abstract：:Keloids exhibit metabolic reprogramming including enhanced glycolysis and attenuated oxidative phosphorylation. Hypoxia induces a series of protective responses in mammalian cells. However, the metabolic phenotype of keloid fibroblasts under hypoxic conditions remains to be elucidated. The present study aimed to inves...

journal_title：Redox biology

authors： Wang Q,Wang P,Qin Z,Yang X,Pan B,Nie F,Bi H

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Macrophages regulate the inflammatory response and affect re-endothelialization. Inflammation and macrophages play important roles in promoting tissue repair, but p38α mitogen-activated protein kinase's role in re-endothelialization is unknown. METHODS AND RESULTS:Wire injuries of carotid arteries and Evans...

journal_title：Redox biology

authors： Zhang M,Gao J,Zhao X,Zhao M,Ma D,Zhang X,Tian D,Pan B,Yan X,Wu J,Meng X,Yin H,Zheng L

更新日期：2021-01-01 00:00:00

abstract：:The biological functions of N6-methyladenosine (m6A) RNA methylation are mainly dependent on the reader; however, its role in lung tumorigenesis remains unclear. Here, we have demonstrated that the m6A reader YT521-B homology domain containing 2 (YTHDC2) is frequently suppressed in lung adenocarcinoma (LUAD). Downregu...

journal_title：Redox biology

authors： Ma L,Chen T,Zhang X,Miao Y,Tian X,Yu K,Xu X,Niu Y,Guo S,Zhang C,Qiu S,Qiao Y,Fang W,Du L,Yu Y,Wang J

更新日期：2021-01-01 00:00:00

abstract：:Superoxide dismutase (SOD) is known to be protective against oxidative stress-mediated skin dysfunction. Here we explore the potential therapeutic activities of RM191A, a novel SOD mimetic, on skin. RM191A is a water-soluble dimeric copper (Cu2+-Cu3+)-centred polyglycine coordination complex. It displays 10-fold highe...

journal_title：Redox biology

authors： Shariev A,Menounos S,Laos AJ,Laxman P,Lai D,Hua S,Zinger A,McRae CR,Casbolt LS,Combes V,Smith G,Hung TT,Dixon KM,Thordarson P,Mason RS,Das A

更新日期：2021-01-01 00:00:00

abstract：:Mechanical ventilation is a life-saving intervention in critically ill patients with respiratory failure due to acute respiratory distress syndrome (ARDS), a refractory lung disease with an unacceptable high mortality rate. Paradoxically, mechanical ventilation also creates excessive mechanical stress that directly au...

journal_title：Redox biology

authors： Lu Q,Zemskov EA,Sun X,Wang H,Yegambaram M,Wu X,Garcia-Flores A,Song S,Tang H,Kangath A,Cabanillas GZ,Yuan JX,Wang T,Fineman JR,Black SM

更新日期：2021-01-01 00:00:00

abstract：:Disulfide bonds play a key function in determining the structure of proteins, and are the most strongly conserved compositional feature across proteomes. They are particularly common in extracellular environments, such as the extracellular matrix and plasma, and in proteins that have structural (e.g. matrix) or bindin...

journal_title：Redox biology

authors： Jiang S,Carroll L,Rasmussen LM,Davies MJ

更新日期：2021-01-01 00:00:00

abstract：:Williamson and colleagues present important data on the effects of MitoQ - an antioxidant compound targeted to mitochondria - on mtDNA damage following exercise. Future studies are needed to elucidate, whether or not the observed prevention of MitoQ on DNA damage is beneficial with regard to functional outcomes in hea...

journal_title：Redox biology

authors： Burtscher J,Burtscher M,Millet GP

更新日期：2021-01-01 00:00:00

abstract：:Chronic alcoholism disrupts mitochondrial function and often results in alcoholic cardiomyopathy (ACM). Fas-activated serine/threonine kinase (FASTK) is newly recognized as a key post-transcriptional regulator of mitochondrial gene expression. However, the modulatory role of FASTK in cardiovascular pathophysiology rem...

