Abstract：
:Neuroblastoma is the most common extra-cranial solid tumor in childhood; and patients in stage IV of the disease have a high propensity for tumor recurrence. Retinoid therapy has been utilized as a means to induce differentiation of tumor cells and to inhibit relapse. In this study, the expression of a common neuronal differentiation marker [neurofilament M (NF-M)] in human SK-N-SH neuroblastoma cells treated with 10μM all-trans retinoic acid (ATRA) showed significantly increased expression in accordance with reduced cell number. This was accompanied by an increase in MitoSOX and DCFH2 oxidation that could be indicative of increased steady-state levels of reactive oxygen species (ROS) such as O2(•-) and H2O2, which correlated with increased levels of MnSOD activity and immuno-reactive protein. Furthermore PEG-catalase inhibited the DCFH2 oxidation signal to a greater extent in the ATRA-treated cells (relative to controls) at 96h indicating that as the cells became more differentiated, steady-state levels of H2O2 increased in the absence of increases in peroxide-scavenging antioxidants (i.e., glutathione, glutathione peroxidase, and catalase). In addition, ATRA-induced stimulation of NF-M at 48 and 72h was enhanced by decreasing SOD activity using siRNA directed at MnSOD. Finally, treatment with ATRA for 96h in the presence of MnSOD siRNA or PEG-catalase inhibited ATRA induced increases in NF-M expression. These results provide strong support for the hypothesis that changes in steady-state levels of O2(•-) and H2O2 significantly contribute to the process of ATRA-induced differentiation in neuroblastoma, and suggest that retinoid therapy for neuroblastoma could potentially be enhanced by redox-based manipulations of superoxide metabolism to improve patient outcome.
journal_name
Redox Bioljournal_title
Redox biologyauthors
Silvis AM,McCormick ML,Spitz DR,Kiningham KKdoi
10.1016/j.redox.2015.11.012subject
Has Abstractpub_date
2016-04-01 00:00:00pages
88-96issn
2213-2317pii
S2213-2317(15)30012-4journal_volume
7pub_type
杂志文章相关文献
Redox Biology文献大全abstract：:Culturing cells and tissues in vitro has provided valuable insights into the molecular mechanisms regulating redox signaling in cells with implications for medicine. However, standard culture techniques maintain mammalian cells in vitro under an artificial physicochemical environment such as ambient air and 5% CO2. Ox...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2014.04.008
更新日期：2014-04-18 00:00:00
abstract：:Transcription factor Nuclear factor erythroid 2-related factor 2 (Nrf2) and its negative regulator, the E3 ligase adaptor Kelch-like ECH-associated protein 1 (Keap1), control the redox and metabolic homeostasis and oxidative stress. Inhibitors of Keap1-Nrf2 interaction are promising in oxidative stress related inflamm...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2020.101565
更新日期：2020-07-01 00:00:00
abstract：:Obesity and excessive inflammation/oxidative stress are pathophysiological forces associated with kidney dysfunction. Although we recently showed that heme-oxygenase (HO) improves renal functions, the mechanisms are largely unclear. Moreover, the effects of the HO-system on podocyte cytoskeletal proteins like podocin,...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2014.09.001
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:While statins may have anti-inflammatory effects, anti-oxidative effects are controversial. We investigated if statin treatment is associated with differences in oxidatively generated nucleotide damage and chronic inflammation, and the relationship between nucleotide damage and chronic inflammation. METHODS...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2018.101088
更新日期：2019-02-01 00:00:00
abstract：:Disulfide bonds play a key function in determining the structure of proteins, and are the most strongly conserved compositional feature across proteomes. They are particularly common in extracellular environments, such as the extracellular matrix and plasma, and in proteins that have structural (e.g. matrix) or bindin...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2020.101822
更新日期：2021-01-01 00:00:00
abstract：:The precise molecular events defining the complex role of oxidative stress in the inactivation of the cerebral sodium pump in radical-induced neurodegenerative diseases is yet to be fully clarified and thus still open. Herein we investigated the modulation of the activity of the cerebral transmembrane electrogenic enz...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2014.12.015
更新日期：2015-01-01 00:00:00
abstract：:Epidemiological studies have shown that estrogens have protective effects in cardiovascular diseases, even though the results from human clinical trials remain controversial, while most of the animal experiments confirmed this effect, but the detailed mechanism remains unclear. In this study, we found that estradiol (...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2014.11.001
