Abstract：
:Angiogenic imbalance contributes to the development of preeclampsia. We evaluated the protein expression of the proangiogenic placental growth factor (PlGF) and transforming growth factor beta 1 (TGF-β1) compared with the anti-angiogenic soluble fms-like tyrosine kinase receptor (sFlt1) and soluble endoglin (sEng) in HIV-infected normotensive and pre-eclamptic pregnancies. Blood was obtained from 110 pregnant women, enrolled in four groups, namely, HIV-negative normotensives (27); HIV-positive normotensives (31); HIV-negative pre-eclamptics (27) and HIV-positive pre-eclamptics (25), and was used to measure PlGF, TGF-β₁, sFlt1 and sEng levels. Increased sFlt1 and sEng levels were associated with the pre-eclamptics (HIV negative and positive) compared with their counterparts. Decreased PlGF levels were observed between the HIV-negative pre-eclamptics versus HIV-negative normotensives, but levels differed significantly (p = 0.02) among the normotensives (HIV negative and positive). TGF-β₁ remained unchanged across all groups. Higher sEng/TGF-β₁ ratios were associated with the pre-eclamptics (HIV negative and positive) compared with their counterparts. This study demonstrated increased sFlt1 and sEng levels in pre-eclamptic compared with normotensive pregnancies, irrespective of the HIV status.
journal_name
Cardiovasc J Afrjournal_title
Cardiovascular journal of Africaauthors
Govender N,Naicker T,Moodley Jdoi
10.5830/CVJA-2013-029subject
Has Abstractpub_date
2013-06-01 00:00:00pages
174-9issue
5eissn
1995-1892issn
1680-0745journal_volume
24pub_type
杂志文章abstract：:We report on a patient who developed cardiogenic shock caused by dynamic left ventricular outflow tract (LVOT) obstruction following percutaneous coronary intervention for anteroseptal acute myocardial infarction. ...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章
doi：10.5830/CVJA-2010-051
更新日期：2011-07-01 00:00:00
abstract：OBJECTIVE:Cardiac resynchronisation therapy has been shown to be an effective treatment to improve functional status and prolong survival of patients in advanced chronic heart failure. This study assessed the surgical outcomes of left anterior mini-thoracotomy for the implantation of left ventricular epicardial pacing ...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章
doi：10.5830/CVJA-2016-046
更新日期：2017-01-01 00:00:00
abstract：INTRODUCTION:The functional significance of coronary artery collateral (CAC) vasculature in humans has been debated for decades and this has been compounded by the lack of a standard, systematic, objective method of grading and documenting CAC flow in man. CACs serve as alternative conduits for blood in obstructive cor...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章
doi：10.5830/CVJA-2016-054
更新日期：2017-03-01 00:00:00
abstract：AIM:The aim of this study was to evaluate the effects of the sphingosine analogue, FTY720 (Fingolimod), on the outcomes of myocardial ischaemia/reperfusion (I/R) injury. METHODS:Two concentrations of FTY720 (1 or 2.5 µM were administered either prior to (PreFTY), or following (PostFTY) 20 minutes' global (GI) or 35 mi...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章
doi：10.5830/CVJA-2016-039
更新日期：2016-11-01 00:00:00
abstract：:Type 2 diabetic patients treated with statins but still experiencing elevated serum levels of triglycerides (2.3 mmol/l or higher) and low HDL cholesterol (0.8 mmol/l or lower), a pre-specified subgroup, benefited from the addition of fenofibrate to their treatment regimen. Risk of cardiovascular events was reduced by...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章
doi：
更新日期：2010-03-01 00:00:00
abstract：:Coronavirus disease 2019 (COVID-19) is a recently recognised pandemic spreading rapidly from Wuhan, Hubei, to other provinces in China and to many countries around the world. The number of COVID-19-related deaths is steadily increasing. Acute ST-segment elevation myocardial infarction (STEMI) is a disease with high mo...