journal_title：Redox biology

authors： Zhang F,Wang K,Zhang S,Li J,Fan R,Chen X,Pei J

更新日期：2021-01-01 00:00:00

abstract：:Preeclampsia affects one in twelve of the 130 million pregnancies a year. The lack of an effective therapeutic to prevent or treat it is responsible for an annual global cost burden of 100 billion US dollars. Preeclampsia also affects these women later in life as it is a recognised risk factor for cardiovascular disea...

journal_title：Redox biology

authors： Rezai H,Ahmad S,Alzahrani FA,Sanchez-Aranguren L,Dias IH,Agrawal S,Sparatore A,Wang K,Ahmed A

更新日期：2021-01-01 00:00:00

abstract：:In this paper, we describe an assay to analyze simultaneously the oxygen consumption rate (OCR) and superoxide production in a biological system. The analytical set-up uses electron paramagnetic resonance (EPR) spectroscopy with two different isotopically-labelled sensors: 15N-PDT (4-oxo-2,2,6,6-tetramethylpiperidine-...

journal_title：Redox biology

authors： Donatienne d'Hose,Danhier P,Northshield H,Isenborghs P,Jordan BF,Gallez B

更新日期：2020-12-28 00:00:00

abstract：:The advent of combined antiretroviral treatment (cART) as a treatment for HIV-1 infection has not only resulted in a dramatic decrease in the peripheral viral load but has also led to increased life expectancy of the infected individuals. Paradoxically, increased lifespan is accompanied with higher prevalence of age-r...

journal_title：Redox biology

authors： Thangaraj A,Chivero ET,Tripathi A,Singh S,Niu F,Guo ML,Pillai P,Periyasamy P,Buch S

更新日期：2020-12-23 00:00:00

abstract：:Matcha and green tea catechins such as (-)-epicatechin (EC), (-)-epigallocatechin (EGC) and (-)-epigallocatechin gallate (EGCG) have long been studied for their antioxidant and health-promoting effects. Using specific fluorophores for H2S (AzMC) and polysulfides (SSP4) as well as IC-MS and UPLC-MS/MS-based techniques ...

journal_title：Redox biology

authors： Olson KR,Briggs A,Devireddy M,Iovino NA,Skora NC,Whelan J,Villa BP,Yuan X,Mannam V,Howard S,Gao Y,Minnion M,Feelisch M

更新日期：2020-10-01 00:00:00

abstract：:Ferroptosis is a newly defined form of cell death induced by iron-dependent accumulation of lethal lipid peroxidation. Ferroptosis represent a therapeutic strategy to suppress therapy-resistant cancer cells with more property of epithelial-mesenchymal transition (EMT). However, epigenetic reprogramming of EMT has been...

journal_title：Redox biology

authors： Lee J,You JH,Kim MS,Roh JL

更新日期：2020-10-01 00:00:00

abstract：:Loneliness and social isolation are common sources of chronic stress in modern society. Epidemiological studies have demonstrated that loneliness and social isolation increase mortality risk as much as smoking or alcohol consumption and more than physical inactivity or obesity. Loneliness in human is associated with h...

journal_title：Redox biology

authors： Li H,Xia N

更新日期：2020-10-01 00:00:00

abstract：:This review focuses on the hypothetical mechanisms for enhanced vulnerability of African Americans to SARS-CoV-2 infection, COVID-19 severity, and increased deaths. A disproportionately higher number of African Americans are afflicted with autoimmune and inflammatory diseases (e.g., diabetes, hypertension, obesity), a...

journal_title：Redox biology

authors： Kalyanaraman B

更新日期：2020-10-01 00:00:00

abstract：:Oxidative stress resulting from the accumulation of high levels of reactive oxygen species is a salient feature of, and a well-recognised pathological factor for, diverse pathologies. One common mechanism for oxidative stress damage is via the disruption of intracellular ion homeostasis to induce cell death. TRPM2 is ...

