Prediction model for patients with acute respiratory distress syndrome: use of a genetic algorithm to develop a neural network model.

Abstract:

Background:Acute respiratory distress syndrome (ARDS) is associated with significantly increased risk of death, and early risk stratification may help to choose the appropriate treatment. The study aimed to develop a neural network model by using a genetic algorithm (GA) for the prediction of mortality in patients with ARDS. Methods:This was a secondary analysis of two multicenter randomized controlled trials conducted in forty-four hospitals that are members of the National Heart, Lung, and Blood Institute, founded to create an acute respiratory distress syndrome Clinical Trials Network. Model training and validation were performed using the SAILS and OMEGA studies, respectively. A GA was employed to screen variables in order to predict 90-day mortality, and a neural network model was trained for the prediction. This machine learning model was compared to the logistic regression model and APACHE III score in the validation cohort. Results:A total number of 1,071 ARDS patients were included for analysis. The GA search identified seven important variables, which were age, AIDS, leukemia, metastatic tumor, hepatic failure, lowest albumin, and FiO2. A representative neural network model was constructed using the forward selection procedure. The area under the curve (AUC) of the neural network model evaluated with the validation cohort was 0.821 (95% CI [0.753-0.888]), which was greater than the APACHE III score (0.665; 95% CI [0.590-0.739]; p = 0.002 by Delong's test) and logistic regression model, albeit not statistically significant (0.743; 95% CI [0.669-0.817], p = 0.130 by Delong's test). Conclusions:The study developed a neural network model using a GA, which outperformed conventional scoring systems for the prediction of mortality in ARDS patients.

journal_name

PeerJ

journal_title

PeerJ

authors

Zhang Z

doi

10.7717/peerj.7719

subject

Has Abstract

pub_date

2019-09-16 00:00:00

pages

e7719

issn

2167-8359

pii

7719

journal_volume

7

pub_type

杂志文章

相关文献

PeerJ文献大全
  • Effects of obesity on the lipid and metabolite profiles of young adults by serum 1H-NMR spectroscopy.

    abstract:Background:Overweight (OW) is considered a risk for various metabolic diseases. However, its effects as a mechanism that alters the metabolite profiles remain unclear. The purpose of this study is to investigate the effects that OW has on the lipid and metabolite profiles in young adults. Methods:The serum metabolite ...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.7137

    authors: Pasanta D,Chancharunee S,Tungjai M,Kim HJ,Kothan S

    更新日期:2019-06-20 00:00:00

  • Transcriptome sequencing and comparative analysis of adult ovary and testis identify potential gonadal maintenance-related genes in Mauremys reevesii with temperature-dependent sex determination.

    abstract::Mauremys reevesii is a classical organism with temperature-dependent sex determination (TSD). Gonad development in early life has recently received considerable attention but gonadal maintenance after sex differentiation in turtles with TSD remains a mystery. In this study, we sequenced the transcriptomes for the adul...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.6557

    authors: Xiong L,Dong J,Jiang H,Zan J,Tong J,Liu J,Wang M,Nie L

    更新日期:2019-03-08 00:00:00

  • Exoskeletons of Bougainvilliidae and other Hydroidolina (Cnidaria, Hydrozoa): structure and composition.

    abstract::The exoskeleton is an important source of characters for the taxonomy of Hydroidolina. It originates as epidermal secretions and, among other functions, protects the coenosarc of the polypoid stage. However, comparative studies on the exoskeletal tissue origin, development, chemical, and structural characteristics, as...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.2964

    authors: Mendoza-Becerril MA,Marian JE,Migotto AE,Marques AC

    更新日期:2017-02-16 00:00:00

  • Associations of ADL and IADL disability with physical and mental dimensions of quality of life in people aged 75 years and older.

    abstract:Background:Quality of life is an important health outcome for older persons. It predicts the adverse outcomes of institutionalization and premature death. The aim of this cross-sectional study was to determine the influence of both disability in activities of daily living (ADL) and instrumental activities of daily livi...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.5425

    authors: Gobbens RJ

    更新日期:2018-08-09 00:00:00

  • Do an ecosystem engineer and environmental gradient act independently or in concert to shape juvenile plant communities? Tests with the leaf-cutter ant Atta laevigata in a Neotropical savanna.

    abstract:Background:Ecosystem engineers are species that transform habitats in ways that influence other species.While the impacts of many engineers have been well described, our understanding of how their impact varies along environmental gradients remains limited. Although disentangling the effects of gradients and engineers ...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.5612

    authors: Costa AN,Bruna EM,Vasconcelos HL

    更新日期:2018-10-09 00:00:00

  • Cheetahs (Acinonyx jubatus) running the gauntlet: an evaluation of translocations into free-range environments in Namibia.