journal_title：Cardiovascular journal of Africa
pub_type：
doi：10.5830-CVJA-2020-016
更新日期：2020-11-01 00:00:00
abstract：OBJECTIVE:Circulatory failure due to acute arterial hypertension in the neonatal period is rare. This study was undertaken to assess the clinical and echocardiographic manifestations of circulatory failure resulting from acute neonatal hypertensive crisis. METHODS:Neonatal and cardiology databases from 2007 to 2010 we...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章
doi：10.5830/CVJA-2013-003
更新日期：2013-04-01 00:00:00
abstract：:An established relationship exists between human immunodeficiency virus (HIV) and the vascular system, which is characterised by clinical expressions of aneurysmal and occlusive disease that emanate from a common pathological process. The exact pathogenesis is currently unknown; attempts to implicate opportunistic pat...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章,评审
doi：10.5830/CVJA-2015-017
更新日期：2015-03-01 00:00:00
abstract：:We present a case of an 85-year-old man with acute myocardial infarction and cardiogenic shock due to left main coronary artery occlusion, with spontaneous dissection of the right coronary artery. ...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章
doi：CVJ-21.036
更新日期：2011-05-01 00:00:00
abstract：BACKGROUND:Rheumatoid arthritis (RA) is associated with increased cardiovascular morbidity and mortality. In the current prospective study, we addressed the impact of RA on left atrial (LA) function and electrical remodelling. Further, we tried to demonstrate the effects of infliximab, an anti-TNF-alpha agent, on echoc...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章
doi：10.5830/CVJA-2014-036
更新日期：2014-07-01 00:00:00
abstract：INTRODUCTION:Rheumatic heart disease (RHD) continues to cause gross distortions of the heart and the associated complications of heart failure and thromboembolic phenomena in this age of numerous high-efficacy drugs and therapeutic interventions. Due to the lack of contemporary local data, there is no national strategy...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章
doi：10.5830/CVJA-2012-076
更新日期：2013-03-01 00:00:00
abstract：:The Fontan operation is the primary surgical technique used for palliation of patients with single-ventricle physiology. Arrhythmias are frequently observed and associated with morbidity and mortality in Fontan patients. The frequency of arrhythmias after the Fontan procedure increases over time and it was reported to...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章
doi：10.5830/CVJA-2014-057
更新日期：2014-11-23 00:00:00
abstract：OBJECTIVE:The surgical approach for effusive constrictive pericarditis (ECP) has not been extensively studied. We present our institution's early and long-term results of pericardiectomy in our cohort of patients with ECP. METHODS:Diagnosis was made primarily by echocardiography. Right heart catheterisation was perfor...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章
doi：10.5830/CVJA-2013-042
更新日期：2013-09-01 00:00:00
abstract：:Very late bare-metal stent (BMS) thrombosis is unusual in clinical practice. To the best of our knowledge, the latest that the thrombosis of a BMS has been reported is 14 years after implantation. Here, we describe a case of BMS thrombosis that occurred two decades after stenting. A 68-year-old male patient was admitt...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章
doi：10.5830/CVJA-2015-034
更新日期：2015-07-23 00:00:00
abstract：INTRODUCTION:Pulmonary thromboembolism (PTE) may increase D-dimer and decrease fibrinogen levels. However, in settings such as intensive care units (ICU) and in long-term hospitalised patients, several factors may influence D-dimer and fibrinogen concentrations and make them unreliable indicators for the diagnosis of P...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章
doi：10.5830/CVJA-2012-041
更新日期：2012-09-01 00:00:00
abstract：:Cardiovascular conditions associated with pregnancy are serious complications. In general, depression is a well-known risk indicator for cardiovascular disease (CVD). Mental distress and depression are associated with physiological responses such as inflammation and oxidative stress. Both inflammation and oxidative st...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章,评审
doi：10.5830/CVJA-2015-087
更新日期：2016-03-01 00:00:00
abstract：BACKGROUND:We aimed to determine the possible factors leading to re-operation in patients undergoing mechanical valve replacement and to investigate the relationship between valvular thrombus formation and mean platelet volume. METHODS:The medical records of 43 patients with mechanical valve implantation, who were adm...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章
doi：10.5830/CVJA-2013-044
更新日期：2013-08-01 00:00:00
abstract：:Resistant hypertension is a common clinical problem in South Africa and is frequently associated with low renin and aldosterone levels, especially in black Africans. In South Africa, novel variants in the epithelial sodium channel (ENaC) have been described to be associated with varying degrees of hypokalaemia and hyp...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章
