Abstract:
:As they proliferate, fungi expose antigens at their cell surface that are potent stimulators of the innate immune response, and yet the commensal fungus Candida albicans is able to colonize immuno competent individuals. We show that C. albicans may evade immune detection by presenting a moving immunological target. We report that the exposure of β-glucan, a key pathogen-associated molecular pattern (PAMP) located at the cell surface of C. albicans and other pathogenic Candida species, is modulated in response to changes in the carbon source. Exposure to lactate induces β-glucan masking in C. albicans via a signalling pathway that has recruited an evolutionarily conserved receptor (Gpr1) and transcriptional factor (Crz1) from other well-characterized pathways. In response to lactate, these regulators control the expression of cell-wall-related genes that contribute to β-glucan masking. This represents the first description of active PAMP masking by a Candida species, a process that reduces the visibility of the fungus to the immune system.
journal_name
Nat Microbioljournal_title
Nature microbiologyauthors
Ballou ER,Avelar GM,Childers DS,Mackie J,Bain JM,Wagener J,Kastora SL,Panea MD,Hardison SE,Walker LA,Erwig LP,Munro CA,Gow NA,Brown GD,MacCallum DM,Brown AJdoi
10.1038/nmicrobiol.2016.238subject
Has Abstractpub_date
2016-12-12 00:00:00pages
16238issn
2058-5276pii
nmicrobiol2016238journal_volume
2pub_type
杂志文章abstract::The core properties of microbial genomes, including GC content and genome size, are known to vary widely among different bacteria and archaea 1,2 . Several hypotheses have been proposed to explain this genomic variability, but the fundamental drivers that shape bacterial and archaeal genomic properties remain uncertai...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-017-0008-3
更新日期:2017-10-01 00:00:00
abstract::The original version of this Letter has been modified in the abstract and main text to better reflect the distribution of Neu5Ac sialoglycans in humans. Additionally, co-author Lingquan Deng's present address has been further clarified. ...
journal_title:Nature microbiology
pub_type: 已发布勘误
doi:10.1038/s41564-017-0070-x
更新日期:2017-12-01 00:00:00
abstract::Clostridium difficile infection is the leading cause of hospital-acquired diarrhoea and pseudomembranous colitis. Disease is mediated by the actions of two toxins, TcdA and TcdB, which cause the diarrhoea, as well as inflammation and necrosis within the colon. The toxins are large (308 and 270 kDa, respectively), homo...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2015.2
更新日期:2016-01-11 00:00:00
abstract::Outbreaks of viral infections are a global health burden. Although type I interferon (IFN-I) exerts broad-spectrum antiviral effects, its antiviral efficacy in host cells is largely restricted by viruses. How the antiviral efficacy of IFN-I can be improved remains to be explored. Here, we identified the ADP-ribosyltra...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-019-0428-3
更新日期:2019-11-01 00:00:00
abstract::Clostridium difficile infection (CDI) is mediated by two major exotoxins, toxin A (TcdA) and toxin B (TcdB), that damage the colonic epithelial barrier and induce inflammatory responses. The function of the colonic vascular barrier during CDI has been relatively understudied. Here we report increased colonic vascular ...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-018-0300-x
更新日期:2019-02-01 00:00:00
abstract::For successful infection, bacteriophages must overcome multiple barriers to transport their genome and proteins across the bacterial cell envelope. We use cryo-electron tomography to study the infection initiation of phage P22 in Salmonella enterica serovar Typhimurium, revealing how a channel forms to allow genome tr...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-019-0403-z
更新日期:2019-06-01 00:00:00
abstract::This corrects the article DOI: 10.1038/nmicrobiol.2016.155. ...
