Growth control switch by a DNA-damage-inducible toxin-antitoxin system in Caulobacter crescentus.

abstract：:Aichi virus (AiV), an unusual and poorly characterized picornavirus, classified in the genus Kobuvirus, can cause severe gastroenteritis and deaths in children below the age of five years, especially in developing countries1,2. The seroprevalence of AiV is approximately 60% in children under the age of ten years and r...

journal_title：Nature microbiology

authors： Zhu L,Wang X,Ren J,Kotecha A,Walter TS,Yuan S,Yamashita T,Tuthill TJ,Fry EE,Rao Z,Stuart DI

更新日期：2016-09-05 00:00:00

abstract：:The Epstein-Barr virus M81 strain, isolated from a nasopharyngeal carcinoma, induces potent spontaneous virus production in infected B cells. We found that the M81 non-coding Epstein-Barr-encoded RNA EBER2, which carries polymorphisms that are mainly restricted to viruses found in endemic nasopharyngeal carcinomas, ma...

journal_title：Nature microbiology

authors： Li Z,Tsai MH,Shumilov A,Baccianti F,Tsao SW,Poirey R,Delecluse HJ

更新日期：2019-12-01 00:00:00

abstract：:A major form of transcriptional regulation in bacteria occurs through the exchange of the primary σ factor of RNA polymerase (RNAP) with an alternative extracytoplasmic function (ECF) σ factor1. ECF σ factors are generally intrinsically active and are retained in an inactive state via the sequestration into σ factor-a...

journal_title：Nature microbiology

authors： Iyer SC,Casas-Pastor D,Kraus D,Mann P,Schirner K,Glatter T,Fritz G,Ringgaard S

更新日期：2020-03-01 00:00:00

abstract：:How does environmental complexity affect the evolution of single genes? Here, we measured the effects of a set of Bacillus subtilis glutamate dehydrogenase mutants across 19 different environments-from phenotypically homogeneous single-cell populations in liquid media to heterogeneous biofilms, plant roots and soil po...

journal_title：Nature microbiology

authors： Noda-García L,Davidi D,Korenblum E,Elazar A,Putintseva E,Aharoni A,Tawfik DS

更新日期：2019-07-01 00:00:00

abstract：:Zika virus is a mosquito-borne pathogen that is rapidly spreading across the Americas. Due to associations between Zika virus infection and a range of fetal maladies(1,2), the epidemic trajectory of this viral infection poses a significant concern for the nearly 15 million children born in the Americas each year. Asce...

journal_title：Nature microbiology

authors： Perkins TA,Siraj AS,Ruktanonchai CW,Kraemer MU,Tatem AJ

更新日期：2016-07-25 00:00:00

abstract：:Staphylococcus epidermidis is a conspicuous member of the human microbiome, widely present on healthy skin. Here we show that S. epidermidis has also evolved to become a formidable nosocomial pathogen. Using genomics, we reveal that three multidrug-resistant, hospital-adapted lineages of S. epidermidis (two ST2 and on...

journal_title：Nature microbiology

authors： Lee JYH,Monk IR,Gonçalves da Silva A,Seemann T,Chua KYL,Kearns A,Hill R,Woodford N,Bartels MD,Strommenger B,Laurent F,Dodémont M,Deplano A,Patel R,Larsen AR,Korman TM,Stinear TP,Howden BP

更新日期：2018-10-01 00:00:00

abstract：:CRISPR-Cas systems are adaptive immune systems that protect bacteria from bacteriophage (phage) infection1. To provide immunity, RNA-guided protein surveillance complexes recognize foreign nucleic acids, triggering their destruction by Cas nucleases2. While the essential requirements for immune activity are well under...

journal_title：Nature microbiology

authors： Borges AL,Castro B,Govindarajan S,Solvik T,Escalante V,Bondy-Denomy J

更新日期：2020-05-01 00:00:00

abstract：:Outbreaks of viral infections are a global health burden. Although type I interferon (IFN-I) exerts broad-spectrum antiviral effects, its antiviral efficacy in host cells is largely restricted by viruses. How the antiviral efficacy of IFN-I can be improved remains to be explored. Here, we identified the ADP-ribosyltra...

