Insect symbiotic bacteria harbour viral pathogens for transovarial transmission.

abstract：:Single-cell RNA sequencing has revealed extensive cellular heterogeneity within many organisms, but few methods have been developed for microbial clonal populations. The yeast genome displays unusually dense transcript spacing, with interleaved and overlapping transcription from both strands, resulting in a minuscule ...

journal_title：Nature microbiology

authors： Nadal-Ribelles M,Islam S,Wei W,Latorre P,Nguyen M,de Nadal E,Posas F,Steinmetz LM

更新日期：2019-04-01 00:00:00

abstract：: ...

journal_title：Nature microbiology

authors： Francetic O

更新日期：2018-11-01 00:00:00

abstract：:Virus taxonomy emerged as a discipline in the middle of the twentieth century. Traditionally, classification by virus taxonomists has been focussed on the grouping of relatively closely related viruses. However, during the past few years, the International Committee on Taxonomy of Viruses (ICTV) has recognized that th...

journal_title：Nature microbiology

authors： International Committee on Taxonomy of Viruses Executive Committee.

更新日期：2020-05-01 00:00:00

abstract：:Staphylococcus epidermidis is a conspicuous member of the human microbiome, widely present on healthy skin. Here we show that S. epidermidis has also evolved to become a formidable nosocomial pathogen. Using genomics, we reveal that three multidrug-resistant, hospital-adapted lineages of S. epidermidis (two ST2 and on...

journal_title：Nature microbiology

authors： Lee JYH,Monk IR,Gonçalves da Silva A,Seemann T,Chua KYL,Kearns A,Hill R,Woodford N,Bartels MD,Strommenger B,Laurent F,Dodémont M,Deplano A,Patel R,Larsen AR,Korman TM,Stinear TP,Howden BP

更新日期：2018-10-01 00:00:00

abstract：:As they proliferate, fungi expose antigens at their cell surface that are potent stimulators of the innate immune response, and yet the commensal fungus Candida albicans is able to colonize immuno competent individuals. We show that C. albicans may evade immune detection by presenting a moving immunological target. We...

journal_title：Nature microbiology

authors： Ballou ER,Avelar GM,Childers DS,Mackie J,Bain JM,Wagener J,Kastora SL,Panea MD,Hardison SE,Walker LA,Erwig LP,Munro CA,Gow NA,Brown GD,MacCallum DM,Brown AJ

更新日期：2016-12-12 00:00:00

abstract：:In the version of this Article originally published, author Carolina Falcón Garcia's name was coded wrongly, resulting in it being incorrect when exported to citation databases. This has now been corrected, though no visible changes will be apparent. ...

journal_title：Nature microbiology

authors： Dragoš A,Martin M,Garcia CF,Kricks L,Pausch P,Heimerl T,Bálint B,Maróti G,Bange G,López D,Lieleg O,Kovács ÁT

更新日期：2019-02-01 00:00:00

abstract：:Mosquito-borne viruses can cause severe inflammatory diseases and there are limited therapeutic solutions targeted specifically at virus-induced inflammation. Chikungunya virus (CHIKV), a re-emerging alphavirus responsible for several outbreaks worldwide in the past decade, causes debilitating joint inflammation and s...

journal_title：Nature microbiology

authors： Chen W,Foo SS,Zaid A,Teng TS,Herrero LJ,Wolf S,Tharmarajah K,Vu LD,van Vreden C,Taylor A,Freitas JR,Li RW,Woodruff TM,Gordon R,Ojcius DM,Nakaya HI,Kanneganti TD,O'Neill LAJ,Robertson AAB,King NJ,Suhrbier A,Coope

更新日期：2017-10-01 00:00:00

abstract：:Most microorganisms live in environments where nutrients are limited and fluctuate over time. Cells respond to nutrient fluctuations by sensing and adapting their physiological state. Recent studies suggest phenotypic heterogeneity(1) in isogenic populations as an alternative strategy in fluctuating environments, wher...