journal_title:Nature microbiology
pub_type: 已发布勘误
doi:10.1038/nmicrobiol.2017.107
更新日期:2017-06-12 00:00:00
abstract::Retroviral infection involves the reverse transcription of the viral RNA genome into DNA, which is subsequently integrated into the host cell genome. Human immunodeficiency virus type 1 (HIV-1) and other lentiviruses mediate the infection of non-dividing cells through the ability of the capsid protein1 to engage the c...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-020-0735-8
更新日期:2020-09-01 00:00:00
abstract::Bacterial toxin-antitoxin systems (TASs) are thought to respond to various stresses, often inducing growth-arrested (persistent) sub-populations of cells whose housekeeping functions are inhibited. Many such TASs induce this effect through the translation-dependent RNA cleavage (RNase) activity of their toxins, which ...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2016.8
更新日期:2016-02-22 00:00:00
abstract::Competition among microorganisms is a key determinant of successful host colonization and persistence. For Streptococcus pneumoniae, lower than predicted rates of co-colonizing strains suggest a competitive advantage for resident bacteria over newcomers. In light of evolutionary theory, we hypothesized that S. pneumon...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-018-0314-4
更新日期:2019-01-01 00:00:00
abstract::The IncC family of broad-host-range plasmids enables the spread of antibiotic resistance genes among human enteric pathogens1-3. Although aspects of IncC plasmid conjugation have been well studied4-9, many roles of conjugation genes have been assigned based solely on sequence similarity. We applied hypersaturated tran...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-020-0775-0
更新日期:2020-11-01 00:00:00
abstract::In the version of this Article originally published, author Carolina Falcón Garcia's name was coded wrongly, resulting in it being incorrect when exported to citation databases. This has now been corrected, though no visible changes will be apparent. ...
journal_title:Nature microbiology
pub_type: 已发布勘误
doi:10.1038/s41564-018-0350-0
更新日期:2019-02-01 00:00:00
abstract::Although bacteria within the Verrucomicrobia phylum are pervasive in soils around the world, they are under-represented in both isolate collections and genomic databases. Here, we describe a single verrucomicrobial group within the class Spartobacteria that is not closely related to any previously described taxa. We e...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2016.198
更新日期:2016-10-31 00:00:00
abstract::Rod-shaped bacteria grow by adding material into their cell wall via the action of two spatially distinct enzymatic systems: the Rod complex moves around the cell circumference, whereas class A penicillin-binding proteins (aPBPs) do not. To understand how the combined action of these two systems defines bacterial dime...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-019-0439-0
更新日期:2019-08-01 00:00:00
abstract::The molecular processes that determine the outcome of influenza virus infection in humans are multifactorial and involve a complex interplay between host, viral and bacterial factors1. However, it is generally accepted that a strong innate immune dysregulation known as 'cytokine storm' contributes to the pathology of ...
journal_title:Nature microbiology
pub_type: 信件
doi:10.1038/s41564-018-0240-5
更新日期:2018-11-01 00:00:00
abstract::Immune responses in insects are differentially triggered depending on the infection route used by the pathogen. In most studies involving Drosophila melanogaster and viruses, infection is done by injection, while oral infection, which is probably the most common route of viral entry in nature, remains unexplored. Here...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-018-0265-9
更新日期:2018-12-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature microbiology
pub_type: 已发布勘误
doi:10.1038/s41564-019-0584-5
更新日期:2019-11-01 00:00:00
abstract::Balancing access to antibiotics with the control of antibiotic resistance is a global public health priority. At present, antibiotic stewardship is informed by a 'use it and lose it' principle, in which antibiotic use by the population is linearly related to resistance rates. However, theoretical and mathematical mode...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-019-0410-0
更新日期:2019-07-01 00:00:00
abstract::Surface ocean waters are dominated by planktonic bacterial lineages with highly reduced genomes. The best examples are the cyanobacterial genus Prochlorococcus, the alphaproteobacterial clade SAR11 and the gammaproteobacterial clade SAR86, which together represent over 50% of the cells in surface oceans. Several studi...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2017.91
