Abstract：
:Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS) were initially regarded mainly as metabolic by-products with damaging properties. Over the last decade, our understanding of their role in metabolism was drastically changed and they were recognized as essential mediators in cellular signaling cascades, as well as modulators of biochemical pathways. Proteostasis is highly affected by the various levels of intracellular and extracellular free radicals with either mild or severe outcomes. As part of the proteostatic network, the proteasome system is equally affected by redox alterations. This short review summarizes the effects of oxidative stress on proteasome status while it also recapitulates conditions and processes where redox alterations signal changes to proteasome expression, assembly and function.
journal_name
Redox Bioljournal_title
Redox biologyauthors
Lefaki M,Papaevgeniou N,Chondrogianni Ndoi
10.1016/j.redox.2017.07.005subject
Has Abstractpub_date
2017-10-01 00:00:00pages
452-458issn
2213-2317pii
S2213-2317(17)30400-7journal_volume
13pub_type
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