Abstract:
Background:The fecal microbiota from obese individuals can induce obesity in animal models. In addition, studies in humans, animal models and dogs have revealed that the fecal microbiota of subjects with obesity is different from that of lean subjects and changes after weight loss. However, the impact of weight loss on the fecal microbiota in dogs with obesity has not been fully characterized. Methods:In this study, we used 16S rRNA gene sequencing to investigate the differences in the fecal microbiota of 20 pet dogs with obesity that underwent a weight loss program. The endpoint of the weight loss program was individually tailored to the ideal body weight of each dog. In addition, we evaluated the qPCR based Dysbiosis Index before and after weight loss. Results:After weight loss, the fecal microbiota structure of dogs with obesity changed significantly (weightedANOSIM; p = 0.016, R = 0.073), showing an increase in bacterial richness (p = 0.007), evenness (p = 0.007) and the number of bacterial species (p = 0.007). The fecal microbiota composition of obese dogs after weight loss was characterized by a decrease in Firmicutes (92.3% to 78.2%, q = 0.001), and increase in Bacteroidetes (1.4% to 10.1%, q = 0.002) and Fusobacteria (1.6% to 6.2%, q = 0.040). The qPCR results revealed an overall decrease in the Dysbiosis Index, driven mostly due to a significant decrease in E. coli (p = 0.030), and increase in Fusobacterium spp. (p = 0.017). Conclusion:The changes observed in the fecal microbiota of dogs with obesity after weight loss with a weight loss diet rich in fiber and protein were in agreement with previous studies in humans, that reported an increase of bacterial biodiversity and a decrease of the ratio Firmicutes/Bacteroidetes.
journal_name
PeerJjournal_title
PeerJauthors
Bermudez Sanchez S,Pilla R,Sarawichitr B,Gramenzi A,Marsilio F,Steiner JM,Lidbury JA,Woods GRT,German AJ,Suchodolski JSdoi
10.7717/peerj.9706subject
Has Abstractpub_date
2020-10-05 00:00:00pages
e9706issn
2167-8359pii
9706journal_volume
8pub_type
杂志文章相关文献
PeerJ文献大全abstract::Wildlife biologists often use grid-based designs to sample animals and generate abundance estimates. Although sampling in grids is theoretically sound, in application, the method can be logistically difficult and expensive when sampling elusive species inhabiting extensive areas. These factors make it challenging to s...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.227
更新日期:2013-12-17 00:00:00
abstract::Temperature-dependent sex determination, or TSD, is a widespread phenomenon in reptiles. The shape of the relationship between constant incubation temperature and sex ratio defines the TSD pattern. The TSD pattern is considered a life-history parameter important for conservation because the wider the range of temperat...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.8451
更新日期:2020-03-04 00:00:00
abstract:BACKGROUND:Individuals with mental illness often experience stigmatization and encounter stereotypes such as being dangerous or unpredictable. To further improve measures against psychiatric stigma, it is of importance to understand its components. In this study, we attend to the step of separation between "us" and "th...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.2360
更新日期:2016-09-27 00:00:00
abstract::Mechanical ventilation (MV) of patients can cause damage to bronchoalveolar epithelium, leading to a sterile inflammatory response, infection and in severe cases sepsis. Limited knowledge is available on the effects of MV on the innate immune defense system in the human lung. In this study, we demonstrate that cyclic ...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.1483
更新日期:2015-12-07 00:00:00
abstract::Mathematical models of collective cell movement often neglect the effects of spatial structure, such as clustering, on the population dynamics. Typically, they assume that individuals interact with one another in proportion to their average density (the mean-field assumption) which means that cell-cell interactions oc...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.1689
更新日期:2016-02-15 00:00:00
abstract:Introduction:Metabolomics has emerged as a valuable tool to discover novel biomarkers and study the pathophysiology of diabetic nephropathy (DN). However, the effect of postoperative acute kidney injury (AKI) on diabetes mellitus (DM) to chronic DN progression has not been evaluated from the perspective of metabolomics...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.9111
更新日期:2020-05-14 00:00:00
abstract::Metoposaurids are representatives of the extinct amphibian clade Temnospondyli, found on almost every continent exclusively in the Late Triassic deposits. Osteohistologically, it is one of the best-known temnospondyl groups, analyzed with a wide spectrum of methods, such as morphology, morphometry, bone histology or c...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.9868
