当前位置： SCI文献检索 > Nature Microbiology期刊下所有文献 > Unexpected mode of engagement between enterovirus 71 and its receptor SCARB2.

Unexpected mode of engagement between enterovirus 71 and its receptor SCARB2.

Abstract：

:Enterovirus 71 (EV71) is a common cause of hand, foot and mouth disease-a disease endemic especially in the Asia-Pacific region1. Scavenger receptor class B member 2 (SCARB2) is the major receptor of EV71, as well as several other enteroviruses responsible for hand, foot and mouth disease, and plays a key role in cell entry2. The isolated structures of EV71 and SCARB2 are known3-6, but how they interact to initiate infection is not. Here, we report the EV71-SCARB2 complex structure determined at 3.4 Å resolution using cryo-electron microscopy. This reveals that SCARB2 binds EV71 on the southern rim of the canyon, rather than across the canyon, as predicted3,7,8. Helices 152-163 (α5) and 183-193 (α7) of SCARB2 and the viral protein 1 (VP1) GH and VP2 EF loops of EV71 dominate the interaction, suggesting an allosteric mechanism by which receptor binding might facilitate the low-pH uncoating of the virus in the endosome/lysosome. Remarkably, many residues within the binding footprint are not conserved across SCARB2-dependent enteroviruses; however, a conserved proline and glycine seem to be key residues. Thus, although the virus maintains antigenic variability even within the receptor-binding footprint, the identification of binding 'hot spots' may facilitate the design of receptor mimic therapeutics less likely to quickly generate resistance.

journal_name

Nat Microbiol

journal_title

Nature microbiology

authors

Zhou D,Zhao Y,Kotecha A,Fry EE,Kelly JT,Wang X,Rao Z,Rowlands DJ,Ren J,Stuart DI

doi

10.1038/s41564-018-0319-z

subject

Has Abstract

pub_date

2019-03-01 00:00:00

pages

414-419

issue

3

issn

2058-5276

pii

10.1038/s41564-018-0319-z

journal_volume

4

pub_type

杂志文章

相关文献

Nature Microbiology文献大全
  • Environmental drivers of a microbial genomic transition zone in the ocean's interior.

    abstract：:The core properties of microbial genomes, including GC content and genome size, are known to vary widely among different bacteria and archaea 1,2 . Several hypotheses have been proposed to explain this genomic variability, but the fundamental drivers that shape bacterial and archaeal genomic properties remain uncertai...

    journal_title：Nature microbiology

    pub_type： 杂志文章

    doi：10.1038/s41564-017-0008-3

    authors： Mende DR,Bryant JA,Aylward FO,Eppley JM,Nielsen T,Karl DM,DeLong EF

    更新日期：2017-10-01 00:00:00

  • Publisher Correction: Enterotypes in the landscape of gut microbial community composition.

    abstract：:In the version of this Perspective originally published, the first and last name of co-author Manimozhiyan Arumugam were switched. This has now been corrected in all versions of the Perspective. ...

    journal_title：Nature microbiology

    pub_type： 已发布勘误

    doi：10.1038/s41564-018-0114-x

    authors： Costea PI,Hildebrand F,Arumugam M,Bäckhed F,Blaser MJ,Bushman FD,de Vos WM,Ehrlich SD,Fraser CM,Hattori M,Huttenhower C,Jeffery IB,Knights D,Lewis JD,Ley RE,Ochman H,O'Toole PW,Quince C,Relman DA,Shanahan F,Sunaga

    更新日期：2018-03-01 00:00:00

  • Tagging the type VI secretion system.

    abstract：: ...

    journal_title：Nature microbiology

    pub_type： 评论,杂志文章

    doi：10.1038/s41564-018-0277-5

    authors： Francetic O

    更新日期：2018-11-01 00:00:00

  • Protective antibodies against Eastern equine encephalitis virus bind to epitopes in domains A and B of the E2 glycoprotein.

