HIV-associated large-vessel vasculopathy: a review of the current and emerging clinicopathological spectrum in vascular surgical practice.

Abstract:

:An established relationship exists between human immunodeficiency virus (HIV) and the vascular system, which is characterised by clinical expressions of aneurysmal and occlusive disease that emanate from a common pathological process. The exact pathogenesis is currently unknown; attempts to implicate opportunistic pathogens have been futile. Theories converge on leucocytoclastic vasculitis with the vaso vasora as the vasculopathic epicentre. It is thought that the virus itself or viral proteins trigger the release of inflammatory mediators that cause endothelial dysfunction and smooth muscle proliferation leading to vascular injury and thrombosis. The beneficial effects of highly active anti-retroviral therapy alter the natural history of the disease profile and promote longevity but are negated by cardiovascular complications. Atherosclerosis is an emerging challenge. Presently patients are managed by standard surgical protocols because of non-existent universal surgical interventional guidelines. Clinical response to treatment is variable and often compounded by complications of graft occlusion, sepsis and poor wound healing. The clinical, imaging and pathological observations position HIV-associated large-vessel vasculopathy as a unique entity. This review highlights the spectrum of HIV-associated large-vessel aneurysmal, occlusive and atherosclerotic disease in vascular surgical practice.

journal_name

Cardiovasc J Afr

authors

Pillay B,Ramdial PK,Naidoo DP

doi

10.5830/CVJA-2015-017

subject

Has Abstract

pub_date

2015-03-01 00:00:00

pages

70-81

issue

2

eissn

1995-1892

issn

1680-0745

journal_volume

26

pub_type

杂志文章,评审
  • Quality of life-associated factors among patients undergoing coronary artery bypass surgery as measured using the WHOQOL-BREF.

    abstract::This was a study of the pre-operative factors that influence quality of life (QoL) in patients with coronary artery disease and the relationship between pre-operative QoL and early outcome after coronary artery bypass surgery (CABG). Using the WHOQOL-BREF questionnaire, 283 patients who underwent isolated coronary art...

    journal_title:Cardiovascular journal of Africa

    pub_type: 杂志文章

    doi:

    authors: Najafi M,Sheikhvatan M,Montazeri A

    更新日期:2009-09-01 00:00:00

  • Neonatal circulatory failure due to acute hypertensive crisis: clinical and echocardiographic clues.

    abstract:OBJECTIVE:Circulatory failure due to acute arterial hypertension in the neonatal period is rare. This study was undertaken to assess the clinical and echocardiographic manifestations of circulatory failure resulting from acute neonatal hypertensive crisis. METHODS:Neonatal and cardiology databases from 2007 to 2010 we...

    journal_title:Cardiovascular journal of Africa

    pub_type: 杂志文章

    doi:10.5830/CVJA-2013-003

    authors: Louw J,Brown S,Thewissen L,Smits A,Eyskens B,Heying R,Cools B,Levtchenko E,Allegaert K,Gewillig M

    更新日期:2013-04-01 00:00:00

  • The hyperparathyroid heart mimicking acute myocardial infarction.

    abstract::Left ventricular hypertrophy is a common complication of primary hyperparathyroidism. Numerous disturbances of myocardial physiology have been described as a result of excess parathyroid hormone action. In this brief communication, another phenotype of the hyperparathyroid heart is proposed, the 'pseudo-myocardial inf...

    journal_title:Cardiovascular journal of Africa

    pub_type: 杂志文章

    doi:

    authors: Ker J

    更新日期:2009-05-01 00:00:00

  • The influence of diabetes on short-term outcome following a prosthetic above-the-knee femoro-popliteal bypass.

    abstract:OBJECTIVES:To assess the influence of diabetes mellitus on early morbidity and mortality following a femoro-popliteal bypass. METHODS:Clinical data on patients subjected to a prosthetic above-the-knee femoro-popliteal bypass for atherothrombotic disease over a four-year period in the Durban Metropolitan Vascular Servi...

    journal_title:Cardiovascular journal of Africa

    pub_type: 杂志文章

    doi:

    authors: Mulaudzi TV,Robbs JV,Paruk N,Pillay B,Madiba TE,Govindsamy V

    更新日期:2009-05-01 00:00:00

  • Maternal imbalance between pro-angiogenic and anti-angiogenic factors in HIV-infected women with pre-eclampsia.

