Abstract:
BACKGROUND:Left atrial remodelling (LAR) has been described in Western populations with chronic hypertension and is associated with a higher risk of adverse cardiovascular events. Although hypertension tends to occur earlier and is more severe in sub-Saharan Africa than in more developed nations, LAR and its associated factors in these African hypertensive subjects have been poorly elucidated. OBJECTIVES:To assess left atrial structural remodelling in black hypertensive patients and determine factors associated with left atrial size. METHODS:This was a cross-sectional, comparative study carried out in two tertiary hospitals in Douala, Cameroon over a period of three months. Fifty-two patients, either newly diagnosed with hypertension or known hypertensives treated for less than a year, were consecutively recruited. These patients were matched (unpaired matching) for age and gender to 40 randomly selected healthy subjects. The posterior-anterior diameter indexed to body surface area (BSA), volume indexed to BSA, and longitudinal and transverse diameters of the left atrium (LA) were measured using transthoracic echocardiography, in accordance with the American Society of Echocardiography guidelines. LAR was defined as increase in LA size, characterised by LA volume ≥ 34 ml/m2. Early morning urine was analysed for microalbuminuria using urine strips to obtain spot albumin/creatinine ratio. Data were analysed using SPSS version 23 and statistical significance was set at p < 0.05. RESULTS:The gender distribution and mean age were similar between the two groups. Hypertensive patients had significantly higher mean body mass index, left ventricular mass and an altered diastolic function. They also had significantly higher LA longitudinal diameter (50.0 vs 47.4 mm; p = 0.045), surface area (17.9 vs 15.5 cm2; p = 0.003) and volume (52.4 vs 43.8 ml; p = 0.002) compared to the non-hypertensive counterparts. Fourteen patients (26.9%) had LA enlargement compared to one (2.5%) in the non-hypertensive group (odds ratio = 9.78, CI: 2.67-35.8, p < 0.0001). Diastolic dysfunction (p = 0.008) was the only independent predictor of LA size in the hypertensive subjects. Microalbuminuria did not significantly correlate with LA size. CONCLUSIONS:Our study shows evidence of LAR in newly diagnosed black African patients with hypertension, characterised by an increase in the LA length, surface area and volume. Future studies are warranted to better elucidate the biological mechanisms underlying the link between the early phase of hypertension and LAR, as well as its prognostic implications in our population.
journal_name
Cardiovasc J Afrjournal_title
Cardiovascular journal of Africaauthors
Gounoue AC,Tamdja AD,Choukem SP,Ba H,Aboubakar SM,Nzali A,Halle MP,Nkoke C,Kadia BM,Abanda MH,Nganou CN,Abzabji MK,Kingue Sdoi
10.5830/CVJA-2019-046subject
Has Abstractpub_date
2020-01-01 00:00:00pages
40-46issue
1eissn
1995-1892issn
1680-0745journal_volume
31pub_type
杂志文章abstract:AIM:To determine whether a single elevated myocardial performance index (MPI) value in the third trimester of pregnancy is a marker for later adverse obstetric outcomes in stable placental-mediated disease, defined as well-controlled pre-eclampsia (PE) on a single agent and/or uncompensated intra-uterine growth restric...
journal_title:Cardiovascular journal of Africa
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abstract::Behcet's syndrome is a systemic inflammatory disease associated with vasculitis, and arterial, venous and cardiac disorders. Thirty-eight Behcet's disease patients were examined prospectively with echocardiography, ultrasonography and computed tomography, and coagulation parameters were determined. Deep venous insuffi...
journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章
doi:10.5830/CVJA-2014-003
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章,随机对照试验
doi:10.5830/CVJA-2019-022
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abstract::Left ventricular hypertrophy is a common complication of primary hyperparathyroidism. Numerous disturbances of myocardial physiology have been described as a result of excess parathyroid hormone action. In this brief communication, another phenotype of the hyperparathyroid heart is proposed, the 'pseudo-myocardial inf...
journal_title:Cardiovascular journal of Africa
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doi:
更新日期:2009-05-01 00:00:00
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journal_title:Cardiovascular journal of Africa
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doi:10.5830/CVJA-2010-078
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章
doi:10.5830/CVJA-2011-004
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journal_title:Cardiovascular journal of Africa
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journal_title:Cardiovascular journal of Africa
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章
doi:10.5830/CVJA-2020-046
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章,评审
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章
doi:
更新日期:2008-01-01 00:00:00
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章
doi:10.5830/CVJA-2012-076
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章
doi:10.5830/CVJA-2013-029
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journal_title:Cardiovascular journal of Africa
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章
doi:10.5830/CVJA-2018-029
更新日期:2018-09-01 00:00:00
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章
doi:10.5830/CVJA-2015-001
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章
doi:
更新日期:2010-03-01 00:00:00
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章
doi:
更新日期:2009-03-01 00:00:00
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章,评审
doi:
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章
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更新日期:2018-09-01 00:00:00
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章
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更新日期:2012-06-12 00:00:00
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章
doi:10.5830/CVJA-2013-044
更新日期:2013-08-01 00:00:00
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章
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更新日期:2013-09-23 00:00:00
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章
doi:10.5830/CVJA-2014-036
更新日期:2014-07-01 00:00:00
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章
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更新日期:2014-08-23 00:00:00
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章
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更新日期:2018-01-01 00:00:00
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journal_title:Cardiovascular journal of Africa
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