Abstract：
:Mitochondria are cellular energy powerhouses that play important roles in maintaining cell survival, cell death and cellular metabolic homeostasis. Timely removal of damaged mitochondria via autophagy (mitophagy) is thus critical for cellular homeostasis and function. Mitochondria are reticular organelles that have high plasticity for their dynamic structures and constantly undergo fission and fusion as well as movement through the cytoskeleton. In this review, we discuss the most recent progress on the molecular mechanisms and roles of mitochondrial fission/fusion and mitochondrial motility in mitophagy. We also discuss multiple pathways leading to the quality control of mitochondria in addition to the traditional mitophagy pathway under different conditions.
journal_name
Redox Bioljournal_title
Redox biologyauthors
Ni HM,Williams JA,Ding WXdoi
10.1016/j.redox.2014.11.006subject
Has Abstractpub_date
2015-01-01 00:00:00pages
6-13issn
2213-2317pii
S2213-2317(14)00118-9journal_volume
4pub_type
杂志文章,评审相关文献
Redox Biology文献大全abstract：:Age-related macular degeneration (AMD) is the leading cause of vision loss in the western world. Recent evidence suggests that RPE and photoreceptors have an interconnected metabolism and that mitochondrial damage in RPE is a trigger for degeneration in both RPE and photoreceptors in AMD. To test this hypothesis, this...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2019.101201
更新日期：2019-06-01 00:00:00
abstract：:Mistakenly thought to be the consequence of oxygen lack in contracting skeletal muscle we now know that the L-enantiomer of the lactate anion is formed under fully aerobic conditions and is utilized continuously in diverse cells, tissues, organs and at the whole-body level. By shuttling between producer (driver) and c...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2020.101454
更新日期：2020-08-01 00:00:00
abstract：:Ganoderma lucidum has high commercial value because it produces many active compounds, such as ganoderic acids (GAs). Salicylic acid (SA) was previously reported to induce the biosynthesis of GA in G. lucidum. In this study, we found that SA induces GA biosynthesis by increasing ROS production, and further research fo...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2018.03.018
更新日期：2018-06-01 00:00:00
abstract：:Mice deficient in the electron transport chain (ETC) complex IV assembly protein SURF1 have reduced assembly and activity of cytochrome c oxidase that is associated with an upregulation of components of the mitochondrial unfolded protein response (UPR(MT)) and increased mitochondrial number. We hypothesized that the u...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2016.05.001
更新日期：2016-08-01 00:00:00
abstract：:Ozone (O3) is a serious public health concern. Recent findings indicate that the damaging health effects of O3 extend to multiple systemic organ systems. Herein, we hypothesize that O3 inhalation will cause downstream alterations to the liver. To test this, male Sprague-Dawley rats were exposed to 0.5ppm O3 for 8h/day...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2013.11.006
更新日期：2014-01-01 00:00:00
abstract：:The generation of NO by the various NO synthases in normal and malignant tissues is manifested by various biological effects that are involved in the regulation of cell survival, differentiation and cell death. The role of NO in the cytotoxic immune response was first revealed by demonstrating the induction of iNOS in...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2015.08.013
更新日期：2015-12-01 00:00:00
abstract：:Acetaminophen (APAP) hepatotoxicity is characterized by an extensive oxidative stress. However, its source, pathophysiological role and possible therapeutic potential if targeted, have been controversially described. Earlier studies argued for cytochrome P450-generated reactive oxygen species (ROS) during APAP metabol...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2016.10.001
更新日期：2016-12-01 00:00:00
abstract：:Hydrogen peroxide appears to be the key reactive oxygen species involved in redox signalling, but comparisons of the low concentrations of hydrogen peroxide that are calculated to exist within cells with those previously shown to activate common signalling events in vitro indicate that direct oxidation of key thiol gr...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2020.101484
更新日期：2020-08-01 00:00:00
