Abstract:
:An established relationship exists between human immunodeficiency virus (HIV) and the vascular system, which is characterised by clinical expressions of aneurysmal and occlusive disease that emanate from a common pathological process. The exact pathogenesis is currently unknown; attempts to implicate opportunistic pathogens have been futile. Theories converge on leucocytoclastic vasculitis with the vaso vasora as the vasculopathic epicentre. It is thought that the virus itself or viral proteins trigger the release of inflammatory mediators that cause endothelial dysfunction and smooth muscle proliferation leading to vascular injury and thrombosis. The beneficial effects of highly active anti-retroviral therapy alter the natural history of the disease profile and promote longevity but are negated by cardiovascular complications. Atherosclerosis is an emerging challenge. Presently patients are managed by standard surgical protocols because of non-existent universal surgical interventional guidelines. Clinical response to treatment is variable and often compounded by complications of graft occlusion, sepsis and poor wound healing. The clinical, imaging and pathological observations position HIV-associated large-vessel vasculopathy as a unique entity. This review highlights the spectrum of HIV-associated large-vessel aneurysmal, occlusive and atherosclerotic disease in vascular surgical practice.
journal_name
Cardiovasc J Afrjournal_title
Cardiovascular journal of Africaauthors
Pillay B,Ramdial PK,Naidoo DPdoi
10.5830/CVJA-2015-017subject
Has Abstractpub_date
2015-03-01 00:00:00pages
70-81issue
2eissn
1995-1892issn
1680-0745journal_volume
26pub_type
杂志文章,评审abstract::This was a study of the pre-operative factors that influence quality of life (QoL) in patients with coronary artery disease and the relationship between pre-operative QoL and early outcome after coronary artery bypass surgery (CABG). Using the WHOQOL-BREF questionnaire, 283 patients who underwent isolated coronary art...
journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章
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journal_title:Cardiovascular journal of Africa
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journal_title:Cardiovascular journal of Africa
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journal_title:Cardiovascular journal of Africa
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journal_title:Cardiovascular journal of Africa
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章
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journal_title:Cardiovascular journal of Africa
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章
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更新日期:2009-03-01 00:00:00
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journal_title:Cardiovascular journal of Africa
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章
doi:10.5830/CVJA-2014-001
更新日期:2014-02-23 00:00:00
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章
doi:10.5830/CVJA-2013-021
更新日期:2013-06-23 00:00:00
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章,评审
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更新日期:2012-11-01 00:00:00
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章
doi:10.5830/CVJA-2012-041
更新日期:2012-09-01 00:00:00
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章,评审
doi:10.5830/CVJA-2017-003
更新日期:2017-11-01 00:00:00
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章
doi:10.5830/CVJA-2014-003
更新日期:2014-03-01 00:00:00
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章,评审
doi:
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章
doi:10.5830/CVJA-2012-063
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章
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journal_title:Cardiovascular journal of Africa
pub_type: 杂志文章
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