    abstract::Angiogenic imbalance contributes to the development of preeclampsia. We evaluated the protein expression of the proangiogenic placental growth factor (PlGF) and transforming growth factor beta 1 (TGF-β1) compared with the anti-angiogenic soluble fms-like tyrosine kinase receptor (sFlt1) and soluble endoglin (sEng) in ...

    journal_title:Cardiovascular journal of Africa

    pub_type: 杂志文章

    doi:10.5830/CVJA-2013-029

    authors: Govender N,Naicker T,Moodley J

    更新日期:2013-06-01 00:00:00

  • Clinical characteristics and outcome of lone atrial fibrillation at a tertiary referral centre: the Groote Schuur Hospital experience.

    abstract:INTRODUCTION:Atrial fibrillation (AF) is a relatively common arrhythmia. When AF represents an electrophysiological phenomenon in structurally normal hearts, it is termed lone AF. This study was a retrospective, case-based analysis of patients attending the Cardiac Clinic at Groote Schuur Hospital (GSH) and describes t...

    journal_title:Cardiovascular journal of Africa

    pub_type: 杂志文章

    doi:10.5830/CVJA-2018-005

    authors: Thomas V,Schulein S,Millar RN,Mayosi BM

    更新日期:2018-09-01 00:00:00

  • Coronary stent restenosis and the association with allergy to metal content of 316L stainless steel.

    abstract:BACKGROUND:Most intra-coronary stents in use are made of 316 L stainless steel, which contains nickel, chromate and molybdenum. Whether inflammatory and allergic reactions to metals contribute to in-stent restenosis is still a matter of debate. AIM:The aim of this study was to ascertain the relationship between metal ...

    journal_title:Cardiovascular journal of Africa

    pub_type: 杂志文章

    doi:10.5830/CVJA-2017-036

    authors: Slodownik D,Danenberg C,Merkin D,Swaid F,Moshe S,Ingber A,Lotan H,Durst R

    更新日期:2018-01-01 00:00:00

  • Reviewing the causes of electrocardiographic pauses.

    abstract::The electrocardiographic term 'pause' refers to the prolonged R-R interval that represents the interruption in ventricular depolarisation. This article presents a case of sinus node dysfunction and provides a diagnostic approach to pauses on the ECG. ...

    journal_title:Cardiovascular journal of Africa

    pub_type: 杂志文章

    doi:10.5830/CVJA-2017-041

    authors: Viljoen C,Smith R,Chin A

    更新日期:2017-07-01 00:00:00

  • Resection of left anterior descending coronary artery aneurysm on a beating heart.

    abstract::We report on the case of a 65-year-old man with unstable angina due to a left anterior descending (LAD) coronary artery single aneurysm. On a beating heart, the aneurysm was partially resected and the left internal thoracic artery was grafted in situ as a patch to the LAD opening. The patient remains well and free of ...

    journal_title:Cardiovascular journal of Africa

    pub_type: 杂志文章

    doi:

    authors: Misthos P,Kokotsakis JN,Lioulias AG,Skouteli EA

    更新日期:2009-03-01 00:00:00

  • Iatrogenic left main-stem dissection extending to the circumflex artery and retrogradely involving the left and non-coronary sinuses of Valsalva: iatrogenic aortocoronary dissection.

    abstract::We present the case of a 57-year-old female who experienced iatrogenic left main-stem (LMS) dissection during elective coronary angiography. The dissection immediately affected the circumflex artery (Cx), causing its total distal occlusion, and the left anterior descending artery (LAD), in which a metal stent, implant...

    journal_title:Cardiovascular journal of Africa

    pub_type: 杂志文章

    doi:10.5830/CVJA-2015-060

    authors: Zwoliński R,Marcinkiewicz A,Szymczyk K,Pietruszyński R,Jaszewski R

    更新日期:2015-11-23 00:00:00

  • p53 negatively regulates the osteogenic differentiation of vascular smooth muscle cells in mice with chronic kidney disease.

    abstract:AIM:To investigate the osteogenic differentiation of vascular smooth muscle cells (VSMCs) in mice with chronic kidney disease (CKD) and to evaluate the effects of p53 on the osteogenic differentiation of the VSMCs. METHODS:Experimental models of CKD-associated vascular calcification generated by five-sixth (5/6) nephr...

