Abstract:
:An amendment to this paper has been published and can be accessed via a link at the top of the paper.
journal_name
Nat Microbioljournal_title
Nature microbiologyauthors
Deme JC,Johnson S,Vickery O,Aron A,Monkhouse H,Griffiths T,James RH,Berks BC,Coulton JW,Stansfeld PJ,Lea SMdoi
10.1038/s41564-020-00825-4subject
Has Abstractpub_date
2020-12-01 00:00:00pages
1616issue
12issn
2058-5276pii
10.1038/s41564-020-00825-4journal_volume
5pub_type
已发布勘误abstract::Virus taxonomy emerged as a discipline in the middle of the twentieth century. Traditionally, classification by virus taxonomists has been focussed on the grouping of relatively closely related viruses. However, during the past few years, the International Committee on Taxonomy of Viruses (ICTV) has recognized that th...
journal_title:Nature microbiology
pub_type: 杂志文章,评审
doi:10.1038/s41564-020-0709-x
更新日期:2020-05-01 00:00:00
abstract::Evidence has accumulated to demonstrate that the intestinal microbiota enhances mammalian enteric virus infections1. For example, we and others previously reported that commensal bacteria stimulate acute and persistent murine norovirus infections2-4. However, in apparent contradiction of these results, the virulence o...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-019-0602-7
更新日期:2020-01-01 00:00:00
abstract::Autophagy and interferon (IFN)-mediated innate immunity are critical antiviral defence mechanisms, and recent evidence indicated that tripartite motif (TRIM) proteins are important regulators of both processes. Although the role of TRIM proteins in modulating antiviral cytokine responses has been well established, muc...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-017-0017-2
更新日期:2017-11-01 00:00:00
abstract::Pathogenic bacteria are armed with potent effector proteins that subvert host signalling processes during infection1. The activities of bacterial effectors and their associated roles within the host cell are often poorly understood, particularly for Chlamydia trachomatis2, a World Health Organization designated neglec...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-018-0271-y
更新日期:2018-12-01 00:00:00
abstract::Staphylococcus epidermidis is a conspicuous member of the human microbiome, widely present on healthy skin. Here we show that S. epidermidis has also evolved to become a formidable nosocomial pathogen. Using genomics, we reveal that three multidrug-resistant, hospital-adapted lineages of S. epidermidis (two ST2 and on...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-018-0230-7
更新日期:2018-10-01 00:00:00
abstract::Inflammasomes are signalling platforms that are assembled in response to infection or sterile inflammation by cytosolic pattern recognition receptors. The consequent inflammasome-triggered caspase-1 activation is critical for the host defence against pathogens. During infection, NLRP3, which is a pattern recognition r...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-020-00832-5
更新日期:2021-01-11 00:00:00
abstract::Crimean-Congo haemorrhagic fever (CCHF) is the most medically significant tick-borne disease, being widespread in the Middle East, Asia, Africa and parts of Europe 1 . Increasing case numbers, westerly movement and broadly ranging case fatality rates substantiate the concern of CCHF as a public health threat. Ixodid t...
journal_title:Nature microbiology
pub_type: 信件
doi:10.1038/s41564-018-0141-7
更新日期:2018-05-01 00:00:00
abstract::Cellular adhesion mediates many important plant-microbe interactions. In the devastating blast fungus Magnaporthe oryzae1, powerful glycoprotein-rich mucilage adhesives2 cement melanized and pressurized dome-shaped infection cells-appressoria-to host rice leaf surfaces. Enormous internal turgor pressure is directed on...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-020-0786-x
更新日期:2020-12-01 00:00:00
abstract::Clostridium difficile infection is the leading cause of hospital-acquired diarrhoea and pseudomembranous colitis. Disease is mediated by the actions of two toxins, TcdA and TcdB, which cause the diarrhoea, as well as inflammation and necrosis within the colon. The toxins are large (308 and 270 kDa, respectively), homo...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2015.2
更新日期:2016-01-11 00:00:00
abstract::The sexually transmitted pathogen Neisseria gonorrhoeae is regarded as being on the way to becoming an untreatable superbug. Despite its clinical importance, little is known about its emergence and evolution, and how this corresponds with the introduction of antimicrobials. We present a genome-based phylogeographical ...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-019-0501-y
更新日期:2019-11-01 00:00:00
abstract::Viruses and plasmids (invasive mobile genetic elements (iMGEs)) have important roles in shaping microbial communities, but their dynamic interactions with CRISPR-based immunity remain unresolved. We analysed generation-resolved iMGE-host dynamics spanning one and a half years in a microbial consortium from a biologica...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-020-00794-8
更新日期:2021-01-01 00:00:00
abstract::The IncC family of broad-host-range plasmids enables the spread of antibiotic resistance genes among human enteric pathogens1-3. Although aspects of IncC plasmid conjugation have been well studied4-9, many roles of conjugation genes have been assigned based solely on sequence similarity. We applied hypersaturated tran...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-020-0775-0
更新日期:2020-11-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature microbiology
pub_type: 已发布勘误
doi:10.1038/s41564-020-0679-z
更新日期:2020-03-01 00:00:00
abstract::As they proliferate, fungi expose antigens at their cell surface that are potent stimulators of the innate immune response, and yet the commensal fungus Candida albicans is able to colonize immuno competent individuals. We show that C. albicans may evade immune detection by presenting a moving immunological target. We...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2016.238
更新日期:2016-12-12 00:00:00
abstract::Glycans are major nutrients for the human gut microbiota (HGM). Arabinogalactan proteins (AGPs) comprise a heterogenous group of plant glycans in which a β1,3-galactan backbone and β1,6-galactan side chains are conserved. Diversity is provided by the variable nature of the sugars that decorate the galactans. The mecha...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-018-0258-8