journal_title：Nature microbiology

authors： Schreiber F,Littmann S,Lavik G,Escrig S,Meibom A,Kuypers MM,Ackermann M

更新日期：2016-05-09 00:00:00

abstract：:The sexually transmitted pathogen Neisseria gonorrhoeae is regarded as being on the way to becoming an untreatable superbug. Despite its clinical importance, little is known about its emergence and evolution, and how this corresponds with the introduction of antimicrobials. We present a genome-based phylogeographical ...

journal_title：Nature microbiology

authors： Sánchez-Busó L,Golparian D,Corander J,Grad YH,Ohnishi M,Flemming R,Parkhill J,Bentley SD,Unemo M,Harris SR

更新日期：2019-11-01 00:00:00

abstract：:Viral discovery is accelerating at an unprecedented rate due to continuing advances in culture-independent sequence-based analyses. One important facet of this discovery is identification of the hosts of these recently characterized uncultured viruses. To this end, we have adapted the viral tagging approach, which byp...

journal_title：Nature microbiology

authors： Džunková M,Low SJ,Daly JN,Deng L,Rinke C,Hugenholtz P

更新日期：2019-12-01 00:00:00

abstract：:Tigecycline is one of the last-resort antibiotics to treat complicated infections caused by both multidrug-resistant Gram-negative and Gram-positive bacteria1. Tigecycline resistance has sporadically occurred in recent years, primarily due to chromosome-encoding mechanisms, such as overexpression of efflux pumps and r...

journal_title：Nature microbiology

authors： Sun J,Chen C,Cui CY,Zhang Y,Liu X,Cui ZH,Ma XY,Feng Y,Fang LX,Lian XL,Zhang RM,Tang YZ,Zhang KX,Liu HM,Zhuang ZH,Zhou SD,Lv JN,Du H,Huang B,Yu FY,Mathema B,Kreiswirth BN,Liao XP,Chen L,Liu YH

更新日期：2019-09-01 00:00:00

abstract：:In structured environments, antibiotic-producing microorganisms can gain a selective advantage by inhibiting nearby competing species1. However, despite their genetic potential2,3, natural isolates often make only small amounts of antibiotics, and laboratory evolution can lead to loss rather than enhancement of antibi...

journal_title：Nature microbiology

authors： Gerardin Y,Springer M,Kishony R

更新日期：2016-09-26 00:00:00

abstract：:The original version of this Letter has been modified in the abstract and main text to better reflect the distribution of Neu5Ac sialoglycans in humans. Additionally, co-author Lingquan Deng's present address has been further clarified. ...

journal_title：Nature microbiology

authors： Gao X,Deng L,Stack G,Yu H,Chen X,Naito-Matsui Y,Varki A,Galán JE

更新日期：2017-12-01 00:00:00

abstract：:Human onchocerciasis is a serious neglected tropical disease caused by the filarial nematode Onchocerca volvulus that can lead to blindness and chronic disability. Control of the disease relies largely on mass administration of a single drug, and the development of new drugs and vaccines depends on a better knowledge ...

journal_title：Nature microbiology

authors： Cotton JA,Bennuru S,Grote A,Harsha B,Tracey A,Beech R,Doyle SR,Dunn M,Hotopp JC,Holroyd N,Kikuchi T,Lambert O,Mhashilkar A,Mutowo P,Nursimulu N,Ribeiro JM,Rogers MB,Stanley E,Swapna LS,Tsai IJ,Unnasch TR,Voronin

更新日期：2016-11-21 00:00:00

abstract：: ...

journal_title：Nature microbiology

authors：

更新日期：2018-12-01 00:00:00

abstract：:Viruses and plasmids (invasive mobile genetic elements (iMGEs)) have important roles in shaping microbial communities, but their dynamic interactions with CRISPR-based immunity remain unresolved. We analysed generation-resolved iMGE-host dynamics spanning one and a half years in a microbial consortium from a biologica...

journal_title：Nature microbiology

authors： Martínez Arbas S,Narayanasamy S,Herold M,Lebrun LA,Hoopmann MR,Li S,Lam TJ,Kunath BJ,Hicks ND,Liu CM,Price LB,Laczny CC,Gillece JD,Schupp JM,Keim PS,Moritz RL,Faust K,Tang H,Ye Y,Skupin A,May P,Muller EEL,Wilm

