Abstract:
:In the version of this Article originally published, author Carolina Falcón Garcia's name was coded wrongly, resulting in it being incorrect when exported to citation databases. This has now been corrected, though no visible changes will be apparent.
journal_name
Nat Microbioljournal_title
Nature microbiologyauthors
Dragoš A,Martin M,Garcia CF,Kricks L,Pausch P,Heimerl T,Bálint B,Maróti G,Bange G,López D,Lieleg O,Kovács ÁTdoi
10.1038/s41564-018-0350-0subject
Has Abstractpub_date
2019-02-01 00:00:00pages
376issue
2issn
2058-5276pii
10.1038/s41564-018-0350-0journal_volume
4pub_type
已发布勘误abstract::Zika virus is a mosquito-borne pathogen that is rapidly spreading across the Americas. Due to associations between Zika virus infection and a range of fetal maladies(1,2), the epidemic trajectory of this viral infection poses a significant concern for the nearly 15 million children born in the Americas each year. Asce...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2016.126
更新日期:2016-07-25 00:00:00
abstract::As they proliferate, fungi expose antigens at their cell surface that are potent stimulators of the innate immune response, and yet the commensal fungus Candida albicans is able to colonize immuno competent individuals. We show that C. albicans may evade immune detection by presenting a moving immunological target. We...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2016.238
更新日期:2016-12-12 00:00:00
abstract::Bacterial toxin-antitoxin systems (TASs) are thought to respond to various stresses, often inducing growth-arrested (persistent) sub-populations of cells whose housekeeping functions are inhibited. Many such TASs induce this effect through the translation-dependent RNA cleavage (RNase) activity of their toxins, which ...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2016.8
更新日期:2016-02-22 00:00:00
abstract::The sexually transmitted pathogen Neisseria gonorrhoeae is regarded as being on the way to becoming an untreatable superbug. Despite its clinical importance, little is known about its emergence and evolution, and how this corresponds with the introduction of antimicrobials. We present a genome-based phylogeographical ...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-019-0501-y
更新日期:2019-11-01 00:00:00
abstract::Monkeypox is a viral zoonotic disease on the rise across endemic habitats. Despite the growing importance of monkeypox virus, our knowledge on its host spectrum and sylvatic maintenance is limited. Here, we describe the recent repeated emergence of monkeypox virus in a wild, human-habituated western chimpanzee (Pan tr...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-020-0706-0
更新日期:2020-07-01 00:00:00
abstract::Many insects, including mosquitoes, planthoppers, aphids and leafhoppers, are the hosts of bacterial symbionts and the vectors for transmitting viral pathogens1-3. In general, symbiotic bacteria can indirectly affect viral transmission by enhancing immunity and resistance to viruses in insects3-5. Whether symbiotic ba...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2017.25
更新日期:2017-03-06 00:00:00
abstract::Autophagy and interferon (IFN)-mediated innate immunity are critical antiviral defence mechanisms, and recent evidence indicated that tripartite motif (TRIM) proteins are important regulators of both processes. Although the role of TRIM proteins in modulating antiviral cytokine responses has been well established, muc...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-017-0017-2
更新日期:2017-11-01 00:00:00
abstract::The evolution of virulence traits is central for the emergence or re-emergence of microbial pathogens and for their adaptation to a specific host 1-5 . Typhoid toxin is an essential virulence factor of the human-adapted bacterial pathogen Salmonella Typhi 6,7 , the cause of typhoid fever in humans 8-12 . Typhoid toxin...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-017-0033-2
更新日期:2017-12-01 00:00:00
abstract::For successful infection, bacteriophages must overcome multiple barriers to transport their genome and proteins across the bacterial cell envelope. We use cryo-electron tomography to study the infection initiation of phage P22 in Salmonella enterica serovar Typhimurium, revealing how a channel forms to allow genome tr...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-019-0403-z
更新日期:2019-06-01 00:00:00
abstract::Single-cell RNA sequencing has revealed extensive cellular heterogeneity within many organisms, but few methods have been developed for microbial clonal populations. The yeast genome displays unusually dense transcript spacing, with interleaved and overlapping transcription from both strands, resulting in a minuscule ...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-018-0346-9
更新日期:2019-04-01 00:00:00
abstract::Helicobacter pylori infection is a proven carcinogen for gastric cancer. Its virulence factor vacuolating cytotoxin A (VacA) promotes more severe disease and gastric colonization. VacA, by an unknown mechanism, usurps lysosomal and autophagy pathways to generate a protected reservoir for H. pylori that confers bacteri...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-019-0441-6
更新日期:2019-08-01 00:00:00
abstract::In structured environments, antibiotic-producing microorganisms can gain a selective advantage by inhibiting nearby competing species1. However, despite their genetic potential2,3, natural isolates often make only small amounts of antibiotics, and laboratory evolution can lead to loss rather than enhancement of antibi...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2016.175
更新日期:2016-09-26 00:00:00
abstract::The development of new drug regimens that allow rapid, sterilizing treatment of tuberculosis has been limited by the complexity and time required for genetic manipulations in Mycobacterium tuberculosis. CRISPR interference (CRISPRi) promises to be a robust, easily engineered and scalable platform for regulated gene si...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2016.274
更新日期:2017-02-06 00:00:00
abstract::We describe Idionectes vortex gen. nov., sp. nov., a unicellular microeukaryote that swims by continuous inversion of its surface, similar to a vortex ring. This previously unreported mode of motility approximates a hypothetical concept called the 'toroidal swimmer', in which a doughnut-shaped object rotates around it...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-019-0478-6
