Abstract:
:
journal_name
Nat Microbioljournal_title
Nature microbiologyauthors
Francetic Odoi
10.1038/s41564-018-0277-5subject
pub_date
2018-11-01 00:00:00pages
1190-1191issue
11issn
2058-5276pii
10.1038/s41564-018-0277-5journal_volume
3pub_type
评论,杂志文章abstract::How does knowing the evolutionary history of microorganisms affect our analysis of microbiological datasets? Depending on the research question, the common ancestry of microorganisms can be a source of confounding variation, or a scaffolding used for inference. For example, when performing regression on traits, common...
journal_title:Nature microbiology
pub_type: 杂志文章,评审
doi:10.1038/s41564-018-0156-0
更新日期:2018-06-01 00:00:00
abstract::Retroviral infection involves the reverse transcription of the viral RNA genome into DNA, which is subsequently integrated into the host cell genome. Human immunodeficiency virus type 1 (HIV-1) and other lentiviruses mediate the infection of non-dividing cells through the ability of the capsid protein1 to engage the c...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-020-0735-8
更新日期:2020-09-01 00:00:00
abstract::In the version of this Perspective originally published, the first and last name of co-author Manimozhiyan Arumugam were switched. This has now been corrected in all versions of the Perspective. ...
journal_title:Nature microbiology
pub_type: 已发布勘误
doi:10.1038/s41564-018-0114-x
更新日期:2018-03-01 00:00:00
abstract::Human onchocerciasis is a serious neglected tropical disease caused by the filarial nematode Onchocerca volvulus that can lead to blindness and chronic disability. Control of the disease relies largely on mass administration of a single drug, and the development of new drugs and vaccines depends on a better knowledge ...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2016.216
更新日期:2016-11-21 00:00:00
abstract::Host factors that silence provirus transcription in CD4+ memory T cells help HIV-1 escape eradication by the host immune system and by antiviral drugs1. These same factors, however, must be overcome for HIV-1 to propagate. Here we show that Vpx and Vpr encoded by diverse primate immunodeficiency viruses activate provi...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-018-0256-x
更新日期:2018-12-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature microbiology
pub_type: 已发布勘误
doi:10.1038/s41564-020-0679-z
更新日期:2020-03-01 00:00:00
abstract::Inflammasomes are signalling platforms that are assembled in response to infection or sterile inflammation by cytosolic pattern recognition receptors. The consequent inflammasome-triggered caspase-1 activation is critical for the host defence against pathogens. During infection, NLRP3, which is a pattern recognition r...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-020-00832-5
更新日期:2021-01-11 00:00:00
abstract::Outbreaks of viral infections are a global health burden. Although type I interferon (IFN-I) exerts broad-spectrum antiviral effects, its antiviral efficacy in host cells is largely restricted by viruses. How the antiviral efficacy of IFN-I can be improved remains to be explored. Here, we identified the ADP-ribosyltra...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-019-0428-3
更新日期:2019-11-01 00:00:00
abstract::Many insects, including mosquitoes, planthoppers, aphids and leafhoppers, are the hosts of bacterial symbionts and the vectors for transmitting viral pathogens1-3. In general, symbiotic bacteria can indirectly affect viral transmission by enhancing immunity and resistance to viruses in insects3-5. Whether symbiotic ba...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2017.25
更新日期:2017-03-06 00:00:00
abstract::Bacteria have evolved diverse mechanisms to fend off predation by bacteriophages. We previously identified the Dnd system, which uses DndABCDE to insert sulfur into the DNA backbone as a double-stranded phosphorothioate (PT) modification, and DndFGH, a restriction component. Here, we describe an unusual SspABCD-SspE P...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-020-0700-6
更新日期:2020-07-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature microbiology
pub_type: 已发布勘误
doi:10.1038/s41564-020-00825-4
更新日期:2020-12-01 00:00:00
abstract::The temporal dynamics of phytoplankton growth and activity have large impacts on fluxes of matter and energy, yet obtaining in situ metabolic measurements of sufficient resolution for even dominant microorganisms remains a considerable challenge. We performed Lagrangian diel sampling with synoptic measurements of popu...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2017.118
更新日期:2017-07-31 00:00:00
abstract::Glycans are major nutrients for the human gut microbiota (HGM). Arabinogalactan proteins (AGPs) comprise a heterogenous group of plant glycans in which a β1,3-galactan backbone and β1,6-galactan side chains are conserved. Diversity is provided by the variable nature of the sugars that decorate the galactans. The mecha...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-018-0258-8
更新日期:2018-11-01 00:00:00
abstract::The evolution of virulence traits is central for the emergence or re-emergence of microbial pathogens and for their adaptation to a specific host 1-5 . Typhoid toxin is an essential virulence factor of the human-adapted bacterial pathogen Salmonella Typhi 6,7 , the cause of typhoid fever in humans 8-12 . Typhoid toxin...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-017-0033-2
更新日期:2017-12-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature microbiology
pub_type: 已发布勘误
doi:10.1038/s41564-019-0584-5
更新日期:2019-11-01 00:00:00
abstract::Monkeypox is a viral zoonotic disease on the rise across endemic habitats. Despite the growing importance of monkeypox virus, our knowledge on its host spectrum and sylvatic maintenance is limited. Here, we describe the recent repeated emergence of monkeypox virus in a wild, human-habituated western chimpanzee (Pan tr...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-020-0706-0
更新日期:2020-07-01 00:00:00
abstract::The dysregulation of intestinal microbial communities is associated with inflammatory bowel diseases (IBD). Studies aimed at understanding the contribution of the microbiota to inflammatory diseases have primarily focused on bacteria, yet the intestine harbours a viral component dominated by prokaryotic viruses known ...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-018-0210-y
更新日期:2018-09-01 00:00:00
abstract::Autophagy and interferon (IFN)-mediated innate immunity are critical antiviral defence mechanisms, and recent evidence indicated that tripartite motif (TRIM) proteins are important regulators of both processes. Although the role of TRIM proteins in modulating antiviral cytokine responses has been well established, muc...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-017-0017-2
更新日期:2017-11-01 00:00:00
abstract::Pathogenic bacteria are armed with potent effector proteins that subvert host signalling processes during infection1. The activities of bacterial effectors and their associated roles within the host cell are often poorly understood, particularly for Chlamydia trachomatis2, a World Health Organization designated neglec...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-018-0271-y
更新日期:2018-12-01 00:00:00
abstract:: ...