更新日期：2021-01-01 00:00:00

abstract：:We describe Idionectes vortex gen. nov., sp. nov., a unicellular microeukaryote that swims by continuous inversion of its surface, similar to a vortex ring. This previously unreported mode of motility approximates a hypothetical concept called the 'toroidal swimmer', in which a doughnut-shaped object rotates around it...

journal_title：Nature microbiology

authors： Hess S,Eme L,Roger AJ,Simpson AGB

更新日期：2019-10-01 00:00:00

abstract：:Bacterial toxin-antitoxin systems (TASs) are thought to respond to various stresses, often inducing growth-arrested (persistent) sub-populations of cells whose housekeeping functions are inhibited. Many such TASs induce this effect through the translation-dependent RNA cleavage (RNase) activity of their toxins, which ...

journal_title：Nature microbiology

authors： Kirkpatrick CL,Martins D,Redder P,Frandi A,Mignolet J,Chapalay JB,Chambon M,Turcatti G,Viollier PH

更新日期：2016-02-22 00:00:00

abstract：:Clostridium difficile infection (CDI) is mediated by two major exotoxins, toxin A (TcdA) and toxin B (TcdB), that damage the colonic epithelial barrier and induce inflammatory responses. The function of the colonic vascular barrier during CDI has been relatively understudied. Here we report increased colonic vascular ...

journal_title：Nature microbiology

authors： Huang J,Kelly CP,Bakirtzi K,Villafuerte Gálvez JA,Lyras D,Mileto SJ,Larcombe S,Xu H,Yang X,Shields KS,Zhu W,Zhang Y,Goldsmith JD,Patel IJ,Hansen J,Huang M,Yla-Herttuala S,Moss AC,Paredes-Sabja D,Pothoulakis C,Shah

更新日期：2019-02-01 00:00:00

abstract：:Helicobacter pylori infection is a proven carcinogen for gastric cancer. Its virulence factor vacuolating cytotoxin A (VacA) promotes more severe disease and gastric colonization. VacA, by an unknown mechanism, usurps lysosomal and autophagy pathways to generate a protected reservoir for H. pylori that confers bacteri...

journal_title：Nature microbiology

authors： Capurro MI,Greenfield LK,Prashar A,Xia S,Abdullah M,Wong H,Zhong XZ,Bertaux-Skeirik N,Chakrabarti J,Siddiqui I,O'Brien C,Dong X,Robinson L,Peek RM Jr,Philpott DJ,Zavros Y,Helmrath M,Jones NL

更新日期：2019-08-01 00:00:00

abstract：:Influenza A virus is a human pathogen with a genome composed of eight viral RNA segments that replicate in the nucleus. Two viral mRNAs are alternatively spliced. The unspliced M1 mRNA is translated into the matrix M1 protein, while the ion channel M2 protein is generated after alternative splicing. These proteins are...

journal_title：Nature microbiology

authors： Mor A,White A,Zhang K,Thompson M,Esparza M,Muñoz-Moreno R,Koide K,Lynch KW,García-Sastre A,Fontoura BM

更新日期：2016-05-27 00:00:00

abstract：:Clostridium difficile infection is the leading cause of hospital-acquired diarrhoea and pseudomembranous colitis. Disease is mediated by the actions of two toxins, TcdA and TcdB, which cause the diarrhoea, as well as inflammation and necrosis within the colon. The toxins are large (308 and 270 kDa, respectively), homo...

journal_title：Nature microbiology

authors： Chumbler NM,Rutherford SA,Zhang Z,Farrow MA,Lisher JP,Farquhar E,Giedroc DP,Spiller BW,Melnyk RA,Lacy DB

更新日期：2016-01-11 00:00:00

abstract：:Glycans are major nutrients for the human gut microbiota (HGM). Arabinogalactan proteins (AGPs) comprise a heterogenous group of plant glycans in which a β1,3-galactan backbone and β1,6-galactan side chains are conserved. Diversity is provided by the variable nature of the sugars that decorate the galactans. The mecha...