    abstract：:Eastern equine encephalitis virus (EEEV) is a mosquito-transmitted alphavirus with a high case mortality rate in humans. EEEV is a biodefence concern because of its potential for aerosol spread and the lack of existing countermeasures. Here, we identify a panel of 18 neutralizing murine monoclonal antibodies (mAbs) ag...

    journal_title：Nature microbiology

    pub_type： 杂志文章

    doi：10.1038/s41564-018-0286-4

    authors： Kim AS,Austin SK,Gardner CL,Zuiani A,Reed DS,Trobaugh DW,Sun C,Basore K,Williamson LE,Crowe JE Jr,Slifka MK,Fremont DH,Klimstra WB,Diamond MS

    更新日期：2019-01-01 00:00:00

  • VacA generates a protective intracellular reservoir for Helicobacter pylori that is eliminated by activation of the lysosomal calcium channel TRPML1.

    abstract：:Helicobacter pylori infection is a proven carcinogen for gastric cancer. Its virulence factor vacuolating cytotoxin A (VacA) promotes more severe disease and gastric colonization. VacA, by an unknown mechanism, usurps lysosomal and autophagy pathways to generate a protected reservoir for H. pylori that confers bacteri...

    journal_title：Nature microbiology

    pub_type： 杂志文章

    doi：10.1038/s41564-019-0441-6

    authors： Capurro MI,Greenfield LK,Prashar A,Xia S,Abdullah M,Wong H,Zhong XZ,Bertaux-Skeirik N,Chakrabarti J,Siddiqui I,O'Brien C,Dong X,Robinson L,Peek RM Jr,Philpott DJ,Zavros Y,Helmrath M,Jones NL

    更新日期：2019-08-01 00:00:00

  • Plasmid-encoded tet(X) genes that confer high-level tigecycline resistance in Escherichia coli.

    abstract：:Tigecycline is one of the last-resort antibiotics to treat complicated infections caused by both multidrug-resistant Gram-negative and Gram-positive bacteria1. Tigecycline resistance has sporadically occurred in recent years, primarily due to chromosome-encoding mechanisms, such as overexpression of efflux pumps and r...

    journal_title：Nature microbiology

    pub_type： 杂志文章

    doi：10.1038/s41564-019-0496-4

    authors： Sun J,Chen C,Cui CY,Zhang Y,Liu X,Cui ZH,Ma XY,Feng Y,Fang LX,Lian XL,Zhang RM,Tang YZ,Zhang KX,Liu HM,Zhuang ZH,Zhou SD,Lv JN,Du H,Huang B,Yu FY,Mathema B,Kreiswirth BN,Liao XP,Chen L,Liu YH

    更新日期：2019-09-01 00:00:00

  • Evolution of host adaptation in the Salmonella typhoid toxin.

    abstract：:The evolution of virulence traits is central for the emergence or re-emergence of microbial pathogens and for their adaptation to a specific host 1-5 . Typhoid toxin is an essential virulence factor of the human-adapted bacterial pathogen Salmonella Typhi 6,7 , the cause of typhoid fever in humans 8-12 . Typhoid toxin...

    journal_title：Nature microbiology

    pub_type： 杂志文章

    doi：10.1038/s41564-017-0033-2

    authors： Gao X,Deng L,Stack G,Yu H,Chen X,Naito-Matsui Y,Varki A,Galán JE

    更新日期：2017-12-01 00:00:00

  • Publisher Correction: Collapse of genetic division of labour and evolution of autonomy in pellicle biofilms.

    abstract：:In the version of this Article originally published, author Carolina Falcón Garcia's name was coded wrongly, resulting in it being incorrect when exported to citation databases. This has now been corrected, though no visible changes will be apparent. ...

    journal_title：Nature microbiology

    pub_type： 已发布勘误

    doi：10.1038/s41564-018-0350-0

    authors： Dragoš A,Martin M,Garcia CF,Kricks L,Pausch P,Heimerl T,Bálint B,Maróti G,Bange G,López D,Lieleg O,Kovács ÁT