    abstract::Following dramatic range and population declines, the cheetah is Africa's most endangered large felid. In Namibia, private land managers still trap cheetahs but increasingly consider moving animals instead of killing them. Across Africa, managers have translocated perceived conflict carnivores for decades, but rarely ...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.1346

    authors: Weise FJ,Lemeris JR Jr,Munro SJ,Bowden A,Venter C,van Vuuren M,van Vuuren RJ

    更新日期:2015-10-22 00:00:00

  • Characterizing abnormal behavior in a large population of zoo-housed chimpanzees: prevalence and potential influencing factors.

    abstract::Abnormal behaviors in captive animals are generally defined as behaviors that are atypical for the species and are often considered to be indicators of poor welfare. Although some abnormal behaviors have been empirically linked to conditions related to elevated stress and compromised welfare in primates, others have l...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.2225

    authors: Jacobson SL,Ross SR,Bloomsmith MA

    更新日期:2016-07-13 00:00:00

  • Vertical distribution of polycyclic aromatic hydrocarbons in the brackish sea water column: ex situ experiment.

    abstract:Background:Oil spills can cause severe damage within a marine ecosystem. Following a spill, the soluble fraction of polycyclic aromatic hydrocarbons is rapidly released into the water column. These remain dissolved in seawater over an extended period of time, even should the insoluble fraction be removed. The vertical ...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.10087

    authors: Kryzevicius Z,Mickuviene K,Bucas M,Vilkiene M,Zukauskaite A

    更新日期:2020-10-27 00:00:00

  • The use of artificial substrate units to improve inventories of cryptic crustacean species on Caribbean coral reefs.

    abstract::Motile cryptofauna inhabiting coral reefs are complex assemblages that utilize the space available among dead coral stands and the surrounding coral rubble substrate. They comprise a group of organisms largely overlooked in biodiversity estimates because they are hard to collect and identify, and their collection caus...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.10389

    authors: Monroy-Velázquez LV,Rodríguez-Martínez RE,Blanchon P,Alvarez F

    更新日期:2020-11-23 00:00:00

  • Transcriptomic evidence for involvement of reactive oxygen species in Rhizoctonia solani AG1 IA sclerotia maturation.

    abstract::Rhizoctonia solani AG1 IA is a soil-borne fungal phytopathogen that can significantly harm crops resulting in economic loss. This species overwinters in grass roots and diseased plants, and produces sclerotia that infect future crops. R. solani AG1 IA does not produce spores; therefore, understanding the molecular mec...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.5103

    authors: Liu B,Wang H,Ma Z,Gai X,Sun Y,He S,Liu X,Wang Y,Xuan Y,Gao Z

    更新日期:2018-06-18 00:00:00

  • Nutritional assessment, phytochemical composition and antioxidant analysis of the pulp and seed of medjool date grown in Mexico.

    abstract::The aim of this study was the characterization of fatty acids, antioxidant activity, some physical properties, nutrient content, sugars, and minerals in the pulp and seeds of the date cultivar 'Medjool' (Phoenix dactylifera L.) grown in Mexico. The samples were obtained at maturity (Tamar) in the 2017 harvest season i...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.6821

    authors: Salomón-Torres R,Ortiz-Uribe N,Valdez-Salas B,Rosas-González N,García-González C,Chávez D,Córdova-Guerrero I,Díaz-Rubio L,Haro-Vázquez MDP,Mijangos-Montiel JL,Morales-Maza A,Mahadevan P,Krueger R

    更新日期:2019-07-17 00:00:00

  • Can non-destructive DNA extraction of bulk invertebrate samples be used for metabarcoding?

    abstract:Background:High throughput DNA sequencing of bulk invertebrate samples or metabarcoding is becoming increasingly used to provide profiles of biological communities for environmental monitoring. As metabarcoding becomes more widely applied, new reference DNA barcodes linked to individual specimens identified by taxonomi...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.4980

    authors: Carew ME,Coleman RA,Hoffmann AA

    更新日期:2018-06-13 00:00:00

  • Impact of the antidepressant citalopram on the behaviour of two different life stages of brown trout.

    abstract:Background:Over the last two decades, there has been a constant increase in prescription rates of antidepressants. In parallel, neuroactive pharmaceuticals are making their way into aquatic environments at increasing concentrations. Among the antidepressants detected in the environment citalopram, a selective serotonin...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.8765

    authors: Ziegler M,Knoll S,Köhler HR,Tisler S,Huhn C,Zwiener C,Triebskorn R

    更新日期:2020-03-12 00:00:00

  • Socio-economic factors and management regimes as drivers of tree cover change in Nepal.