journal_title：Nature microbiology

authors： Cartmell A,Muñoz-Muñoz J,Briggs JA,Ndeh DA,Lowe EC,Baslé A,Terrapon N,Stott K,Heunis T,Gray J,Yu L,Dupree P,Fernandes PZ,Shah S,Williams SJ,Labourel A,Trost M,Henrissat B,Gilbert HJ

更新日期：2018-11-01 00:00:00

abstract：:Zika virus is a mosquito-borne pathogen that is rapidly spreading across the Americas. Due to associations between Zika virus infection and a range of fetal maladies(1,2), the epidemic trajectory of this viral infection poses a significant concern for the nearly 15 million children born in the Americas each year. Asce...

journal_title：Nature microbiology

authors： Perkins TA,Siraj AS,Ruktanonchai CW,Kraemer MU,Tatem AJ

更新日期：2016-07-25 00:00:00

abstract：:The Epstein-Barr virus M81 strain, isolated from a nasopharyngeal carcinoma, induces potent spontaneous virus production in infected B cells. We found that the M81 non-coding Epstein-Barr-encoded RNA EBER2, which carries polymorphisms that are mainly restricted to viruses found in endemic nasopharyngeal carcinomas, ma...

journal_title：Nature microbiology

authors： Li Z,Tsai MH,Shumilov A,Baccianti F,Tsao SW,Poirey R,Delecluse HJ

更新日期：2019-12-01 00:00:00

abstract：:In most Gram-negative pathogens, the hydrolysis of UDP-2,3-diacylglucosamine to generate lipid X in lipid A biosynthesis is catalysed by the membrane-associated enzyme LpxH. We report the crystal structure of LpxH in complex with its product, lipid X, unveiling a unique insertion lid above the conserved architecture o...

journal_title：Nature microbiology

authors： Cho J,Lee CJ,Zhao J,Young HE,Zhou P

更新日期：2016-08-15 00:00:00

abstract：:In the version of this Perspective originally published, the first and last name of co-author Manimozhiyan Arumugam were switched. This has now been corrected in all versions of the Perspective. ...

journal_title：Nature microbiology

authors： Costea PI,Hildebrand F,Arumugam M,Bäckhed F,Blaser MJ,Bushman FD,de Vos WM,Ehrlich SD,Fraser CM,Hattori M,Huttenhower C,Jeffery IB,Knights D,Lewis JD,Ley RE,Ochman H,O'Toole PW,Quince C,Relman DA,Shanahan F,Sunaga

更新日期：2018-03-01 00:00:00

abstract：:Understanding metabolism in live microalgae is crucial for efficient biomaterial engineering, but conventional methods fail to evaluate heterogeneous populations of motile microalgae due to the labelling requirements and limited imaging speeds. Here, we demonstrate label-free video-rate metabolite imaging of live Eugl...

journal_title：Nature microbiology

authors： Wakisaka Y,Suzuki Y,Iwata O,Nakashima A,Ito T,Hirose M,Domon R,Sugawara M,Tsumura N,Watarai H,Shimobaba T,Suzuki K,Goda K,Ozeki Y

更新日期：2016-08-01 00:00:00

abstract：:Zika virus (ZIKV) is associated with neonatal microcephaly and Guillain-Barré syndrome1,2. While progress has been made in understanding the causal link between ZIKV infection and microcephaly3-9, the life cycle and pathogenesis of ZIKV are less well understood. In particular, there are conflicting reports on the role...

journal_title：Nature microbiology

authors： Chen J,Yang YF,Yang Y,Zou P,Chen J,He Y,Shui SL,Cui YR,Bai R,Liang YJ,Hu Y,Jiang B,Lu L,Zhang X,Liu J,Xu J

更新日期：2018-03-01 00:00:00

abstract：:Phylogenetic and geological evidence supports the hypothesis that life on Earth originated in thermal environments and conserved energy through methanogenesis or sulfur reduction. Here we describe two populations of the deeply rooted archaeal phylum Korarchaeota, which were retrieved from the metagenome of a circumneu...

journal_title：Nature microbiology

authors： McKay LJ,Dlakić M,Fields MW,Delmont TO,Eren AM,Jay ZJ,Klingelsmith KB,Rusch DB,Inskeep WP

更新日期：2019-04-01 00:00:00