Abstract：
:Hydrogen peroxide appears to be the key reactive oxygen species involved in redox signalling, but comparisons of the low concentrations of hydrogen peroxide that are calculated to exist within cells with those previously shown to activate common signalling events in vitro indicate that direct oxidation of key thiol groups on "redox-sensitive" signalling proteins is unlikely to occur. A number of potential mechanisms have been proposed to explain how cells overcome this block to hydrogen peroxide-stimulated redox signalling and these will be discussed in the context of the redox-stimulation of specific adaptations of skeletal muscle to contractile activity and exercise. It is argued that current data implicate a role for currently unidentified effector molecules (likely to be highly reactive peroxidases) in propagation of the redox signal from sites of hydrogen peroxide generation to common adaptive signalling pathways.
journal_name
Redox Bioljournal_title
Redox biologyauthors
Jackson MJ,Stretton C,McArdle Adoi
10.1016/j.redox.2020.101484subject
Has Abstractpub_date
2020-08-01 00:00:00pages
101484issn
2213-2317pii
S2213-2317(20)30114-2journal_volume
35pub_type
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