Abstract：
:In this study the baroreflex sensitivity of conscious, juvenile, spontaneously hypertensive rats (SHRs) was compared. The study population consisted of 19 eight-week-old male SHRs. The baroreflex sensitivity was quantified as the derivative of the variation in heart rate (HR) and the variation of mean arterial pressure (baroreflex sensitivity = ΔHR/ΔMAP). MAP was manipulated with sodium nitroprusside (SNP) and phenylephrine (PHE), administered via an inserted cannula in the right femoral vein. The SHRs were divided into four groups: (1) low bradycardic baroreflex (LB) where the baroreflex gain (BG) was between 0 and -1 bpm/mmHg with PHE; (2) high bradycardic baroreflex (HB), where the BG was < -1 bpm/mmHg with PHE; (3) low tachycardic baroreflex (LT) where the BG was between 0 and 3 bpm/mmHg with SNP; (4) high tachycardic baroreflex (HT) where the BG was > 3 bpm/mmHg with SNP. We noted that 36.8% of the rats presented with an increased bradycardic reflex, while 27.8% demonstrated an attenuated tachycardic reflex. No significant alterations were noted regarding the basal MAP and HR. There were significant differences in the baroreflex sensitivity between SHRs in the same laboratory. One should be careful when interpreting studies employing the SHR as a research model.
journal_name
Cardiovasc J Afrjournal_title
Cardiovascular journal of Africaauthors
Valenti VE,De Abreu LC,Colombari E,Sato MA,Ferreira Cdoi
10.5830/cvja-2010-007subject
Has Abstractpub_date
2011-01-01 00:00:00pages
14-7issue
1eissn
1995-1892issn
1680-0745journal_volume
22pub_type
杂志文章abstract：:Pulmonary hypertension (PH) has progressively moved from an orphan disease to a significant global health problem with a major disease burden in limited7hyphen;resource countries, where over 97% of patients live. The aetiologies of PH differ between high- and low-income nations, but PH due to left heart disease is cre...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章,评审
doi：10.5830/CVJA-2018-042
更新日期：2019-01-01 00:00:00
abstract：:We researched hypertrophic cardiomyopathy (HCM) and long QT syndrome (LQTS) as models for studying the pathophysiology of arrhythmias and hypertrophy, and in the process we have had the opportunity to compare local disease profiles with global patterns. We trawled our database entries over the past 20 years to identif...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章
doi：
更新日期：2007-09-01 00:00:00
abstract：BACKGROUND:The incidence of hypertension (HTN) has increased rapidly in the Sudan in the last few years. The aim of this study was to determine the prevalence of uncontrolled HTN and the risk factors associated with it in Sudanese adults. METHODS:This study was cross sectional. Data were collected using structured que...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章
doi：10.5830/CVJA-2013-035
更新日期：2013-07-01 00:00:00
abstract：:Aneurysms of the left atrial appendage are extremely rare. Enlargement of the left atrial appendage can be congenital or acquired. Dysplasia of the left atrial muscles leads to congenital left atrial appendage aneurysm and usually presents as atrial tachyarrhythmia or embolic events in the second or third decade of li...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章
doi：10.5830/CVJA-2011-051
更新日期：2012-06-12 00:00:00
abstract：AIM:To provide imaging data and report associations between human immunodeficiency virus (HIV), tuberculosis (TB) and pulmonary embolism (PE) in a South African population that underwent computed tomography pulmonary angiography (CTPA) for suspected PE. METHODS:A validated Qanadli severity scoring system for PE was us...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章
doi：10.5830/CVJA-2016-083
更新日期：2017-07-01 00:00:00
abstract：:In developing countries, rheumatoid arthritis (RA) remains a seriously under-prioritised disease, particularly among the underprivileged, often resulting in presentation of patients late in the course of their disease, further complicated by limited therapeutic options and inconsistent follow up. The consequences are ...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章,评审
doi：10.5830/CVJA-2018-018