doi：10.5830/CVJA-2017-012
更新日期：2017-09-23 00:00:00
abstract：:Acute aortic dissection is a life-threatening disease that requires immediate surgical intervention. Although aortic dissection is a rare condition during pregnancy, it is of high risk for both mother and foetus. Most cases of aortic dissection during pregnancy have certain risk factors, including Marfan syndrome and ...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章
doi：10.5830/CVJA-2012-063
更新日期：2012-11-23 00:00:00
abstract：:Hypertension is more prevalent and severe in urban black populations compared to whites, and is associated with a greater degree of target-organ damage for any given blood pressure level. In general, compared to whites, blacks respond well to diuretics and calcium channel blockers and less well to beta-blockers and AC...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章,评审
doi：
更新日期：2007-07-01 00:00:00
abstract：INTRODUCTION:A coronary artery anomaly precludes the use of a trans-annular patch in right ventricular outflow tract (RVOT) reconstruction. Herein we present three patients with coronary artery anomalies who underwent total corrective operations without using a conduit. METHODS:Between 2007 and 2010, 84 patients with ...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章
doi：10.5830/CVJA-2011-004
更新日期：2012-03-12 00:00:00
abstract：BACKGROUND:Most intra-coronary stents in use are made of 316 L stainless steel, which contains nickel, chromate and molybdenum. Whether inflammatory and allergic reactions to metals contribute to in-stent restenosis is still a matter of debate. AIM:The aim of this study was to ascertain the relationship between metal ...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章
doi：10.5830/CVJA-2017-036
更新日期：2018-01-01 00:00:00
abstract：:We present the case of a 57-year-old female who experienced iatrogenic left main-stem (LMS) dissection during elective coronary angiography. The dissection immediately affected the circumflex artery (Cx), causing its total distal occlusion, and the left anterior descending artery (LAD), in which a metal stent, implant...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章
doi：10.5830/CVJA-2015-060
更新日期：2015-11-23 00:00:00
abstract：:We are deeply saddened by the loss of our great teacher Donald Ross, a truly global mentor in cardiac surgery, a friend, a respectful colleague, an admirer, and custodian of our profession, who passed away on July 7, 2014. ...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章
doi：
更新日期：2014-07-01 00:00:00
abstract：:We report on the case of a 65-year-old man with unstable angina due to a left anterior descending (LAD) coronary artery single aneurysm. On a beating heart, the aneurysm was partially resected and the left internal thoracic artery was grafted in situ as a patch to the LAD opening. The patient remains well and free of ...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章
doi：
更新日期：2009-03-01 00:00:00
abstract：:Tricuspid annular ventricular tachycardia (VT) is a rarely encountered entity. Despite abundant data on idiopathic VTs, the prevalence and clinical characteristics of this infrequent form are not well defined and the efficacy of radiofrequency (RF) catheter ablation treatment remains unknown. We report on a case of a ...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章
doi：10.5830/CVJA-2012-010
更新日期：2012-07-12 00:00:00
abstract：OBJECTIVE:Pulmonary embolism (PE) is a potentially fatal disease. In Angola, few data are available on its occurrence. The aim of the study was to characterise the clinical profile, management and outcomes of patients with PE. METHODS:A retrospective observational study was conducted at the Girassol Clinic in Luanda, ...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章
doi：10.5830/CVJA-2017-017
更新日期：2017-11-01 00:00:00
abstract：OBJECTIVES:Previous studies have suggested that failure of the synthesis of nitric oxide is involved in the pathophysiology of myocardial ischaemia-reperfusion injury. In this study, we investigated the effect of mebudipine, a new dihydropyridine calcium channel blocker, on cardiac function and activity of the myocardi...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章
doi：10.5830/CVJA-2010-078
更新日期：2011-11-01 00:00:00
abstract：AIM:There are few studies to be found in the literature on ankle-brachial index in sickle cell disease. The aim of this study was to compare ankle-brachial index of steadystate adult sickle cell anaemia patients with that of normal controls. METHODS:A descriptive cross-sectional study of 62 sickle cell anaemia patient...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章
doi：10.5830/CVJA-2011-013
更新日期：2012-02-01 00:00:00
abstract：BACKGROUND:Previous studies have shown controversial results on the role of androgens in coronary artery disease (CAD). We performed this study to assess the relationship between androgen levels and selective coronary angiography (SCA) findings. METHODS:This study was conducted on 502 consecutive men who underwent SCA...
journal_title：Cardiovascular journal of Africa
pub_type： 杂志文章
doi：
更新日期：2007-11-01 00:00:00