更新日期：2014-01-01 00:00:00
abstract：:Heme oxygenase-1 (HO-1) is an important anti-inflammatory, antioxidative and cytoprotective enzyme that is regulated by the activation of the major transcription factor, nuclear factor (erythroid-derived 2)-like 2 (Nrf2). In the present study, six stilbene derivatives isolated from Rheum undulatum L. were assessed for...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2014.02.001
更新日期：2014-02-18 00:00:00
abstract：:Despite extensive research that has been carried out over the past three decades in the field of renal ischaemia-reperfusion (I/R) injury, the pathogenic role of mitochondrial fission in renal I/R injury is poorly understood. The aim of our study is to investigate the molecular mechanism by which mammalian STE20-like ...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2018.10.012
更新日期：2019-01-01 00:00:00
abstract：:Mechanistic/mammalian target of rapamycin (mTOR) has emerged as a new potential therapeutic target for gastric cancer. Rapamycin and rapamycin analogs are undergoing clinical trials and have produced clinical responses in a subgroup of cancer patients. However, monotherapy with rapamycin at safe dosage fails to induce...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2016.09.006
更新日期：2016-12-01 00:00:00
abstract：:Adropin, a secretory signal peptide, has shown beneficial effects on improving glucose homeostasis and dyslipidemia. However, whether this peptide affects nonalcoholic steatohepatitis (NASH) has remained unclear. In this study, the serum adropin levels, liver injury and oxidative stress were measured in diet-induced N...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2018.101068
更新日期：2019-02-01 00:00:00
abstract：:Hypoxia, a common element in the tumor environment, leads to Hypoxia-Inducible Factor-1α (HIF-1α) stabilization to modulate cellular metabolism as an adaptive response. In a previous study, we showed that inhibition of the nuclear factor erythroid 2-like-2 (NFE2L2; NRF2), a master regulator of many genes coping with e...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2019.101210
更新日期：2019-06-01 00:00:00
abstract：:The system (PTTRS) formed by typical 2-Cys peroxiredoxins (Prx), thioredoxin (Trx), Trx reductase (TrxR), and sulfiredoxin (Srx) is central in antioxidant protection and redox signaling in the cytoplasm of eukaryotic cells. Understanding how the PTTRS integrates these functions requires tracing phenotypes to molecular...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2017.12.008
更新日期：2018-05-01 00:00:00
abstract：:Free radicals originate from both exogenous environmental sources and as by-products of the respiratory chain and cellular oxygen metabolism. Sustained accumulation of free radicals, beyond a physiological level, induces oxidative stress that is harmful for the cellular homeodynamics as it promotes the oxidative damag...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2014.01.017
更新日期：2014-01-30 00:00:00
abstract：:Strenuous exercise is a potent stimulus to induce beneficial skeletal muscle adaptations, ranging from increased endurance due to mitochondrial biogenesis and angiogenesis, to increased strength from hypertrophy. While exercise is necessary to trigger and stimulate muscle adaptations, the post-exercise recovery period...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2020.101480
更新日期：2020-08-01 00:00:00
abstract：:Oxidative stress is reported to regulate several apoptotic and necrotic cell death pathways in auditory tissues. Poly(ADP-ribose) polymerase-1 (PARP-1) can be activated under oxidative stress, which is the hallmark of parthanatos. Autophagy, which serves either a pro-survival or pro-death function, can also be stimula...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2017.10.002
更新日期：2018-04-01 00:00:00
abstract：:Loneliness and social isolation are common sources of chronic stress in modern society. Epidemiological studies have demonstrated that loneliness and social isolation increase mortality risk as much as smoking or alcohol consumption and more than physical inactivity or obesity. Loneliness in human is associated with h...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2020.101585
更新日期：2020-10-01 00:00:00
abstract：:Hydrogen sulfide (H2S) has emerged as an important physiological and pathophysiological signaling molecule in the cardiovascular system influencing vascular tone, cytoprotective responses, redox reactions, vascular adaptation, and mitochondrial respiration. However, bioavailable levels of H2S in its various biochemica...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2018.01.007
更新日期：2018-05-01 00:00:00
abstract：:The widespread detection of elevated oxidative stress levels in many medical conditions has led to numerous efforts to design interventions to reduce its effects. Efforts have been wide-ranging, from dietary changes to administration of antioxidants, supplements, e.g., omega-3-fatty acids, and many medications. Howeve...