journal_title：Nature microbiology

authors： Guo T,Zuo Y,Qian L,Liu J,Yuan Y,Xu K,Miao Y,Feng Q,Chen X,Jin L,Zhang L,Dong C,Xiong S,Zheng H

更新日期：2019-11-01 00:00:00

abstract：:Toxoplasma gondii establishes a lifelong chronic infection in humans and animals1. Host cell entry and egress are key steps in the lytic cycle of this obligate intracellular parasite, ensuring its survival and dissemination. Egress is temporally orchestrated, underpinned by the exocytosis of secretory organelles calle...

journal_title：Nature microbiology

authors： Bisio H,Lunghi M,Brochet M,Soldati-Favre D

更新日期：2019-03-01 00:00:00

abstract：:In the version of this Perspective originally published, the first and last name of co-author Manimozhiyan Arumugam were switched. This has now been corrected in all versions of the Perspective. ...

journal_title：Nature microbiology

authors： Costea PI,Hildebrand F,Arumugam M,Bäckhed F,Blaser MJ,Bushman FD,de Vos WM,Ehrlich SD,Fraser CM,Hattori M,Huttenhower C,Jeffery IB,Knights D,Lewis JD,Ley RE,Ochman H,O'Toole PW,Quince C,Relman DA,Shanahan F,Sunaga

更新日期：2018-03-01 00:00:00

abstract：:Retinoic acid-inducible gene I (RIG-I) receptor recognizes 5'-triphosphorylated RNA and triggers a signalling cascade that results in the induction of type-I interferon (IFN)-dependent responses. Its precise regulation represents a pivotal balance between antiviral defences and autoimmunity. To elucidate the cellular ...

journal_title：Nature microbiology

authors： Soonthornvacharin S,Rodriguez-Frandsen A,Zhou Y,Galvez F,Huffmaster NJ,Tripathi S,Balasubramaniam VR,Inoue A,de Castro E,Moulton H,Stein DA,Sánchez-Aparicio MT,De Jesus PD,Nguyen Q,König R,Krogan NJ,García-Sastre A,Yoh

更新日期：2017-03-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature microbiology

authors： Cartmell A,Muñoz-Muñoz J,Briggs JA,Ndeh DA,Lowe EC,Baslé A,Terrapon N,Stott K,Heunis T,Gray J,Yu L,Dupree P,Fernandes PZ,Shah S,Williams SJ,Labourel A,Trost M,Henrissat B,Gilbert HJ

更新日期：2019-11-01 00:00:00

abstract：:Despite recent progress, the organization and ecological properties of the intestinal microbial ecosystem remain under-investigated. Here, using a manually curated metabolic module framework for (meta-)genomic data analysis, we studied species-function relationships in gut microbial genomes and microbiomes. Half of gu...

journal_title：Nature microbiology

authors： Vieira-Silva S,Falony G,Darzi Y,Lima-Mendez G,Garcia Yunta R,Okuda S,Vandeputte D,Valles-Colomer M,Hildebrand F,Chaffron S,Raes J

更新日期：2016-06-13 00:00:00

abstract：:Rod-shaped bacteria grow by adding material into their cell wall via the action of two spatially distinct enzymatic systems: the Rod complex moves around the cell circumference, whereas class A penicillin-binding proteins (aPBPs) do not. To understand how the combined action of these two systems defines bacterial dime...

journal_title：Nature microbiology

authors： Dion MF,Kapoor M,Sun Y,Wilson S,Ryan J,Vigouroux A,van Teeffelen S,Oldenbourg R,Garner EC

更新日期：2019-08-01 00:00:00

abstract：:We describe Idionectes vortex gen. nov., sp. nov., a unicellular microeukaryote that swims by continuous inversion of its surface, similar to a vortex ring. This previously unreported mode of motility approximates a hypothetical concept called the 'toroidal swimmer', in which a doughnut-shaped object rotates around it...

journal_title：Nature microbiology

authors： Hess S,Eme L,Roger AJ,Simpson AGB

更新日期：2019-10-01 00:00:00

abstract：:Dimethylsulfoniopropionate (DMSP) is one of the Earth's most abundant organosulfur molecules, a signalling molecule1, a key nutrient for marine microorganisms2,3 and the major precursor for gaseous dimethyl sulfide (DMS). DMS, another infochemical in signalling pathways4, is important in global sulfur cycling2 and aff...