    更新日期：2019-02-01 00:00:00

  • A competitive trade-off limits the selective advantage of increased antibiotic production.

    abstract：:In structured environments, antibiotic-producing microorganisms can gain a selective advantage by inhibiting nearby competing species1. However, despite their genetic potential2,3, natural isolates often make only small amounts of antibiotics, and laboratory evolution can lead to loss rather than enhancement of antibi...

    journal_title：Nature microbiology

    pub_type： 杂志文章

    doi：10.1038/nmicrobiol.2016.175

    authors： Gerardin Y,Springer M,Kishony R

    更新日期：2016-09-26 00:00:00

  • Commensal Escherichia coli are a reservoir for the transfer of XDR plasmids into epidemic fluoroquinolone-resistant Shigella sonnei.

    abstract：:Despite the sporadic detection of fluoroquinolone-resistant Shigella in Asia in the early 2000s and the subsequent global spread of ciprofloxacin-resistant (cipR) Shigella sonnei from 2010, fluoroquinolones remain the recommended therapy for shigellosis1-7. The potential for cipR S. sonnei to develop resistance to alt...

    journal_title：Nature microbiology

    pub_type： 杂志文章

    doi：10.1038/s41564-019-0645-9

    authors： Thanh Duy P,Thi Nguyen TN,Vu Thuy D,Chung The H,Alcock F,Boinett C,Dan Thanh HN,Thanh Tuyen H,Thwaites GE,Rabaa MA,Baker S

    更新日期：2020-02-01 00:00:00

  • Structural dynamics of bacteriophage P22 infection initiation revealed by cryo-electron tomography.

    abstract：:For successful infection, bacteriophages must overcome multiple barriers to transport their genome and proteins across the bacterial cell envelope. We use cryo-electron tomography to study the infection initiation of phage P22 in Salmonella enterica serovar Typhimurium, revealing how a channel forms to allow genome tr...

    journal_title：Nature microbiology

    pub_type： 杂志文章

    doi：10.1038/s41564-019-0403-z

    authors： Wang C,Tu J,Liu J,Molineux IJ

    更新日期：2019-06-01 00:00:00

  • Carcinogenesis and therapeutics: the microbiota perspective.

    abstract：:Cancer arises from the acquisition of multiple genetic and epigenetic changes in host cells over the span of many years, promoting oncogenic traits and carcinogenesis. Most cancers develop following random somatic alterations of key oncogenic genes, which are favoured by a number of risk factors, including lifestyle, ...

    journal_title：Nature microbiology

    pub_type： 杂志文章,评审

    doi：10.1038/nmicrobiol.2017.8

    authors： Tsilimigras MC,Fodor A,Jobin C

    更新日期：2017-02-22 00:00:00

  • The genome of Onchocerca volvulus, agent of river blindness.

    abstract：:Human onchocerciasis is a serious neglected tropical disease caused by the filarial nematode Onchocerca volvulus that can lead to blindness and chronic disability. Control of the disease relies largely on mass administration of a single drug, and the development of new drugs and vaccines depends on a better knowledge ...

    journal_title：Nature microbiology

    pub_type： 杂志文章

    doi：10.1038/nmicrobiol.2016.216

    authors： Cotton JA,Bennuru S,Grote A,Harsha B,Tracey A,Beech R,Doyle SR,Dunn M,Hotopp JC,Holroyd N,Kikuchi T,Lambert O,Mhashilkar A,Mutowo P,Nursimulu N,Ribeiro JM,Rogers MB,Stanley E,Swapna LS,Tsai IJ,Unnasch TR,Voronin

    更新日期：2016-11-21 00:00:00

  • ADP-ribosyltransferase PARP11 modulates the interferon antiviral response by mono-ADP-ribosylating the ubiquitin E3 ligase β-TrCP.