journal_title：Redox biology
pub_type： 杂志文章,meta分析
doi：10.1016/j.redox.2018.05.003
更新日期：2018-07-01 00:00:00
abstract：:PARP inhibitors have been widely tested in clinical trials, especially for the treatment of breast cancer and ovarian cancer, and were shown to be highly successful. Because PARP primarily functions in sensing and repairing DNA strand breaks, the therapeutic effect of PARP inhibition is generally believed to be attrib...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2018.03.016
更新日期：2018-07-01 00:00:00
abstract：:Ascorbate (AscH-) functions as a versatile reducing agent. At pharmacological doses (P-AscH-; [plasma AscH-] ≥≈20mM), achievable through intravenous delivery, oxidation of P-AscH- can produce a high flux of H2O2 in tumors. Catalase is the major enzyme for detoxifying high concentrations of H2O2. We hypothesize that se...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2016.10.010
更新日期：2016-12-01 00:00:00
abstract：:Activity-induced nitric oxide (NO) imbalance and "nitrosative stress" are proposed mechanisms of disrupted Ca(2+) homeostasis in atrophic skeletal muscle. We thus mapped S-nitrosylated (SNO) functional muscle proteins in healthy male subjects in a long-term bed rest study (BBR2-2 Study) without and with exercise as co...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2013.10.006
更新日期：2013-10-28 00:00:00
abstract：:Neutrophils produce a cocktail of oxidative species during the so-called oxidative burst to attack phagocytized bacteria. However, little is known about the neutrophils' redox homeostasis during the oxidative burst and there is currently no consensus about the interplay between oxidative species and cellular signaling...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2019.101344
更新日期：2020-01-01 00:00:00
abstract：AIMS:Hyperoxic breathing might lead to redox imbalance and signaling changes that affect cerebral function. Paradoxically, hypoxic breathing is also believed to cause oxidative stress. Our aim is to dissect the cerebral tissue responses to altered O2 fractions in breathed air by assessing the redox imbalance and the re...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2016.10.018
更新日期：2017-04-01 00:00:00
abstract：:Highly active anti-retrovirus therapy (HAART) has been used to block the progression and symptoms of human immunodeficiency virus infection. Although it decreases morbidity and mortality, clinical use of HAART has also been linked to various adverse effects such as severe cardiomyopathy resulting from compromised mito...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2017.06.011
更新日期：2017-10-01 00:00:00
abstract：BACKGROUND:Obstructive Jaundice (OJ) is associated with a significant risk of developing acute renal failure (ARF). The involvement of oxidative stress in the development of cholestasis has been demonstrated in different experimental models. However, its role in the morbidity of human cholestasis is far to be elucidate...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2015.12.009
更新日期：2016-08-01 00:00:00
abstract：:Natural products are characterized by extreme structural diversity and thus they offer a unique source for the identification of novel anti-tumor agents. Herein, we report that the herbal substance acteoside being isolated by advanced phytochemical methods from Lippia citriodora leaves showed enhanced cytotoxicity aga...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2018.02.015
更新日期：2018-06-01 00:00:00
abstract：:Keloids exhibit metabolic reprogramming including enhanced glycolysis and attenuated oxidative phosphorylation. Hypoxia induces a series of protective responses in mammalian cells. However, the metabolic phenotype of keloid fibroblasts under hypoxic conditions remains to be elucidated. The present study aimed to inves...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2020.101815
更新日期：2021-01-01 00:00:00
abstract：:Products of ultraviolet (UV) irradiation such as reactive oxygen species (ROS) and nitric oxide (NO) stimulate melanin synthesis. Reactive sulfur species (RSS) have been shown to have strong ROS and NO scavenging effects. However, the instability and low retention of RSS limit their use as inhibitors of melanin synthe...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2017.10.007
更新日期：2018-04-01 00:00:00
abstract：:Protein disulfide isomerases (PDI) are a family of redox chaperones that catalyze formation or isomerization of disulfide bonds in proteins. Previous studies have shown that one member, PDIA3, interacts with influenza A virus (IAV) hemagglutinin (HA), and this interaction is required for efficient oxidative folding of...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2019.101129
更新日期：2019-04-01 00:00:00