更新日期：2018-09-01 00:00:00
abstract：BACKGROUND:We explored the association of N-terminal probrain natriuretic peptide (NT-proBNP) with metabolic traits in a bi-ethnic African-Caucasian cohort. METHODS:Baseline examinations of the Sympathetic activity and Ambulatory Blood Pressure in African (SABPA) prospective cohort study were performed between 2008 an...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章
doi：10.5830/CVJA-2020-017
更新日期：2020-11-01 00:00:00
abstract：OBJECTIVE:Cardiac resynchronisation therapy has been shown to be an effective treatment to improve functional status and prolong survival of patients in advanced chronic heart failure. This study assessed the surgical outcomes of left anterior mini-thoracotomy for the implantation of left ventricular epicardial pacing ...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章
doi：10.5830/CVJA-2016-046
更新日期：2017-01-01 00:00:00
abstract：:We report on a patient who developed cardiogenic shock caused by dynamic left ventricular outflow tract (LVOT) obstruction following percutaneous coronary intervention for anteroseptal acute myocardial infarction. ...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章
doi：10.5830/CVJA-2010-051
更新日期：2011-07-01 00:00:00
abstract：:Surgical repair or replacement of the mitral valve is currently the only recommended therapy for severe primary mitral regurgitation. The chronic elevation of wall stress caused by the resulting volume overload leads to structural remodelling of the muscular, vascular and extracellular matrix components of the myocard...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章,评审
doi：10.5830/CVJA-2017-009
更新日期：2018-01-01 00:00:00
abstract：:Peripheral arterial disease (PAD) represents a major public health problem due to its high and increasing prevalence, worldwide distribution, and significant morbidity and mortality rate. Female gender is a risk factor for PAD globally and especially in low-income countries. In this review, we summarise the present kn...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章,评审
doi：10.5830/CVJA-2018-023
更新日期：2018-09-01 00:00:00
abstract：OBJECTIVE:To identify case fatality rates and predictors of stroke in a private clinic in Kinshasa, Democratic Republic of Congo. METHODS:Two hundred and twelve black Africans were consecutively admitted to a clinic and prospectively assessed during the first 30 days by CT scan-proven stroke types and outcome. Univari...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章
doi：
更新日期：2008-03-01 00:00:00
abstract：BACKGROUND:Most intra-coronary stents in use are made of 316 L stainless steel, which contains nickel, chromate and molybdenum. Whether inflammatory and allergic reactions to metals contribute to in-stent restenosis is still a matter of debate. AIM:The aim of this study was to ascertain the relationship between metal ...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章
doi：10.5830/CVJA-2017-036
更新日期：2018-01-01 00:00:00
abstract：AIM:To investigate the osteogenic differentiation of vascular smooth muscle cells (VSMCs) in mice with chronic kidney disease (CKD) and to evaluate the effects of p53 on the osteogenic differentiation of the VSMCs. METHODS:Experimental models of CKD-associated vascular calcification generated by five-sixth (5/6) nephr...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章
doi：10.5830/CVJA-2011-069
更新日期：2012-07-12 00:00:00
abstract：AIM:Flow-mediated dilatation (FMD) and retinal vascular analysis (RVA) may assist in predicting cardiovascular disease (CVD) but are poorly characterised in South Africa. We recorded baseline FMD and retinal vascular widths in healthy participants, and investigated associations with cardiovascular risk factors. METHOD...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章
doi：10.5830/CVJA-2020-046
更新日期：2020-11-13 00:00:00
abstract：:The biennial Congress of the Pan-African Society of Cardiology (PASCAR) was held in Dakar from 16 to 19 May 2013 under the patronage of his Excellency, Macky Sall, president of the Republic of Senegal. This meeting was remarkable in the diversity of its 700 participants from English-, French- and Portuguese-speaking A...