    abstract：:Outbreaks of viral infections are a global health burden. Although type I interferon (IFN-I) exerts broad-spectrum antiviral effects, its antiviral efficacy in host cells is largely restricted by viruses. How the antiviral efficacy of IFN-I can be improved remains to be explored. Here, we identified the ADP-ribosyltra...

    journal_title：Nature microbiology

    pub_type： 杂志文章

    doi：10.1038/s41564-019-0428-3

    authors： Guo T,Zuo Y,Qian L,Liu J,Yuan Y,Xu K,Miao Y,Feng Q,Chen X,Jin L,Zhang L,Dong C,Xiong S,Zheng H

    更新日期：2019-11-01 00:00:00

  • Mini viral RNAs act as innate immune agonists during influenza virus infection.

    abstract：:The molecular processes that determine the outcome of influenza virus infection in humans are multifactorial and involve a complex interplay between host, viral and bacterial factors1. However, it is generally accepted that a strong innate immune dysregulation known as 'cytokine storm' contributes to the pathology of ...

    journal_title：Nature microbiology

    pub_type： 信件

    doi：10.1038/s41564-018-0240-5

    authors： Te Velthuis AJW,Long JC,Bauer DLV,Fan RLY,Yen HL,Sharps J,Siegers JY,Killip MJ,French H,Oliva-Martín MJ,Randall RE,de Wit E,van Riel D,Poon LLM,Fodor E

    更新日期：2018-11-01 00:00:00

  • Exploitation of the Leishmania exosomal pathway by Leishmania RNA virus 1.

    abstract：:Leishmania are ancient eukaryotes that have retained the exosome pathway through evolution. Leishmania RNA virus 1 (LRV1)-infected Leishmania species are associated with a particularly aggressive mucocutaneous disease triggered in response to the double-stranded RNA (dsRNA) virus. However, it is unclear how LRV1 is ex...

    journal_title：Nature microbiology

    pub_type： 杂志文章

    doi：10.1038/s41564-018-0352-y

    authors： Atayde VD,da Silva Lira Filho A,Chaparro V,Zimmermann A,Martel C,Jaramillo M,Olivier M

    更新日期：2019-04-01 00:00:00

  • Excess of non-conservative amino acid changes in marine bacterioplankton lineages with reduced genomes.

    abstract：:Surface ocean waters are dominated by planktonic bacterial lineages with highly reduced genomes. The best examples are the cyanobacterial genus Prochlorococcus, the alphaproteobacterial clade SAR11 and the gammaproteobacterial clade SAR86, which together represent over 50% of the cells in surface oceans. Several studi...

    journal_title：Nature microbiology

    pub_type： 杂志文章

    doi：10.1038/nmicrobiol.2017.91

    authors： Luo H,Huang Y,Stepanauskas R,Tang J

    更新日期：2017-06-12 00:00:00

  • A surface endogalactanase in Bacteroides thetaiotaomicron confers keystone status for arabinogalactan degradation.

    abstract：:Glycans are major nutrients for the human gut microbiota (HGM). Arabinogalactan proteins (AGPs) comprise a heterogenous group of plant glycans in which a β1,3-galactan backbone and β1,6-galactan side chains are conserved. Diversity is provided by the variable nature of the sugars that decorate the galactans. The mecha...

    journal_title：Nature microbiology

    pub_type： 杂志文章

    doi：10.1038/s41564-018-0258-8

    authors： Cartmell A,Muñoz-Muñoz J,Briggs JA,Ndeh DA,Lowe EC,Baslé A,Terrapon N,Stott K,Heunis T,Gray J,Yu L,Dupree P,Fernandes PZ,Shah S,Williams SJ,Labourel A,Trost M,Henrissat B,Gilbert HJ

    更新日期：2018-11-01 00:00:00

  • Influenza virus mRNA trafficking through host nuclear speckles.

