Abstract:
:Mesalamine serves as the gold standard in treating ulcerative colitis. However, its precise mechanism(s) of action remains unclear. Here, we show that mesalamine treatment rapidly decreases polyphosphate levels in diverse bacteria, including members of the human gut microbiome. This decrease sensitizes bacteria towards oxidative stress, reduces colonization and attenuates persister cell and biofilm formation, suggesting that mesalamine aids in diminishing the capacity of bacteria to persist within chronically inflamed environments.
journal_name
Nat Microbioljournal_title
Nature microbiologyauthors
Dahl JU,Gray MJ,Bazopoulou D,Beaufay F,Lempart J,Koenigsknecht MJ,Wang Y,Baker JR,Hasler WL,Young VB,Sun D,Jakob Udoi
10.1038/nmicrobiol.2016.267subject
Has Abstractpub_date
2017-01-23 00:00:00pages
16267issn
2058-5276pii
nmicrobiol2016267journal_volume
2pub_type
杂志文章abstract::Helicobacter pylori infection is a proven carcinogen for gastric cancer. Its virulence factor vacuolating cytotoxin A (VacA) promotes more severe disease and gastric colonization. VacA, by an unknown mechanism, usurps lysosomal and autophagy pathways to generate a protected reservoir for H. pylori that confers bacteri...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-019-0441-6
更新日期:2019-08-01 00:00:00
abstract::Retroviral infection involves the reverse transcription of the viral RNA genome into DNA, which is subsequently integrated into the host cell genome. Human immunodeficiency virus type 1 (HIV-1) and other lentiviruses mediate the infection of non-dividing cells through the ability of the capsid protein1 to engage the c...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-020-0735-8
更新日期:2020-09-01 00:00:00
abstract::Understanding metabolism in live microalgae is crucial for efficient biomaterial engineering, but conventional methods fail to evaluate heterogeneous populations of motile microalgae due to the labelling requirements and limited imaging speeds. Here, we demonstrate label-free video-rate metabolite imaging of live Eugl...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2016.124
更新日期:2016-08-01 00:00:00
abstract::In most Gram-negative pathogens, the hydrolysis of UDP-2,3-diacylglucosamine to generate lipid X in lipid A biosynthesis is catalysed by the membrane-associated enzyme LpxH. We report the crystal structure of LpxH in complex with its product, lipid X, unveiling a unique insertion lid above the conserved architecture o...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2016.154
更新日期:2016-08-15 00:00:00
abstract::Bacterial toxin-antitoxin systems (TASs) are thought to respond to various stresses, often inducing growth-arrested (persistent) sub-populations of cells whose housekeeping functions are inhibited. Many such TASs induce this effect through the translation-dependent RNA cleavage (RNase) activity of their toxins, which ...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2016.8
更新日期:2016-02-22 00:00:00
abstract::Phylogenetic and geological evidence supports the hypothesis that life on Earth originated in thermal environments and conserved energy through methanogenesis or sulfur reduction. Here we describe two populations of the deeply rooted archaeal phylum Korarchaeota, which were retrieved from the metagenome of a circumneu...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-019-0362-4
更新日期:2019-04-01 00:00:00
abstract::Although bacteria within the Verrucomicrobia phylum are pervasive in soils around the world, they are under-represented in both isolate collections and genomic databases. Here, we describe a single verrucomicrobial group within the class Spartobacteria that is not closely related to any previously described taxa. We e...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2016.198
更新日期:2016-10-31 00:00:00
abstract::The evolution of virulence traits is central for the emergence or re-emergence of microbial pathogens and for their adaptation to a specific host 1-5 . Typhoid toxin is an essential virulence factor of the human-adapted bacterial pathogen Salmonella Typhi 6,7 , the cause of typhoid fever in humans 8-12 . Typhoid toxin...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-017-0033-2
更新日期:2017-12-01 00:00:00
abstract::Viruses and plasmids (invasive mobile genetic elements (iMGEs)) have important roles in shaping microbial communities, but their dynamic interactions with CRISPR-based immunity remain unresolved. We analysed generation-resolved iMGE-host dynamics spanning one and a half years in a microbial consortium from a biologica...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-020-00794-8
更新日期:2021-01-01 00:00:00
abstract::Virus taxonomy emerged as a discipline in the middle of the twentieth century. Traditionally, classification by virus taxonomists has been focussed on the grouping of relatively closely related viruses. However, during the past few years, the International Committee on Taxonomy of Viruses (ICTV) has recognized that th...
