解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Osteosarcoma is a common malignancy seen mainly in children and adolescents. The disease is characterized by poor overall prognosis and lower survival due to a lack of predictive markers. Many gene signatures with diagnostic, prognostic, and predictive values were evaluated to achieve better clinical outcomes. Two pub...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10633
更新日期:2021-01-15 00:00:00
abstract:Background:Fibroblast growth factor 2 (FGF2) is a highly pleiotropic cytokine with antifibrotic activity in wound healing. During the process of wound healing and fibrosis, fibroblasts are the key players. Although accumulating evidence has suggested the antagonistic effects of FGF2 in the activation process of fibrobl...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10671
更新日期:2021-01-15 00:00:00
abstract::Although liver cirrhosis and hepatocellular carcinoma are major consequences of hepatitis C (HCV), there has been an increasing number of studies examining extrahepatic manifestations, especially those caused by systemic chronic inflammation and metabolic complications that might predispose HCV patients to atheroscler...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10723
更新日期:2021-01-14 00:00:00
abstract::Staphylococcus aureus is a drug-resistant pathogen, capable of colonizing diverse ecological niches and causing a broad spectrum of infections related to a community and healthcare. In this study, we choose four methicillin-resistant S. aureus (MRSA) clinical isolates from Germany and Hungary based on our previous pol...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10185
更新日期:2021-01-13 00:00:00
abstract::Bird communities in lowland Neotropical forests exhibit temporal and spatial variation in species composition and abundance at multiple scales. Detecting and explaining such variation requires adequate methods for sampling those bird communities but counting birds in highly diverse lowland forests of the Neotropics ca...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10565
更新日期:2021-01-13 00:00:00
abstract::A feeding trial was conducted to assess the feasibility of supplementing taurine in soy-based diets for juvenile starry flounder Platichthys stellatus. The basal diet (Crude protein 66.5%, crude lipid 8.5%) was supplemented with 0 (control), 0.5%, 1.0%, 1.5%, 2.0% and 2.5% taurine to formulate six test diets. Each die...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10597
更新日期:2021-01-11 00:00:00
abstract::Aerosol optical depth (AOD) is a key parameter that reflects aerosol characteristics. However, research on the AOD of dust aerosols and various environmental variables is scarce. Therefore, we conducted in-depth studies on the distributions and variations of AOD in the Taklimakan Desert and its margins, China. We exam...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10542
更新日期:2021-01-05 00:00:00
abstract:Background:Vitamin D 1α-hydroxylase CYP27B1 is the key factor in the vitamin D pathway. Previously, we analyzed the expression of CYP27B1 in human gingival fibroblasts in vitro. In the present study, we analyzed the gingival expression of CYP27B1 in vivo. Methods:Forty-two patients with periodontitis Stage IV Grade C ...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10279
更新日期:2021-01-04 00:00:00
abstract:Background:Oral cancer progresses from hyperplastic epithelial lesions through dysplasia to invasive carcinoma. The critical needs in oral cancer treatment are expanding our knowledge of malignant tumour progression and the development of useful approaches to prevent dysplastic lesions. This study was designed to gain ...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10619
更新日期:2021-01-04 00:00:00
abstract:Background:RNA sequencing is an indispensable research tool used in a broad range of transcriptome analysis studies. The most common application of RNA Sequencing is differential expression analysis and it is used to determine genetic loci with distinct expression across different conditions. An emerging field called s...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10469
更新日期:2020-12-22 00:00:00
abstract:Background:Recently, SARS-CoV-2 virus with the D614G mutation has become a public concern due to rapid dissemination of this variant across many countries. Our study aims were (1) to report full-length genome sequences of SARS-CoV-2 collected from four COVID-19 patients in the Special Region of Yogyakarta and Central J...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10575
更新日期:2020-12-21 00:00:00
abstract::The p53 activation is induced by stressors, such as DNA damage, oxidative stress, and activated oncogenes, and can promote cell cycle arrest, cellular senescence, and apoptosis. The large yellow croaker (Larimichthys crocea) is an important warm temperate marine fish in the Chinese aquiculture industry. However, few s...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10532
更新日期:2020-12-18 00:00:00
abstract:Background:In 2020, to limit the spread of Coronavirus (COVID-19), many countries, including Italy, have issued a lengthy quarantine period for the entire population. For this reason lifestyle has changed, bringing inevitable repercussions to the Quality of Life (QoL). The present study aims to identify which psychosoc...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10611
更新日期:2020-12-18 00:00:00