    abstract::Despite the local and global importance of forests, deforestation is driven by various socio-economic and biophysical factors continues in many countries. In Nepal, in response to massive deforestation, the community forestry program has been implemented to reduce deforestation and support livelihoods. After four deca...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.4855

    authors: Shrestha S,Shrestha UB,Bawa K

    更新日期:2018-05-29 00:00:00

  • Mice that gorged during dietary restriction increased foraging related behaviors and differed in their macronutrient preference when released from restriction.

    abstract::Caloric restriction (CR) can trigger gorging behavior. We examined macronutrient choice and behavior in mice that gorged during restriction compared to restricted non-gorgers and controls. Fifty MF1 male mice were restricted to 75% of ad-libitum food intake (FI), while ten controls were fed ad-lib. Body mass (BM) and ...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.1091

    authors: Hambly C,Speakman JR

    更新日期:2015-07-02 00:00:00

  • Fecal microbiota in client-owned obese dogs changes after weight loss with a high-fiber-high-protein diet.

    abstract:Background:The fecal microbiota from obese individuals can induce obesity in animal models. In addition, studies in humans, animal models and dogs have revealed that the fecal microbiota of subjects with obesity is different from that of lean subjects and changes after weight loss. However, the impact of weight loss on...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.9706

    authors: Bermudez Sanchez S,Pilla R,Sarawichitr B,Gramenzi A,Marsilio F,Steiner JM,Lidbury JA,Woods GRT,German AJ,Suchodolski JS

    更新日期:2020-10-05 00:00:00

  • Monte Carlo simulation of OLS and linear mixed model inference of phenotypic effects on gene expression.

    abstract:BACKGROUND:Self-contained tests estimate and test the association between a phenotype and mean expression level in a gene set defined a priori. Many self-contained gene set analysis methods have been developed but the performance of these methods for phenotypes that are continuous rather than discrete and with multiple...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.2575

    authors: Walker JA

    更新日期:2016-10-11 00:00:00

  • Can we measure beauty? Computational evaluation of coral reef aesthetics.

    abstract::The natural beauty of coral reefs attracts millions of tourists worldwide resulting in substantial revenues for the adjoining economies. Although their visual appearance is a pivotal factor attracting humans to coral reefs current monitoring protocols exclusively target biogeochemical parameters, neglecting changes in...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.1390

    authors: Haas AF,Guibert M,Foerschner A,Co T,Calhoun S,George E,Hatay M,Dinsdale E,Sandin SA,Smith JE,Vermeij MJ,Felts B,Dustan P,Salamon P,Rohwer F

    更新日期:2015-11-10 00:00:00

  • Influence of hydropower stations on the water microbiota in the downstream of Jinsha River, China.

    abstract::Construction of hydropower stations has been an important approach to meet China's increasing power demand, but the impact of construction of hydropower stations on river microbiota is not fully understood. To evaluate this, the microbial composition from 18 sampling sites in the downstream of Jinsha River of China, u...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.9500

    authors: Chen X,He D,Zhou L,Cao Y,Li Z

    更新日期:2020-07-16 00:00:00

  • The systematic relationships and biogeographic history of ornithischian dinosaurs.

    abstract::The systematic relationships of taxa traditionally referred to as 'basal ornithopods' or 'hypsilophodontids' remain poorly resolved since it was discovered that these taxa are not a monophyletic group, but rather a paraphyletic set of neornithischian taxa. Thus, even as the known diversity of these taxa has dramatical...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.1523

    authors: Boyd CA

    更新日期:2015-12-22 00:00:00

  • Experimental moose reduction lowers wolf density and stops decline of endangered caribou.

    abstract::The expansion of moose into southern British Columbia caused the decline and extirpation of woodland caribou due to their shared predators, a process commonly referred to as apparent competition. Using an adaptive management experiment, we tested the hypothesis that reducing moose to historic levels would reduce appar...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.3736

    authors: Serrouya R,McLellan BN,van Oort H,Mowat G,Boutin S

    更新日期:2017-08-29 00:00:00

  • Sedimentology and ichnology of the Mafube dinosaur track site (Lower Jurassic, eastern Free State, South Africa): a report on footprint preservation and palaeoenvironment.

    abstract::Footprint morphology (e.g., outline shape, depth of impression) is one of the key diagnostic features used in the interpretation of ancient vertebrate tracks. Over 80 tridactyl tracks, confined to the same bedding surface in the Lower Jurassic Elliot Formation at Mafube (eastern Free State, South Africa), show large s...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.2285

    authors: Sciscio L,Bordy EM,Reid M,Abrahams M

    更新日期:2016-08-23 00:00:00

  • Facilitating permeability of landscapes impacted by roads for protected amphibians: patterns of movement for the great crested newt.