journal_title:Nature microbiology
pub_type: 杂志文章,评审
doi:10.1038/s41564-020-0709-x
更新日期:2020-05-01 00:00:00
abstract::Balancing access to antibiotics with the control of antibiotic resistance is a global public health priority. At present, antibiotic stewardship is informed by a 'use it and lose it' principle, in which antibiotic use by the population is linearly related to resistance rates. However, theoretical and mathematical mode...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-019-0410-0
更新日期:2019-07-01 00:00:00
abstract::Clostridium difficile infection (CDI) is mediated by two major exotoxins, toxin A (TcdA) and toxin B (TcdB), that damage the colonic epithelial barrier and induce inflammatory responses. The function of the colonic vascular barrier during CDI has been relatively understudied. Here we report increased colonic vascular ...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-018-0300-x
更新日期:2019-02-01 00:00:00
abstract::CRISPR-Cas systems are adaptive immune systems that protect bacteria from bacteriophage (phage) infection1. To provide immunity, RNA-guided protein surveillance complexes recognize foreign nucleic acids, triggering their destruction by Cas nucleases2. While the essential requirements for immune activity are well under...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-020-0691-3
更新日期:2020-05-01 00:00:00
abstract::Monkeypox is a viral zoonotic disease on the rise across endemic habitats. Despite the growing importance of monkeypox virus, our knowledge on its host spectrum and sylvatic maintenance is limited. Here, we describe the recent repeated emergence of monkeypox virus in a wild, human-habituated western chimpanzee (Pan tr...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-020-0706-0
更新日期:2020-07-01 00:00:00
abstract::Marine microeukaryotes play a fundamental role in biogeochemical cycling through the transfer of energy to higher trophic levels and vertical carbon transport. Despite their global importance, microeukaryote physiology, nutrient metabolism and contributions to carbon cycling across offshore ecosystems are poorly chara...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-020-00814-7
更新日期:2021-02-01 00:00:00
abstract::It is generally believed that exchange of secondary metabolite biosynthetic gene clusters (BGCs) among closely related bacteria is an important driver of BGC evolution and diversification. Applying this idea may help researchers efficiently connect many BGCs to their products and characterize the products' roles in va...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-019-0573-8
更新日期:2019-12-01 00:00:00
abstract::Autophagy and interferon (IFN)-mediated innate immunity are critical antiviral defence mechanisms, and recent evidence indicated that tripartite motif (TRIM) proteins are important regulators of both processes. Although the role of TRIM proteins in modulating antiviral cytokine responses has been well established, muc...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-017-0017-2
更新日期:2017-11-01 00:00:00
abstract::Zika virus (ZIKV) is associated with neonatal microcephaly and Guillain-Barré syndrome1,2. While progress has been made in understanding the causal link between ZIKV infection and microcephaly3-9, the life cycle and pathogenesis of ZIKV are less well understood. In particular, there are conflicting reports on the role...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-017-0092-4
更新日期:2018-03-01 00:00:00
abstract::The original version of this Letter has been modified in the abstract and main text to better reflect the distribution of Neu5Ac sialoglycans in humans. Additionally, co-author Lingquan Deng's present address has been further clarified. ...
journal_title:Nature microbiology
pub_type: 已发布勘误
doi:10.1038/s41564-017-0070-x
更新日期:2017-12-01 00:00:00
abstract::Dimethylsulfoniopropionate (DMSP) is one of the Earth's most abundant organosulfur molecules, a signalling molecule1, a key nutrient for marine microorganisms2,3 and the major precursor for gaseous dimethyl sulfide (DMS). DMS, another infochemical in signalling pathways4, is important in global sulfur cycling2 and aff...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2017.9
更新日期:2017-02-13 00:00:00
abstract::Bacteria have evolved diverse mechanisms to fend off predation by bacteriophages. We previously identified the Dnd system, which uses DndABCDE to insert sulfur into the DNA backbone as a double-stranded phosphorothioate (PT) modification, and DndFGH, a restriction component. Here, we describe an unusual SspABCD-SspE P...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-020-0700-6
更新日期:2020-07-01 00:00:00
abstract::Human onchocerciasis is a serious neglected tropical disease caused by the filarial nematode Onchocerca volvulus that can lead to blindness and chronic disability. Control of the disease relies largely on mass administration of a single drug, and the development of new drugs and vaccines depends on a better knowledge ...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2016.216
更新日期:2016-11-21 00:00:00
abstract::Competition among microorganisms is a key determinant of successful host colonization and persistence. For Streptococcus pneumoniae, lower than predicted rates of co-colonizing strains suggest a competitive advantage for resident bacteria over newcomers. In light of evolutionary theory, we hypothesized that S. pneumon...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-018-0314-4
更新日期:2019-01-01 00:00:00
abstract::The Epstein-Barr virus M81 strain, isolated from a nasopharyngeal carcinoma, induces potent spontaneous virus production in infected B cells. We found that the M81 non-coding Epstein-Barr-encoded RNA EBER2, which carries polymorphisms that are mainly restricted to viruses found in endemic nasopharyngeal carcinomas, ma...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-019-0546-y
更新日期:2019-12-01 00:00:00
abstract::The temporal dynamics of phytoplankton growth and activity have large impacts on fluxes of matter and energy, yet obtaining in situ metabolic measurements of sufficient resolution for even dominant microorganisms remains a considerable challenge. We performed Lagrangian diel sampling with synoptic measurements of popu...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2017.118
更新日期:2017-07-31 00:00:00
abstract::Despite recent progress, the organization and ecological properties of the intestinal microbial ecosystem remain under-investigated. Here, using a manually curated metabolic module framework for (meta-)genomic data analysis, we studied species-function relationships in gut microbial genomes and microbiomes. Half of gu...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2016.88
更新日期:2016-06-13 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature microbiology
pub_type: 已发布勘误
doi:10.1038/s41564-020-00825-4
更新日期:2020-12-01 00:00:00
abstract::In the version of this Perspective originally published, the first and last name of co-author Manimozhiyan Arumugam were switched. This has now been corrected in all versions of the Perspective. ...
journal_title:Nature microbiology
pub_type: 已发布勘误
doi:10.1038/s41564-018-0114-x
更新日期:2018-03-01 00:00:00
abstract::Toxoplasma gondii establishes a lifelong chronic infection in humans and animals1. Host cell entry and egress are key steps in the lytic cycle of this obligate intracellular parasite, ensuring its survival and dissemination. Egress is temporally orchestrated, underpinned by the exocytosis of secretory organelles calle...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-018-0339-8
更新日期:2019-03-01 00:00:00
abstract::Cellular adhesion mediates many important plant-microbe interactions. In the devastating blast fungus Magnaporthe oryzae1, powerful glycoprotein-rich mucilage adhesives2 cement melanized and pressurized dome-shaped infection cells-appressoria-to host rice leaf surfaces. Enormous internal turgor pressure is directed on...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-020-0786-x
更新日期:2020-12-01 00:00:00