Abstract:
:An amendment to this paper has been published and can be accessed via a link at the top of the paper.
journal_name
Nat Microbioljournal_title
Nature microbiologyauthors
Cartmell A,Muñoz-Muñoz J,Briggs JA,Ndeh DA,Lowe EC,Baslé A,Terrapon N,Stott K,Heunis T,Gray J,Yu L,Dupree P,Fernandes PZ,Shah S,Williams SJ,Labourel A,Trost M,Henrissat B,Gilbert HJdoi
10.1038/s41564-019-0584-5subject
Has Abstractpub_date
2019-11-01 00:00:00pages
2021-2023issue
11issn
2058-5276pii
10.1038/s41564-019-0584-5journal_volume
4pub_type
已发布勘误abstract::The original version of this Letter has been modified in the abstract and main text to better reflect the distribution of Neu5Ac sialoglycans in humans. Additionally, co-author Lingquan Deng's present address has been further clarified. ...
journal_title:Nature microbiology
pub_type: 已发布勘误
doi:10.1038/s41564-017-0070-x
更新日期:2017-12-01 00:00:00
abstract::Toxoplasma gondii establishes a lifelong chronic infection in humans and animals1. Host cell entry and egress are key steps in the lytic cycle of this obligate intracellular parasite, ensuring its survival and dissemination. Egress is temporally orchestrated, underpinned by the exocytosis of secretory organelles calle...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-018-0339-8
更新日期:2019-03-01 00:00:00
abstract::In most Gram-negative pathogens, the hydrolysis of UDP-2,3-diacylglucosamine to generate lipid X in lipid A biosynthesis is catalysed by the membrane-associated enzyme LpxH. We report the crystal structure of LpxH in complex with its product, lipid X, unveiling a unique insertion lid above the conserved architecture o...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2016.154
更新日期:2016-08-15 00:00:00
abstract::Inflammasomes are signalling platforms that are assembled in response to infection or sterile inflammation by cytosolic pattern recognition receptors. The consequent inflammasome-triggered caspase-1 activation is critical for the host defence against pathogens. During infection, NLRP3, which is a pattern recognition r...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-020-00832-5
更新日期:2021-01-11 00:00:00
abstract:: ...
journal_title:Nature microbiology
pub_type: 社论
doi:10.1038/s41564-019-0408-7
更新日期:2019-03-01 00:00:00
abstract::Immune responses in insects are differentially triggered depending on the infection route used by the pathogen. In most studies involving Drosophila melanogaster and viruses, infection is done by injection, while oral infection, which is probably the most common route of viral entry in nature, remains unexplored. Here...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-018-0265-9
更新日期:2018-12-01 00:00:00
abstract::Influenza A virus is a human pathogen with a genome composed of eight viral RNA segments that replicate in the nucleus. Two viral mRNAs are alternatively spliced. The unspliced M1 mRNA is translated into the matrix M1 protein, while the ion channel M2 protein is generated after alternative splicing. These proteins are...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2016.69
更新日期:2016-05-27 00:00:00
abstract::Viruses and plasmids (invasive mobile genetic elements (iMGEs)) have important roles in shaping microbial communities, but their dynamic interactions with CRISPR-based immunity remain unresolved. We analysed generation-resolved iMGE-host dynamics spanning one and a half years in a microbial consortium from a biologica...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-020-00794-8
更新日期:2021-01-01 00:00:00
abstract::For successful infection, bacteriophages must overcome multiple barriers to transport their genome and proteins across the bacterial cell envelope. We use cryo-electron tomography to study the infection initiation of phage P22 in Salmonella enterica serovar Typhimurium, revealing how a channel forms to allow genome tr...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-019-0403-z
更新日期:2019-06-01 00:00:00
abstract::The Epstein-Barr virus M81 strain, isolated from a nasopharyngeal carcinoma, induces potent spontaneous virus production in infected B cells. We found that the M81 non-coding Epstein-Barr-encoded RNA EBER2, which carries polymorphisms that are mainly restricted to viruses found in endemic nasopharyngeal carcinomas, ma...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-019-0546-y
更新日期:2019-12-01 00:00:00
abstract::The microbial environment influences animal physiology. However, the underlying molecular mechanisms of such functional interactions are largely undefined. Previously, we showed that during chronic undernutrition, strains of Lactobacillus plantarum, a major commensal partner of Drosophila, promote host juvenile growth...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-017-0038-x
更新日期:2017-12-01 00:00:00
abstract::As they proliferate, fungi expose antigens at their cell surface that are potent stimulators of the innate immune response, and yet the commensal fungus Candida albicans is able to colonize immuno competent individuals. We show that C. albicans may evade immune detection by presenting a moving immunological target. We...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2016.238
更新日期:2016-12-12 00:00:00
abstract::Glycans are major nutrients for the human gut microbiota (HGM). Arabinogalactan proteins (AGPs) comprise a heterogenous group of plant glycans in which a β1,3-galactan backbone and β1,6-galactan side chains are conserved. Diversity is provided by the variable nature of the sugars that decorate the galactans. The mecha...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-018-0258-8
更新日期:2018-11-01 00:00:00
abstract::Marine microeukaryotes play a fundamental role in biogeochemical cycling through the transfer of energy to higher trophic levels and vertical carbon transport. Despite their global importance, microeukaryote physiology, nutrient metabolism and contributions to carbon cycling across offshore ecosystems are poorly chara...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-020-00814-7
更新日期:2021-02-01 00:00:00
abstract::Balancing access to antibiotics with the control of antibiotic resistance is a global public health priority. At present, antibiotic stewardship is informed by a 'use it and lose it' principle, in which antibiotic use by the population is linearly related to resistance rates. However, theoretical and mathematical mode...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-019-0410-0
更新日期:2019-07-01 00:00:00
abstract::The evolution of antibiotic resistance is a major threat to society and has been predicted to lead to 10 million casualties annually by 2050(1). Further aggravating the problem, multidrug tolerance in bacteria not only relies on the build-up of resistance mutations, but also on some cells epigenetically switching to a...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2016.20
更新日期:2016-03-07 00:00:00
abstract::Virus taxonomy emerged as a discipline in the middle of the twentieth century. Traditionally, classification by virus taxonomists has been focussed on the grouping of relatively closely related viruses. However, during the past few years, the International Committee on Taxonomy of Viruses (ICTV) has recognized that th...