journal_title：Redox biology

authors： Malko P,Jiang LH

更新日期：2020-10-01 00:00:00

abstract：:Reactive oxygen species (ROS) are generated during physiological bouts of synaptic activity and as a consequence of pathological conditions in the central nervous system. How neurons respond to and distinguish between ROS in these different contexts is currently unknown. In Drosophila mutants with enhanced JNK activit...

journal_title：Redox biology

authors： Ugbode C,Garnham N,Fort-Aznar L,Evans GJO,Chawla S,Sweeney ST

更新日期：2020-10-01 00:00:00

abstract：:Macrophage recruitment and pro-inflammatory differentiation are hallmarks of various diseases, including infection and sepsis. Although studies suggest that mitochondria may regulate macrophage immune responses, it remains unclear whether mitochondrial mass affects macrophage pro-inflammatory differentiation. Here, we...

journal_title：Redox biology

authors： Yu W,Wang X,Zhao J,Liu R,Liu J,Wang Z,Peng J,Wu H,Zhang X,Long Z,Kong D,Li W,Hai C

更新日期：2020-10-01 00:00:00

abstract：:We previously reported that the highly reactive cell-free heme (CFH) is increased in the plasma of patients with chronic lung injury and causes pulmonary edema in animal model of acute respiratory distress syndrome (ARDS) post inhalation of halogen gas. However, the mechanisms by which CFH causes pulmonary edema are u...

journal_title：Redox biology

authors： Aggarwal S,Lazrak A,Ahmad I,Yu Z,Bryant A,Mobley JA,Ford DA,Matalon S

更新日期：2020-09-01 00:00:00

abstract：:The massive production and activation of myofibroblasts (MFB) is key to the development of liver fibrosis. In many studies, it has been proven that hepatocytes are an important part of MFB, and can be transformed into MFB through epithelial-mesenchymal transition (EMT) during hepatic fibrogenesis. In our previous stud...

journal_title：Redox biology

authors： Kong D,Zhang Z,Chen L,Huang W,Zhang F,Wang L,Wang Y,Cao P,Zheng S

更新日期：2020-09-01 00:00:00

abstract：:Hydrogen peroxide (H2O2) modulates critical phosphorylation pathways in vascular endothelial cells, many of which affect endothelial nitric oxide synthase (eNOS) signal transduction. Both intracellular and extracellular sources of H2O2 have been implicated in eNOS regulation, yet the specific endothelial pathways rema...

journal_title：Redox biology

authors： Saeedi Saravi SS,Eroglu E,Waldeck-Weiermair M,Sorrentino A,Steinhorn B,Belousov V,Michel T

更新日期：2020-09-01 00:00:00

abstract：:Calcium (Ca2+) and reactive oxygen species (ROS) are versatile signaling molecules coordinating physiological and pathophysiological processes. While channels and pumps shuttle Ca2+ ions between extracellular space, cytosol and cellular compartments, short-lived and highly reactive ROS are constantly generated by vari...

journal_title：Redox biology

authors： Madreiter-Sokolowski CT,Thomas C,Ristow M

更新日期：2020-09-01 00:00:00

abstract：:Microglia-mediated neuroinflammation plays a crucial role in the pathophysiological process of multiple neurological disorders such as ischemic stroke, yet lacks effective therapeutic agents. Previously, we discovered one novel synthetic compound, tanshinol borneol ester (DBZ), possesses anti-inflammatory and anti-ath...

journal_title：Redox biology

authors： Liao S,Wu J,Liu R,Wang S,Luo J,Yang Y,Qin Y,Li T,Zheng X,Song J,Zhao X,Xiao C,Zhang Y,Bian L,Jia P,Bai Y,Zheng X

