p53 negatively regulates the osteogenic differentiation of vascular smooth muscle cells in mice with chronic kidney disease.

abstract：OBJECTIVES:Previous studies have suggested that failure of the synthesis of nitric oxide is involved in the pathophysiology of myocardial ischaemia-reperfusion injury. In this study, we investigated the effect of mebudipine, a new dihydropyridine calcium channel blocker, on cardiac function and activity of the myocardi...

journal_title：Cardiovascular journal of Africa

authors： Ghyasi R,Mohammadi M,Badalzadeh R,Rashidi B,Sepehri G

更新日期：2011-11-01 00:00:00

abstract：AIM:To determine whether a single elevated myocardial performance index (MPI) value in the third trimester of pregnancy is a marker for later adverse obstetric outcomes in stable placental-mediated disease, defined as well-controlled pre-eclampsia (PE) on a single agent and/or uncompensated intra-uterine growth restric...

journal_title：Cardiovascular journal of Africa

authors： Bhorat I,Pillay M,Reddy T

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:Methods of closing patent ductus arteriosus (PDA) have evolved over time. We review this development in our setting. METHODS:This was a retrospective analysis of children who had transcatheter PDA closure at Chris Hani Baragwanath Hospital between 1993 and 2008. RESULTS:Over 15 years, 1 254 PDAs were diagn...

journal_title：Cardiovascular journal of Africa

authors： Adams PE,Chersich MF,Cilliers A

更新日期：2018-07-01 00:00:00

abstract：:In this study the baroreflex sensitivity of conscious, juvenile, spontaneously hypertensive rats (SHRs) was compared. The study population consisted of 19 eight-week-old male SHRs. The baroreflex sensitivity was quantified as the derivative of the variation in heart rate (HR) and the variation of mean arterial pressur...

journal_title：Cardiovascular journal of Africa

authors： Valenti VE,De Abreu LC,Colombari E,Sato MA,Ferreira C

更新日期：2011-01-01 00:00:00

abstract：:We describe the case of a patient who developed torsade de pointes during temporary pacemaker insertion after administration of intravenous erythromycin. The case highlights the dangers of administering drugs that prolong the QT interval in patients with complete atrioventricular block, and we discuss the underlying p...

journal_title：Cardiovascular journal of Africa

authors： McCutcheon K,Manga P

更新日期：2015-05-01 00:00:00

abstract：:We researched hypertrophic cardiomyopathy (HCM) and long QT syndrome (LQTS) as models for studying the pathophysiology of arrhythmias and hypertrophy, and in the process we have had the opportunity to compare local disease profiles with global patterns. We trawled our database entries over the past 20 years to identif...

journal_title：Cardiovascular journal of Africa

authors： Heradien M,Goosen A,Moolman-Smook JC,Brink PA

更新日期：2007-09-01 00:00:00

abstract：:We present the case of a 57-year-old female who experienced iatrogenic left main-stem (LMS) dissection during elective coronary angiography. The dissection immediately affected the circumflex artery (Cx), causing its total distal occlusion, and the left anterior descending artery (LAD), in which a metal stent, implant...

journal_title：Cardiovascular journal of Africa

authors： Zwoliński R,Marcinkiewicz A,Szymczyk K,Pietruszyński R,Jaszewski R

更新日期：2015-11-23 00:00:00

abstract：INTRODUCTION:Pulmonary thromboembolism (PTE) may increase D-dimer and decrease fibrinogen levels. However, in settings such as intensive care units (ICU) and in long-term hospitalised patients, several factors may influence D-dimer and fibrinogen concentrations and make them unreliable indicators for the diagnosis of P...

journal_title：Cardiovascular journal of Africa

authors： Hajsadeghi S,Kerman SR,Khojandi M,Vaferi H,Ramezani R,Jourshari NM,Mousavi SA,Pouraliakbar H

更新日期：2012-09-01 00:00:00

abstract：INTRODUCTION:A coronary artery anomaly precludes the use of a trans-annular patch in right ventricular outflow tract (RVOT) reconstruction. Herein we present three patients with coronary artery anomalies who underwent total corrective operations without using a conduit. METHODS:Between 2007 and 2010, 84 patients with ...

journal_title：Cardiovascular journal of Africa

authors： Saritas B,Ozker E,Vuran E,Yoruker U,Ayabakan C,Turkoz R

更新日期：2012-03-12 00:00:00

abstract：:We report on a patient who developed cardiogenic shock caused by dynamic left ventricular outflow tract (LVOT) obstruction following percutaneous coronary intervention for anteroseptal acute myocardial infarction. ...

