Abstract:
Background:Over the last two decades, there has been a constant increase in prescription rates of antidepressants. In parallel, neuroactive pharmaceuticals are making their way into aquatic environments at increasing concentrations. Among the antidepressants detected in the environment citalopram, a selective serotonin reuptake inhibitor, is one of the most commonly found. Given citalopram is specifically designed to alter mood and behaviour in humans, there is growing concern it can adversely affect the behaviour on non-target wildlife. Methods:In our study, brown trout were exposed to citalopram (nominal concentrations: 1, 10, 100, 1000 µg/L) in two different life stages. Larvae were exposed at 7 and 11 °C from the eyed ova stage until 8 weeks post yolk sac consumption, and juvenile brown trout were exposed for 4 weeks at 7 °C. At both stages we measured mortality, weight, length, tissue citalopram concentration, behaviour during exposure and behaviour in a stressfull environment. For brown trout larvae additionally hatching rate and heart rate, and for juvenile brown trout the tissue cortisol concentration were assessed. Results:During the exposure, both larvae and juvenile fish exposed to the highest test concentration of citalopram (1 mg/L) had higher swimming activity and spent longer in the upper part of the aquaria compared to control fish, which is an indicator for decreased anxiety. Most probably due to the higher swimming activity during the exposure, the juveniles and larvae exposed to 1 mg/L citalopram showed decreased weight and length. Additionally, in a stressful artificial swimming measurement device, brown trout larvae displayed the anxiolytic effect of the antidepressant by reduced swimming activity during this stress situation, already at concentrations of 100 µg/L citalopram. Chemical analysis of the tissue revealed rising citalopram tissue concentrations with rising exposure concentrations. Tissue concentrations were 10 times higher in juvenile fish compared to brown trout larvae. Fish plasma concentrations were calculated, which exceeded human therapeutic levels for the highest exposure concentration, matching the behavioural results. Developmental parameters like hatching rate and heart rate, as well as mortality and tissue cortisol content were unaffected by the antidepressant. Overall, we could trace the pharmacological mode of action of the antidepressant citalopram in the non-target organism brown trout in two different life stages.
journal_name
PeerJjournal_title
PeerJauthors
Ziegler M,Knoll S,Köhler HR,Tisler S,Huhn C,Zwiener C,Triebskorn Rdoi
10.7717/peerj.8765subject
Has Abstractpub_date
2020-03-12 00:00:00pages
e8765issn
2167-8359pii
8765journal_volume
8pub_type
杂志文章相关文献
PeerJ文献大全abstract::Multidrug and toxic compound extrusion (MATE) transporters contribute to multidrug resistance and play major determinants of aluminum (Al) tolerance in plants. Alfalfa (Medicago sativa L.) is the most extensively cultivated forage crop in the world, yet most alfalfa cultivars are not Al tolerant. The basic knowledge o...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.6302
更新日期:2019-01-31 00:00:00
abstract:Background:Dengue infection represents a global health issue of growing importance. Dengue non-structural protein 1 (NS1) plays a central role in the early detection of the disease. The most common method for NS1 detection is testing by lateral flow immunoassays (LFIAs) with varying sensitivity. In this study, we prese...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.7779
更新日期:2019-09-25 00:00:00
abstract::Heterotrophic plants-plants that have lost the ability to photosynthesize-are characterized by a number of changes at all levels of organization. Heterotrophic plants are divided into two large categories-parasitic and mycoheterotrophic (MHT). The question of to what extent such changes are similar in these two catego...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.9309
更新日期:2020-06-19 00:00:00
abstract::Gammaherpesviruses (GHVs) are host specific DNA viruses that infect a large range of mammalian species. These viruses preferentially target host lymphocyte cell populations and infection may lead to morbidity or mortality in immunocompromised, co-infected, or non-adapted hosts. In this study, we tested for the presenc...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.4982
更新日期:2018-06-22 00:00:00
abstract::In the field of invasion ecology, the determination of a species' environmental tolerance, is a key parameter in the prediction of its potential distribution, particularly in the context of global warming. In poikilothermic species such as insects, temperature is often considered the most important abiotic factor that...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.676
更新日期:2014-11-25 00:00:00
abstract::In recent years, the use of lectins for screening of potential biomarkers has gained increased importance in cancer research, given the development in glycobiology that highlights altered structural changes of glycans in cancer associated processes. Lectins, having the properties of recognizing specific carbohydrate m...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.3784