更新日期:2020-09-08 00:00:00
abstract::Wildlife demography is typically studied at a single point in time within a year when species, often during the reproductive season, are more active and therefore easier to find. However, this provides only a low-resolution glimpse into demographic temporal patterns over time and may hamper a more complete understandi...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.8658
更新日期:2020-02-25 00:00:00
abstract::Arbuscular mycorrhizal fungi (AMF) colonization, sampled at 32-50 days post-inoculation (dpi), was significantly reduced in suppressor of prosystemin-mediated responses2 (spr2) mutant tomato plants impaired in the ω-3 FATTY ACID DESATURASE7 (FAD7) gene that limits the generation of linolenic acid and, consequently, th...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.8888
更新日期:2020-04-16 00:00:00
abstract::The coevolutionary relationships between brood parasites and their hosts are often studied by examining the egg rejection behaviour of host species using artificial eggs. However, the traditional methods for producing artificial eggs out of plasticine, plastic, wood, or plaster-of-Paris are laborious, imprecise, and p...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.965
更新日期:2015-05-26 00:00:00
abstract:Background:Systemic inflammation and nutritional status both play roles in the survival of cancer patients. Therefore, it is important to understand the effects of prognostic nutritional index (PNI) and lymphocyte-to-monocyte ratio (LMR) on the survival of patients with advanced p16-negative oropharyngeal cancer. Meth...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10465
更新日期:2020-12-01 00:00:00
abstract::In species that live in one-male groups, resident males monopolize access to a group of females and are assumed to have higher reproductive success than bachelors. We tested this assumption using genetic, demographic, and behavioral data from 8 groups of wild blue monkeys observed over 10 years to quantify reproductio...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.1043
更新日期:2015-06-23 00:00:00
abstract::Autophagy serves as a turnover mechanism for the recycling of redundant and/or damaged macromolecules present in eukaryotic cells to re-use them under starvation conditions via a double-membrane structure known as autophagosome. A set of eukaryotic genes called autophagy-related genes (ATGs) orchestrate this highly el...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.2878
更新日期:2017-01-17 00:00:00
abstract:BACKGROUND:The human microbiota plays a key role in health and disease, and bacteriocins, which are small, bacterially produced, antimicrobial peptides, are likely to have an important function in the stability and dynamics of this community. Here we examined the density and distribution of the subclass I lantibiotic m...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.3254
更新日期:2017-04-27 00:00:00
abstract::Exclosures that exclude large herbivores are effective tools for the protection and restoration of grazed plant communities. However, previous studies have shown that the installation of an exclosure does not ensure plant community recovery. Our study aimed to determine the effects of the domination of unpalatable pla...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.7833
更新日期:2019-10-01 00:00:00
abstract::The mammalian pelvis is thought to exhibit adaptations to the functional demands of locomotor behaviors. Previous work in primates has identified form-function relationships between pelvic shape and locomotor behavior; few studies have documented such relationships in carnivorans, instead focusing on long bones. Most ...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.8574
更新日期:2020-02-20 00:00:00
abstract::A new species of the genus Mesacanthion Filipjev, 1927 was discovered during a survey of natural beaches of Jeju Island in South Korea. The new species Mesacanthion jejuensissp. nov. shares general morphology of the genus such as the outer labial and cephalic setae being situated at the middle of cephalic capsule, wel...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.8023
更新日期:2019-11-18 00:00:00
abstract::Quantification of fine-scale movement, performance, and energetics of hunting by large carnivores is critical for understanding the physiological underpinnings of trophic interactions. This is particularly challenging for wide-ranging terrestrial canid and felid predators, which can each affect ecosystem structure thr...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.3701
更新日期:2017-08-17 00:00:00
