Abstract：
:Cancer arises from the acquisition of multiple genetic and epigenetic changes in host cells over the span of many years, promoting oncogenic traits and carcinogenesis. Most cancers develop following random somatic alterations of key oncogenic genes, which are favoured by a number of risk factors, including lifestyle, diet and inflammation. Importantly, the environment where tumours evolve provides a unique source of signalling cues that affects cancer cell growth, survival, movement and metastasis. Recently, there has been increased interest in how the microbiota, the collection of microorganisms inhabiting the host body surface and cavities, shapes a micro-environment for host cells that can either promote or prevent cancer formation. The microbiota, particularly the intestinal biota, plays a central role in host physiology, and the composition and activity of this consortium of microorganisms is directly influenced by known cancer risk factors such as lifestyle, diet and inflammation. In this REVIEW, we discuss the pro- and anticarcinogenic role of the microbiota, as well as highlighting the therapeutic potential of microorganisms in tumourigenesis. The broad impacts, and, at times, opposing roles of the microbiota in carcinogenesis serve to illustrate the complex and sometimes conflicted relationship between microorganisms and the host-a relationship that could potentially be harnessed for therapeutic benefits.
journal_name
Nat Microbioljournal_title
Nature microbiologyauthors
Tsilimigras MC,Fodor A,Jobin Cdoi
10.1038/nmicrobiol.2017.8subject
Has Abstractpub_date
2017-02-22 00:00:00pages
17008issn
2058-5276pii
nmicrobiol20178journal_volume
2pub_type
杂志文章,评审abstract：:Balancing access to antibiotics with the control of antibiotic resistance is a global public health priority. At present, antibiotic stewardship is informed by a 'use it and lose it' principle, in which antibiotic use by the population is linearly related to resistance rates. However, theoretical and mathematical mode...
journal_title：Nature microbiology
pub_type： 杂志文章
doi：10.1038/s41564-019-0410-0
更新日期：2019-07-01 00:00:00
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journal_title：Nature microbiology
pub_type： 杂志文章
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journal_title：Nature microbiology
pub_type： 杂志文章
doi：10.1038/s41564-017-0017-2
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journal_title：Nature microbiology
pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Nature microbiology
pub_type： 杂志文章
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journal_title：Nature microbiology
pub_type： 杂志文章
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journal_title：Nature microbiology
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2020-12-01 00:00:00
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journal_title：Nature microbiology
pub_type： 杂志文章
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更新日期：2016-11-21 00:00:00
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journal_title：Nature microbiology
pub_type： 杂志文章,评审
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更新日期：2020-05-01 00:00:00
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journal_title：Nature microbiology
pub_type： 杂志文章
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更新日期：2019-08-01 00:00:00
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journal_title：Nature microbiology
pub_type： 杂志文章
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更新日期：2020-07-01 00:00:00
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journal_title：Nature microbiology
pub_type： 杂志文章,评审
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更新日期：2018-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：2019-06-01 00:00:00
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journal_title：Nature microbiology
pub_type： 杂志文章
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更新日期：2018-10-01 00:00:00
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pub_type： 杂志文章
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更新日期：2020-05-01 00:00:00
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journal_title：Nature microbiology
pub_type： 杂志文章
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更新日期：2016-08-15 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Nature microbiology
pub_type： 已发布勘误
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更新日期：2019-11-01 00:00:00
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journal_title：Nature microbiology
pub_type： 杂志文章
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journal_title：Nature microbiology
pub_type： 杂志文章
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pub_type： 已发布勘误
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更新日期：2018-03-01 00:00:00
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journal_title：Nature microbiology
pub_type： 杂志文章
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更新日期：2019-11-01 00:00:00
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journal_title：Nature microbiology
pub_type： 杂志文章
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更新日期：2018-12-01 00:00:00
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journal_title：Nature microbiology
pub_type： 杂志文章
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更新日期：2019-11-01 00:00:00
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journal_title：Nature microbiology
pub_type： 杂志文章
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更新日期：2019-07-01 00:00:00
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journal_title：Nature microbiology
pub_type： 杂志文章
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更新日期：2017-02-06 00:00:00
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journal_title：Nature microbiology
pub_type： 杂志文章
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更新日期：2017-12-01 00:00:00
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journal_title：Nature microbiology
pub_type： 杂志文章
doi：10.1038/nmicrobiol.2017.9
更新日期：2017-02-13 00:00:00