abstract:Background:Panulirus argus is an ecologically relevant species in shallow water hard-bottom environments and coral reefs and target of the most lucrative fishery in the greater Caribbean region. Methods:This study reports, for the first time, the genome size and nuclear repetitive elements, including the 45S ribosomal...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10554
更新日期:2020-12-17 00:00:00
abstract:Background:In idiopathic sudden sensorineural hearing loss (ISSNHL), the relationship between the administration duration of vitamin B12 (vit B12) with adenosine triphosphate (ATP) and their therapeutic effect is not fully understood. Objective:To investigate the therapeutic effect of long-term 16 (≥weeks) administrat...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10406
更新日期:2020-12-16 00:00:00
abstract:Background:Sprint performance is an essential skill to target within soccer, which can be likely achieved with a variety of methods, including different on-field training options. One such method could be heavy resisted sprint training. However, the effects of such overload on sprint performance and the related kinetic...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10507
更新日期:2020-12-15 00:00:00
abstract::Turbidity currents are the main drivers behind the transportation of terrestrial sediments to the deep sea, and turbidite deposits from such currents have been widely used in geological studies. Nevertheless, the contribution of turbidity currents to vertical displacement of seawater has rarely been discussed. This is...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10429
更新日期:2020-12-09 00:00:00
abstract::Carrot is an important root vegetable crop abundant in bioactive compounds including carotenoids, vitamins, and dietary fibers. Carrot intake and its products are gradually growing owing to its high antioxidant activity. Auxins are a class of plant hormones that control many processes of plant growth and development. ...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10492
更新日期:2020-12-08 00:00:00
abstract::Xiphosurans are aquatic chelicerates with a fossil record extending into the Early Ordovician and known from a total of 88 described species, four of which are extant. Known for their apparent morphological conservatism, for which they have gained notoriety as supposed 'living fossils', recent analyses have demonstrat...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10431
更新日期:2020-12-04 00:00:00
abstract::Ticks are globally distributed arthropods and a public health concern due to the many human pathogens they carry and transmit, including the causative agent of Lyme disease, Borrelia burgdorferi. As tick species' ranges increase, so do the number of reported tick related illnesses. The microbiome is a critical part of...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10424
更新日期:2020-12-02 00:00:00
abstract::Sea cucumbers possess the remarkable capacity to regenerate their body parts or organs. Regeneration of host organs and/or body parts involves reconstruction of the host associated microbiota, however, the dynamics and contribution of microbiota to the regeneration process are largely unknown due to a lack of experime...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10260
更新日期:2020-12-01 00:00:00
abstract:Background:Systemic inflammation and nutritional status both play roles in the survival of cancer patients. Therefore, it is important to understand the effects of prognostic nutritional index (PNI) and lymphocyte-to-monocyte ratio (LMR) on the survival of patients with advanced p16-negative oropharyngeal cancer. Meth...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10465
更新日期:2020-12-01 00:00:00
abstract:Background:Endometrial cancer poses a serious threat to women's health worldwide, and its pathogenesis, although actively explored, is not fully understood. DLGAP5 is a recently identified cell cycle-regulation gene not reported in endometrial cancer. This study was aiming to analyze the role of DLGAP5 in tumorigenesis...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10433
更新日期:2020-11-27 00:00:00
abstract:Background:The coronavirus 19 (COVID-19) pandemic has heightened the threat to the health and lives of patients with comorbid diseases. Infection by COVID-19 is especially detrimental to patients on hemodialysis. In this study, we evaluated the clinical characteristics, laboratory findings, treatments and prognoses of ...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10459
更新日期:2020-11-26 00:00:00
abstract::Gymnosperms such as ginkgo, conifers, cycads, and gnetophytes are vital components of land ecosystems, and they have significant economic and ecologic value, as well as important roles as forest vegetation. In this study, we investigated the structural variation and evolution of chloroplast transfer RNAs (tRNAs) in gy...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10312
更新日期:2020-11-25 00:00:00
abstract::Wild greens can contribute to the human diet as an important source of essential nutrients and drugs. Since environmental factors, including soil properties, may affect the chemical composition of plants, it is necessary among others to assess various habitats in terms of their usefulness for wild plant harvesting and...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10233
更新日期:2020-11-24 00:00:00
abstract::Motile cryptofauna inhabiting coral reefs are complex assemblages that utilize the space available among dead coral stands and the surrounding coral rubble substrate. They comprise a group of organisms largely overlooked in biodiversity estimates because they are hard to collect and identify, and their collection caus...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10389
