Abstract：
:Superoxide dismutase (SOD) is known to be protective against oxidative stress-mediated skin dysfunction. Here we explore the potential therapeutic activities of RM191A, a novel SOD mimetic, on skin. RM191A is a water-soluble dimeric copper (Cu2+-Cu3+)-centred polyglycine coordination complex. It displays 10-fold higher superoxide quenching activity compared to SOD as well as significant antioxidant, anti-inflammatory and immunomodulatory activities through beneficial modulation of several significant inflammatory cytokines in vitro and in vivo. We tested the therapeutic potential of RM191A in a topical gel using a human skin explant model and observed that it significantly inhibits UV-induced DNA damage in the epidermis and dermis, including cyclobutane pyrimidine dimers (CPD), 8-oxo-guanine (8-oxoG) and 8-nitroguanine (8NGO). RM191A topical gel is found to be non-toxic, non-teratogenic and readily distributed in the body of mice. Moreover, it significantly accelerates excisional wound healing, reduces 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation and attenuates age-associated oxidative stress in skin, demonstrating both skin regenerative and geroprotective properties of RM191A.
journal_name
Redox Bioljournal_title
Redox biologyauthors
Shariev A,Menounos S,Laos AJ,Laxman P,Lai D,Hua S,Zinger A,McRae CR,Casbolt LS,Combes V,Smith G,Hung TT,Dixon KM,Thordarson P,Mason RS,Das Adoi
10.1016/j.redox.2020.101790subject
Has Abstractpub_date
2021-01-01 00:00:00pages
101790issn
2213-2317pii
S2213-2317(20)30995-2journal_volume
38pub_type
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