The impact of PI3K inhibitors on breast cancer cell and its tumor microenvironment.

abstract：:RNA sequencing (RNA-Seq) enables the measurement and comparison of gene expression with isoform-level quantification. Differences in the effect of each isoform may make traditional methods, which aggregate isoforms, ineffective. Here, we introduce a variance component-based test that can jointly test multiple isoforms...

journal_title：PeerJ

authors： Yang S,Shao F,Duan W,Zhao Y,Chen F

更新日期：2017-09-08 00:00:00

abstract：:The objectives of this experiment were to determine the effects of graded dietary lead (Pb) concentrations on body weight and Pb concentrations in blood, hair, soft tissues, and urine from pigs and to generate equations for estimating daily Pb intake. Sixteen barrows with initial body weight 36.3 kg (standard deviatio...

journal_title：PeerJ

authors： Reddy KE,Park KR,Lee SD,Yoo JH,Son AR,Lee HJ

更新日期：2017-11-01 00:00:00

abstract：Background:Human sapovirus (SaV) is an etiologic agent of acute gastroenteritis (AGE) in all age groups worldwide. Genetic recombination of SaV has been reported from many countries. So far, none of SaV recombinant strain has been reported from Thailand. This study examined the genetic recombination and genotype divers...

journal_title：PeerJ

authors： Kumthip K,Khamrin P,Ushijima H,Chen L,Li S,Maneekarn N

更新日期：2020-02-06 00:00:00

abstract：:MicoRNAs (miRNAs), usually as gene regulators, participate in various biological processes, including stress responses. The hypothalamus-pituitary-adrenal axis (HPA axis) is an important pathway in regulating stress response. Although the mechanism that HPA axis regulates stress response has been basically revealed, t...

journal_title：PeerJ

authors： Luo W,Fang M,Xu H,Xing H,Fu J,Nie Q

更新日期：2016-02-18 00:00:00

abstract：:In biological research the analysis of gene expression levels in cells and tissues can be a powerful tool to gain insights into biological processes. For this, quantitative RT-PCR (RT-qPCR) is a popular method that often involve the use of constitutively expressed endogenous reference (or 'housekeeping') gene for norm...

journal_title：PeerJ

authors： Svingen T,Letting H,Hadrup N,Hass U,Vinggaard AM

更新日期：2015-03-24 00:00:00

abstract：:As more and more prokaryotic sequencing takes place, a method to quickly and accurately analyze this data is needed. Previous tools are mainly designed for metagenomic analysis and have limitations; such as long runtimes and significant false positive error rates. The online tool GenomePeek (edwards.sdsu.edu/GenomePee...

journal_title：PeerJ

authors： McNair K,Edwards RA

更新日期：2015-06-16 00:00:00

abstract：:Myocardial infarction has been carefully studied in numerous experimental models. Most of these models are based on electrophysiological and functional data, and pay less attention to histological discoveries. During the last decade, treatment using advanced therapies, mainly cell therapy, has prevailed from among all...

journal_title：PeerJ

authors： García Gómez-Heras S,Largo C,Larrea JL,Vega-Clemente L,Calderón Flores M,Ruiz-Pérez D,García-Olmo D,García-Arranz M

更新日期：2019-07-22 00:00:00

abstract：:We have developed a novel bio-tofu, made from mixed soy and cow milk (MSCM), using Lactobacillus helveticus MB2-1 and Lactobacillus plantarum B1-6 incorporated with microbial transglutaminase (MTGase) as coagulant. MTGase was added to improve the textural properties and suit for cooking. However, the effect of MTGase ...

journal_title：PeerJ

authors： Xing G,Rui X,Jiang M,Xiao Y,Guan Y,Wang D,Dong M

更新日期：2016-12-15 00:00:00

abstract：:The aim of this study was the characterization of fatty acids, antioxidant activity, some physical properties, nutrient content, sugars, and minerals in the pulp and seeds of the date cultivar 'Medjool' (Phoenix dactylifera L.) grown in Mexico. The samples were obtained at maturity (Tamar) in the 2017 harvest season i...

journal_title：PeerJ

authors： Salomón-Torres R,Ortiz-Uribe N,Valdez-Salas B,Rosas-González N,García-González C,Chávez D,Córdova-Guerrero I,Díaz-Rubio L,Haro-Vázquez MDP,Mijangos-Montiel JL,Morales-Maza A,Mahadevan P,Krueger R

更新日期：2019-07-17 00:00:00

abstract：:Consumer-grade GPS units are a staple of modern field ecology, but the relatively large error radii reported by manufacturers (up to 10 m) ostensibly precludes their utility in measuring fine-scale movement of small animals such as insects. Here we demonstrate that for data collected at fine spatio-temporal scales, th...