    abstract：:Influenza A virus is a human pathogen with a genome composed of eight viral RNA segments that replicate in the nucleus. Two viral mRNAs are alternatively spliced. The unspliced M1 mRNA is translated into the matrix M1 protein, while the ion channel M2 protein is generated after alternative splicing. These proteins are...

    journal_title：Nature microbiology

    pub_type： 杂志文章

    doi：10.1038/nmicrobiol.2016.69

    authors： Mor A,White A,Zhang K,Thompson M,Esparza M,Muñoz-Moreno R,Koide K,Lynch KW,García-Sastre A,Fontoura BM

    更新日期：2016-05-27 00:00:00

  • Phenotypic heterogeneity driven by nutrient limitation promotes growth in fluctuating environments.

    abstract：:Most microorganisms live in environments where nutrients are limited and fluctuate over time. Cells respond to nutrient fluctuations by sensing and adapting their physiological state. Recent studies suggest phenotypic heterogeneity(1) in isogenic populations as an alternative strategy in fluctuating environments, wher...

    journal_title：Nature microbiology

    pub_type： 信件

    doi：10.1038/nmicrobiol.2016.55

    authors： Schreiber F,Littmann S,Lavik G,Escrig S,Meibom A,Kuypers MM,Ackermann M

    更新日期：2016-05-09 00:00:00

  • Structure-function analysis of neutralizing antibodies to H7N9 influenza from naturally infected humans.

    abstract：:Little is known about the specificities and neutralization breadth of the H7-reactive antibody repertoire induced by natural H7N9 infection in humans. We have isolated and characterized 73 H7-reactive monoclonal antibodies from peripheral B cells from four donors infected in 2013 and 2014. Of these, 45 antibodies were...

    journal_title：Nature microbiology

    pub_type： 杂志文章

    doi：10.1038/s41564-018-0303-7

    authors： Huang KA,Rijal P,Jiang H,Wang B,Schimanski L,Dong T,Liu YM,Chang P,Iqbal M,Wang MC,Chen Z,Song R,Huang CC,Yang JH,Qi J,Lin TY,Li A,Powell TJ,Jan JT,Ma C,Gao GF,Shi Y,Townsend AR

    更新日期：2019-02-01 00:00:00

  • A Chlamydia effector combining deubiquitination and acetylation activities induces Golgi fragmentation.

    abstract：:Pathogenic bacteria are armed with potent effector proteins that subvert host signalling processes during infection1. The activities of bacterial effectors and their associated roles within the host cell are often poorly understood, particularly for Chlamydia trachomatis2, a World Health Organization designated neglec...

    journal_title：Nature microbiology

    pub_type： 杂志文章

    doi：10.1038/s41564-018-0271-y

    authors： Pruneda JN,Bastidas RJ,Bertsoulaki E,Swatek KN,Santhanam B,Clague MJ,Valdivia RH,Urbé S,Komander D

    更新日期：2018-12-01 00:00:00

  • Exaggerated headline shock.

    abstract：: ...

    journal_title：Nature microbiology

    pub_type： 社论

    doi：10.1038/s41564-019-0408-7

    authors：

    更新日期：2019-03-01 00:00:00

  • Professional titles matter.

    abstract：: ...

    journal_title：Nature microbiology

    pub_type： 社论

    doi：10.1038/s41564-018-0320-6

    authors：

    更新日期：2018-12-01 00:00:00

  • Frequency of antibiotic application drives rapid evolutionary adaptation of Escherichia coli persistence.

    abstract：:The evolution of antibiotic resistance is a major threat to society and has been predicted to lead to 10 million casualties annually by 2050(1). Further aggravating the problem, multidrug tolerance in bacteria not only relies on the build-up of resistance mutations, but also on some cells epigenetically switching to a...

    journal_title：Nature microbiology

    pub_type： 杂志文章

    doi：10.1038/nmicrobiol.2016.20

    authors： Van den Bergh B,Michiels JE,Wenseleers T,Windels EM,Boer PV,Kestemont D,De Meester L,Verstrepen KJ,Verstraeten N,Fauvart M,Michiels J

