Abstract：
:Fibrosis is one of the most prevalent features of age-related diseases like obesity, diabetes, non-alcoholic fatty liver disease, chronic kidney disease, or cardiomyopathy and affects millions of people in all countries. Although the understanding about the pathophysiology of fibrosis has improved a lot during the recent years, a number of mechanisms still remain unknown. Although TGF-β1 signaling, loss of metabolic homeostasis and chronic low-grade inflammation appear to play important roles in the pathogenesis of fibrosis, recent evidence indicates that oxidative stress and the antioxidant system may also be crucial for fibrosis development and persistence. These findings point to a concept of a redox-fibrosis where the cellular oxidant and antioxidant system could be potential therapeutic targets. The current review aims to summarize the existing links between TGF-β1 signaling, generation and action of reactive oxygen species, expression of antioxidative enzymes, and functional consequences including epigenetic redox-mediated responses during fibrosis.
journal_name
Redox Bioljournal_title
Redox biologyauthors
Richter K,Konzack A,Pihlajaniemi T,Heljasvaara R,Kietzmann Tdoi
10.1016/j.redox.2015.08.015subject
Has Abstractpub_date
2015-12-01 00:00:00pages
344-352issn
2213-2317pii
S2213-2317(15)00105-6journal_volume
6pub_type
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