journal_title：Cardiovascular journal of Africa

authors： Karabay CY,Kocabay G,Kalayci A,Tanboga H,Mert M,Kirma C

更新日期：2011-07-01 00:00:00

abstract：AIM:Flow-mediated dilatation (FMD) and retinal vascular analysis (RVA) may assist in predicting cardiovascular disease (CVD) but are poorly characterised in South Africa. We recorded baseline FMD and retinal vascular widths in healthy participants, and investigated associations with cardiovascular risk factors. METHOD...

journal_title：Cardiovascular journal of Africa

authors： Marincowitz C,Webster I,Westcott C,Goswami N,de Boever P,Seidel G,Strijdom H

更新日期：2020-11-13 00:00:00

abstract：OBJECTIVE:Circulatory failure due to acute arterial hypertension in the neonatal period is rare. This study was undertaken to assess the clinical and echocardiographic manifestations of circulatory failure resulting from acute neonatal hypertensive crisis. METHODS:Neonatal and cardiology databases from 2007 to 2010 we...

journal_title：Cardiovascular journal of Africa

authors： Louw J,Brown S,Thewissen L,Smits A,Eyskens B,Heying R,Cools B,Levtchenko E,Allegaert K,Gewillig M

更新日期：2013-04-01 00:00:00

abstract：:Peripheral arterial disease (PAD) represents a major public health problem due to its high and increasing prevalence, worldwide distribution, and significant morbidity and mortality rate. Female gender is a risk factor for PAD globally and especially in low-income countries. In this review, we summarise the present kn...

journal_title：Cardiovascular journal of Africa

authors： Comşa HI,Zdrenghea D,Man SC,Pop D

更新日期：2018-09-01 00:00:00

abstract：:Acute aortic dissection is a life-threatening disease that requires immediate surgical intervention. Although aortic dissection is a rare condition during pregnancy, it is of high risk for both mother and foetus. Most cases of aortic dissection during pregnancy have certain risk factors, including Marfan syndrome and ...

journal_title：Cardiovascular journal of Africa

authors： Simsek Y,Colak C,Yilmaz E,Celik E,Erdil N,Celik O

更新日期：2012-11-23 00:00:00

abstract：AIM:To provide imaging data and report associations between human immunodeficiency virus (HIV), tuberculosis (TB) and pulmonary embolism (PE) in a South African population that underwent computed tomography pulmonary angiography (CTPA) for suspected PE. METHODS:A validated Qanadli severity scoring system for PE was us...

journal_title：Cardiovascular journal of Africa

authors： Ramlakhan R,Andronikou S,Rajkumar A

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:We aimed to determine the possible factors leading to re-operation in patients undergoing mechanical valve replacement and to investigate the relationship between valvular thrombus formation and mean platelet volume. METHODS:The medical records of 43 patients with mechanical valve implantation, who were adm...

journal_title：Cardiovascular journal of Africa

authors： Aydin E,Yapici F

更新日期：2013-08-01 00:00:00

abstract：OBJECTIVE:Few data are available on heart failure (HF) in sub-Saharan Africa. We aimed to provide a current picture of HF aetiologies in urban Uganda, access to heart surgery, and outcomes. METHODS:We prospectively collected clinical and echocardiographic data from 272 consecutive patients referred for suspected heart...

journal_title：Cardiovascular journal of Africa

authors： Grimaldi A,Ammirati E,Karam N,Vermi AC,de Concilio A,Trucco G,Aloi F,Arioli F,Figini F,Ferrarello S,Sacco FM,Grottola R,D'Arbela PG,Alfieri O,Marijon E,Freers J,Mirabel M

更新日期：2014-09-01 00:00:00

abstract：:We report on the case of a 65-year-old man with unstable angina due to a left anterior descending (LAD) coronary artery single aneurysm. On a beating heart, the aneurysm was partially resected and the left internal thoracic artery was grafted in situ as a patch to the LAD opening. The patient remains well and free of ...

journal_title：Cardiovascular journal of Africa

authors： Misthos P,Kokotsakis JN,Lioulias AG,Skouteli EA

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND:Cardiovascular disease (CVD) has been the leading cause of death in developed countries for most of the last century. Most CVD deaths, however, occur in low- and middle-income, developing countries (LMICs) and there is great concern that CVD mortality and burden are rapidly increasing in LMICs as a result of...

journal_title：Cardiovascular journal of Africa

authors： Mensah GA,Roth GA,Sampson UK,Moran AE,Feigin VL,Forouzanfar MH,Naghavi M,Murray CJ,GBD 2013 Mortality and Causes of Death Collaborators.