更新日期：2020-09-01 00:00:00

abstract：:Fanconi Anemia (FA) is a disease characterized by bone marrow (BM) failure and aplastic anemia. In addition to a defective DNA repair system, other mechanisms are involved in its pathogenesis, such as defective mitochondrial metabolism, accumulation of lipids, and increment of oxidative stress production. To better un...

journal_title：Redox biology

authors： Cappelli E,Degan P,Bruno S,Pierri F,Miano M,Raggi F,Farruggia P,Mecucci C,Crescenzi B,Naim V,Dufour C,Ravera S

更新日期：2020-09-01 00:00:00

abstract：:Of the various transcription factors that play a role in controlling oxidative stress, the role of FoxO proteins in skin aging has recently become of interest. Unlike other FoxOs, FoxO6 remains in the nucleus due to the lack of nuclear export signal, so that it may respond sensitively to intracellular stimuli for the ...

journal_title：Redox biology

authors： Moon KM,Lee B,Kim DH,Chung HY

更新日期：2020-09-01 00:00:00

abstract：:In recent years, the gasotransmitter hydrogen sulphide (H2S), produced by the transsulphuration pathway, has been recognized as a biological mediator playing an important role under normal conditions and in various pathologies in both eukaryotes and prokaryotes. The transsulphuration pathway (TSP) includes the convers...

journal_title：Redox biology

authors： Zatsepina O,Karpov D,Chuvakova L,Rezvykh A,Funikov S,Sorokina S,Zakluta A,Garbuz D,Shilova V,Evgen'ev M

更新日期：2020-09-01 00:00:00

abstract：:NADPH oxidase 5 (NOX5) is a transmembrane signaling enzyme that produces superoxide in response to elevated cytosolic calcium. In addition to its association with numerous human diseases, NOX5 has recently been discovered to play crucial roles in the immune response and cardiovascular system. Details of NOX5 maturatio...

journal_title：Redox biology

authors： Sweeny EA,Schlanger S,Stuehr DJ

更新日期：2020-09-01 00:00:00

abstract：:In the present study, we aimed to investigate the impact of permanent cystathionine-β-Synthase (CBS) gene knockdown in human telomerase reverse transcriptase (hTERT) immortalized human adipose-derived mesenchymal stem cells (ASC52telo) and in their capacity to differentiate into adipocytes. CBS gene KD in ASC52telo ce...

journal_title：Redox biology

authors： Comas F,Latorre J,Ortega F,Oliveras-Cañellas N,Lluch A,Ricart W,Fernández-Real JM,Moreno-Navarrete JM

更新日期：2020-08-02 00:00:00

abstract：:Mistakenly thought to be the consequence of oxygen lack in contracting skeletal muscle we now know that the L-enantiomer of the lactate anion is formed under fully aerobic conditions and is utilized continuously in diverse cells, tissues, organs and at the whole-body level. By shuttling between producer (driver) and c...

journal_title：Redox biology

authors： Brooks GA

更新日期：2020-08-01 00:00:00

abstract：:Strenuous exercise is a potent stimulus to induce beneficial skeletal muscle adaptations, ranging from increased endurance due to mitochondrial biogenesis and angiogenesis, to increased strength from hypertrophy. While exercise is necessary to trigger and stimulate muscle adaptations, the post-exercise recovery period...

journal_title：Redox biology

authors： Cheng AJ,Jude B,Lanner JT

更新日期：2020-08-01 00:00:00

abstract：:Hydrogen peroxide appears to be the key reactive oxygen species involved in redox signalling, but comparisons of the low concentrations of hydrogen peroxide that are calculated to exist within cells with those previously shown to activate common signalling events in vitro indicate that direct oxidation of key thiol gr...

journal_title：Redox biology

authors： Jackson MJ,Stretton C,McArdle A

更新日期：2020-08-01 00:00:00

abstract：:Muscle mass and strength are very important for exercise performance. Training-induced musculoskeletal injuries usually require periods of complete immobilization to prevent any muscle contraction of the affected muscle groups. Disuse muscle wasting will likely affect every sport practitioner in his or her lifetime. E...

