Abstract：
:Highly active anti-retrovirus therapy (HAART) has been used to block the progression and symptoms of human immunodeficiency virus infection. Although it decreases morbidity and mortality, clinical use of HAART has also been linked to various adverse effects such as severe cardiomyopathy resulting from compromised mitochondrial functioning. However, the mechanistic basis for these effects remains unclear. Here, we demonstrate that a key component of HAART, 3ꞌ-azido-3ꞌ-deoxythymidine (AZT), particularly, its active metabolite AZT-triphosphate (AZT-TP), caused mitochondrial dysfunction, leading to induction of cell death in H9c2 cells derived from rat embryonic myoblasts, which serve as a model for cardiomyopathy. Specifically, treatment with 100µM AZT for 48h disrupted the mitochondrial tubular network via accumulation of AZT-TP. The mRNA expression of dynamin-related protein (Drp)1 and the Drp1 receptor mitochondrial fission factor (Mff) was upregulated whereas that of optic atrophy 1 (Opa1) was downregulated following AZT treatment. Increased mitochondrial translocation of Drp1, Mff upregulation, and decreased functional Opa1 expression induced by AZT impaired the balance of mitochondrial fission vs. fusion. These data demonstrate that AZT-TP causes cell death by altering mitochondrial dynamics.
journal_name
Redox Bioljournal_title
Redox biologyauthors
Nomura R,Sato T,Sato Y,Medin JA,Kushimoto S,Yanagisawa Tdoi
10.1016/j.redox.2017.06.011subject
Has Abstractpub_date
2017-10-01 00:00:00pages
407-417issn
2213-2317pii
S2213-2317(17)30411-1journal_volume
13pub_type
杂志文章相关文献
Redox Biology文献大全abstract：:Williamson and colleagues present important data on the effects of MitoQ - an antioxidant compound targeted to mitochondria - on mtDNA damage following exercise. Future studies are needed to elucidate, whether or not the observed prevention of MitoQ on DNA damage is beneficial with regard to functional outcomes in hea...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2020.101732
更新日期：2021-01-01 00:00:00
abstract：:Gallbladder cancer (GBC) is a highly malignant bile duct cancer with poor prognosis characterized by its insensitivity to chemotherapy. Emerging evidence indicates that cytoprotective antioxidation is involved in drug resistance of various cancers; however, the underlying molecular mechanisms remain obscure. Here, we ...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2019.101149
更新日期：2019-04-01 00:00:00
abstract：OBJECTIVE:Cellular repressor of E1A-stimulated genes (CREG), a vasculoprotective molecule, is significantly downregulated in atherosclerotic vessels through unclear mechanisms. While epigenetic regulation is involved in atherosclerosis development, it is not known if the CREG gene is epigenetically regulated. The aim o...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2020.101444
更新日期：2020-05-01 00:00:00
abstract：:Alterations in the NRF2/KEAP1 pathway result in the constitutive activation of NRF2, leading to the aberrant induction of antioxidant and detoxification enzymes, including NQO1. The NQO1 bioactivatable agent β-lapachone can target cells with high NQO1 expression but relies in the generation of reactive oxygen species ...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2020.101440
更新日期：2020-02-01 00:00:00
abstract：:This review focuses on the hypothetical mechanisms for enhanced vulnerability of African Americans to SARS-CoV-2 infection, COVID-19 severity, and increased deaths. A disproportionately higher number of African Americans are afflicted with autoimmune and inflammatory diseases (e.g., diabetes, hypertension, obesity), a...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2020.101721
更新日期：2020-10-01 00:00:00
abstract：:Superoxide dismutase (SOD) is known to be protective against oxidative stress-mediated skin dysfunction. Here we explore the potential therapeutic activities of RM191A, a novel SOD mimetic, on skin. RM191A is a water-soluble dimeric copper (Cu2+-Cu3+)-centred polyglycine coordination complex. It displays 10-fold highe...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2020.101790
更新日期：2021-01-01 00:00:00
abstract：:Microglia-mediated neuroinflammation plays a crucial role in the pathophysiological process of multiple neurological disorders such as ischemic stroke, yet lacks effective therapeutic agents. Previously, we discovered one novel synthetic compound, tanshinol borneol ester (DBZ), possesses anti-inflammatory and anti-ath...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2020.101644
更新日期：2020-09-01 00:00:00
abstract：:Adropin, a secretory signal peptide, has shown beneficial effects on improving glucose homeostasis and dyslipidemia. However, whether this peptide affects nonalcoholic steatohepatitis (NASH) has remained unclear. In this study, the serum adropin levels, liver injury and oxidative stress were measured in diet-induced N...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2018.101068
更新日期：2019-02-01 00:00:00
abstract：:Nitrite and nitrate restore deficient endogenous nitric oxide (NO) production as they are converted back to NO, and therefore complement the classic enzymatic NO synthesis. Circulating nitrate and nitrite must cross membrane barriers to produce their effects and increased nitrate concentrations may attenuate the nitri...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2017.03.003
