Abstract：
:Mitochondria are principal regulators of cellular function and metabolism through production of ATP for energy homeostasis, maintenance of calcium homeostasis, regulation of apoptosis and fatty acid oxidation to provide acetyl CoA for fueling the electron transport chain. In addition, mitochondria play a key role in cell signaling through production of reactive oxygen species that modulate redox signaling. Recent findings support an additional mechanism for control of cellular and tissue function by mitochondria through complex mitochondrial-nuclear communication mechanisms and potentially through extracellular release of mitochondrial components that can act as signaling molecules. The activation of stress responses including mitophagy, mitochondrial number, fission and fusion events, and the mitochondrial unfolded protein response (UPR(MT)) requires mitochondrial-nuclear communication for the transcriptional activation of nuclear genes involved in mitochondrial quality control and metabolism. The induction of these signaling pathways is a shared feature in long-lived organisms spanning from yeast to mice. As a result, the role of mitochondrial stress signaling in longevity has been expansively studied. Current and exciting studies provide evidence that mitochondria can also signal among tissues to up-regulate cytoprotective activities to promote healthy aging. Alternatively, mitochondria release signals to modulate innate immunity and systemic inflammatory responses and could consequently promote inflammation during aging. In this review, established and emerging models of mitochondrial stress response pathways and their potential role in modulating longevity are discussed.
journal_name
Redox Bioljournal_title
Redox biologyauthors
Hill S,Van Remmen Hdoi
10.1016/j.redox.2014.07.005subject
Has Abstractpub_date
2014-07-27 00:00:00pages
936-44issn
2213-2317pii
S2213-2317(14)00088-3journal_volume
2pub_type
杂志文章,评审相关文献
Redox Biology文献大全abstract：:Adult progenitor cells reside in specialized microenvironments which maintain their undifferentiated cell state and trigger regenerative responses following injury. Although these environments are well described in several tissues, the cellular components that comprise the cardiac environment where progenitor cells ar...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2019.101156
更新日期：2019-04-01 00:00:00
abstract：:PARP inhibitors have been widely tested in clinical trials, especially for the treatment of breast cancer and ovarian cancer, and were shown to be highly successful. Because PARP primarily functions in sensing and repairing DNA strand breaks, the therapeutic effect of PARP inhibition is generally believed to be attrib...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2018.03.016
更新日期：2018-07-01 00:00:00
abstract：:Oxidative modification of cysteine residues has been shown to regulate the activity of several protein-tyrosine kinases. We explored the possibility that Fms-like tyrosine kinase 3 (FLT3), a hematopoietic receptor-tyrosine kinase, is subject to this type of regulation. An underlying rationale was that the FLT3 gene is...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2019.101325
更新日期：2020-01-01 00:00:00
abstract：:Physical exercise represents one of the strongest physiological stimuli capable to induce functional and structural modifications in all biological systems. Indeed, beside the traditional genetic mechanisms, physical exercise can modulate gene expression through epigenetic modifications, namely DNA methylation, post-t...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2020.101477
更新日期：2020-08-01 00:00:00
abstract：:The traditional Asian diet is rich in fruits, vegetables and soy, the latter representing a significant source of dietary isoflavones. The isoflavone prunetin was recently identified to improve intestinal epithelial barrier function in vitro and to ameliorate general survival and overall health state in vivo in male D...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2016.01.001
更新日期：2016-08-01 00:00:00
abstract：:Neutrophils produce a cocktail of oxidative species during the so-called oxidative burst to attack phagocytized bacteria. However, little is known about the neutrophils' redox homeostasis during the oxidative burst and there is currently no consensus about the interplay between oxidative species and cellular signaling...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2019.101344
更新日期：2020-01-01 00:00:00
abstract：:Mice deficient in the electron transport chain (ETC) complex IV assembly protein SURF1 have reduced assembly and activity of cytochrome c oxidase that is associated with an upregulation of components of the mitochondrial unfolded protein response (UPR(MT)) and increased mitochondrial number. We hypothesized that the u...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2016.05.001
更新日期：2016-08-01 00:00:00
abstract：:Glutaredoxin 2 (GRX2), a mitochondrial glutathione-dependent oxidoreductase, is central to glutathione homeostasis and mitochondrial redox, which is crucial in highly metabolic tissues like the heart. Previous research showed that absence of Grx2, leads to impaired mitochondrial complex I function, hypertension and ca...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2017.10.019
更新日期：2018-04-01 00:00:00
abstract：:Mistakenly thought to be the consequence of oxygen lack in contracting skeletal muscle we now know that the L-enantiomer of the lactate anion is formed under fully aerobic conditions and is utilized continuously in diverse cells, tissues, organs and at the whole-body level. By shuttling between producer (driver) and c...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2020.101454
更新日期：2020-08-01 00:00:00
abstract：:Simvastatin reduces the blood concentration of cholesterol by inhibiting hydroxymethylglutaryl-coenzyme A reductase, the rate-limiting enzyme in cholesterol synthesis, and thereby reduces the risk of cardiovascular disease. In addition, simvastatin treatment leads to a reduction in fluxes in mitochondrial respiratory ...
