Abstract:
BACKGROUND:Hypertension is a common cardiovascular disease, affecting adults worldwide and it accounts for up to 30% of all deaths. The need for better control of arterial hypertension justifies observational studies designed to better understand the real-life management of hypertensive patients. The ASTRAL study was primarily designed to evaluate the percentage of hypertensive patients achieving blood pressure goals after eight weeks of treatment with a fixeddose combination of ramipril/hydrochlorothiazide (HCTZ). METHODS:The study was a multi-centre, non-comparative, Open-label, observational study conducted in 36 centres in five sub-Saharan African countries, namely Cameroon, Congo Brazzaville, Democratic Republic of Congo (DRC), Madagascar and Nigeria. Four hundred and forty-nine men and women 18 years of age or older with hypertension not controlled by an ACE inhibitor, a diuretic or any other monotherapy or anti-hypertensive combination not containing a diuretic in a fixed dose were considered eligible for inclusion in this eight-week study. The study consisted of three visits, visit one (V1) at baseline, visit two (V2) after four weeks and visit three (V3) after eight weeks. RESULTS:The mean age of the patients was 54.7 ± 11.7 years (20-90 years) and most were categorised by the WHO criteria as either overweight or obese (71.6%). After four and eight weeks of treatment with the study drug, systolic and diastolic blood pressures significantly changed from baseline: -24.7/-14.2 mmHg (p < 0.001) and -31.7/-17.9 mmHg (p < 0.001), respectively. There were 60.2% of the non-diabetics on prior monotherapy who, at eight weeks, fulfilled the primary blood pressure goal for SBP and DBP, versus 26.5% of the diabetic patients, also on monotherapy. Few adverse events were reported, with facial oedema and dry cough recurring twice in two patients. CONCLUSION:Fixed-dose combination of ramipril/HCTZ is therefore effective, tolerable and has a good safety profile for blood pressure control in black Africans.
journal_name
Cardiovasc J Afrjournal_title
Cardiovascular journal of Africaauthors
Okpechi IG,Schoeman HS,Longo-Mbenza B,Oke DA,Kingue S,Nkoua JL,Rayner BLdoi
10.5830/cvja-2010-086subject
Has Abstractpub_date
2011-03-01 00:00:00pages
79-84issue
2eissn
1995-1892issn
1680-0745journal_volume
22pub_type
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journal_title:Cardiovascular journal of Africa
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journal_title:Cardiovascular journal of Africa
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journal_title:Cardiovascular journal of Africa
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journal_title:Cardiovascular journal of Africa
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章,评审
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章,评审
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章
doi:
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journal_title:Cardiovascular journal of Africa
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journal_title:Cardiovascular journal of Africa
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章
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