Abstract：
:Physical exercise represents one of the strongest physiological stimuli capable to induce functional and structural modifications in all biological systems. Indeed, beside the traditional genetic mechanisms, physical exercise can modulate gene expression through epigenetic modifications, namely DNA methylation, post-translational histone modification and non-coding RNA transcripts. Initially considered as merely damaging molecules, it is now well recognized that both reactive oxygen (ROS) and nitrogen species (RNS) produced under voluntary exercise play an important role as regulatory mediators in signaling processes. While robust scientific evidences highlight the role of exercise-associated redox modifications in modulating gene expression through the genetic machinery, the understanding of their specific impact on epigenomic profile is still at an early stage. This review will provide an overview of the role of ROS and RNS in modulating the epigenetic landscape in the context of exercise-related adaptations.
journal_name
Redox Bioljournal_title
Redox biologyauthors
Dimauro I,Paronetto MP,Caporossi Ddoi
10.1016/j.redox.2020.101477subject
Has Abstractpub_date
2020-08-01 00:00:00pages
101477issn
2213-2317pii
S2213-2317(20)30068-9journal_volume
35pub_type
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