The anti-inflammatory drug mesalamine targets bacterial polyphosphate accumulation.

Abstract:

:Mesalamine serves as the gold standard in treating ulcerative colitis. However, its precise mechanism(s) of action remains unclear. Here, we show that mesalamine treatment rapidly decreases polyphosphate levels in diverse bacteria, including members of the human gut microbiome. This decrease sensitizes bacteria towards oxidative stress, reduces colonization and attenuates persister cell and biofilm formation, suggesting that mesalamine aids in diminishing the capacity of bacteria to persist within chronically inflamed environments.

journal_name

Nat Microbiol

journal_title

Nature microbiology

authors

Dahl JU,Gray MJ,Bazopoulou D,Beaufay F,Lempart J,Koenigsknecht MJ,Wang Y,Baker JR,Hasler WL,Young VB,Sun D,Jakob U

doi

10.1038/nmicrobiol.2016.267

subject

Has Abstract

pub_date

2017-01-23 00:00:00

pages

16267

issn

2058-5276

pii

nmicrobiol2016267

journal_volume

2

pub_type

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