更新日期:2017-06-12 00:00:00
abstract::The sexually transmitted pathogen Neisseria gonorrhoeae is regarded as being on the way to becoming an untreatable superbug. Despite its clinical importance, little is known about its emergence and evolution, and how this corresponds with the introduction of antimicrobials. We present a genome-based phylogeographical ...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-019-0501-y
更新日期:2019-11-01 00:00:00
abstract::Tigecycline is one of the last-resort antibiotics to treat complicated infections caused by both multidrug-resistant Gram-negative and Gram-positive bacteria1. Tigecycline resistance has sporadically occurred in recent years, primarily due to chromosome-encoding mechanisms, such as overexpression of efflux pumps and r...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-019-0496-4
更新日期:2019-09-01 00:00:00
abstract::Marine microeukaryotes play a fundamental role in biogeochemical cycling through the transfer of energy to higher trophic levels and vertical carbon transport. Despite their global importance, microeukaryote physiology, nutrient metabolism and contributions to carbon cycling across offshore ecosystems are poorly chara...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-020-00814-7
更新日期:2021-02-01 00:00:00
abstract::Cellular adhesion mediates many important plant-microbe interactions. In the devastating blast fungus Magnaporthe oryzae1, powerful glycoprotein-rich mucilage adhesives2 cement melanized and pressurized dome-shaped infection cells-appressoria-to host rice leaf surfaces. Enormous internal turgor pressure is directed on...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-020-0786-x
更新日期:2020-12-01 00:00:00
abstract::Monkeypox is a viral zoonotic disease on the rise across endemic habitats. Despite the growing importance of monkeypox virus, our knowledge on its host spectrum and sylvatic maintenance is limited. Here, we describe the recent repeated emergence of monkeypox virus in a wild, human-habituated western chimpanzee (Pan tr...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-020-0706-0
更新日期:2020-07-01 00:00:00
abstract::The development of new drug regimens that allow rapid, sterilizing treatment of tuberculosis has been limited by the complexity and time required for genetic manipulations in Mycobacterium tuberculosis. CRISPR interference (CRISPRi) promises to be a robust, easily engineered and scalable platform for regulated gene si...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2016.274
更新日期:2017-02-06 00:00:00
abstract::The Epstein-Barr virus M81 strain, isolated from a nasopharyngeal carcinoma, induces potent spontaneous virus production in infected B cells. We found that the M81 non-coding Epstein-Barr-encoded RNA EBER2, which carries polymorphisms that are mainly restricted to viruses found in endemic nasopharyngeal carcinomas, ma...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-019-0546-y
更新日期:2019-12-01 00:00:00
abstract::Zika virus (ZIKV) is associated with neonatal microcephaly and Guillain-Barré syndrome1,2. While progress has been made in understanding the causal link between ZIKV infection and microcephaly3-9, the life cycle and pathogenesis of ZIKV are less well understood. In particular, there are conflicting reports on the role...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-017-0092-4
更新日期:2018-03-01 00:00:00
abstract::How does environmental complexity affect the evolution of single genes? Here, we measured the effects of a set of Bacillus subtilis glutamate dehydrogenase mutants across 19 different environments-from phenotypically homogeneous single-cell populations in liquid media to heterogeneous biofilms, plant roots and soil po...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-019-0412-y
更新日期:2019-07-01 00:00:00
abstract::Coenzymes are vital for cellular metabolism and act on the full spectrum of enzymatic reactions. Intrinsic chemical reactivity, enzyme promiscuity and high flux through their catalytic cycles make coenzymes prone to damage. To counteract such compromising factors and ensure stable levels of functional coenzymes, cells...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2017.73
更新日期:2017-05-15 00:00:00
abstract::We describe Idionectes vortex gen. nov., sp. nov., a unicellular microeukaryote that swims by continuous inversion of its surface, similar to a vortex ring. This previously unreported mode of motility approximates a hypothetical concept called the 'toroidal swimmer', in which a doughnut-shaped object rotates around it...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-019-0478-6
更新日期:2019-10-01 00:00:00