journal_title：Redox biology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.redox.2016.05.007
更新日期：2016-10-01 00:00:00
abstract：:Hypoxia triggers a wide range of protective responses in mammalian cells, which are mediated through transcriptional and post-translational mechanisms. Redox signaling in cells by reactive oxygen species (ROS) such as hydrogen peroxide (H2O2) occurs through the reversible oxidation of cysteine thiol groups, resulting ...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2017.05.020
更新日期：2017-10-01 00:00:00
abstract：OBJECTIVE:Cellular repressor of E1A-stimulated genes (CREG), a vasculoprotective molecule, is significantly downregulated in atherosclerotic vessels through unclear mechanisms. While epigenetic regulation is involved in atherosclerosis development, it is not known if the CREG gene is epigenetically regulated. The aim o...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2020.101444
更新日期：2020-05-01 00:00:00
abstract：:Superoxide dismutase (SOD) is known to be protective against oxidative stress-mediated skin dysfunction. Here we explore the potential therapeutic activities of RM191A, a novel SOD mimetic, on skin. RM191A is a water-soluble dimeric copper (Cu2+-Cu3+)-centred polyglycine coordination complex. It displays 10-fold highe...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2020.101790
更新日期：2021-01-01 00:00:00
abstract：:Ozone (O3) is a serious public health concern. Recent findings indicate that the damaging health effects of O3 extend to multiple systemic organ systems. Herein, we hypothesize that O3 inhalation will cause downstream alterations to the liver. To test this, male Sprague-Dawley rats were exposed to 0.5ppm O3 for 8h/day...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2013.11.006
更新日期：2014-01-01 00:00:00
abstract：:Heme oxygenase-1 (HO-1) is an important anti-inflammatory, antioxidative and cytoprotective enzyme that is regulated by the activation of the major transcription factor, nuclear factor (erythroid-derived 2)-like 2 (Nrf2). In the present study, six stilbene derivatives isolated from Rheum undulatum L. were assessed for...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2014.02.001
更新日期：2014-02-18 00:00:00
abstract：:Despite extensive research that has been carried out over the past three decades in the field of renal ischaemia-reperfusion (I/R) injury, the pathogenic role of mitochondrial fission in renal I/R injury is poorly understood. The aim of our study is to investigate the molecular mechanism by which mammalian STE20-like ...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2018.10.012
更新日期：2019-01-01 00:00:00
abstract：:Endometriosis is a chronic, painful condition with unknown etiology. A differential expression of microRNAs in the endometriotic tissues from women with endometriosis with pain compared to those without suggested a plausible role for miRNA or epigenetic mechanisms in the etiology of endometriotic pain. The peritoneal ...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2017.04.037
更新日期：2017-08-01 00:00:00
abstract：:Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS) were initially regarded mainly as metabolic by-products with damaging properties. Over the last decade, our understanding of their role in metabolism was drastically changed and they were recognized as essential mediators in cellular signaling cascades,...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2017.07.005
更新日期：2017-10-01 00:00:00
abstract：:Coronary artery disease (CAD) is the primary critical cardiovascular event. Endothelial cell and monocyte dysfunction with subsequent extravagant inflammation are the main causes of vessel damage in CAD. Thus, strategies that repress cell death and manage unsuitable pro-inflammatory responses in CAD are potential ther...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2017.05.027
更新日期：2017-10-01 00:00:00
abstract：:Mitogen-activated protein kinase (MAPK) cascades are evolutionarily conserved modules among eukaryotic species that range from yeast, plants, flies to mammals. In eukaryotic cells, reactive oxygen species (ROS) has both physiological and toxic effects. Both MAPK cascades and ROS signaling are involved in plant respons...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2016.12.009