journal_title：PeerJ

authors： Breed GA,Severns PM

更新日期：2015-08-20 00:00:00

abstract：BACKGROUND:Highlighted text in the Internet (i.e., hypertext) is predominantly blue and underlined. The perceptibility of these hypertext characteristics was heavily questioned by applied research and empirical tests resulted in inconclusive results. The ability to recognize blue text in foveal and parafoveal vision wa...

journal_title：PeerJ

authors： Gagl B

更新日期：2016-09-20 00:00:00

abstract：:Sanderlings (Calidris alba) are long-distance migratory shorebirds with a non-breeding range that spans temperate and tropical coastal habitats. Breeding in the High Arctic combined with non-breeding seasons in the tropics necessitate long migrations, which are energetically demanding. On an annual basis, the higher e...

journal_title：PeerJ

authors： Grond K,Ntiamoa-Baidu Y,Piersma T,Reneerkens J

更新日期：2015-08-11 00:00:00

abstract：:Niche production is intended to produce premium pork, but several husbandry factors may affect the meat fatty acid composition and aroma. Fatty acid profile (by GC-FID) of raw meat and volatile compounds (by SPME-GC-MS) of cooked meat were analysed in loin samples from two pig genetic types-75% Duroc (Du) and 50% Piet...

journal_title：PeerJ

authors： Argemí-Armengol I,Villalba D,Tor M,Pérez-Santaescolástica C,Purriños L,Manuel Lorenzo J,Álvarez-Rodríguez J

更新日期：2019-07-17 00:00:00

abstract：:Soil sickness is the progressive loss of soil quality due to continuous monocropping. The bacterial populations are critical to sustaining agroecosystems, but their responses to long-term peanut monocropping have not been determined. In this study, based on a previously constructed gradient of continuous monocropped p...

journal_title：PeerJ

authors： Chen M,Liu H,Yu S,Wang M,Pan L,Chen N,Wang T,Chi X,Du B

更新日期：2020-04-28 00:00:00

abstract：BACKGROUND:Profiling of microbial communities via metagenomic shotgun sequencing has enabled researches to gain unprecedented insight into microbial community structure and the functional roles of community members. This study describes a method and basic analysis for a metagenomic adaptation of the double digest restr...

journal_title：PeerJ

authors： Liu MY,Worden P,Monahan LG,DeMaere MZ,Burke CM,Djordjevic SP,Charles IG,Darling AE

更新日期：2017-09-19 00:00:00

abstract：:Miniature inverted-repeat transposable elements (MITEs) have been associated with genic regions in plant genomes and may play important roles in the regulation of nearby genes via recruitment of small RNAs (sRNA) to the MITEs loci. We identified eight families of MITEs in the sugarcane genome assembly with MITE-Hunter...

journal_title：PeerJ

authors： Grativol C,Thiebaut F,Sangi S,Montessoro P,Santos WDS,Hemerly AS,Ferreira PCG

更新日期：2019-01-11 00:00:00

abstract：:This study examined whether being aware of the repetition of stimuli in a simple numerosity task could aid the development of automaticity. The numerosity task used in this study was a simple counting task. Thirty-four participants were divided into two groups. One group was instructed that the stimuli would repeat ma...

journal_title：PeerJ

authors： Speelman CP,Shadbolt E

更新日期：2018-01-31 00:00:00

abstract：:To investigate community shelter effects of two invasive decapod species, Hemigrapsus sanguineus and Carcinus maenas, in the Long Island Sound (LIS), we deployed artificial shelters in the intertidal and immediate subtidal zones. These consisted of five groups during the summer: a control, a resident H. sanguineus mal...

journal_title：PeerJ

authors： Hudson DM,Reagan D,Crivello JF

更新日期：2016-07-27 00:00:00

abstract：Background:The association between asthma (AS), allergic rhinitis (AR) and oral diseases remains inconclusive in adults. AS and AR often coexist. However, studies that investigate AS, AR together and their association with oral diseases are scarce. Methods:Data from 22,898 men and 28,541 women, aged 21 to 25 years, we...

journal_title：PeerJ

authors： Ho SW,Lue KH,Ku MS

更新日期：2019-09-10 00:00:00

abstract：Background:Stoichiometric relations drive powerful constraints in several fundamental ecosystem processes. However, limited studies have been conducted on the ecological stoichiometry of plants after the change of community composition induced by Stellera chamaejasme removal in alpine grassland in the Qinghai-Tibetan P...