更新日期:2018-11-01 00:00:00
abstract::Host adaptation is a key factor contributing to the emergence of new bacterial, viral and parasitic pathogens. Many pathogens are considered promiscuous because they cause disease across a range of host species, while others are host-adapted, infecting particular hosts(1). Host adaptation can potentially progress to h...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2015.23
更新日期:2016-01-25 00:00:00
abstract::Legionella pneumophila, the causative bacterium for Legionnaires' disease, hijacks host membrane trafficking for the maturation of the Legionella-containing vacuole (LCV). The LCV membrane mainly contains PtdIns4P, which is important for anchoring many secreted Legionella effectors onto the LCV. Here, we identify a cr...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2016.236
更新日期:2016-12-12 00:00:00
abstract::Outbreaks of viral infections are a global health burden. Although type I interferon (IFN-I) exerts broad-spectrum antiviral effects, its antiviral efficacy in host cells is largely restricted by viruses. How the antiviral efficacy of IFN-I can be improved remains to be explored. Here, we identified the ADP-ribosyltra...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-019-0428-3
更新日期:2019-11-01 00:00:00
abstract::We describe Idionectes vortex gen. nov., sp. nov., a unicellular microeukaryote that swims by continuous inversion of its surface, similar to a vortex ring. This previously unreported mode of motility approximates a hypothetical concept called the 'toroidal swimmer', in which a doughnut-shaped object rotates around it...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-019-0478-6
更新日期:2019-10-01 00:00:00
abstract::In the version of this Perspective originally published, the first and last name of co-author Manimozhiyan Arumugam were switched. This has now been corrected in all versions of the Perspective. ...
journal_title:Nature microbiology
pub_type: 已发布勘误
doi:10.1038/s41564-018-0114-x
更新日期:2018-03-01 00:00:00
abstract::Primary sclerosing cholangitis (PSC) is a chronic inflammatory liver disease and its frequent complication with ulcerative colitis highlights the pathogenic role of epithelial barrier dysfunction. Intestinal barrier dysfunction has been implicated in the pathogenesis of PSC, yet its underlying mechanism remains unknow...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-018-0333-1
更新日期:2019-03-01 00:00:00
abstract::Viral discovery is accelerating at an unprecedented rate due to continuing advances in culture-independent sequence-based analyses. One important facet of this discovery is identification of the hosts of these recently characterized uncultured viruses. To this end, we have adapted the viral tagging approach, which byp...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-019-0526-2
更新日期:2019-12-01 00:00:00
abstract::Retinoic acid-inducible gene I (RIG-I) receptor recognizes 5'-triphosphorylated RNA and triggers a signalling cascade that results in the induction of type-I interferon (IFN)-dependent responses. Its precise regulation represents a pivotal balance between antiviral defences and autoimmunity. To elucidate the cellular ...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2017.22
更新日期:2017-03-01 00:00:00
abstract::Marine microeukaryotes play a fundamental role in biogeochemical cycling through the transfer of energy to higher trophic levels and vertical carbon transport. Despite their global importance, microeukaryote physiology, nutrient metabolism and contributions to carbon cycling across offshore ecosystems are poorly chara...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-020-00814-7
更新日期:2021-02-01 00:00:00
abstract::Mesalamine serves as the gold standard in treating ulcerative colitis. However, its precise mechanism(s) of action remains unclear. Here, we show that mesalamine treatment rapidly decreases polyphosphate levels in diverse bacteria, including members of the human gut microbiome. This decrease sensitizes bacteria toward...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2016.267
更新日期:2017-01-23 00:00:00
abstract::CRISPR-Cas systems are adaptive immune systems that protect bacteria from bacteriophage (phage) infection1. To provide immunity, RNA-guided protein surveillance complexes recognize foreign nucleic acids, triggering their destruction by Cas nucleases2. While the essential requirements for immune activity are well under...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-020-0691-3
更新日期:2020-05-01 00:00:00
abstract::CRISPR-Cas adaptive immune systems protect bacteria and archaea against their invading genetic parasites, including bacteriophages/viruses and plasmids. In response to this immunity, many phages have anti-CRISPR (Acr) proteins that inhibit CRISPR-Cas targeting. To date, anti-CRISPR genes have primarily been discovered...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-020-0692-2
更新日期:2020-04-01 00:00:00
abstract::A major form of transcriptional regulation in bacteria occurs through the exchange of the primary σ factor of RNA polymerase (RNAP) with an alternative extracytoplasmic function (ECF) σ factor1. ECF σ factors are generally intrinsically active and are retained in an inactive state via the sequestration into σ factor-a...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-019-0648-6
更新日期:2020-03-01 00:00:00
abstract::Enterovirus 71 (EV71) is a common cause of hand, foot and mouth disease-a disease endemic especially in the Asia-Pacific region1. Scavenger receptor class B member 2 (SCARB2) is the major receptor of EV71, as well as several other enteroviruses responsible for hand, foot and mouth disease, and plays a key role in cell...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-018-0319-z
更新日期:2019-03-01 00:00:00
abstract::Host factors that silence provirus transcription in CD4+ memory T cells help HIV-1 escape eradication by the host immune system and by antiviral drugs1. These same factors, however, must be overcome for HIV-1 to propagate. Here we show that Vpx and Vpr encoded by diverse primate immunodeficiency viruses activate provi...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-018-0256-x
更新日期:2018-12-01 00:00:00