更新日期：2017-08-01 00:00:00
abstract：:The system (PTTRS) formed by typical 2-Cys peroxiredoxins (Prx), thioredoxin (Trx), Trx reductase (TrxR), and sulfiredoxin (Srx) is central in antioxidant protection and redox signaling in the cytoplasm of eukaryotic cells. Understanding how the PTTRS integrates these functions requires tracing phenotypes to molecular...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2017.12.008
更新日期：2018-05-01 00:00:00
abstract：:For years, there have been studies based on the use of natural compounds plant-derived as potential therapeutic agents for various diseases in humans. Curcumin is a phenolic compound extracted from Curcuma longa rhizome commonly used in Asia as a spice, pigment and additive. In traditional medicine of India and China,...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2013.09.003
更新日期：2013-09-17 00:00:00
abstract：:Preeclampsia affects one in twelve of the 130 million pregnancies a year. The lack of an effective therapeutic to prevent or treat it is responsible for an annual global cost burden of 100 billion US dollars. Preeclampsia also affects these women later in life as it is a recognised risk factor for cardiovascular disea...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2020.101768
更新日期：2021-01-01 00:00:00
abstract：:Physical exercise represents one of the strongest physiological stimuli capable to induce functional and structural modifications in all biological systems. Indeed, beside the traditional genetic mechanisms, physical exercise can modulate gene expression through epigenetic modifications, namely DNA methylation, post-t...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2020.101477
更新日期：2020-08-01 00:00:00
abstract：:Ganoderma lucidum has high commercial value because it produces many active compounds, such as ganoderic acids (GAs). Salicylic acid (SA) was previously reported to induce the biosynthesis of GA in G. lucidum. In this study, we found that SA induces GA biosynthesis by increasing ROS production, and further research fo...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2018.03.018
更新日期：2018-06-01 00:00:00
abstract：:With the goal to enhance the distribution of cationic Mn porphyrins within mitochondria, the lipophilic Mn(III)meso-tetrakis(N-n-hexylpyridinium-2-yl)porphyrin, MnTnHex-2-PyP(5+) has been synthesized and tested in several different model of diseases, where it shows remarkable efficacy at as low as 50 µg/kg single or m...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2013.12.017
更新日期：2014-01-09 00:00:00
abstract：:Mechanical ventilation is a life-saving intervention in critically ill patients with respiratory failure due to acute respiratory distress syndrome (ARDS), a refractory lung disease with an unacceptable high mortality rate. Paradoxically, mechanical ventilation also creates excessive mechanical stress that directly au...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2020.101785
更新日期：2021-01-01 00:00:00
abstract：:Loneliness and social isolation are common sources of chronic stress in modern society. Epidemiological studies have demonstrated that loneliness and social isolation increase mortality risk as much as smoking or alcohol consumption and more than physical inactivity or obesity. Loneliness in human is associated with h...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2020.101585
更新日期：2020-10-01 00:00:00
abstract：:Oxidative stress and neuronal apoptosis have been demonstrated to be key features in early brain injury (EBI) after subarachnoid hemorrhage (SAH). Previous studies have indicated that Mas receptor activation initiates an anti-oxidative and anti-apoptotic role in the brain. However, whether Mas activation can attenuate...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2018.09.022
更新日期：2019-01-01 00:00:00
abstract：:The development of hypertension is associated with mitochondrial redox balance disruptions. NADP+-dependent isocitrate dehydrogenase 2 (IDH2) plays an important role in the maintenance of mitochondrial redox balance by producing mitochondrial NADPH, which is an essential cofactor in the reduction of glutathione (from ...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2020.101548
更新日期：2020-07-01 00:00:00
abstract：:Dietary nitrate is now recognized as an alternative substrate for nitric oxide (•NO) production in the gut. This novel pathway implies the sequential reduction of nitrate to nitrite, •NO and other bioactive nitrogen oxides but the physiological relevance of these oxidants has remained elusive. We have previously shown...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2016.04.002
更新日期：2016-08-01 00:00:00
abstract：:Calcium (Ca2+) and reactive oxygen species (ROS) are versatile signaling molecules coordinating physiological and pathophysiological processes. While channels and pumps shuttle Ca2+ ions between extracellular space, cytosol and cellular compartments, short-lived and highly reactive ROS are constantly generated by vari...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2020.101678
更新日期：2020-09-01 00:00:00
abstract：:Hydroxytyrosol (HT) is a main phenolic component of olive oil. In this study, we investigated the safety and effects produced by HT purified (99.5%) from olive mill waste. HT was administered at a daily dosage of 45mg for 8 weeks to volunteers with mild hyperlipidemia (n=14). We measured markers of cardiovascular dise...
