Abstract:
:While much progress has been made in how brain organization supports language function, the language network's ability to adapt to immediate disturbances by means of reorganization remains unclear. The aim of this study was to examine acute reorganizational changes in brain activity related to conceptual and lexical retrieval in unimpaired language production following transient disruption of the left middle temporal gyrus (MTG). In a randomized single-blind within-subject experiment, we recorded the electroencephalogram from 16 healthy participants during a context-driven picture-naming task. Prior to the task, the left MTG was perturbed with real continuous theta-burst stimulation (cTBS) or sham stimulation. During the task, participants read lead-in sentences creating a constraining (e.g., "The farmer milks the") or nonconstraining context (e.g., "The farmer buys the"). The last word was shown as a picture that participants had to name (e.g., "cow"). Replicating behavioral studies, participants were overall faster in naming pictures following a constraining relative to a nonconstraining context, but this effect did not differ between real and sham cTBS. In contrast, real cTBS increased overall error rates compared to sham cTBS. In line with previous studies, we observed a decrease in alpha-beta (8-24 Hz) oscillatory power for constraining relative to nonconstraining contexts over left temporal-parietal cortex after participants received sham cTBS. However, following real cTBS, this decrease extended toward left prefrontal regions associated with both domain-general and domain-specific control mechanisms. Our findings provide evidence that immediately after perturbing the left MTG, the lexical-semantic network is able to quickly reconfigure, also recruiting domain-general regions.
journal_name
Hum Brain Mappjournal_title
Human brain mappingauthors
Klaus J,Schutter DJLG,Piai Vdoi
10.1002/hbm.24860subject
Has Abstractpub_date
2020-03-01 00:00:00pages
1061-1071issue
4eissn
1065-9471issn
1097-0193journal_volume
41pub_type
杂志文章abstract::We present a novel, computerized method of examining cerebral cortical thickness. The normal cortex varies in thickness from 2 to 4 mm, reflecting the morphology of neuronal sublayers. Cortical pathologies often manifest abnormal variations in thickness, with examples of Alzheimer's disease and cortical dysplasia as t...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/1097-0193(200009)11:1<12::aid-hbm20>3.0.co
更新日期:2000-09-01 00:00:00
abstract::We used computer simulations to investigate finite element models of the layered structure of the human skull in EEG source analysis. Local models, where each skull location was modeled differently, and global models, where the skull was assumed to be homogeneous, were compared to a reference model, in which spongy an...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21114
更新日期:2011-09-01 00:00:00
abstract::Functional neuroimaging studies in adults show that aggression involves reduced brain communication between subcortical and cortical areas dedicated to motivation and control, respectively. Prior research indicates that sex steroid hormone production during adolescence negatively influences the rapid development of wh...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22684
更新日期:2015-03-01 00:00:00
abstract::The development of language, social interaction, and communicative skills are remarkably different in the child with autism spectrum disorder (ASD). Atypical brain connectivity has frequently been reported in this patient population. However, the interplay between their brain connectivity and language performance rema...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22424
更新日期:2014-08-01 00:00:00
abstract::In early blindness, the primary visual area (PVA) loses the ability to process visual information, and shifts to working on the processing of somatosensory input, auditory input, and some higher-level cognitive functions. It has not yet been investigated whether such functional changes can lead to alterations of the f...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20420
更新日期:2008-05-01 00:00:00
abstract::Inattentional deafness is the failure to hear otherwise audible sounds (usually alarms) that may occur under high workload conditions. One potential cause for its occurrence could be an attentional bottleneck that occurs when task demands are high, resulting in lack of resources for processing of additional tasks. In ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23735
更新日期:2017-11-01 00:00:00
abstract::The amygdala, a small deep brain structure involved in behavioral processing through interactions with other brain regions, has garnered increased attention in recent years in relation to pain processing. As pain is a multidimensional experience that encompasses physical sensation, affect, and cognition, the amygdala ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22199
更新日期:2014-02-01 00:00:00
abstract::Although the brain areas in the default-mode network (DMN) act in a coordinated way during rest, the activity levels in the individual areas of the DMN are highly heterogeneous. The relation between the activity levels and the pattern of causal interaction among the DMN areas remains unknown. In the present fMRI study...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21065
更新日期:2011-01-01 00:00:00
abstract::The willingness to incur personal costs to enforce prosocial norms represents a hallmark of human civilization. Although recent neuroscience studies have used the ultimatum game to understand the neuropsychological mechanisms that underlie the enforcement of fairness norms; however, a precise characterization of the n...
