Abstract：
:The effects of baicalein, a flavonoid, and alpha-tocopherol (vitamin E) on lipid peroxidation in rat forebrain homogenates, on free radical scavenging action against diphenyl-p-picrylhydrazyl (DPPH), and on 12-O-tetradecanoylphorbol acetate (TPA)-induced ear edema in mice were studied. Baicalein inhibited lipid peroxidation in forebrain homogenates, DPPH-induced free radical and TPA-induced ear edema as potently as did quercetin and nordihydroguaiaretic acid (NDGA), a lipoxygenase inhibitor, and more potently than BW755C, a mixed cyclooxygenase and lipoxygenase inhibitor. Lipid peroxidation in forebrain homogenates, DPPH-induced free radical and TPA-induced ear edema were also inhibited by alpha-tocopherol. Flavone showed no reaction. These results suggest that lipid peroxidation may play an important role in the pathogenesis of TPA-induced ear edema in mice.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Hara H,Sukamoto T,Ohtaka H,Abe K,Tatumi Y,Saito Y,Suzuki A,Tsukamoto Gdoi
10.1016/0014-2999(92)90700-ekeywords:
subject
Has Abstractpub_date
1992-10-20 00:00:00pages
193-8issue
2-3eissn
0014-2999issn
1879-0712pii
0014-2999(92)90700-Ejournal_volume
221pub_type
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