Abstract：
:Hypoxia triggers a wide range of protective responses in mammalian cells, which are mediated through transcriptional and post-translational mechanisms. Redox signaling in cells by reactive oxygen species (ROS) such as hydrogen peroxide (H2O2) occurs through the reversible oxidation of cysteine thiol groups, resulting in structural modifications that can change protein function profoundly. Mitochondria are an important source of ROS generation, and studies reveal that superoxide generation by the electron transport chain increases during hypoxia. Other sources of ROS, such as the NAD(P)H oxidases, may also generate oxidant signals in hypoxia. This review considers the growing body of work indicating that increased ROS signals during hypoxia are responsible for regulating the activation of protective mechanisms in diverse cell types.
journal_name
Redox Bioljournal_title
Redox biologyauthors
Smith KA,Waypa GB,Schumacker PTdoi
10.1016/j.redox.2017.05.020subject
Has Abstractpub_date
2017-10-01 00:00:00pages
228-234issn
2213-2317pii
S2213-2317(17)30235-5journal_volume
13pub_type
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