journal_title:Human brain mapping
pub_type: 杂志文章,meta分析
doi:10.1002/hbm.22649
更新日期:2015-02-01 00:00:00
abstract::This paper describes a Bayesian method for three-dimensional registration of brain images. A finite element approach is used to obtain a maximum a posteriori estimate of the deformation field at every voxel of a template volume. The priors used by the MAP estimate penalize unlikely deformations and enforce a continuou...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/(sici)1097-0193(200004)9:4<212::aid-hbm3>3
更新日期:2000-04-01 00:00:00
abstract::Magnetic resonance imaging (MRI) studies of fetal alcohol spectrum disorder (FASD) have shown reductions of brain volume associated with prenatal exposure to alcohol. Previous studies consider regional brain volumes independently but ignore potential relationships across numerous structures. This study aims to (a) ide...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24867
更新日期:2020-04-01 00:00:00
abstract::Estimating the thickness of the cerebral cortex is a key step in many brain imaging studies, revealing valuable information on development or disease progression. In this work, we present a framework for measuring the cortical thickness, based on minimizing line integrals over the probability map of the gray matter in...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20740
更新日期:2009-10-01 00:00:00
abstract::We investigated neural substrates of global/local processing of bilateral hierarchical stimuli using functional magnetic resonance imaging (fMRI). Subjects were presented with two compound letters that were displayed simultaneously in the left and right visual fields, respectively. In a steady-state, block-design para...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20044
更新日期:2004-08-01 00:00:00
abstract::The functional role of the left ventral occipito-temporal cortex (vOT) in visual word processing has been studied extensively. A prominent observation is higher activation for unfamiliar but pronounceable letter strings compared to regular words in this region. Some functional accounts have interpreted this finding as...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22281
更新日期:2014-04-01 00:00:00
abstract::To test a prediction of our previous computational model of cortico-hippocampal interaction (Gluck and Myers [1993, 2001]) for characterizing individual differences in category learning, we studied young healthy subjects using an fMRI-adapted category-learning task that has two phases, an initial phase in which associ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22389
更新日期:2014-07-01 00:00:00
abstract::Studies have found non-negligible differences in cortical thickness estimates across versions of software that are used for processing and quantifying MRI-based cortical measurements, and issues have arisen regarding these differences, as obtained estimates could potentially affect the validity of the results. However...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23139
更新日期:2016-05-01 00:00:00
abstract::Previous studies on crossmodal spatial orienting typically used simple and stereotyped stimuli in the absence of any meaningful context. This study combined computational models, behavioural measures and functional magnetic resonance imaging to investigate audiovisual spatial interactions in naturalistic settings. We ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22276
更新日期:2014-04-01 00:00:00
abstract::It is assumed widely that the clinical expression of Parkinson's Disease (PD), both motor and cognitive, is subtended by topographically distributed brain networks. However, little is known about the functional neuroanatomy of executive dysfunction in PD. Our objective was to validate further in a PD group the use of ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20033
更新日期:2004-07-01 00:00:00
abstract::During complex tasks, patterns of functional connectivity differ from those in the resting state. However, what accounts for such differences remains unclear. Brain activity during a task reflects an unknown mixture of spontaneous and task-evoked activities. The difference in functional connectivity between a task sta...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24335
更新日期:2018-12-01 00:00:00
abstract::The neurons of the human cerebral cortex are arranged in a highly folded sheet, with the majority of the cortical surface area buried in folds. Cortical maps are typically arranged with a topography oriented parallel to the cortical surface. Despite this unambiguous sheetlike geometry, the most commonly used coordinat...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/(sici)1097-0193(1999)8:4<272::aid-hbm10>3.
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVES:Recovery of independent ambulation after stroke is a major goal. However, which rehabilitation regimen best benefits each individual is unknown and decisions are currently made on a subjective basis. Predictors of response to specific therapies would guide the type of therapy most appropriate for each patien...
journal_title:Human brain mapping
pub_type: 杂志文章,随机对照试验
doi:10.1002/hbm.23059
更新日期:2016-02-01 00:00:00
abstract::Human albinism is characterized by a disturbance of the chiasmatic projection system leading to predominant representation of just one eye in the contralateral hemisphere. Patients show congenital nystagmus without perceiving oscillopsia. The purpose of the present study was to demonstrate the consequences of atypical...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20046
更新日期:2004-09-01 00:00:00
abstract::Mirror neurons, originally described in the monkey premotor area F5, are embedded in a frontoparietal network for action execution and observation. A similar Mirror Neuron System (MNS) exists in humans, including precentral gyrus, inferior parietal lobule, and superior temporal sulcus. Controversial is the inclusion o...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22682
更新日期:2015-03-01 00:00:00
abstract::Task-switching performance relies on a broadly distributed frontoparietal network and declines in older adults. In this study, they investigated whether this age-related decline in task switching performance was mediated by variability in global or regional white matter microstructural health. Seventy cognitively inta...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23473
更新日期:2017-03-01 00:00:00
abstract::Current theories of automatic or preattentive change detection suggest a regularity or prediction violation mechanism involving functional connectivity between the inferior frontal cortex (IFC) and the superior temporal cortex (STC). By disrupting the IFC function with transcranial magnetic stimulation (TMS) and recor...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24984
更新日期:2020-08-01 00:00:00
abstract::Recent work has demonstrated that functional connectivity between remote brain regions can be modulated by task learning or the performance of an already well-learned task. Here, we investigated the extent to which initial learning and stable performance of a spatial navigation task modulates functional connectivity b...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22700
更新日期:2015-04-01 00:00:00
abstract::Own body perception, and differentiating and comparing one's body to another person's body, are common cognitive functions that have relevance for self-identity and social interactions. In several psychiatric conditions, including anorexia nervosa, body dysmorphic disorder, gender dysphoria, and autism spectrum disord...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24388
更新日期:2019-02-01 00:00:00
abstract::Active listening has been reported to elicit a different sensory response from passive listening and is generally observed as an increase in the magnitude of activation. Sensory activation differences may therefore be masked by the effect of attention. The present study measured activation induced by static and modula...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:
更新日期:2000-07-01 00:00:00
abstract::Machine learning has increasingly been applied to classification of schizophrenia in neuroimaging research. However, direct replication studies and studies seeking to investigate generalizability are scarce. To address these issues, we assessed within-site and between-site generalizability of a machine learning classi...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24797
更新日期:2020-01-01 00:00:00
abstract::The present study examines the neural substrates for the perception of speech rhythm and intonation. Subjects listened passively to synthesized speech stimuli that contained no semantic and phonological information, in three conditions: (1) continuous speech stimuli with fixed syllable duration and fundamental frequen...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20922
更新日期:2010-07-01 00:00:00