    更新日期：2016-03-07 00:00:00

  • Primate immunodeficiency virus proteins Vpx and Vpr counteract transcriptional repression of proviruses by the HUSH complex.

    abstract：:Host factors that silence provirus transcription in CD4+ memory T cells help HIV-1 escape eradication by the host immune system and by antiviral drugs1. These same factors, however, must be overcome for HIV-1 to propagate. Here we show that Vpx and Vpr encoded by diverse primate immunodeficiency viruses activate provi...

    journal_title：Nature microbiology

    pub_type： 杂志文章

    doi：10.1038/s41564-018-0256-x

    authors： Yurkovetskiy L,Guney MH,Kim K,Goh SL,McCauley S,Dauphin A,Diehl WE,Luban J

    更新日期：2018-12-01 00:00:00

  • Modulation of membrane phosphoinositide dynamics by the phosphatidylinositide 4-kinase activity of the Legionella LepB effector.

    abstract：:Legionella pneumophila, the causative bacterium for Legionnaires' disease, hijacks host membrane trafficking for the maturation of the Legionella-containing vacuole (LCV). The LCV membrane mainly contains PtdIns4P, which is important for anchoring many secreted Legionella effectors onto the LCV. Here, we identify a cr...

    journal_title：Nature microbiology

    pub_type： 杂志文章

    doi：10.1038/nmicrobiol.2016.236

    authors： Dong N,Niu M,Hu L,Yao Q,Zhou R,Shao F

    更新日期：2016-12-12 00:00:00

  • Bacterial alginate regulators and phage homologs repress CRISPR-Cas immunity.

    abstract：:CRISPR-Cas systems are adaptive immune systems that protect bacteria from bacteriophage (phage) infection1. To provide immunity, RNA-guided protein surveillance complexes recognize foreign nucleic acids, triggering their destruction by Cas nucleases2. While the essential requirements for immune activity are well under...

    journal_title：Nature microbiology

    pub_type： 杂志文章

    doi：10.1038/s41564-020-0691-3

    authors： Borges AL,Castro B,Govindarajan S,Solvik T,Escalante V,Bondy-Denomy J

    更新日期：2020-05-01 00:00:00

  • CRAGE enables rapid activation of biosynthetic gene clusters in undomesticated bacteria.

    abstract：:It is generally believed that exchange of secondary metabolite biosynthetic gene clusters (BGCs) among closely related bacteria is an important driver of BGC evolution and diversification. Applying this idea may help researchers efficiently connect many BGCs to their products and characterize the products' roles in va...

    journal_title：Nature microbiology

    pub_type： 杂志文章

    doi：10.1038/s41564-019-0573-8

    authors： Wang G,Zhao Z,Ke J,Engel Y,Shi YM,Robinson D,Bingol K,Zhang Z,Bowen B,Louie K,Wang B,Evans R,Miyamoto Y,Cheng K,Kosina S,De Raad M,Silva L,Luhrs A,Lubbe A,Hoyt DW,Francavilla C,Otani H,Deutsch S,Washton NM,

    更新日期：2019-12-01 00:00:00

  • Lactate signalling regulates fungal β-glucan masking and immune evasion.

    abstract：:As they proliferate, fungi expose antigens at their cell surface that are potent stimulators of the innate immune response, and yet the commensal fungus Candida albicans is able to colonize immuno competent individuals. We show that C. albicans may evade immune detection by presenting a moving immunological target. We...

    journal_title：Nature microbiology

    pub_type： 杂志文章

    doi：10.1038/nmicrobiol.2016.238

    authors： Ballou ER,Avelar GM,Childers DS,Mackie J,Bain JM,Wagener J,Kastora SL,Panea MD,Hardison SE,Walker LA,Erwig LP,Munro CA,Gow NA,Brown GD,MacCallum DM,Brown AJ

    更新日期：2016-12-12 00:00:00