Abstract:
:Resistant hypertension is a common clinical problem in South Africa and is frequently associated with low renin and aldosterone levels, especially in black Africans. In South Africa, novel variants in the epithelial sodium channel (ENaC) have been described to be associated with varying degrees of hypokalaemia and hypertension due to primary sodium retention. We report here a case of Liddle's syndrome due to a novel c.1709del11 (p.Ser570Tyrfs*20) deletion in the beta-subunit of the ENaC in a young black African male. We discuss the likely pathogenesis of hypertension in this setting as well as the treatment options available in South Africa aimed at the ENaC. This case highlights the need for vigilance in detecting and appropriately treating low-renin and low-aldosterone hypertension in view of the frequency of the described variants of the ENaC channel in our country. Specific therapy such as amiloride should be made more widely available.
journal_name
Cardiovasc J Afrjournal_title
Cardiovascular journal of Africaauthors
Freercks R,Meldau S,Jones E,Ensor J,Weimers-Willard C,Rayner Bdoi
10.5830/CVJA-2017-012subject
Has Abstractpub_date
2017-09-23 00:00:00pages
e4-e6issue
4eissn
1995-1892issn
1680-0745journal_volume
28pub_type
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journal_title:Cardiovascular journal of Africa
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journal_title:Cardiovascular journal of Africa
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journal_title:Cardiovascular journal of Africa
pub_type: 社论,历史文章
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journal_title:Cardiovascular journal of Africa
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journal_title:Cardiovascular journal of Africa
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journal_title:Cardiovascular journal of Africa
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journal_title:Cardiovascular journal of Africa
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journal_title:Cardiovascular journal of Africa
pub_type: 历史文章,杂志文章
doi:
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章
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journal_title:Cardiovascular journal of Africa
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pub_type: 杂志文章,随机对照试验
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章,评审
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章
doi:10.5830/CVJA-2010-078
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章,评审
doi:
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pub_type: 杂志文章,多中心研究
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更新日期:2020-09-01 00:00:00
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章
doi:10.5830/CVJA-2011-004
更新日期:2012-03-12 00:00:00
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章
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更新日期:2014-05-01 00:00:00
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journal_title:Cardiovascular journal of Africa
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journal_title:Cardiovascular journal of Africa
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章
doi:
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章
doi:10.5830/CVJA-2015-048
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:Cardiovascular journal of Africa
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