Abstract:
:In the version of this Perspective originally published, the first and last name of co-author Manimozhiyan Arumugam were switched. This has now been corrected in all versions of the Perspective.
journal_name
Nat Microbioljournal_title
Nature microbiologyauthors
Costea PI,Hildebrand F,Arumugam M,Bäckhed F,Blaser MJ,Bushman FD,de Vos WM,Ehrlich SD,Fraser CM,Hattori M,Huttenhower C,Jeffery IB,Knights D,Lewis JD,Ley RE,Ochman H,O'Toole PW,Quince C,Relman DA,Shanahan F,Sunagadoi
10.1038/s41564-018-0114-xsubject
Has Abstractpub_date
2018-03-01 00:00:00pages
388issue
3issn
2058-5276pii
10.1038/s41564-018-0114-xjournal_volume
3pub_type
已发布勘误abstract::Surface ocean waters are dominated by planktonic bacterial lineages with highly reduced genomes. The best examples are the cyanobacterial genus Prochlorococcus, the alphaproteobacterial clade SAR11 and the gammaproteobacterial clade SAR86, which together represent over 50% of the cells in surface oceans. Several studi...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2017.91
更新日期:2017-06-12 00:00:00
abstract::Coenzymes are vital for cellular metabolism and act on the full spectrum of enzymatic reactions. Intrinsic chemical reactivity, enzyme promiscuity and high flux through their catalytic cycles make coenzymes prone to damage. To counteract such compromising factors and ensure stable levels of functional coenzymes, cells...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2017.73
更新日期:2017-05-15 00:00:00
abstract::Primary sclerosing cholangitis (PSC) is a chronic inflammatory liver disease and its frequent complication with ulcerative colitis highlights the pathogenic role of epithelial barrier dysfunction. Intestinal barrier dysfunction has been implicated in the pathogenesis of PSC, yet its underlying mechanism remains unknow...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-018-0333-1
更新日期:2019-03-01 00:00:00
abstract::Understanding metabolism in live microalgae is crucial for efficient biomaterial engineering, but conventional methods fail to evaluate heterogeneous populations of motile microalgae due to the labelling requirements and limited imaging speeds. Here, we demonstrate label-free video-rate metabolite imaging of live Eugl...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2016.124
更新日期:2016-08-01 00:00:00
abstract::Enterovirus 71 (EV71) is a common cause of hand, foot and mouth disease-a disease endemic especially in the Asia-Pacific region1. Scavenger receptor class B member 2 (SCARB2) is the major receptor of EV71, as well as several other enteroviruses responsible for hand, foot and mouth disease, and plays a key role in cell...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-018-0319-z
更新日期:2019-03-01 00:00:00
abstract::The evolution of virulence traits is central for the emergence or re-emergence of microbial pathogens and for their adaptation to a specific host 1-5 . Typhoid toxin is an essential virulence factor of the human-adapted bacterial pathogen Salmonella Typhi 6,7 , the cause of typhoid fever in humans 8-12 . Typhoid toxin...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-017-0033-2
更新日期:2017-12-01 00:00:00
abstract::CRISPR-Cas systems are adaptive immune systems that protect bacteria from bacteriophage (phage) infection1. To provide immunity, RNA-guided protein surveillance complexes recognize foreign nucleic acids, triggering their destruction by Cas nucleases2. While the essential requirements for immune activity are well under...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-020-0691-3
更新日期:2020-05-01 00:00:00
abstract::Immune responses in insects are differentially triggered depending on the infection route used by the pathogen. In most studies involving Drosophila melanogaster and viruses, infection is done by injection, while oral infection, which is probably the most common route of viral entry in nature, remains unexplored. Here...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-018-0265-9
更新日期:2018-12-01 00:00:00
abstract::Inflammasomes are signalling platforms that are assembled in response to infection or sterile inflammation by cytosolic pattern recognition receptors. The consequent inflammasome-triggered caspase-1 activation is critical for the host defence against pathogens. During infection, NLRP3, which is a pattern recognition r...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-020-00832-5