更新日期:2019-10-01 00:00:00
abstract::The temporal dynamics of phytoplankton growth and activity have large impacts on fluxes of matter and energy, yet obtaining in situ metabolic measurements of sufficient resolution for even dominant microorganisms remains a considerable challenge. We performed Lagrangian diel sampling with synoptic measurements of popu...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2017.118
更新日期:2017-07-31 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature microbiology
pub_type: 已发布勘误
doi:10.1038/s41564-020-00825-4
更新日期:2020-12-01 00:00:00
abstract::Clostridium difficile infection (CDI) is mediated by two major exotoxins, toxin A (TcdA) and toxin B (TcdB), that damage the colonic epithelial barrier and induce inflammatory responses. The function of the colonic vascular barrier during CDI has been relatively understudied. Here we report increased colonic vascular ...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-018-0300-x
更新日期:2019-02-01 00:00:00
abstract::Many animal viruses are enveloped in a lipid bilayer taken up from cellular membranes. Because viral surface proteins bind to these membranes to initiate infection, we hypothesized that free virions may also be capable of interacting with the envelopes of other virions extracellularly. Here, we demonstrate this hypoth...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2017.78
更新日期:2017-05-22 00:00:00
abstract::The microbial environment influences animal physiology. However, the underlying molecular mechanisms of such functional interactions are largely undefined. Previously, we showed that during chronic undernutrition, strains of Lactobacillus plantarum, a major commensal partner of Drosophila, promote host juvenile growth...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-017-0038-x
更新日期:2017-12-01 00:00:00
abstract::A major form of transcriptional regulation in bacteria occurs through the exchange of the primary σ factor of RNA polymerase (RNAP) with an alternative extracytoplasmic function (ECF) σ factor1. ECF σ factors are generally intrinsically active and are retained in an inactive state via the sequestration into σ factor-a...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-019-0648-6
更新日期:2020-03-01 00:00:00
abstract::Despite recent progress, the organization and ecological properties of the intestinal microbial ecosystem remain under-investigated. Here, using a manually curated metabolic module framework for (meta-)genomic data analysis, we studied species-function relationships in gut microbial genomes and microbiomes. Half of gu...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2016.88
更新日期:2016-06-13 00:00:00
abstract:: ...
journal_title:Nature microbiology
pub_type: 社论
doi:10.1038/s41564-019-0408-7
更新日期:2019-03-01 00:00:00
abstract::Enterovirus 71 (EV71) is a common cause of hand, foot and mouth disease-a disease endemic especially in the Asia-Pacific region1. Scavenger receptor class B member 2 (SCARB2) is the major receptor of EV71, as well as several other enteroviruses responsible for hand, foot and mouth disease, and plays a key role in cell...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-018-0319-z
更新日期:2019-03-01 00:00:00
abstract::How does knowing the evolutionary history of microorganisms affect our analysis of microbiological datasets? Depending on the research question, the common ancestry of microorganisms can be a source of confounding variation, or a scaffolding used for inference. For example, when performing regression on traits, common...
journal_title:Nature microbiology
pub_type: 杂志文章,评审
doi:10.1038/s41564-018-0156-0
更新日期:2018-06-01 00:00:00
abstract::Outbreaks of viral infections are a global health burden. Although type I interferon (IFN-I) exerts broad-spectrum antiviral effects, its antiviral efficacy in host cells is largely restricted by viruses. How the antiviral efficacy of IFN-I can be improved remains to be explored. Here, we identified the ADP-ribosyltra...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-019-0428-3
更新日期:2019-11-01 00:00:00
abstract::Here, we developed hCK, a Madin-Darby canine kidney (MDCK) cell line that expresses high levels of human influenza virus receptors and low levels of avian virus receptors. hCK cells supported human A/H3N2 influenza virus isolation and growth much more effectively than conventional MDCK or human virus receptor-overexpr...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-019-0433-6
更新日期:2019-08-01 00:00:00
abstract::The Epstein-Barr virus M81 strain, isolated from a nasopharyngeal carcinoma, induces potent spontaneous virus production in infected B cells. We found that the M81 non-coding Epstein-Barr-encoded RNA EBER2, which carries polymorphisms that are mainly restricted to viruses found in endemic nasopharyngeal carcinomas, ma...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-019-0546-y
更新日期:2019-12-01 00:00:00
abstract::Aichi virus (AiV), an unusual and poorly characterized picornavirus, classified in the genus Kobuvirus, can cause severe gastroenteritis and deaths in children below the age of five years, especially in developing countries1,2. The seroprevalence of AiV is approximately 60% in children under the age of ten years and r...
journal_title:Nature microbiology
pub_type: 信件
doi:10.1038/nmicrobiol.2016.150
更新日期:2016-09-05 00:00:00
abstract::Evidence has accumulated to demonstrate that the intestinal microbiota enhances mammalian enteric virus infections1. For example, we and others previously reported that commensal bacteria stimulate acute and persistent murine norovirus infections2-4. However, in apparent contradiction of these results, the virulence o...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-019-0602-7
更新日期:2020-01-01 00:00:00
abstract::The core properties of microbial genomes, including GC content and genome size, are known to vary widely among different bacteria and archaea 1,2 . Several hypotheses have been proposed to explain this genomic variability, but the fundamental drivers that shape bacterial and archaeal genomic properties remain uncertai...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-017-0008-3
更新日期:2017-10-01 00:00:00