更新日期:2017-09-07 00:00:00
abstract:Background:The leading cause of surface water impairment in United States' rivers and streams is pathogen contamination. Although use of fecal indicators has reduced human health risk, current approaches to identify and reduce exposure can be improved. One important knowledge gap within exposure assessment is character...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.5610
更新日期:2018-09-13 00:00:00
abstract:Background/Aims:Medical and behavioral needs are relevant in organizing and providing support strategies that improve the quality of life for children, along with their families. The present study aims to examine the impact of medical and behavioral needs on the need for support of children with disabilities. Methods:...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.9557
更新日期:2020-09-15 00:00:00
abstract::Background. A large proportion of natural grasslands around the world is exposed to overgrazing resulting in land degradation and biodiversity loss. Although there is an increasing effort in the promotion of sustainable livestock management, rangeland degradation still occurs because animals' foraging behaviour is hig...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.2152
更新日期:2016-06-21 00:00:00
abstract::The octopus fauna from the southern Caribbean is an understudied field. However, recent taxonomic work in the Colombian Caribbean has led to the discovery of several new species in the family Octopodidae. To provide molecular evidence for recent descriptions in the area (i.e., Octopus taganga, O. tayrona and Macrotrit...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.7300
更新日期:2019-07-29 00:00:00
abstract:BACKGROUND:Digital medicine and smartphone-enabled health technologies provide a novel source of human health and human biology data. However, in part due to its intricacies, few methods have been established to analyze and interpret data in this domain. We previously conducted a six-month interventional trial examinin...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.2284
更新日期:2016-08-02 00:00:00
abstract::Osteogenesis imperfecta (OI) is a genetic disorder that is usually caused by disturbed production of collagen type I. Depending on its severity in the patient, this disorder may create difficulties and challenges for the dental practitioner. The goal of this article is to provide guidelines based on scientific evidenc...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.5464
更新日期:2018-08-17 00:00:00
abstract::Hepatocellular carcinoma (HCC) is one of the most heterogeneous malignant cancers with no effective targets and treatments. However, the molecular pathogenesis of HCC remains largely uncertain. The aims of our study were to find crucial genes involved in HCC through multidimensional methods and revealed potential mole...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.7436
更新日期:2019-08-08 00:00:00
abstract::It has been reported that fermented products (FPs) prepared from sweet potato-shochu distillery by-product suppressed weight gain and decreased serum cholesterol levels in mice under normal dietary conditions. Furthermore, from the information gained from the above data regarding health benefits of the FPs, the aim of...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.7671
更新日期:2019-09-12 00:00:00
abstract:Background:Nurses are often the first to activate the chain of survival when a cardiorespiratory arrest happens. That is why it is crucial that they keep their knowledge and skills up-to-date and their attitudes to resuscitation are very important. The main aim of this study was to analyse whether the level of theoreti...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.6410
更新日期:2019-02-07 00:00:00
abstract::Tyrosine phosphorylation has emerged as an important regulator of plasma membrane-localized immune receptors activity. Here, we investigate the role of tyrosine phosphorylation in the regulation of rice XANTHOMONAS RESISTANCE 21 (XA21)-mediated immunity. We demonstrate that the juxtamembrane and kinase domain of Esche...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.6074
更新日期:2018-12-11 00:00:00
abstract::Loud calls are used by many species as long-distance signals for group defense, mate attraction, and inter- and intragroup spacing. Chimpanzee loud calls, or pant hoots, are used in a variety of contexts including group coordination and during male contests. Here, we observed an alpha male takeover in wild chimpanzees...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.5079
更新日期:2018-06-28 00:00:00
abstract::Rhodioloside, the main effective constituent of Rhodiola rosea, demonstrates antiaging and antioxidative stress functions and inhibits calcium overloading in cells. These functions imply that rhodioloside may exert protective effects on hippocampal neurons after total cerebral ischemia/reperfusion injury. In this stud...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10056