    abstract::Amphibian populations are highly vulnerable to road mortality and habitat fragmentation caused by road networks. Wildlife road tunnels are considered the most promising road mitigation measure for amphibians yet generally remain inadequately monitored, resulting in mixed success rates in the short-term and uncertain c...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.2922

    authors: Matos C,Petrovan S,Ward AI,Wheeler P

    更新日期:2017-02-28 00:00:00

  • A novel computational approach to the silencing of Sugarcane Bacilliform Guadeloupe A Virus determines potential host-derived MicroRNAs in sugarcane (Saccharum officinarum L.).

    abstract::Sugarcane Bacilliform Guadeloupe A Virus (SCBGAV, genus Badnavirus, family Caulimoviridae) is an emerging, deleterious pathogen of sugarcane which presents a substantial barrier to producing high sugarcane earnings. Sugarcane bacilliform viruses (SCBVs) are one of the main species that infect sugarcane. During the las...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.8359

    authors: Ashraf F,Ashraf MA,Hu X,Zhang S

    更新日期:2020-01-13 00:00:00

  • Rapid screening mutations of first-line-drug-resistant genes in Mycobacterium tuberculosis strains by allele-specific real-time quantitative PCR.

    abstract::Tuberculosis (TB) is a worldwide health, economic, and social burden, especially in developing countries. Drug-resistant TB is the most serious type of this burden. Thus, it is necessary to screen drug-resistant mutations by using a simple and rapid detection method. A total of 32 pairs of allele-specific PCR (AS-PCR)...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.6696

    authors: Yang P,Song Y,Xia X,Zhang AM

    更新日期:2019-04-01 00:00:00

  • A six-year grazing exclusion changed plant species diversity of a Stipa breviflora desert steppe community, northern China.

    abstract::Excluding grazers is one of most efficient ways to restore degraded grasslands in desert-steppe communities, but may negatively affect the recovery of plant species diversity. However, diversity differences between grazed and fenced grasslands in desert-steppe are poorly known. In a Stipa breviflora desert steppe comm...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.4359

    authors: Wang X,Yang X,Wang L,Chen L,Song N,Gu J,Xue Y

    更新日期:2018-02-13 00:00:00

  • The influence of scopolamine on motor control and attentional processes.

    abstract:BACKGROUND:Motion sickness may be caused by a sensory conflict between the visual and the vestibular systems. Scopolamine, known to be the most effective therapy to control the vegetative symptoms of motion sickness, acts on the vestibular nucleus and potentially the vestibulospinal pathway, which may affect balance an...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.2008

    authors: Bestaven E,Kambrun C,Guehl D,Cazalets JR,Guillaud E

    更新日期:2016-05-05 00:00:00

  • Validation of endogenous reference genes in rat cerebral cortex for RT-qPCR analyses in developmental toxicity studies.

    abstract::Relative gene expression data obtained from quantitative RT-PCR (RT-qPCR) experiments are dependent on appropriate normalization to represent true values. It is common to use constitutively expressed endogenous reference genes (RGs) for normalization, but for this strategy to be valid the RGs must be stably expressed ...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.7181

    authors: Ramhøj L,Axelstad M,Svingen T

    更新日期:2019-06-26 00:00:00

  • Computer modelling reveals new conformers of the ATP binding loop of Na+/K+-ATPase involved in the transphosphorylation process of the sodium pump.

    abstract::Hydrolysis of ATP by Na+/K+-ATPase, a P-Type ATPase, catalyzing active Na+ and K+ transport through cellular membranes leads transiently to a phosphorylation of its catalytical α-subunit. Surprisingly, three-dimensional molecular structure analysis of P-type ATPases reveals that binding of ATP to the N-domain connecte...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.3087

    authors: Tejral G,Sopko B,Necas A,Schoner W,Amler E

    更新日期:2017-03-14 00:00:00

  • N-acetylcysteine protects against motor, optomotor and morphological deficits induced by 6-OHDA in zebrafish larvae.

    abstract:Background:Parkinson's disease (PD) is the second most common neurodegenerative disorder. In addition to its highly debilitating motor symptoms, non-motor symptoms may precede their motor counterparts by many years, which may characterize a prodromal phase of PD. A potential pharmacological strategy is to introduce neu...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.4957

    authors: Benvenutti R,Marcon M,Reis CG,Nery LR,Miguel C,Herrmann AP,Vianna MRM,Piato A

    更新日期:2018-06-01 00:00:00