更新日期:2021-01-11 00:00:00
abstract::Host factors that silence provirus transcription in CD4+ memory T cells help HIV-1 escape eradication by the host immune system and by antiviral drugs1. These same factors, however, must be overcome for HIV-1 to propagate. Here we show that Vpx and Vpr encoded by diverse primate immunodeficiency viruses activate provi...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-018-0256-x
更新日期:2018-12-01 00:00:00
abstract::The microbial environment influences animal physiology. However, the underlying molecular mechanisms of such functional interactions are largely undefined. Previously, we showed that during chronic undernutrition, strains of Lactobacillus plantarum, a major commensal partner of Drosophila, promote host juvenile growth...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-017-0038-x
更新日期:2017-12-01 00:00:00
abstract::Many animal viruses are enveloped in a lipid bilayer taken up from cellular membranes. Because viral surface proteins bind to these membranes to initiate infection, we hypothesized that free virions may also be capable of interacting with the envelopes of other virions extracellularly. Here, we demonstrate this hypoth...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2017.78
更新日期:2017-05-22 00:00:00
abstract::Viral discovery is accelerating at an unprecedented rate due to continuing advances in culture-independent sequence-based analyses. One important facet of this discovery is identification of the hosts of these recently characterized uncultured viruses. To this end, we have adapted the viral tagging approach, which byp...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-019-0526-2
更新日期:2019-12-01 00:00:00
abstract::Bacterial toxin-antitoxin systems (TASs) are thought to respond to various stresses, often inducing growth-arrested (persistent) sub-populations of cells whose housekeeping functions are inhibited. Many such TASs induce this effect through the translation-dependent RNA cleavage (RNase) activity of their toxins, which ...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2016.8
更新日期:2016-02-22 00:00:00
abstract::Single-cell RNA sequencing has revealed extensive cellular heterogeneity within many organisms, but few methods have been developed for microbial clonal populations. The yeast genome displays unusually dense transcript spacing, with interleaved and overlapping transcription from both strands, resulting in a minuscule ...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-018-0346-9
更新日期:2019-04-01 00:00:00
abstract::Dimethylsulfoniopropionate (DMSP) is one of the Earth's most abundant organosulfur molecules, a signalling molecule1, a key nutrient for marine microorganisms2,3 and the major precursor for gaseous dimethyl sulfide (DMS). DMS, another infochemical in signalling pathways4, is important in global sulfur cycling2 and aff...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2017.9
更新日期:2017-02-13 00:00:00
abstract::Phylogenetic and geological evidence supports the hypothesis that life on Earth originated in thermal environments and conserved energy through methanogenesis or sulfur reduction. Here we describe two populations of the deeply rooted archaeal phylum Korarchaeota, which were retrieved from the metagenome of a circumneu...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-019-0362-4
更新日期:2019-04-01 00:00:00
abstract::Many insects, including mosquitoes, planthoppers, aphids and leafhoppers, are the hosts of bacterial symbionts and the vectors for transmitting viral pathogens1-3. In general, symbiotic bacteria can indirectly affect viral transmission by enhancing immunity and resistance to viruses in insects3-5. Whether symbiotic ba...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2017.25
更新日期:2017-03-06 00:00:00
abstract::Little is known about the specificities and neutralization breadth of the H7-reactive antibody repertoire induced by natural H7N9 infection in humans. We have isolated and characterized 73 H7-reactive monoclonal antibodies from peripheral B cells from four donors infected in 2013 and 2014. Of these, 45 antibodies were...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-018-0303-7
更新日期:2019-02-01 00:00:00
