Abstract：
:This review focuses on the hypothetical mechanisms for enhanced vulnerability of African Americans to SARS-CoV-2 infection, COVID-19 severity, and increased deaths. A disproportionately higher number of African Americans are afflicted with autoimmune and inflammatory diseases (e.g., diabetes, hypertension, obesity), and SARS-CoV-2 has helped expose these health disparities. Several factors including socioeconomic status, inferior health care, and work circumstances contribute to these disparities. Identifying potential inflammatory biomarkers and decreasing basal levels in high-risk individuals with comorbidities through preventive measures is critical. Immune cells, particularly neutrophils, protect us against pathogens (bacteria, fungi, and viruses) through increased generation of free radicals or oxidants and neutrophil extracellular traps (NETs) that ensnare pathogens, killing them extracellularly. However, continued generation of NETs coupled with the lack of prompt removal pose danger to host cells. NET levels are increased during pro-inflammatory diseases. COVID-19 patients exhibit elevated NET levels, depending upon disease severity. Conceivably, high-risk individuals with elevated basal NET levels would exhibit hyper-inflammation when infected with SARS-CoV-2, amplifying disease severity and deaths. Drugs inhibiting oxidant formation and vitamin supplements decreased NET formation in mice models of inflammation. Thus, it is conceivable that preventive treatments lowering NET levels and inflammation in high-risk individuals could mitigate SARS-CoV-2-induced complications and decrease mortality.
journal_name
Redox Bioljournal_title
Redox biologyauthors
Kalyanaraman Bdoi
10.1016/j.redox.2020.101721subject
Has Abstractpub_date
2020-10-01 00:00:00pages
101721issn
2213-2317pii
S2213-2317(20)30926-5journal_volume
37pub_type
杂志文章,评审相关文献
Redox Biology文献大全abstract：:Sporadic cases account for 90-95% of all patients with Parkinson's Disease (PD). Atypical Parkinsonism comprises approximately 20% of all patients with parkinsonism. Progressive Supranuclear Palsy (PSP) belongs to the atypical parkinsonian diseases and is histopathologically classified as a tauopathy. Here, we report ...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2017.10.016
更新日期：2018-04-01 00:00:00
abstract：:Compared to other organs, the brain is especially exposed to oxidative stress. In general, brains from young females tend to present lower oxidative damage in comparison to their male counterparts. This has been attributed to higher antioxidant defenses and a better mitochondrial function in females, which has been li...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2020.101505
更新日期：2020-04-01 00:00:00
abstract：:In this paper, we describe an assay to analyze simultaneously the oxygen consumption rate (OCR) and superoxide production in a biological system. The analytical set-up uses electron paramagnetic resonance (EPR) spectroscopy with two different isotopically-labelled sensors: 15N-PDT (4-oxo-2,2,6,6-tetramethylpiperidine-...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2020.101852
更新日期：2020-12-28 00:00:00
abstract：:Matcha and green tea catechins such as (-)-epicatechin (EC), (-)-epigallocatechin (EGC) and (-)-epigallocatechin gallate (EGCG) have long been studied for their antioxidant and health-promoting effects. Using specific fluorophores for H2S (AzMC) and polysulfides (SSP4) as well as IC-MS and UPLC-MS/MS-based techniques ...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2020.101731
更新日期：2020-10-01 00:00:00
abstract：:For years, there have been studies based on the use of natural compounds plant-derived as potential therapeutic agents for various diseases in humans. Curcumin is a phenolic compound extracted from Curcuma longa rhizome commonly used in Asia as a spice, pigment and additive. In traditional medicine of India and China,...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2013.09.003
更新日期：2013-09-17 00:00:00
abstract：:Hydrogen sulfide (H2S) has emerged as an important physiological and pathophysiological signaling molecule in the cardiovascular system influencing vascular tone, cytoprotective responses, redox reactions, vascular adaptation, and mitochondrial respiration. However, bioavailable levels of H2S in its various biochemica...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2018.01.007
更新日期：2018-05-01 00:00:00
abstract：:Muscle mass and strength are very important for exercise performance. Training-induced musculoskeletal injuries usually require periods of complete immobilization to prevent any muscle contraction of the affected muscle groups. Disuse muscle wasting will likely affect every sport practitioner in his or her lifetime. E...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2020.101531
