Lactate signalling regulates fungal β-glucan masking and immune evasion.

Abstract:

:As they proliferate, fungi expose antigens at their cell surface that are potent stimulators of the innate immune response, and yet the commensal fungus Candida albicans is able to colonize immuno competent individuals. We show that C. albicans may evade immune detection by presenting a moving immunological target. We report that the exposure of β-glucan, a key pathogen-associated molecular pattern (PAMP) located at the cell surface of C. albicans and other pathogenic Candida species, is modulated in response to changes in the carbon source. Exposure to lactate induces β-glucan masking in C. albicans via a signalling pathway that has recruited an evolutionarily conserved receptor (Gpr1) and transcriptional factor (Crz1) from other well-characterized pathways. In response to lactate, these regulators control the expression of cell-wall-related genes that contribute to β-glucan masking. This represents the first description of active PAMP masking by a Candida species, a process that reduces the visibility of the fungus to the immune system.

journal_name

Nat Microbiol

journal_title

Nature microbiology

authors

Ballou ER,Avelar GM,Childers DS,Mackie J,Bain JM,Wagener J,Kastora SL,Panea MD,Hardison SE,Walker LA,Erwig LP,Munro CA,Gow NA,Brown GD,MacCallum DM,Brown AJ

doi

10.1038/nmicrobiol.2016.238

subject

Has Abstract

pub_date

2016-12-12 00:00:00

pages

16238

issn

2058-5276

pii

nmicrobiol2016238

journal_volume

2

pub_type

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