Abstract：
:Heart failure (HF) is the single largest cause for increased hospitalization after fine particulate matter (PM2.5) exposure. Patients with left HF often progress to right ventricular (RV) failure even with optimal medical care. An increase of PM2.5 of 10 μg per cubic meter was associated with a 76% increase in the risk of death from cardiovascular disease in 4 years' period. However, the role and mechanism of PM2.5 in HF progression are not known. Here we investigated the role of PM2.5 exposure in mice with existing HF mice produced by transverse aortic constriction (TAC). TAC-induced HF caused lung inflammation, vascular remodeling and RV hypertrophy. We found increased PM2.5 profoundly exacerbated lung oxidative stress in mice with existing left HF. To our surprise, PM2.5 exposure had no effect on LV hypertrophy and function, but profoundly exacerbated lung inflammation, vascular remodeling, and RV hypertrophy in mice with existing left HF. These striking findings demonstrate that PM2.5 and/or air pollution is a critical factor for overall HF progression by regulating lung oxidative stress, inflammation and remodeling as well as RV hypertrophy. Improving air quality may save HF patients from a dismal fate.
journal_name
Redox Bioljournal_title
Redox biologyauthors
Yue W,Tong L,Liu X,Weng X,Chen X,Wang D,Dudley SC,Weir EK,Ding W,Lu Z,Xu Y,Chen Ydoi
10.1016/j.redox.2019.101161subject
Has Abstractpub_date
2019-04-01 00:00:00pages
101161issn
2213-2317pii
S2213-2317(18)31265-5journal_volume
22pub_type
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