journal_title：Nature microbiology

authors： Curson AR,Liu J,Bermejo Martínez A,Green RT,Chan Y,Carrión O,Williams BT,Zhang SH,Yang GP,Bulman Page PC,Zhang XH,Todd JD

更新日期：2017-02-13 00:00:00

abstract：:Coenzymes are vital for cellular metabolism and act on the full spectrum of enzymatic reactions. Intrinsic chemical reactivity, enzyme promiscuity and high flux through their catalytic cycles make coenzymes prone to damage. To counteract such compromising factors and ensure stable levels of functional coenzymes, cells...

journal_title：Nature microbiology

authors： Hartl J,Kiefer P,Meyer F,Vorholt JA

更新日期：2017-05-15 00:00:00

abstract：:Viruses and plasmids (invasive mobile genetic elements (iMGEs)) have important roles in shaping microbial communities, but their dynamic interactions with CRISPR-based immunity remain unresolved. We analysed generation-resolved iMGE-host dynamics spanning one and a half years in a microbial consortium from a biologica...

journal_title：Nature microbiology

authors： Martínez Arbas S,Narayanasamy S,Herold M,Lebrun LA,Hoopmann MR,Li S,Lam TJ,Kunath BJ,Hicks ND,Liu CM,Price LB,Laczny CC,Gillece JD,Schupp JM,Keim PS,Moritz RL,Faust K,Tang H,Ye Y,Skupin A,May P,Muller EEL,Wilm

更新日期：2021-01-01 00:00:00

abstract：:Legionella pneumophila, the causative bacterium for Legionnaires' disease, hijacks host membrane trafficking for the maturation of the Legionella-containing vacuole (LCV). The LCV membrane mainly contains PtdIns4P, which is important for anchoring many secreted Legionella effectors onto the LCV. Here, we identify a cr...

journal_title：Nature microbiology

authors： Dong N,Niu M,Hu L,Yao Q,Zhou R,Shao F

更新日期：2016-12-12 00:00:00

abstract：:Many animal viruses are enveloped in a lipid bilayer taken up from cellular membranes. Because viral surface proteins bind to these membranes to initiate infection, we hypothesized that free virions may also be capable of interacting with the envelopes of other virions extracellularly. Here, we demonstrate this hypoth...

journal_title：Nature microbiology

authors： Cuevas JM,Durán-Moreno M,Sanjuán R

更新日期：2017-05-22 00:00:00

abstract：:Marine microeukaryotes play a fundamental role in biogeochemical cycling through the transfer of energy to higher trophic levels and vertical carbon transport. Despite their global importance, microeukaryote physiology, nutrient metabolism and contributions to carbon cycling across offshore ecosystems are poorly chara...

journal_title：Nature microbiology

authors： Cohen NR,McIlvin MR,Moran DM,Held NA,Saunders JK,Hawco NJ,Brosnahan M,DiTullio GR,Lamborg C,McCrow JP,Dupont CL,Allen AE,Saito MA

更新日期：2021-02-01 00:00:00

abstract：:Host factors that silence provirus transcription in CD4+ memory T cells help HIV-1 escape eradication by the host immune system and by antiviral drugs1. These same factors, however, must be overcome for HIV-1 to propagate. Here we show that Vpx and Vpr encoded by diverse primate immunodeficiency viruses activate provi...

journal_title：Nature microbiology

authors： Yurkovetskiy L,Guney MH,Kim K,Goh SL,McCauley S,Dauphin A,Diehl WE,Luban J

更新日期：2018-12-01 00:00:00

abstract：:Primary sclerosing cholangitis (PSC) is a chronic inflammatory liver disease and its frequent complication with ulcerative colitis highlights the pathogenic role of epithelial barrier dysfunction. Intestinal barrier dysfunction has been implicated in the pathogenesis of PSC, yet its underlying mechanism remains unknow...