    journal_title:Cardiovascular journal of Africa

    pub_type: 杂志文章

    doi:10.5830/CVJA-2011-069

    authors: Li KL,Chen J,Li ZH,Zhao L,He YN

    更新日期:2012-07-12 00:00:00

  • Successful primary percutaneous coronary intervention in a centenarian patient with acute myocardial infarction.

    abstract::A 104-year-old male patient was admitted to the emergency department with chest pain. An electrocardiogram showed ST-segment elevation in the anterior leads. He was immediately taken to the catheterisation laboratory for emergency angiography, which showed thrombotic stenosis at the proximal portion of the left anteri...

    journal_title:Cardiovascular journal of Africa

    pub_type: 杂志文章

    doi:10.5830/CVJA-2014-001

    authors: Aksoy S,Velibey Y,Koroglu B,Cagdas M,Guzelburc O,Cam N,Eren M

    更新日期:2014-02-23 00:00:00

  • [Acute myocardial infarction complicated by acute pulmonary oedema and cardiogenic collapse during dobutamine stress echocardiography].

    abstract::Acute myocardial infarction is a rare complication of dobutamine stress echocardiography. We describe the case of a diabetic patient who presented with an anterior myocardial infarction complicated by an acute pulmonary oedema and cardiogenic collapse during dobutamine stress echocardiography, requiring five days' hos...

    journal_title:Cardiovascular journal of Africa

    pub_type: 杂志文章

    doi:10.5830/CVJA-2013-021

    authors: Yameogo NV,Mbaye A,Kagambega LJ,Dioum M,Diagne-Sow D,Kane M,Diack B,Kane A

    更新日期:2013-06-23 00:00:00

  • Cardiomyopathies and myocardial disorders in Africa: present status and the way forward.

    abstract::A review of heart diseases in Africa shows that the cardiomyopathies continue to be important causes of morbidity and mortality in the population. Hypertension remains the commonest cause of myocardial disease, followed by the cardiomyopathies. Ischaemic heart disease continues to be rare. Of the cardiomyopathies, dil...

    journal_title:Cardiovascular journal of Africa

    pub_type: 杂志文章,评审

    doi:10.5830/CVJA-2012-046

    authors: Falase AO,Ogah OS

    更新日期:2012-11-01 00:00:00

  • The dangerous fifth chamber: congenital left atrial appendage aneurysm.

    abstract::Aneurysms of the left atrial appendage are extremely rare. Enlargement of the left atrial appendage can be congenital or acquired. Dysplasia of the left atrial muscles leads to congenital left atrial appendage aneurysm and usually presents as atrial tachyarrhythmia or embolic events in the second or third decade of li...

    journal_title:Cardiovascular journal of Africa

    pub_type: 杂志文章

    doi:10.5830/CVJA-2011-051

    authors: Tigen KM,Dogan C,Guler A,Hatipoglu S,Yanartas M,Kirma C

    更新日期:2012-06-12 00:00:00

  • Accuracy of D-dimer:fibrinogen ratio to diagnose pulmonary thromboembolism in patients admitted to intensive care units.

    abstract:INTRODUCTION:Pulmonary thromboembolism (PTE) may increase D-dimer and decrease fibrinogen levels. However, in settings such as intensive care units (ICU) and in long-term hospitalised patients, several factors may influence D-dimer and fibrinogen concentrations and make them unreliable indicators for the diagnosis of P...

    journal_title:Cardiovascular journal of Africa

    pub_type: 杂志文章

    doi:10.5830/CVJA-2012-041

    authors: Hajsadeghi S,Kerman SR,Khojandi M,Vaferi H,Ramezani R,Jourshari NM,Mousavi SA,Pouraliakbar H

    更新日期:2012-09-01 00:00:00

  • The effect of lifestyle interventions on maternal body composition during pregnancy in developing countries: a systematic review.

    abstract::Optimal maternal body composition during pregnancy is a public health priority due to its implications on maternal health and infant development. We therefore aimed to conduct a systematic review of randomised, controlled trials, and case-control and cohort studies using lifestyle interventions to improve body composi...

    journal_title:Cardiovascular journal of Africa

    pub_type: 杂志文章,评审

    doi:10.5830/CVJA-2017-003

    authors: Watson ED,Macaulay S,Lamont K,Gradidge PJ,Pretorius S,Crowther NJ,Libhaber E

    更新日期:2017-11-01 00:00:00

  • Behcet's disease and cardiovascular involvement: our experience of asymptomatic Behcet's patients.