journal_title：Redox biology
pub_type： 临床试验,杂志文章
doi：10.1016/j.redox.2016.12.014
更新日期：2017-04-01 00:00:00
abstract：:Reactivation of p53 and induction of tumor cell apoptosis (RITA) is a small molecule that blocks p53-MDM2 interaction, thereby reactivating p53 in tumors. RITA can induce exclusive apoptosis in cancer cells independently of the p53 pathway; however, the resistance of cancer cells remains a major drawback. Here, we fou...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2017.05.025
更新日期：2017-10-01 00:00:00
abstract：:Oxidative modification of cysteine residues has been shown to regulate the activity of several protein-tyrosine kinases. We explored the possibility that Fms-like tyrosine kinase 3 (FLT3), a hematopoietic receptor-tyrosine kinase, is subject to this type of regulation. An underlying rationale was that the FLT3 gene is...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2019.101325
更新日期：2020-01-01 00:00:00
abstract：:Heme oxygenase-1 (HO-1) is an important anti-inflammatory, antioxidative and cytoprotective enzyme that is regulated by the activation of the major transcription factor, nuclear factor (erythroid-derived 2)-like 2 (Nrf2). In the present study, six stilbene derivatives isolated from Rheum undulatum L. were assessed for...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2014.02.001
更新日期：2014-02-18 00:00:00
abstract：:Mice deficient in the electron transport chain (ETC) complex IV assembly protein SURF1 have reduced assembly and activity of cytochrome c oxidase that is associated with an upregulation of components of the mitochondrial unfolded protein response (UPR(MT)) and increased mitochondrial number. We hypothesized that the u...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2016.05.001
更新日期：2016-08-01 00:00:00
abstract：:The inducible form of Heme Oxygenase-1 (HO-1), a major endoplasmic reticulum (ER) associated heme protein, is known to play important roles in protection against oxidative and chemical stress by degrading free heme released from degradation of heme proteins. In this study we show that induced expression of HO-1 by sub...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2013.07.004
更新日期：2013-07-23 00:00:00
abstract：:The liver has a multitude of functions which are necessary to maintain whole body homeostasis. This requires that various metabolic pathways can run in parallel in the most efficient manner and that futile cycles are kept to a minimum. To a large extent this is achieved due to a functional specialization of the liver ...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2017.01.012
更新日期：2017-04-01 00:00:00
abstract：:We have previously demonstrated that DGLA treatment along with Delta-5-Desaturase (D5D) siRNA in various types of cancer cells enhances the formation of 8-HOA from COX-2-catalyzed DGLA peroxidation, which in turn inhibits cancer cell growth and migration. However, delivery of naked siRNA remains a formidable challenge...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2018.101085
更新日期：2019-02-01 00:00:00
abstract：:Oxidation-reduction chemistry is fundamental to the metabolism of all living organisms, and hence quantifying the principal redox players is important for a comprehensive understanding of cell metabolism in normal and pathological states. In mammalian cells, this is accomplished by measuring oxygen partial pressure (p...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2020.101549
更新日期：2020-07-01 00:00:00