abstract：:Cellular senescence plays essential roles in tissue homeostasis as well as a host of diseases ranging from cancers to age-related neurodegeneration. Various molecular pathways can induce senescence and these different pathways dictate the phenotypic and metabolic changes that accompany the transition to, and maintenan...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2018.05.008
更新日期：2018-07-01 00:00:00
abstract：:Ultraviolet light is the dominant environmental oxidative skin stressor and a major skin aging factor. We studied which oxidized phospholipid (OxPL) mediators would be generated in primary human keratinocytes (KC) upon exposure to ultraviolet A light (UVA) and investigated the contribution of OxPL to UVA responses. Ma...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2018.11.006
更新日期：2019-01-01 00:00:00
abstract：:Oxidative stress plays a major part in the pathogenesis of drug-induced liver injury. Yet, overcoming it with other xenobiotics impose additional risks. In this study, we consider the use of natural-occurring and purified Vitamin E analogs as hepatoprotective agents. Vitamin E is well-known for its intrinsic antioxida...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2015.01.013
更新日期：2015-01-01 00:00:00
abstract：:Artesunate (ART) is a prominent anti-malarial with significant anti-cancer properties. Our previous studies showed that ART enhances lysosomal function and ferritin degradation, which was necessary for its anti-cancer properties. ART targeting to mitochondria also significantly improved its efficacy, but the effect of...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2018.07.025
更新日期：2018-10-01 00:00:00
abstract：:Preeclampsia affects one in twelve of the 130 million pregnancies a year. The lack of an effective therapeutic to prevent or treat it is responsible for an annual global cost burden of 100 billion US dollars. Preeclampsia also affects these women later in life as it is a recognised risk factor for cardiovascular disea...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2020.101768
更新日期：2021-01-01 00:00:00
abstract：:Matcha and green tea catechins such as (-)-epicatechin (EC), (-)-epigallocatechin (EGC) and (-)-epigallocatechin gallate (EGCG) have long been studied for their antioxidant and health-promoting effects. Using specific fluorophores for H2S (AzMC) and polysulfides (SSP4) as well as IC-MS and UPLC-MS/MS-based techniques ...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2020.101731
更新日期：2020-10-01 00:00:00
abstract：:Nitric oxide (NO) inhibits cell respiration reversibly and in competition with O2 through the inhibition of the mitochondrial cytochrome c oxidase (Complex IV). At concentrations lower than those required to inhibit respiration, endogenous NO enhances the reduction of the electron transport chain, thus enabling cells ...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2015.09.034
更新日期：2015-08-01 00:00:00
abstract：:Mechanical ventilation is a life-saving intervention in critically ill patients with respiratory failure due to acute respiratory distress syndrome (ARDS), a refractory lung disease with an unacceptable high mortality rate. Paradoxically, mechanical ventilation also creates excessive mechanical stress that directly au...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2020.101785
更新日期：2021-01-01 00:00:00
abstract：BACKGROUND:Macrophages regulate the inflammatory response and affect re-endothelialization. Inflammation and macrophages play important roles in promoting tissue repair, but p38α mitogen-activated protein kinase's role in re-endothelialization is unknown. METHODS AND RESULTS:Wire injuries of carotid arteries and Evans...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2020.101775
更新日期：2021-01-01 00:00:00
abstract：:NADPH oxidase 5 (NOX5) is a transmembrane signaling enzyme that produces superoxide in response to elevated cytosolic calcium. In addition to its association with numerous human diseases, NOX5 has recently been discovered to play crucial roles in the immune response and cardiovascular system. Details of NOX5 maturatio...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2020.101656
更新日期：2020-09-01 00:00:00
abstract：:Hydrogen peroxide (H2O2) modulates critical phosphorylation pathways in vascular endothelial cells, many of which affect endothelial nitric oxide synthase (eNOS) signal transduction. Both intracellular and extracellular sources of H2O2 have been implicated in eNOS regulation, yet the specific endothelial pathways rema...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2020.101605
更新日期：2020-09-01 00:00:00