更新日期：2020-08-01 00:00:00
abstract：:Fibrosis is one of the most prevalent features of age-related diseases like obesity, diabetes, non-alcoholic fatty liver disease, chronic kidney disease, or cardiomyopathy and affects millions of people in all countries. Although the understanding about the pathophysiology of fibrosis has improved a lot during the rec...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2015.08.015
更新日期：2015-12-01 00:00:00
abstract：:The aim of the present study was to define the role of Trx and Grx on metabolic thiol redox regulation and identify their protein and metabolite targets. The hepatocarcinoma-derived HepG2 cell line under both normal and oxidative/nitrosative conditions by overexpression of NO synthase (NOS3) was used as experimental m...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2018.11.007
更新日期：2019-02-01 00:00:00
abstract：:The liver has a multitude of functions which are necessary to maintain whole body homeostasis. This requires that various metabolic pathways can run in parallel in the most efficient manner and that futile cycles are kept to a minimum. To a large extent this is achieved due to a functional specialization of the liver ...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2017.01.012
更新日期：2017-04-01 00:00:00
abstract：:Mitogen-activated protein kinase (MAPK) cascades are evolutionarily conserved modules among eukaryotic species that range from yeast, plants, flies to mammals. In eukaryotic cells, reactive oxygen species (ROS) has both physiological and toxic effects. Both MAPK cascades and ROS signaling are involved in plant respons...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2016.12.009
更新日期：2017-04-01 00:00:00
abstract：BACKGROUND:Obstructive Jaundice (OJ) is associated with a significant risk of developing acute renal failure (ARF). The involvement of oxidative stress in the development of cholestasis has been demonstrated in different experimental models. However, its role in the morbidity of human cholestasis is far to be elucidate...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2015.12.009
更新日期：2016-08-01 00:00:00
abstract：:The development of hypertension is associated with mitochondrial redox balance disruptions. NADP+-dependent isocitrate dehydrogenase 2 (IDH2) plays an important role in the maintenance of mitochondrial redox balance by producing mitochondrial NADPH, which is an essential cofactor in the reduction of glutathione (from ...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2020.101548
更新日期：2020-07-01 00:00:00
abstract：:Loneliness and social isolation are common sources of chronic stress in modern society. Epidemiological studies have demonstrated that loneliness and social isolation increase mortality risk as much as smoking or alcohol consumption and more than physical inactivity or obesity. Loneliness in human is associated with h...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2020.101585
更新日期：2020-10-01 00:00:00
abstract：:It has been shown that anti-inflammatory cytokines interleukin-35 (IL-35) and IL-10 could inhibit acute endothelial cell (EC) activation, however, it remains unknown if and by what pathways IL-35 and IL-10 could block atherogenic lipid lysophosphatidylcholine (LPC)-induced sustained EC activation; and if mitochondrial...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2019.101373
更新日期：2020-01-01 00:00:00
abstract：:Glutathione (GSH), the most abundant vertebrate endogenous redox buffer, plays key roles in organogenesis and embryonic development, however, organ-specific GSH utilization during development remains understudied. Monochlorobimane (MCB), a dye conjugated with GSH by glutathione-s-transferase (GST) to form a fluorescen...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2019.101235
更新日期：2019-09-01 00:00:00
abstract：BACKGROUND:Many neuroprotective approaches targeting neurons in animal models fail to provide benefits for the treatment of ischemic stroke in clinic and glial cells have become the targets in some basic studies. Baicalin has neuroprotective effects but the mechanisms related to glial cells are not revealed. This study...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2020.101559
更新日期：2020-07-01 00:00:00
abstract：:Hydroxytyrosol (HT) is a main phenolic component of olive oil. In this study, we investigated the safety and effects produced by HT purified (99.5%) from olive mill waste. HT was administered at a daily dosage of 45mg for 8 weeks to volunteers with mild hyperlipidemia (n=14). We measured markers of cardiovascular dise...