    abstract::Behcet's syndrome is a systemic inflammatory disease associated with vasculitis, and arterial, venous and cardiac disorders. Thirty-eight Behcet's disease patients were examined prospectively with echocardiography, ultrasonography and computed tomography, and coagulation parameters were determined. Deep venous insuffi...

    journal_title:Cardiovascular journal of Africa

    pub_type: 杂志文章

    doi:10.5830/CVJA-2014-003

    authors: Ulusan Z,Karadag AS,Tasar M,Kalender M,Darcin OT

    更新日期:2014-03-01 00:00:00

  • Cardiomyopathy in Africa: heredity versus environment.

    abstract::Unlike other parts of the world in which cardiomyopathy is rare, heart muscle disease is endemic in Africa. The major forms of cardiomyopathy in Africa are dilated cardiomyopathy (DCM) and endomyocardial fibrosis (EMF). Whereas DCM is a major cause of heart failure throughout the continent, EMF is restricted to the tr...

    journal_title:Cardiovascular journal of Africa

    pub_type: 杂志文章,评审

    doi:

    authors: Mayosi BM,Somers K

    更新日期:2007-05-01 00:00:00

  • Evaluation of ventricular arrhythmogenesis in children with acute rheumatic carditis.

    abstract:BACKGROUND:Recent studies have shown that the Tp-e interval, which on an electrocardiogram (ECG) is the interval between the peak and the end of the T wave, can be used as an index of transmural dispersion of ventricular repolarisation (TDR). Both Tp-e/QT and Tp-e/QTc ratios have also been used in that capacity. Howeve...

    journal_title:Cardiovascular journal of Africa

    pub_type: 杂志文章

    doi:10.5830/CVJA-2018-043

    authors: Kucuk M,Karadeniz C,Ozdemir R,Meşe T

    更新日期:2018-11-01 00:00:00

  • An antibiotic recipe for an arrhythmic disaster.

    abstract::We describe the case of a patient who developed torsade de pointes during temporary pacemaker insertion after administration of intravenous erythromycin. The case highlights the dangers of administering drugs that prolong the QT interval in patients with complete atrioventricular block, and we discuss the underlying p...

    journal_title:Cardiovascular journal of Africa

    pub_type: 杂志文章

    doi:10.5830/CVJA-2015-006

    authors: McCutcheon K,Manga P

    更新日期:2015-05-01 00:00:00

  • The therapeutic management of South African dyslipidaemic patients at very high cardiovascular risk (CARDIO TRACK): a cross-sectional study.

    abstract:BACKGROUND:Dyslipidaemia is a major modifiable risk factor for atherosclerotic cardiovascular disease. At the time the study was conducted, guidelines recommended a low-density lipoprotein cholesterol (LDL-C) target of less than 1.8 mmol/l and a reduction of at least 50% if the baseline LDL-C was between 1.8 and 3.5 mm...

    journal_title:Cardiovascular journal of Africa

    pub_type: 杂志文章,多中心研究

    doi:10.5830/CVJA-2020-010

    authors: Blom DJ,Ranjith N,Joshi P,Naidoo P,van Tonder A,Musa MG,Joshi S,Leisegang R,Trokis JS,Makan H,Raal FJ

    更新日期:2020-09-01 00:00:00

  • Electrocardiographic abnormalities in treatment-naïve HIV subjects in south-east Nigeria.

    abstract:BACKGROUND:Cardiac complications of human immunodeficiency virus (HIV) infection are important causes of morbidity and mortality. We set out to determine the electrocardiographic (ECG) abnormalities in treatment-naïve HIV-positive patients in Enugu, south-east Nigeria. METHODS:This was a cross-sectional study involvin...

    journal_title:Cardiovascular journal of Africa

    pub_type: 杂志文章

    doi:10.5830/CVJA-2017-013

    authors: Okoye IC,Anyabolu EN

    更新日期:2017-09-01 00:00:00

  • Vascular health assessment with flow-mediated dilatation and retinal image analysis: a pilot study in an adult population from Cape Town.

    abstract:AIM:Flow-mediated dilatation (FMD) and retinal vascular analysis (RVA) may assist in predicting cardiovascular disease (CVD) but are poorly characterised in South Africa. We recorded baseline FMD and retinal vascular widths in healthy participants, and investigated associations with cardiovascular risk factors. METHOD...