journal_title：PeerJ

authors： Song M,Wang Y,Bao G,Wang H,Yin Y,Li X,Zhang C

更新日期：2020-06-23 00:00:00

abstract：:Following a radiation incident, preliminary dose estimates made by γ-H2AX foci analysis can supplement the early triage of casualties based on clinical symptoms. Sample processing time is important when many individuals need to be rapidly assessed. A protocol was therefore developed for high sample throughput that req...

journal_title：PeerJ

authors： Moquet J,Barnard S,Rothkamm K

更新日期：2014-03-06 00:00:00

abstract：Background:Laryngeal squamous cell carcinoma (LSCC) is one of the most common malignant tumours of the head and neck. Recent evidence has demonstrated that lncRNAs play important roles in tumour progression and could be used as biomarkers for early diagnosis, prognosis, and potential therapeutic targets. The "competiti...

journal_title：PeerJ

authors： Liu Y,Ye F

更新日期：2019-07-22 00:00:00

abstract：:Mesacanthus is a common and speciose genus of acanthodian fish from Lower Old Red Sandstone and Middle Old Red Sandstone assemblages (representing the Lower Devonian and Middle Devonian respectively) and is well represented in many palaeoichthyology collections in the UK. Based upon descriptions given during the 19th ...

journal_title：PeerJ

authors： Baron MG

更新日期：2015-10-29 00:00:00

abstract：:A new species of freshwater crab, Fredius ibiapaba, is described and illustrated from a mid-altitude forested patch in Ipú (Ibiapaba plateau, Ceará, northeastern Brazil), between 635 to 782 m. The new species can be separated from its congeners by the morphology of its first gonopod: proximal half remarkably swollen, ...

journal_title：PeerJ

authors： Santos LC,Tavares M,Silva JRF,Cervini M,Pinheiro AP,Santana W

更新日期：2020-06-29 00:00:00

abstract：BACKGROUND:Quercus infectoria G. Olivier (Fagaceae) nutgalls have been widely employed in traditional Asian medicine for several treatments, especially wounds and skin disorders. However, the effects of this plant on wound healing have not yet been clearly elucidated. This present work was focused on utilization of Que...

journal_title：PeerJ

authors： Chokpaisarn J,Chusri S,Amnuaikit T,Udomuksorn W,Voravuthikunchai SP

更新日期：2017-07-24 00:00:00

abstract：:Objective. We hypothesized that a significant percentage of patients who are referred to the Emergency Department (ED) after calling their primary care physician's (PCP) office receive such instructions without the input of a physician. Methods. We enrolled a convenience sample of stable adults at an inner-city ED. Pa...

journal_title：PeerJ

authors： Hill R,Gest A,Smith C,Guardiola JH,Apolinario M,Ha J,Gonzalez JR,Richman PB

更新日期：2016-03-28 00:00:00

abstract：:Sugarcane bagasse is an abundant source of lignocellulosic material for bioethanol production. Utilisation of bagasse for biofuel production would be environmentally and economically beneficial, but the recalcitrance of lignin continues to provide a challenge. Further understanding of lignin production in specific cul...

journal_title：PeerJ

authors： Bewg WP,Coleman HD

更新日期：2017-12-05 00:00:00

abstract：:We describe a new iguanodontian ornithopod, Choyrodon barsboldi gen. et sp. nov. from the Albian-aged Khuren Dukh Formation of Mongolia based on several partial skeletons interpreted to represent a subadult growth stage based on osteohistological features. This new taxon is diagnosed by many autapomorphies of the maxi...

journal_title：PeerJ

authors： Gates TA,Tsogtbaatar K,Zanno LE,Chinzorig T,Watabe M

更新日期：2018-08-03 00:00:00

abstract：Background:Nurses are often the first to activate the chain of survival when a cardiorespiratory arrest happens. That is why it is crucial that they keep their knowledge and skills up-to-date and their attitudes to resuscitation are very important. The main aim of this study was to analyse whether the level of theoreti...

journal_title：PeerJ

authors： Tíscar-González V,Blanco-Blanco J,Gea-Sánchez M,Rodriguez Molinuevo A,Moreno-Casbas T

更新日期：2019-02-07 00:00:00

abstract：:Sugarcane-soybean intercropping has been widely used to control disease and improve nutrition in the field. However, the response of the soil microbial community diversity and structure to intercropping is not well understood. Since microbial diversity corresponds to soil quality and plant health, a pot experiment was...

journal_title：PeerJ

authors： Lian T,Mu Y,Jin J,Ma Q,Cheng Y,Cai Z,Nian H

更新日期：2019-02-08 00:00:00