abstract::Taphonomic deformation, the distortion of fossils as a result of geological processes, poses problems for the use of geometric morphometrics in addressing paleobiological questions. Signal from biological variation, such as ontogenetic trends and sexual dimorphism, may be lost if variation from deformation is too high...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.9925
更新日期:2020-10-07 00:00:00
abstract::Over the last decades several studies have identified that the directional changes in climate induced by anthropogenic emissions of greenhouse gases are affecting the ecology of desert ecosystems. In the Southwest United States, the impacts of climate change to plant abundance and distribution have already been report...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.5623
更新日期:2018-09-19 00:00:00
abstract:Background:Skeletal muscle wound healing is dependent on complex interactions between fibroblasts, myofibroblasts, myogenic cells, and cytokines, such as TGF-β1. This study sought to clarify the impact of TGF-β1 signaling on skeletal muscle cells and discern between the individual contributions of fibroblasts and myofi...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.4939
更新日期:2018-07-11 00:00:00
abstract:Background:Cholera, an acute enteric infection, is a serious health challenge in both the underdeveloped and the developing world. It is caused by Vibrio cholerae after ingestion of fecal contaminated food or water. Cholera outbreaks have recently been observed in regions facing natural calamities (i.e., earthquake in ...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.6223
更新日期:2019-06-19 00:00:00
abstract::The objective of this study was to quantify consumption of clothianidin-treated corn seed by birds following standard planting practices. Based on post-planting seed counts on 21 fields in southwestern Ontario, Canada, between 29 and 813 seeds/ha (mean of 224 ± 167 (SD)) were estimated to remain on the soil surface im...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.5880
更新日期:2018-11-07 00:00:00
abstract::Sea cucumbers possess the remarkable capacity to regenerate their body parts or organs. Regeneration of host organs and/or body parts involves reconstruction of the host associated microbiota, however, the dynamics and contribution of microbiota to the regeneration process are largely unknown due to a lack of experime...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10260
更新日期:2020-12-01 00:00:00
abstract::Background. The age at which most young people are in tertiary education is also the age of peak onset for mental illness. Because mental health problems can have adverse effects on students' academic performance and welfare, institutions require guidance how they can best provide support. However, the scientific evid...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.43
更新日期:2013-02-26 00:00:00
abstract::The phosphoinositide 3-kinase (PI3K) pathway shows frequent aberrant alterations and pathological activation in breast cancer cells. While PI3K inhibitors have not achieved expectant therapeutic efficacy in clinical trials, and several studies provide promising combination strategies to substantially maximize therapeu...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.5092
更新日期:2018-06-19 00:00:00
abstract::We explored the genetic background of social interactions in two breeding metapopulations of the pied flycatcher (Ficedula hypoleuca) in Western Siberia. In 2005, we sampled blood from birds breeding in study areas located in the city of Tomsk and in a natural forest 13 km southward of Tomsk (Western Siberia, Russia)....
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.6059
更新日期:2018-12-06 00:00:00
abstract:Background:WRKY proteins play a vital role in the plants response to different stresses, growth and development. Studies of WRKY proteins have been mainly focused on model plant Arabidopsis and a few other vegetable plants. However, the systematical study of eggplant WRKY transcription factor superfamily is scarce. Me...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.8777
更新日期:2020-03-17 00:00:00
abstract::Ceratopsids ("horned dinosaurs") are known from western North America and Asia, a distribution reflecting an inferred subaerial link between the two landmasses during the Late Cretaceous. However, this clade was previously unknown from eastern North America, presumably due to limited outcrop of the appropriate age and...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.3342
更新日期:2017-05-23 00:00:00
abstract::We point out complications inherent in biodiversity inventory metrics when applied to large-scale datasets. The number of units of inventory effort (e.g., days of inventory effort) in which a species is detected saturates, such that crucial numbers of detections of rare species approach zero. Any rare errors can then ...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.8872
更新日期:2020-05-13 00:00:00