journal_title:Nature microbiology
pub_type: 社论
doi:10.1038/s41564-018-0320-6
更新日期:2018-12-01 00:00:00
abstract::Despite the sporadic detection of fluoroquinolone-resistant Shigella in Asia in the early 2000s and the subsequent global spread of ciprofloxacin-resistant (cipR) Shigella sonnei from 2010, fluoroquinolones remain the recommended therapy for shigellosis1-7. The potential for cipR S. sonnei to develop resistance to alt...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-019-0645-9
更新日期:2020-02-01 00:00:00
abstract::It is generally believed that exchange of secondary metabolite biosynthetic gene clusters (BGCs) among closely related bacteria is an important driver of BGC evolution and diversification. Applying this idea may help researchers efficiently connect many BGCs to their products and characterize the products' roles in va...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-019-0573-8
更新日期:2019-12-01 00:00:00
abstract::Dimethylsulfoniopropionate (DMSP) is one of the Earth's most abundant organosulfur molecules, a signalling molecule1, a key nutrient for marine microorganisms2,3 and the major precursor for gaseous dimethyl sulfide (DMS). DMS, another infochemical in signalling pathways4, is important in global sulfur cycling2 and aff...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2017.9
更新日期:2017-02-13 00:00:00
abstract::Clostridium difficile infection is the leading cause of hospital-acquired diarrhoea and pseudomembranous colitis. Disease is mediated by the actions of two toxins, TcdA and TcdB, which cause the diarrhoea, as well as inflammation and necrosis within the colon. The toxins are large (308 and 270 kDa, respectively), homo...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2015.2
更新日期:2016-01-11 00:00:00
abstract::Clostridium difficile infection (CDI) is mediated by two major exotoxins, toxin A (TcdA) and toxin B (TcdB), that damage the colonic epithelial barrier and induce inflammatory responses. The function of the colonic vascular barrier during CDI has been relatively understudied. Here we report increased colonic vascular ...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-018-0300-x
更新日期:2019-02-01 00:00:00
abstract::The microbial environment influences animal physiology. However, the underlying molecular mechanisms of such functional interactions are largely undefined. Previously, we showed that during chronic undernutrition, strains of Lactobacillus plantarum, a major commensal partner of Drosophila, promote host juvenile growth...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-017-0038-x
更新日期:2017-12-01 00:00:00
abstract::We describe Idionectes vortex gen. nov., sp. nov., a unicellular microeukaryote that swims by continuous inversion of its surface, similar to a vortex ring. This previously unreported mode of motility approximates a hypothetical concept called the 'toroidal swimmer', in which a doughnut-shaped object rotates around it...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-019-0478-6
更新日期:2019-10-01 00:00:00
abstract::Little is known about the specificities and neutralization breadth of the H7-reactive antibody repertoire induced by natural H7N9 infection in humans. We have isolated and characterized 73 H7-reactive monoclonal antibodies from peripheral B cells from four donors infected in 2013 and 2014. Of these, 45 antibodies were...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-018-0303-7
更新日期:2019-02-01 00:00:00
abstract::How does environmental complexity affect the evolution of single genes? Here, we measured the effects of a set of Bacillus subtilis glutamate dehydrogenase mutants across 19 different environments-from phenotypically homogeneous single-cell populations in liquid media to heterogeneous biofilms, plant roots and soil po...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-019-0412-y
更新日期:2019-07-01 00:00:00
abstract::As they proliferate, fungi expose antigens at their cell surface that are potent stimulators of the innate immune response, and yet the commensal fungus Candida albicans is able to colonize immuno competent individuals. We show that C. albicans may evade immune detection by presenting a moving immunological target. We...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2016.238
更新日期:2016-12-12 00:00:00