was tested in a microdialysis study in rats. CGS 21680 (10 mu M), infused intrastriatally through the microdialysis probe, greatly enhanced glutamate extracellular levels. These results show that striatal adenosin...

journal_title：European journal of pharmacology

authors： Popoli P,Betto P,Reggio R,Ricciarello G

更新日期：1995-12-12 00:00:00

abstract：:Irisin, the soluble secreted form of fibronectin type III domain containing 5 (FNDC5)-cleaved product, is a recently identified adipo-myokine that has been indicated as a possible link between physical exercise and energetic homeostasis. The co-localization of irisin with neuropeptide Y in hypothalamic sections of par...

journal_title：European journal of pharmacology

authors： Ferrante C,Orlando G,Recinella L,Leone S,Chiavaroli A,Di Nisio C,Shohreh R,Manippa F,Ricciuti A,Vacca M,Brunetti L

更新日期：2016-11-15 00:00:00

abstract：:Osthole is a coumarin extracted from Cnidium monnieri (L.) Cusson. The medicinal plant is widely used in Vietnamese as well as Chinese traditional medicine as a vasodilating and antihypertensive agent. Here we have tested the proposition that the block of Ca(v)1.2 channels is mainly responsible for its vascular activi...

journal_title：European journal of pharmacology

authors： Fusi F,Sgaragli G,Ha le M,Cuong NM,Saponara S

更新日期：2012-04-05 00:00:00

abstract：:Agmatine, an endogenous ligand for imidazoline I(1) receptor, has previously been shown to prevent opioid tolerance in rats and mice, but the cellular mechanisms remain unknown. In the present study, the effects of agmatine activation on imidazoline I(1) receptor on the desensitization, down-regulation and internaliza...

journal_title：European journal of pharmacology

authors： Gao Y,Li F,Wu N,Su RB,Liu Y,Lu XQ,Liu Y,Li J

更新日期：2008-12-03 00:00:00

abstract：:We have shown that the major active agent of Cannabis sativa, Delta(9)-tetrahydrocannabinol, activates peroxisome proliferator-activated receptor gamma [PPARgamma, O'Sullivan, S.E., Tarling, E.J., Bennett, A.J., Kendall, D.A., Randall, M.D., 2005c. Novel time-dependent vascular actions of delta9-tetrahydrocannabinol m...

journal_title：European journal of pharmacology

authors： O'Sullivan SE,Sun Y,Bennett AJ,Randall MD,Kendall DA

更新日期：2009-06-10 00:00:00

abstract：:Nitric oxide (NO) and prostacyclin (PGI(2)) are two of the most important vasodilators produced by endothelial cells, the regulation of NO on PGI(2) production has not been fully clear yet. Polyaspartoyl.L-arginine (PDR) is an L-arginine residue-rich compound with inhibitory effects of platelet aggregation and thrombo...

journal_title：European journal of pharmacology

authors： Tang Z,Yang J,Liu X,Wang Y,Peng S

更新日期：2008-12-28 00:00:00

abstract：:The effect of diethyldithiocarbamate (DETC, 10(-3) M) on the vasorelaxant activity of acetylcholine, nitric oxide (NO), nitrite, glyceryl trinitrate or dinitrosyl iron cysteine complexes was studied in isolated rat aortic rings contracted with norepinephrine. Pretreatment of these segments with DETC attenuated the vas...

journal_title：European journal of pharmacology

authors： Vedernikov YP,Mordvintcev PI,Malenkova IV,Vanin AF

更新日期：1992-02-25 00:00:00

abstract：:The effects of hyperosmotic solutions of xylitol were tested on acid and bicarbonate outputs from the rat stomach as well as on acid back-diffusion. Hyperosmotic solutions were instilled into anesthetized rats by an esophageal cannula and drained through a duodenal catheter. Spontaneously secreting and histamine-stimu...

journal_title：European journal of pharmacology

authors： Assouline G,Danon A

更新日期：1984-07-13 00:00:00

abstract：:Thirteen Ca2+ entry blockers were compared with respect to their inhibitory effects on the activity of smooth muscle myosin light-chain kinase and smooth muscle protein kinase C, and the Ca2+-induced contraction of basilar artery rings. Comparison of the IC50 values obtained for these compounds, suggests that with the...

journal_title：European journal of pharmacology

authors： Schächtele C,Wagner B,Rudolph C

更新日期：1989-04-12 00:00:00

abstract：:Pirfenidone recently received FDA approval as one of the first two drugs designed to treat idiopathic pulmonary fibrosis. While the clinical data continues to support the efficacy of pirfenidone, the specific molecular mechanism of action of this drug has not been fully defined. From a chemical perspective the compara...

journal_title：European journal of pharmacology

authors： Haak AJ,Girtman MA,Ali MF,Carmona EM,Limper AH,Tschumperlin DJ

更新日期：2017-09-15 00:00:00

abstract：:Alopecia is resulted from various factors that can decrease the regeneration capability of hair follicles and affect hair cycles. This process can be devastating physically and psychologically. Nevertheless, the available treatment strategies are limited, and the therapeutic outcomes are not satisfactory. According to...

journal_title：European journal of pharmacology

authors： Yuan AR,Bian Q,Gao JQ

更新日期：2020-08-15 00:00:00

abstract：:Recently, it has been revealed that angiotensin II type 1 receptor (AT(1)) antagonists act as antiarrhythmic agents and that the T-type Ca2+ channel plays an important role in arrhythmia. However, it remains unclear how the T-type Ca2+ channel expression system is involved in angiotensin II-mediated arrhythmogenesis i...

journal_title：European journal of pharmacology

authors： Morishima M,Wang Y,Akiyoshi Y,Miyamoto S,Ono K

更新日期：2009-05-01 00:00:00