更新日期：2017-04-01 00:00:00
abstract：:Matcha and green tea catechins such as (-)-epicatechin (EC), (-)-epigallocatechin (EGC) and (-)-epigallocatechin gallate (EGCG) have long been studied for their antioxidant and health-promoting effects. Using specific fluorophores for H2S (AzMC) and polysulfides (SSP4) as well as IC-MS and UPLC-MS/MS-based techniques ...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2020.101731
更新日期：2020-10-01 00:00:00
abstract：:The nuclear protein HMGB1 (high mobility group box 1) is secreted by monocytes-macrophages in response to inflammatory stimuli and serves as a danger-associated molecular pattern. Acetylation and phosphorylation of HMGB1 are implicated in the regulation of its nucleocytoplasmic translocation for secretion, although in...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2019.101203
更新日期：2019-06-01 00:00:00
abstract：:Dilated cardiomyopathy (DCM) is a severe disorder caused by medications or genetic mutations. D5 dopamine receptor (D5R) gene knockout (D5-/-) mice have cardiac hypertrophy and high blood pressure. To investigate the role and mechanism by which the D5R regulates cardiac function, we generated cardiac-specific human D5...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2018.07.008
更新日期：2018-10-01 00:00:00
abstract：:We have previously demonstrated that DGLA treatment along with Delta-5-Desaturase (D5D) siRNA in various types of cancer cells enhances the formation of 8-HOA from COX-2-catalyzed DGLA peroxidation, which in turn inhibits cancer cell growth and migration. However, delivery of naked siRNA remains a formidable challenge...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2018.101085
更新日期：2019-02-01 00:00:00
abstract：:Emerging evidence indicates that mitochondrial cardiolipins (CL) are prone to free radical oxidation and this process appears to be intimately associated with multiple biological functions of mitochondria. Our previous work demonstrated that a significant amount of potent lipid electrophiles including 4-hydroxy-nonena...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2014.04.003
更新日期：2014-04-13 00:00:00
abstract：:Fibrosis is one of the most prevalent features of age-related diseases like obesity, diabetes, non-alcoholic fatty liver disease, chronic kidney disease, or cardiomyopathy and affects millions of people in all countries. Although the understanding about the pathophysiology of fibrosis has improved a lot during the rec...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2015.08.015
更新日期：2015-12-01 00:00:00
abstract：:We previously reported that oncogenic KRAS activation of the PI3K/AKT pathway stimulates the remaining wild-type HRAS and NRAS proteins in a manner dependent upon both eNOS expression and C118 in HRAS and NRAS, which promoted tumor growth. Interestingly however, we recently found that loss of wild-type HRAS, NRAS, and...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2015.09.023
更新日期：2015-08-01 00:00:00
abstract：:Oxidative stress plays a major part in the pathogenesis of drug-induced liver injury. Yet, overcoming it with other xenobiotics impose additional risks. In this study, we consider the use of natural-occurring and purified Vitamin E analogs as hepatoprotective agents. Vitamin E is well-known for its intrinsic antioxida...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2015.01.013
更新日期：2015-01-01 00:00:00
abstract：:The generation of NO by the various NO synthases in normal and malignant tissues is manifested by various biological effects that are involved in the regulation of cell survival, differentiation and cell death. The role of NO in the cytotoxic immune response was first revealed by demonstrating the induction of iNOS in...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2015.08.013
更新日期：2015-12-01 00:00:00
abstract：:The precise molecular events defining the complex role of oxidative stress in the inactivation of the cerebral sodium pump in radical-induced neurodegenerative diseases is yet to be fully clarified and thus still open. Herein we investigated the modulation of the activity of the cerebral transmembrane electrogenic enz...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2014.12.015
更新日期：2015-01-01 00:00:00