journal_title：Redox biology

authors： Gomez-Cabrera MC,Arc-Chagnaud C,Salvador-Pascual A,Brioche T,Chopard A,Olaso-Gonzalez G,Viña J

更新日期：2020-08-01 00:00:00

abstract：:Physical exercise represents one of the strongest physiological stimuli capable to induce functional and structural modifications in all biological systems. Indeed, beside the traditional genetic mechanisms, physical exercise can modulate gene expression through epigenetic modifications, namely DNA methylation, post-t...

journal_title：Redox biology

authors： Dimauro I,Paronetto MP,Caporossi D

更新日期：2020-08-01 00:00:00

abstract：:Transcription factor Nuclear factor erythroid 2-related factor 2 (Nrf2) and its negative regulator, the E3 ligase adaptor Kelch-like ECH-associated protein 1 (Keap1), control the redox and metabolic homeostasis and oxidative stress. Inhibitors of Keap1-Nrf2 interaction are promising in oxidative stress related inflamm...

journal_title：Redox biology

authors： Lu M,Zhang X,Zhao J,You Q,Jiang Z

更新日期：2020-07-01 00:00:00

abstract：:The development of hypertension is associated with mitochondrial redox balance disruptions. NADP+-dependent isocitrate dehydrogenase 2 (IDH2) plays an important role in the maintenance of mitochondrial redox balance by producing mitochondrial NADPH, which is an essential cofactor in the reduction of glutathione (from ...

journal_title：Redox biology

authors： Noh MR,Kong MJ,Han SJ,Kim JI,Park KM

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Many neuroprotective approaches targeting neurons in animal models fail to provide benefits for the treatment of ischemic stroke in clinic and glial cells have become the targets in some basic studies. Baicalin has neuroprotective effects but the mechanisms related to glial cells are not revealed. This study...

journal_title：Redox biology

authors： Song X,Gong Z,Liu K,Kou J,Liu B,Liu K

更新日期：2020-07-01 00:00:00

abstract：:Myo-satellite cells regenerate and differentiate into skeletal muscle (SM) after acute or chronic injury. Changes in the redox milieu towards the oxidative arm at the wound site are known to compromise SM regeneration. Recently, we reported that abrogation of Nrf2/antioxidant signaling promotes oxidative stress and im...

journal_title：Redox biology

authors： Rajasekaran NS,Shelar SB,Jones DP,Hoidal JR

更新日期：2020-07-01 00:00:00

abstract：:Neurodegenerative diseases (NDD) such as Alzheimer's (AD) and Parkinson's disease (PD) are distinct clinical entities, however, the aggregation of key neuronal proteins, presumably leading to neuronal demise appears to represent a common mechanism. It has become evident, that advanced glycation end products (AGEs) tri...

journal_title：Redox biology

authors： Sharma A,Weber D,Raupbach J,Dakal TC,Fließbach K,Ramirez A,Grune T,Wüllner U

更新日期：2020-07-01 00:00:00

abstract：:Glioblastoma (GBM) is the most common and most aggressive brain tumor, associated with high levels of reactive oxidative species (ROS) due to metabolic and signaling aberrations. High ROS levels are detrimental to cells, but it remains incompletely understood how cancer cells cope with the adverse effects. Here we sho...

journal_title：Redox biology

authors： Lei K,Xia Y,Wang XC,Ahn EH,Jin L,Ye K

更新日期：2020-07-01 00:00:00

abstract：:Ischemia heart disease is the leading cause of death world-widely and has increased prevalence and exacerbated myocardial infarction with aging. Sestrin2, a stress-inducible protein, declines with aging in the heart and the rescue of Sestrin2 in the aged mouse heart improves the resistance to ischemic insults caused b...

journal_title：Redox biology

authors： Ren D,Quan N,Fedorova J,Zhang J,He Z,Li J

更新日期：2020-07-01 00:00:00