更新日期:2020-11-09 00:00:00
abstract::Complete, articulated crinoids from the Ordovician peri-Gondwanan margin are rare. Here, we describe a new species, Iocrinus africanus sp. nov., from the Darriwilian-age Taddrist Formation of Morocco. The anatomy of this species was studied using a combination of traditional palaeontological methods and non-destructiv...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.1450
更新日期:2015-12-07 00:00:00
abstract::Dinocephalian therapsids are renowned for their massive, pachyostotic and ornamented skulls adapted for head-to-head fighting during intraspecific combat. Synchrotron scanning of the tapinocephalid Moschops capensis reveals, for the first time, numerous anatomical adaptations of the central nervous system related to t...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.3496
更新日期:2017-08-10 00:00:00
abstract:Background:Leucojum aestivum L. is an important medicinal plant which produces Amaryllidaceae alkaloids, especially galanthamine and lycorine. Research is currently exploring the possibility of producing these alkaloids using biotechnological methods, including in vitro cultures. The biosynthesis of alkaloids may be af...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.8688
更新日期:2020-03-16 00:00:00
abstract::As the most widely distributed snake in Eurasia, the adder (Vipera berus) has been extensively investigated in Europe but poorly understood in Asia. The Southern Altay Mountains represent the adder's southern distribution limit in Central Asia, whereas its population status has never been assessed. We conducted, for t...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.2342
更新日期:2016-08-16 00:00:00
abstract:Background:Plant reproduction is influenced by the net outcome of plant-herbivore and plant-pollinator interactions. While both herbivore impacts and pollinator impacts on plant reproduction have been widely studied, few studies examine them in concert. Methodology:Here, we review the contemporary literature that exam...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.9049
更新日期:2020-06-08 00:00:00
abstract::Lead (Pb) is a ubiquitous pollutant which poses serious threats to plants, animals and humans once entered into the food chain via contaminated industrial effluents on their discharge into the surface of water bodies and/or geological materials. This study aimed to examine and compare the biosorption potential of natu...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.5672
更新日期:2018-09-28 00:00:00
abstract:BACKGROUND:Dengue studies at the urban scale are scarce and required for guiding control efforts. In Brazil, the burden of dengue is high and challenges city public health administrations with limited resources. Here we studied the dynamics of a dengue epidemic in a single city. METHODS:Serum samples from dengue suspe...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.1892
更新日期:2016-04-05 00:00:00
abstract:Background:Complement factor C3 represents the central component of the complement cascade and its activation split product C3a plays an important role in inflammation and disease. Many human disorders are linked to dysregulation of the complement system and alteration in interaction molecules. Therefore, various thera...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.8218
更新日期:2019-12-16 00:00:00
abstract::Molecular stress responses associated with coral diseases represent an under-studied area of cnidarian transcriptome investigations. Caribbean Yellow Band Disease (CYBD) is considered a disease of Symbiodinium within the tissues of the coral host Orbicella faveolata. There is a paucity of diagnostic tools to assist in...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.1371
更新日期:2015-11-03 00:00:00
abstract:Background:In 2020, to limit the spread of Coronavirus (COVID-19), many countries, including Italy, have issued a lengthy quarantine period for the entire population. For this reason lifestyle has changed, bringing inevitable repercussions to the Quality of Life (QoL). The present study aims to identify which psychosoc...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10611
更新日期:2020-12-18 00:00:00
abstract:Background & Aims:Endothelial precursor cell (EPC) dysfunction is one of the risk factors for diabetes mellitus (DM) which results in delayed wound healing. Rosiglitazone (RSG) is a frequently prescribed oral glucose-lowering drug. Previous studies have shown the positive effects of RSG on ameliorating EPC dysfunction ...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.7815
更新日期:2019-10-17 00:00:00
abstract::Demand for lumpfish (Cyclopterus lumpus) has increased exponentially over the last decade, both for their roe, which is used as a caviar substitute, and increasingly also as cleaner fish to control sea lice in salmon farming. The species is classified as Near Threatened by the IUCN and there are growing concerns that ...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.5974
更新日期:2018-11-20 00:00:00