journal_title：Redox biology
pub_type： 临床试验,杂志文章
doi：10.1016/j.redox.2016.12.014
更新日期：2017-04-01 00:00:00
abstract：:Disulfide bonds play a key function in determining the structure of proteins, and are the most strongly conserved compositional feature across proteomes. They are particularly common in extracellular environments, such as the extracellular matrix and plasma, and in proteins that have structural (e.g. matrix) or bindin...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2020.101822
更新日期：2021-01-01 00:00:00
abstract：:Glucose starvation is one of the major forms of metabolic stress in cancer cells. Deprivation of glucose impairs glycolysis and the pentose phosphate pathway, which elicits oxidative stress due to enhanced production of reactive oxygen species (ROS) and impaired antioxidant system, leading to redox imbalance and cell ...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2019.101154
更新日期：2019-07-01 00:00:00
abstract：:Mouse hindlimb ischemia has been widely used as a model to study peripheral artery disease. Genetic modulation of the enzymatic source of oxidants or components of the antioxidant system reveal that physiological levels of oxidants are essential to promote the process of arteriogenesis and angiogenesis after femoral a...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2017.04.040
更新日期：2017-08-01 00:00:00
abstract：:Mechanical ventilation is a life-saving intervention in critically ill patients with respiratory failure due to acute respiratory distress syndrome (ARDS), a refractory lung disease with an unacceptable high mortality rate. Paradoxically, mechanical ventilation also creates excessive mechanical stress that directly au...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2020.101785
更新日期：2021-01-01 00:00:00
abstract：:Oxidative stress has a critical role in the pathogenesis of Age-related Macular Degeneration (AMD), a multifactorial disease that includes age, gene variants of complement regulatory proteins and smoking as the main risk factors. Stress-induced premature cellular senescence (SIPS) is postulated to contribute to this c...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2015.11.011
更新日期：2016-04-01 00:00:00
abstract：:Neonatal hypoxic-ischemic (HI) injury is a major cause of neonatal death and neurological dysfunction. H2S has been shown to protect against hypoxia-induced injury and apoptosis of neurons. L-Cysteine is catalyzed by cystathionine-β-synthase (CBS) in the brain and sequentially produces endogenous H2S. The present stud...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2017.06.007
更新日期：2017-10-01 00:00:00
abstract：:Reactivation of p53 and induction of tumor cell apoptosis (RITA) is a small molecule that blocks p53-MDM2 interaction, thereby reactivating p53 in tumors. RITA can induce exclusive apoptosis in cancer cells independently of the p53 pathway; however, the resistance of cancer cells remains a major drawback. Here, we fou...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2017.05.025
更新日期：2017-10-01 00:00:00
abstract：:Many physiological functions of hydrogen sulfide (H2S) have been reported in mammalian cells over the last 20 years. These physiological effects have been ascertained through in vitro treatment of cells with Na2S or NaHS, both of which are precursors of H2S. Since H2S exists as HS- in a neutral solution, a disulfide c...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2017.03.020
更新日期：2017-08-01 00:00:00
abstract：BACKGROUND:While statins may have anti-inflammatory effects, anti-oxidative effects are controversial. We investigated if statin treatment is associated with differences in oxidatively generated nucleotide damage and chronic inflammation, and the relationship between nucleotide damage and chronic inflammation. METHODS...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2018.101088
更新日期：2019-02-01 00:00:00
abstract：:Metabolic control of cellular function is significant in the context of inflammation-induced metabolic dysregulation in immune cells. Generation of reactive oxygen species (ROS) such as hydrogen peroxide and superoxide are one of the critical events that modulate the immune response in neutrophils. When activated, neu...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2016.06.003
更新日期：2016-10-01 00:00:00
abstract：:Mitochondria are principal regulators of cellular function and metabolism through production of ATP for energy homeostasis, maintenance of calcium homeostasis, regulation of apoptosis and fatty acid oxidation to provide acetyl CoA for fueling the electron transport chain. In addition, mitochondria play a key role in c...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2014.07.005
更新日期：2014-07-27 00:00:00
abstract：:Mitochondria are critical sources of hydrogen peroxide (H2O2), an important secondary messenger in mammalian cells. Recent work has shown that O2•-/H2O2 emission from individual sites of production in mitochondria is regulated by protein S-glutathionylation. Here, we conducted the first examination of O2•-/H2O2 releas...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2017.12.006
更新日期：2018-05-01 00:00:00