journal_title：Cardiovascular journal of Africa
pub_type： 社论
doi：
更新日期：2013-06-01 00:00:00
abstract：:Resistant hypertension is a common clinical problem in South Africa and is frequently associated with low renin and aldosterone levels, especially in black Africans. In South Africa, novel variants in the epithelial sodium channel (ENaC) have been described to be associated with varying degrees of hypokalaemia and hyp...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章
doi：10.5830/CVJA-2017-012
更新日期：2017-09-23 00:00:00
abstract：:Hypertension is more prevalent and severe in urban black populations compared to whites, and is associated with a greater degree of target-organ damage for any given blood pressure level. In general, compared to whites, blacks respond well to diuretics and calcium channel blockers and less well to beta-blockers and AC...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章,评审
doi：
更新日期：2007-07-01 00:00:00
abstract：BACKGROUND:Cardiovascular disease (CVD) has been the leading cause of death in developed countries for most of the last century. Most CVD deaths, however, occur in low- and middle-income, developing countries (LMICs) and there is great concern that CVD mortality and burden are rapidly increasing in LMICs as a result of...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章
doi：10.5830/CVJA-2015-036
更新日期：2015-03-01 00:00:00
abstract：OBJECTIVE:Few data are available on heart failure (HF) in sub-Saharan Africa. We aimed to provide a current picture of HF aetiologies in urban Uganda, access to heart surgery, and outcomes. METHODS:We prospectively collected clinical and echocardiographic data from 272 consecutive patients referred for suspected heart...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章
doi：10.5830/CVJA-2014-034
更新日期：2014-09-01 00:00:00
abstract：:The Fontan operation is the primary surgical technique used for palliation of patients with single-ventricle physiology. Arrhythmias are frequently observed and associated with morbidity and mortality in Fontan patients. The frequency of arrhythmias after the Fontan procedure increases over time and it was reported to...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章
doi：10.5830/CVJA-2014-057
更新日期：2014-11-23 00:00:00
abstract：OBJECTIVE:To document maternal and foetal morbidity and mortality in anticoagulated, pregnant patients with mechanical heart valves until 42 days postpartum. METHODS:In a tertiary single-centre, prospective cohort, 178 consecutive patients at the cardiac-obstetric clinic were screened for warfarin use between 1 July 2...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章
doi：10.5830/CVJA-2018-029
更新日期：2018-09-01 00:00:00
abstract：:Acute myocardial infarction is a rare complication of dobutamine stress echocardiography. We describe the case of a diabetic patient who presented with an anterior myocardial infarction complicated by an acute pulmonary oedema and cardiogenic collapse during dobutamine stress echocardiography, requiring five days' hos...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章
doi：10.5830/CVJA-2013-021
更新日期：2013-06-23 00:00:00
abstract：INTRODUCTION:Coronary artery bypass grafting (CABG) results in higher morbidity and mortality rates in end-stage renal disease (ESRD) patient populations than in patients with normal renal function. This study aimed to identify the early results of CABG performed on ESRD patients, and the factors that affected the mort...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章
doi：10.5830/CVJA-2016-066
更新日期：2017-03-01 00:00:00
abstract：BACKGROUND:A four-amino acid deletion was identified within the alpha 2C-adrenergic receptor (alpha 2C Del322-325) that, when homozygous, increases the risk of heart failure in African-Americans nearly six-fold. We hypothesised that homozygosity for the alpha 2C Del322-325 polymorphism may be a risk factor for heart fa...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
abstract：BACKGROUND:Cardiac complications of human immunodeficiency virus (HIV) infection are important causes of morbidity and mortality. We set out to determine the electrocardiographic (ECG) abnormalities in treatment-naïve HIV-positive patients in Enugu, south-east Nigeria. METHODS:This was a cross-sectional study involvin...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章
doi：10.5830/CVJA-2017-013
更新日期：2017-09-01 00:00:00
abstract：AIM:There are few studies to be found in the literature on ankle-brachial index in sickle cell disease. The aim of this study was to compare ankle-brachial index of steadystate adult sickle cell anaemia patients with that of normal controls. METHODS:A descriptive cross-sectional study of 62 sickle cell anaemia patient...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章
doi：10.5830/CVJA-2011-013
更新日期：2012-02-01 00:00:00
abstract：AIM:It has previously been shown that β-blocker therapy reduces QT dynamics in heart failure patients. The aim of this study was to demonstrate this improvement with the third-generation β-blocker, nebivolol. METHODS:A total of 72 heart failure patients with systolic dysfunction were included in the study. Corrected Q...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章
doi：10.5830/CVJA-2011-046
更新日期：2012-05-01 00:00:00
abstract：BACKGROUND:The South African National Development Plan (SANDP) vision for 2030 highlights key recommendations for reducing the prevalence of non-communicable diseases (NCDs) by 28% by 2030. These are mirrored by the World Heart Federation, although it focuses on reducing the NCD prevalence by 25% by 2025. The targeted ...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章
doi：10.5830/CVJA-2018-059
更新日期：2019-01-01 00:00:00
abstract：:Type 2 diabetic patients treated with statins but still experiencing elevated serum levels of triglycerides (2.3 mmol/l or higher) and low HDL cholesterol (0.8 mmol/l or lower), a pre-specified subgroup, benefited from the addition of fenofibrate to their treatment regimen. Risk of cardiovascular events was reduced by...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章
doi：
更新日期：2010-03-01 00:00:00