更新日期：2015-03-01 00:00:00

abstract：:Behcet's syndrome is a systemic inflammatory disease associated with vasculitis, and arterial, venous and cardiac disorders. Thirty-eight Behcet's disease patients were examined prospectively with echocardiography, ultrasonography and computed tomography, and coagulation parameters were determined. Deep venous insuffi...

journal_title：Cardiovascular journal of Africa

authors： Ulusan Z,Karadag AS,Tasar M,Kalender M,Darcin OT

更新日期：2014-03-01 00:00:00

abstract：:Heparin-induced thrombocytopenia (HIT) is a rare but potentially devastating and life-threatening complication from using heparin. HIT not only causes thrombocytopenia, but it also carries an increased risk for fatal thrombotic complications. In this report, we describe the case of a patient in whom fatal HIT develope...

journal_title：Cardiovascular journal of Africa

authors： Nazli Y,Colak N,Demircelik B,Alpay MF,Cakir O,Cagli K

更新日期：2015-05-23 00:00:00

abstract：BACKGROUND:A four-amino acid deletion was identified within the alpha 2C-adrenergic receptor (alpha 2C Del322-325) that, when homozygous, increases the risk of heart failure in African-Americans nearly six-fold. We hypothesised that homozygosity for the alpha 2C Del322-325 polymorphism may be a risk factor for heart fa...

journal_title：Cardiovascular journal of Africa

authors： Du Preez J,Matolweni LO,Greenberg J,Mntla P,Adeyemo AA,Mayosi BM

更新日期：2008-01-01 00:00:00

abstract：:In developing countries, rheumatoid arthritis (RA) remains a seriously under-prioritised disease, particularly among the underprivileged, often resulting in presentation of patients late in the course of their disease, further complicated by limited therapeutic options and inconsistent follow up. The consequences are ...

journal_title：Cardiovascular journal of Africa

authors： Meyer PW,Anderson R,Ker JA,Ally MT

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:Guidelines advise early angiography in non-ST elevation myocardial infarction (NSTEMI) to ensure an optimal outcome. Resource limitations in secondary hospitals in the Western Cape dictate a local guideline to treat NSTEMIs medically with out-patient assessment for angiography, unless mandatory indications f...

journal_title：Cardiovascular journal of Africa

authors： Moses J,Doubell AF,Herbst PG,Klusmann KJ,Weich HS

更新日期：2013-05-01 00:00:00

abstract：:Pulmonary hypertension (PH) has progressively moved from an orphan disease to a significant global health problem with a major disease burden in limited7hyphen;resource countries, where over 97% of patients live. The aetiologies of PH differ between high- and low-income nations, but PH due to left heart disease is cre...

journal_title：Cardiovascular journal of Africa

authors： Dzudie A,Kengne AP,Lamont K,Dzekem BS,Aminde LN,Abanda MH,Thienemann F,Sliwa K

更新日期：2019-01-01 00:00:00

abstract：:A review of heart diseases in Africa shows that the cardiomyopathies continue to be important causes of morbidity and mortality in the population. Hypertension remains the commonest cause of myocardial disease, followed by the cardiomyopathies. Ischaemic heart disease continues to be rare. Of the cardiomyopathies, dil...

journal_title：Cardiovascular journal of Africa

authors： Falase AO,Ogah OS

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Previous studies have shown controversial results on the role of androgens in coronary artery disease (CAD). We performed this study to assess the relationship between androgen levels and selective coronary angiography (SCA) findings. METHODS:This study was conducted on 502 consecutive men who underwent SCA...

journal_title：Cardiovascular journal of Africa

authors： Davoodi G,Amirezadegan A,Borumand MA,Dehkori MR,Kazemisaeid A,Yaminisharif A

更新日期：2007-11-01 00:00:00

abstract：:Angiogenic imbalance contributes to the development of preeclampsia. We evaluated the protein expression of the proangiogenic placental growth factor (PlGF) and transforming growth factor beta 1 (TGF-β1) compared with the anti-angiogenic soluble fms-like tyrosine kinase receptor (sFlt1) and soluble endoglin (sEng) in ...

journal_title：Cardiovascular journal of Africa

authors： Govender N,Naicker T,Moodley J

更新日期：2013-06-01 00:00:00

abstract：AIM:There are few studies to be found in the literature on ankle-brachial index in sickle cell disease. The aim of this study was to compare ankle-brachial index of steadystate adult sickle cell anaemia patients with that of normal controls. METHODS:A descriptive cross-sectional study of 62 sickle cell anaemia patient...

journal_title：Cardiovascular journal of Africa

authors： Oguanobi NI,Onwubere BJ,Ibegbulam OG,Ike SO,Ejim EC,Agwu O

更新日期：2012-02-01 00:00:00

abstract：:Type 2 diabetic patients treated with statins but still experiencing elevated serum levels of triglycerides (2.3 mmol/l or higher) and low HDL cholesterol (0.8 mmol/l or lower), a pre-specified subgroup, benefited from the addition of fenofibrate to their treatment regimen. Risk of cardiovascular events was reduced by...

journal_title：Cardiovascular journal of Africa

authors： Aalbers J

更新日期：2010-03-01 00:00:00