abstract：:Oxidative stress resulting from the accumulation of high levels of reactive oxygen species is a salient feature of, and a well-recognised pathological factor for, diverse pathologies. One common mechanism for oxidative stress damage is via the disruption of intracellular ion homeostasis to induce cell death. TRPM2 is ...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2020.101755
更新日期：2020-10-01 00:00:00
abstract：:The nuclear protein HMGB1 (high mobility group box 1) is secreted by monocytes-macrophages in response to inflammatory stimuli and serves as a danger-associated molecular pattern. Acetylation and phosphorylation of HMGB1 are implicated in the regulation of its nucleocytoplasmic translocation for secretion, although in...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2019.101203
更新日期：2019-06-01 00:00:00
abstract：:The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor regulating the expression of genes, for instance encoding the monooxygenases cytochrome P450 (CYP) 1A1 and CYP1A2, which are important enzymes in metabolism of xenobiotics. The AHR is activated upon binding of polycyclic aromatic hydrocarbo...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2020.101530
更新日期：2020-07-01 00:00:00
abstract：:Cells employ multiple defence mechanisms to sustain a wide range of stress conditions associated with accumulation of modified self-biomolecules leading to lipo- and proteotoxicity. One of such mechanisms involves activation of the autophagy-lysosomal pathway for removal and degradation of modified lipids, proteins an...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2019.101123
更新日期：2019-05-01 00:00:00
abstract：:In this paper, we describe an assay to analyze simultaneously the oxygen consumption rate (OCR) and superoxide production in a biological system. The analytical set-up uses electron paramagnetic resonance (EPR) spectroscopy with two different isotopically-labelled sensors: 15N-PDT (4-oxo-2,2,6,6-tetramethylpiperidine-...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2020.101852
更新日期：2020-12-28 00:00:00
abstract：:The precise molecular events defining the complex role of oxidative stress in the inactivation of the cerebral sodium pump in radical-induced neurodegenerative diseases is yet to be fully clarified and thus still open. Herein we investigated the modulation of the activity of the cerebral transmembrane electrogenic enz...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2014.12.015
更新日期：2015-01-01 00:00:00
abstract：:Mitochondria are principal regulators of cellular function and metabolism through production of ATP for energy homeostasis, maintenance of calcium homeostasis, regulation of apoptosis and fatty acid oxidation to provide acetyl CoA for fueling the electron transport chain. In addition, mitochondria play a key role in c...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2014.07.005
更新日期：2014-07-27 00:00:00
abstract：:Highly active anti-retrovirus therapy (HAART) has been used to block the progression and symptoms of human immunodeficiency virus infection. Although it decreases morbidity and mortality, clinical use of HAART has also been linked to various adverse effects such as severe cardiomyopathy resulting from compromised mito...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2017.06.011
更新日期：2017-10-01 00:00:00
abstract：:Culturing cells and tissues in vitro has provided valuable insights into the molecular mechanisms regulating redox signaling in cells with implications for medicine. However, standard culture techniques maintain mammalian cells in vitro under an artificial physicochemical environment such as ambient air and 5% CO2. Ox...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2014.04.008
更新日期：2014-04-18 00:00:00
abstract：:Fibrosis is one of the most prevalent features of age-related diseases like obesity, diabetes, non-alcoholic fatty liver disease, chronic kidney disease, or cardiomyopathy and affects millions of people in all countries. Although the understanding about the pathophysiology of fibrosis has improved a lot during the rec...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2015.08.015
更新日期：2015-12-01 00:00:00
abstract：:Neonatal hypoxic-ischemic (HI) injury is a major cause of neonatal death and neurological dysfunction. H2S has been shown to protect against hypoxia-induced injury and apoptosis of neurons. L-Cysteine is catalyzed by cystathionine-β-synthase (CBS) in the brain and sequentially produces endogenous H2S. The present stud...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2017.06.007
更新日期：2017-10-01 00:00:00