journal_title：Nature microbiology

authors： Nakamoto N,Sasaki N,Aoki R,Miyamoto K,Suda W,Teratani T,Suzuki T,Koda Y,Chu PS,Taniki N,Yamaguchi A,Kanamori M,Kamada N,Hattori M,Ashida H,Sakamoto M,Atarashi K,Narushima S,Yoshimura A,Honda K,Sato T,Kanai T

更新日期：2019-03-01 00:00:00

abstract：:Enterovirus 71 (EV71) is a common cause of hand, foot and mouth disease-a disease endemic especially in the Asia-Pacific region1. Scavenger receptor class B member 2 (SCARB2) is the major receptor of EV71, as well as several other enteroviruses responsible for hand, foot and mouth disease, and plays a key role in cell...

journal_title：Nature microbiology

authors： Zhou D,Zhao Y,Kotecha A,Fry EE,Kelly JT,Wang X,Rao Z,Rowlands DJ,Ren J,Stuart DI

更新日期：2019-03-01 00:00:00

abstract：:Bacteria have evolved diverse mechanisms to fend off predation by bacteriophages. We previously identified the Dnd system, which uses DndABCDE to insert sulfur into the DNA backbone as a double-stranded phosphorothioate (PT) modification, and DndFGH, a restriction component. Here, we describe an unusual SspABCD-SspE P...

journal_title：Nature microbiology

authors： Xiong X,Wu G,Wei Y,Liu L,Zhang Y,Su R,Jiang X,Li M,Gao H,Tian X,Zhang Y,Hu L,Chen S,Tang Y,Jiang S,Huang R,Li Z,Wang Y,Deng Z,Wang J,Dedon PC,Chen S,Wang L

更新日期：2020-07-01 00:00:00

abstract：:The evolution of virulence traits is central for the emergence or re-emergence of microbial pathogens and for their adaptation to a specific host 1-5 . Typhoid toxin is an essential virulence factor of the human-adapted bacterial pathogen Salmonella Typhi 6,7 , the cause of typhoid fever in humans 8-12 . Typhoid toxin...

journal_title：Nature microbiology

authors： Gao X,Deng L,Stack G,Yu H,Chen X,Naito-Matsui Y,Varki A,Galán JE

更新日期：2017-12-01 00:00:00

abstract：:The molecular processes that determine the outcome of influenza virus infection in humans are multifactorial and involve a complex interplay between host, viral and bacterial factors1. However, it is generally accepted that a strong innate immune dysregulation known as 'cytokine storm' contributes to the pathology of ...

journal_title：Nature microbiology

authors： Te Velthuis AJW,Long JC,Bauer DLV,Fan RLY,Yen HL,Sharps J,Siegers JY,Killip MJ,French H,Oliva-Martín MJ,Randall RE,de Wit E,van Riel D,Poon LLM,Fodor E

更新日期：2018-11-01 00:00:00

abstract：:This corrects the article DOI: 10.1038/nmicrobiol.2016.155. ...

journal_title：Nature microbiology

authors： Buffalo CZ,Bahn-Suh AJ,Hirakis SP,Biswas T,Amaro RE,Nizet V,Ghosh P

更新日期：2017-06-12 00:00:00

abstract：:How does knowing the evolutionary history of microorganisms affect our analysis of microbiological datasets? Depending on the research question, the common ancestry of microorganisms can be a source of confounding variation, or a scaffolding used for inference. For example, when performing regression on traits, common...

journal_title：Nature microbiology

authors： Washburne AD,Morton JT,Sanders J,McDonald D,Zhu Q,Oliverio AM,Knight R

更新日期：2018-06-01 00:00:00

abstract：:Zika virus (ZIKV) is associated with neonatal microcephaly and Guillain-Barré syndrome1,2. While progress has been made in understanding the causal link between ZIKV infection and microcephaly3-9, the life cycle and pathogenesis of ZIKV are less well understood. In particular, there are conflicting reports on the role...

journal_title：Nature microbiology

authors： Chen J,Yang YF,Yang Y,Zou P,Chen J,He Y,Shui SL,Cui YR,Bai R,Liang YJ,Hu Y,Jiang B,Lu L,Zhang X,Liu J,Xu J

更新日期：2018-03-01 00:00:00