更新日期:2020-11-23 00:00:00
abstract::Populations undergoing rapid climate-driven range expansion experience distinct selection regimes dominated both by increased dispersal at the leading edges and steep environmental gradients. Characterisation of traits associated with such expansions provides insight into the selection pressures and evolutionary const...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10352
更新日期:2020-11-19 00:00:00
abstract:Purpose:Yes associated protein 1 (YAP1), which is a standout amongst the most essential effectors of the Hippo pathway, assumes a vital part in a few kinds of cancer. However, whether YAP1 is an oncogene in CRC (colorectal cancer) remains controversial, and the association between the subcellular localization of YAP1 a...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10397
更新日期:2020-11-19 00:00:00
abstract:Background:SHOX mutations have previously been described as causes of Léri-Weill dyschondrosteosis (LWD), Langer mesomelic dysplasia (LMD), and idiopathic short stature. The loss of X chromosome-Turner syndrome or mosaic 45,X/46,XX or 46,XY-also leads to the heterozygous loss of SHOX in patients with short stature only...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10236
更新日期:2020-11-17 00:00:00
abstract:Background:Although integrated pest management (IPM) is essential for conservation agriculture, this method can be inadequate for severely infected fields. The ability to predict the potential occurrence of severe infestation of soil-borne disease would enable farmers to adopt suitable methods for high-risk areas, such...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10290
更新日期:2020-11-17 00:00:00
abstract:Background:Foam cells (FCs) play crucial roles in the process of all stages of atherosclerosis. Smooth muscle cells (SMCs) and macrophages are the major sources of FCs. This study aimed to identify the common molecular mechanism in these two types of FCs. Methods:GSE28829, GSE43292, GSE68021, and GSE54666 were include...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10336
更新日期:2020-11-17 00:00:00
abstract:Background:A key step in embryo implantation is the adhesion to and invasion of the endometrium by the blastocyst trophectoderm. The envelope proteins of HERV-W and -FRD (human endogenous retrovirus-W and -FRD), syncytin-1 and syncytin-2, are mainly distributed in the placenta, and play important roles in the developme...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10368
更新日期:2020-11-17 00:00:00
abstract::Earthworms enrich the soil and protect the health of their ecological environment. Previous studies on these invertebrates determined their protein content, hormone secretions, medicinal value, and ecological habits, but their whole genomic sequence remains incomplete. We performed whole genome sequencing of Metaphire...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10313
更新日期:2020-11-12 00:00:00
abstract::Jatropha curcas L. belongs to Euphorbiaceae family, and it synthesizes flavonoid and diterpene compounds that have showed antioxidant, anti-inflammatory, anticancer, antiviral, antimicrobial, antifungal and insecticide activity. Seeds of this plant accumulate phorbol esters, which are tigliane type diterpenes, reporte...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10172
更新日期:2020-11-11 00:00:00
abstract:Background:Dye wastewater increases cancer risk in humans. For the treatment of dyestuffs, biodegradation has the advantages of economy, high efficiency, and environmental protection compared with traditional physical and chemical methods. Laccase is the best candidate for dye degradation because of its multiple substr...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10267
更新日期:2020-11-11 00:00:00
abstract::Rhodioloside, the main effective constituent of Rhodiola rosea, demonstrates antiaging and antioxidative stress functions and inhibits calcium overloading in cells. These functions imply that rhodioloside may exert protective effects on hippocampal neurons after total cerebral ischemia/reperfusion injury. In this stud...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10056
更新日期:2020-11-09 00:00:00
abstract::The interplay between historical and contemporary processes can produce complex patterns of genetic differentiation in the marine realm. Recent mitochondrial and nuclear sequence analyses revealed cryptic speciation in the Japanese mantis shrimp Oratosquilla oratoria. Herein, we applied nuclear microsatellite markers ...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10270
更新日期:2020-11-05 00:00:00
abstract:Background:Several heart malformations are associated with mutations in the regulatory regions of cardiac genes. Troponin I type 1b (tnni1b) is important for the formation of the atrioventricular canal in zebrafish hearts; however, the regulation of tnni1b is poorly understand. We aimed to identify a small but function...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10289
更新日期:2020-11-04 00:00:00
abstract:Background:Acute infective gastroenteritis (AIG) is a leading cause of mortality in children worldwide. In Peru, more than 40% of cases of AIG occurring in children under 5 years old. The disruption of the gut microbiota can increase risk for several health complications especially in patients with gastric infections c...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.9964
更新日期:2020-11-03 00:00:00