journal_title:Nature microbiology
pub_type: 杂志文章,评审
doi:10.1038/s41564-020-0709-x
更新日期:2020-05-01 00:00:00
abstract::Viral discovery is accelerating at an unprecedented rate due to continuing advances in culture-independent sequence-based analyses. One important facet of this discovery is identification of the hosts of these recently characterized uncultured viruses. To this end, we have adapted the viral tagging approach, which byp...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-019-0526-2
更新日期:2019-12-01 00:00:00
abstract::Evidence has accumulated to demonstrate that the intestinal microbiota enhances mammalian enteric virus infections1. For example, we and others previously reported that commensal bacteria stimulate acute and persistent murine norovirus infections2-4. However, in apparent contradiction of these results, the virulence o...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-019-0602-7
更新日期:2020-01-01 00:00:00
abstract::A major form of transcriptional regulation in bacteria occurs through the exchange of the primary σ factor of RNA polymerase (RNAP) with an alternative extracytoplasmic function (ECF) σ factor1. ECF σ factors are generally intrinsically active and are retained in an inactive state via the sequestration into σ factor-a...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-019-0648-6
更新日期:2020-03-01 00:00:00
abstract::Mesalamine serves as the gold standard in treating ulcerative colitis. However, its precise mechanism(s) of action remains unclear. Here, we show that mesalamine treatment rapidly decreases polyphosphate levels in diverse bacteria, including members of the human gut microbiome. This decrease sensitizes bacteria toward...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2016.267
更新日期:2017-01-23 00:00:00
abstract::Coenzymes are vital for cellular metabolism and act on the full spectrum of enzymatic reactions. Intrinsic chemical reactivity, enzyme promiscuity and high flux through their catalytic cycles make coenzymes prone to damage. To counteract such compromising factors and ensure stable levels of functional coenzymes, cells...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2017.73
更新日期:2017-05-15 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature microbiology
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41564-020-0698-9
更新日期:2020-04-01 00:00:00
abstract::Phylogenetic and geological evidence supports the hypothesis that life on Earth originated in thermal environments and conserved energy through methanogenesis or sulfur reduction. Here we describe two populations of the deeply rooted archaeal phylum Korarchaeota, which were retrieved from the metagenome of a circumneu...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-019-0362-4
更新日期:2019-04-01 00:00:00
abstract::Helicobacter pylori infection is a proven carcinogen for gastric cancer. Its virulence factor vacuolating cytotoxin A (VacA) promotes more severe disease and gastric colonization. VacA, by an unknown mechanism, usurps lysosomal and autophagy pathways to generate a protected reservoir for H. pylori that confers bacteri...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-019-0441-6
更新日期:2019-08-01 00:00:00
abstract::Cancer arises from the acquisition of multiple genetic and epigenetic changes in host cells over the span of many years, promoting oncogenic traits and carcinogenesis. Most cancers develop following random somatic alterations of key oncogenic genes, which are favoured by a number of risk factors, including lifestyle, ...
journal_title:Nature microbiology
pub_type: 杂志文章,评审
doi:10.1038/nmicrobiol.2017.8
更新日期:2017-02-22 00:00:00
abstract::Host adaptation is a key factor contributing to the emergence of new bacterial, viral and parasitic pathogens. Many pathogens are considered promiscuous because they cause disease across a range of host species, while others are host-adapted, infecting particular hosts(1). Host adaptation can potentially progress to h...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2015.23
更新日期:2016-01-25 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature microbiology
pub_type: 已发布勘误
doi:10.1038/s41564-020-00825-4
更新日期:2020-12-01 00:00:00
abstract:: ...
journal_title:Nature microbiology
pub_type: 评论,杂志文章
doi:10.1038/s41564-018-0277-5
更新日期:2018-11-01 00:00:00
abstract::CRISPR-Cas systems are adaptive immune systems that protect bacteria from bacteriophage (phage) infection1. To provide immunity, RNA-guided protein surveillance complexes recognize foreign nucleic acids, triggering their destruction by Cas nucleases2. While the essential requirements for immune activity are well under...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-020-0691-3
更新日期:2020-05-01 00:00:00