abstract::Eastern equine encephalitis virus (EEEV) is a mosquito-transmitted alphavirus with a high case mortality rate in humans. EEEV is a biodefence concern because of its potential for aerosol spread and the lack of existing countermeasures. Here, we identify a panel of 18 neutralizing murine monoclonal antibodies (mAbs) ag...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-018-0286-4
更新日期:2019-01-01 00:00:00
abstract::Viruses and plasmids (invasive mobile genetic elements (iMGEs)) have important roles in shaping microbial communities, but their dynamic interactions with CRISPR-based immunity remain unresolved. We analysed generation-resolved iMGE-host dynamics spanning one and a half years in a microbial consortium from a biologica...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-020-00794-8
更新日期:2021-01-01 00:00:00
abstract::Bacteria have evolved diverse mechanisms to fend off predation by bacteriophages. We previously identified the Dnd system, which uses DndABCDE to insert sulfur into the DNA backbone as a double-stranded phosphorothioate (PT) modification, and DndFGH, a restriction component. Here, we describe an unusual SspABCD-SspE P...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-020-0700-6
更新日期:2020-07-01 00:00:00
abstract::Influenza A virus is a human pathogen with a genome composed of eight viral RNA segments that replicate in the nucleus. Two viral mRNAs are alternatively spliced. The unspliced M1 mRNA is translated into the matrix M1 protein, while the ion channel M2 protein is generated after alternative splicing. These proteins are...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2016.69
更新日期:2016-05-27 00:00:00
abstract::Staphylococcus epidermidis is a conspicuous member of the human microbiome, widely present on healthy skin. Here we show that S. epidermidis has also evolved to become a formidable nosocomial pathogen. Using genomics, we reveal that three multidrug-resistant, hospital-adapted lineages of S. epidermidis (two ST2 and on...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-018-0230-7
更新日期:2018-10-01 00:00:00
abstract::Despite recent progress, the organization and ecological properties of the intestinal microbial ecosystem remain under-investigated. Here, using a manually curated metabolic module framework for (meta-)genomic data analysis, we studied species-function relationships in gut microbial genomes and microbiomes. Half of gu...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2016.88
更新日期:2016-06-13 00:00:00
abstract::Despite the sporadic detection of fluoroquinolone-resistant Shigella in Asia in the early 2000s and the subsequent global spread of ciprofloxacin-resistant (cipR) Shigella sonnei from 2010, fluoroquinolones remain the recommended therapy for shigellosis1-7. The potential for cipR S. sonnei to develop resistance to alt...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-019-0645-9
更新日期:2020-02-01 00:00:00
abstract::This corrects the article DOI: 10.1038/nmicrobiol.2016.155. ...
journal_title:Nature microbiology
pub_type: 已发布勘误
doi:10.1038/nmicrobiol.2017.107
更新日期:2017-06-12 00:00:00
abstract::Retroviral infection involves the reverse transcription of the viral RNA genome into DNA, which is subsequently integrated into the host cell genome. Human immunodeficiency virus type 1 (HIV-1) and other lentiviruses mediate the infection of non-dividing cells through the ability of the capsid protein1 to engage the c...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/s41564-020-0735-8
更新日期:2020-09-01 00:00:00
abstract::Although bacteria within the Verrucomicrobia phylum are pervasive in soils around the world, they are under-represented in both isolate collections and genomic databases. Here, we describe a single verrucomicrobial group within the class Spartobacteria that is not closely related to any previously described taxa. We e...
journal_title:Nature microbiology
pub_type: 杂志文章
doi:10.1038/nmicrobiol.2016.198
更新日期:2016-10-31 00:00:00
abstract::How does knowing the evolutionary history of microorganisms affect our analysis of microbiological datasets? Depending on the research question, the common ancestry of microorganisms can be a source of confounding variation, or a scaffolding used for inference. For example, when performing regression on traits, common...
journal_title:Nature microbiology
pub_type: 杂志文章,评审
doi:10.1038/s41564-018-0156-0
更新日期:2018-06-01 00:00:00