    journal_title:Cardiovascular journal of Africa

    pub_type: 杂志文章

    doi:10.5830/CVJA-2020-046

    authors: Marincowitz C,Webster I,Westcott C,Goswami N,de Boever P,Seidel G,Strijdom H

    更新日期:2020-11-13 00:00:00

  • Successful management of spontaneous aortic dissection type B in the third trimester of pregnancy.

    abstract::Acute aortic dissection is a life-threatening disease that requires immediate surgical intervention. Although aortic dissection is a rare condition during pregnancy, it is of high risk for both mother and foetus. Most cases of aortic dissection during pregnancy have certain risk factors, including Marfan syndrome and ...

    journal_title:Cardiovascular journal of Africa

    pub_type: 杂志文章

    doi:10.5830/CVJA-2012-063

    authors: Simsek Y,Colak C,Yilmaz E,Celik E,Erdil N,Celik O

    更新日期:2012-11-23 00:00:00

  • Surgical placement of left ventricular lead for cardiac resynchronisation therapy after failure of percutaneous attempt.

    abstract:OBJECTIVE:Cardiac resynchronisation therapy has been shown to be an effective treatment to improve functional status and prolong survival of patients in advanced chronic heart failure. This study assessed the surgical outcomes of left anterior mini-thoracotomy for the implantation of left ventricular epicardial pacing ...

    journal_title:Cardiovascular journal of Africa

    pub_type: 杂志文章

    doi:10.5830/CVJA-2016-046

    authors: Ezelsoy M,Bayram M,Yazici S,Yazicioglu N,Sagbas E

    更新日期:2017-01-01 00:00:00

  • Cardiac surgery for patients with heart failure due to structural heart disease in Uganda: access to surgery and outcomes.

    abstract:OBJECTIVE:Few data are available on heart failure (HF) in sub-Saharan Africa. We aimed to provide a current picture of HF aetiologies in urban Uganda, access to heart surgery, and outcomes. METHODS:We prospectively collected clinical and echocardiographic data from 272 consecutive patients referred for suspected heart...

    journal_title:Cardiovascular journal of Africa

    pub_type: 杂志文章

    doi:10.5830/CVJA-2014-034

    authors: Grimaldi A,Ammirati E,Karam N,Vermi AC,de Concilio A,Trucco G,Aloi F,Arioli F,Figini F,Ferrarello S,Sacco FM,Grottola R,D'Arbela PG,Alfieri O,Marijon E,Freers J,Mirabel M

    更新日期:2014-09-01 00:00:00

  • Dual effect of quercetin on rat isolated portal vein smooth muscle contractility.

    abstract::This study examined the effects of quercetin on spontaneously contracting portal veins isolated from healthy young adult male and female Wistar rats (250-300 g). Quercetin (10(-7)-10(-4) M) always produced significant biphasic effects, comprising an initial brief stimulant effect (rise in basal tone), followed by a su...

    journal_title:Cardiovascular journal of Africa

    pub_type: 杂志文章

    doi:

    authors: Chiwororo WD,Ojewole JA

    更新日期:2010-05-01 00:00:00

  • ACCORD LIPID study results strengthen guideline approach of adding fenofibrate to therapy of dyslipidaemic type 2 diabetic patients.

    abstract::Type 2 diabetic patients treated with statins but still experiencing elevated serum levels of triglycerides (2.3 mmol/l or higher) and low HDL cholesterol (0.8 mmol/l or lower), a pre-specified subgroup, benefited from the addition of fenofibrate to their treatment regimen. Risk of cardiovascular events was reduced by...

    journal_title:Cardiovascular journal of Africa

    pub_type: 杂志文章

    doi:

    authors: Aalbers J

    更新日期:2010-03-01 00:00:00

  • The role of coronary artery collaterals in the preservation of left ventricular function: a study to address a long-standing controversy.

    abstract:INTRODUCTION:The functional significance of coronary artery collateral (CAC) vasculature in humans has been debated for decades and this has been compounded by the lack of a standard, systematic, objective method of grading and documenting CAC flow in man. CACs serve as alternative conduits for blood in obstructive cor...

    journal_title:Cardiovascular journal of Africa

    pub_type: 杂志文章

    doi:10.5830/CVJA-2016-054

    authors: Ajayi NO,Vanker EA,Satyapal KS

    更新日期:2017-03-01 00:00:00