Abstract:
:In most Gram-negative pathogens, the hydrolysis of UDP-2,3-diacylglucosamine to generate lipid X in lipid A biosynthesis is catalysed by the membrane-associated enzyme LpxH. We report the crystal structure of LpxH in complex with its product, lipid X, unveiling a unique insertion lid above the conserved architecture of calcineurin-like phosphoesterases. This structure reveals elaborate interactions surrounding lipid X and provides molecular insights into the substrate selectivity, catalysis and inhibition of LpxH.
journal_name
Nat Microbioljournal_title
Nature microbiologyauthors
Cho J,Lee CJ,Zhao J,Young HE,Zhou Pdoi
10.1038/nmicrobiol.2016.154subject
Has Abstractpub_date
2016-08-15 00:00:00pages
16154issue
11issn
2058-5276pii
nmicrobiol2016154journal_volume
1pub_type
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abstract:: ...
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