Model-based projections of Zika virus infections in childbearing women in the Americas.

abstract：:Host factors that silence provirus transcription in CD4+ memory T cells help HIV-1 escape eradication by the host immune system and by antiviral drugs1. These same factors, however, must be overcome for HIV-1 to propagate. Here we show that Vpx and Vpr encoded by diverse primate immunodeficiency viruses activate provi...

journal_title：Nature microbiology

authors： Yurkovetskiy L,Guney MH,Kim K,Goh SL,McCauley S,Dauphin A,Diehl WE,Luban J

更新日期：2018-12-01 00:00:00

abstract：:Surface ocean waters are dominated by planktonic bacterial lineages with highly reduced genomes. The best examples are the cyanobacterial genus Prochlorococcus, the alphaproteobacterial clade SAR11 and the gammaproteobacterial clade SAR86, which together represent over 50% of the cells in surface oceans. Several studi...

journal_title：Nature microbiology

authors： Luo H,Huang Y,Stepanauskas R,Tang J

更新日期：2017-06-12 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature microbiology

authors： Cartmell A,Muñoz-Muñoz J,Briggs JA,Ndeh DA,Lowe EC,Baslé A,Terrapon N,Stott K,Heunis T,Gray J,Yu L,Dupree P,Fernandes PZ,Shah S,Williams SJ,Labourel A,Trost M,Henrissat B,Gilbert HJ

更新日期：2019-11-01 00:00:00

abstract：:Enterovirus 71 (EV71) is a common cause of hand, foot and mouth disease-a disease endemic especially in the Asia-Pacific region1. Scavenger receptor class B member 2 (SCARB2) is the major receptor of EV71, as well as several other enteroviruses responsible for hand, foot and mouth disease, and plays a key role in cell...

journal_title：Nature microbiology

authors： Zhou D,Zhao Y,Kotecha A,Fry EE,Kelly JT,Wang X,Rao Z,Rowlands DJ,Ren J,Stuart DI

更新日期：2019-03-01 00:00:00

abstract：:Primary sclerosing cholangitis (PSC) is a chronic inflammatory liver disease and its frequent complication with ulcerative colitis highlights the pathogenic role of epithelial barrier dysfunction. Intestinal barrier dysfunction has been implicated in the pathogenesis of PSC, yet its underlying mechanism remains unknow...

journal_title：Nature microbiology

authors： Nakamoto N,Sasaki N,Aoki R,Miyamoto K,Suda W,Teratani T,Suzuki T,Koda Y,Chu PS,Taniki N,Yamaguchi A,Kanamori M,Kamada N,Hattori M,Ashida H,Sakamoto M,Atarashi K,Narushima S,Yoshimura A,Honda K,Sato T,Kanai T

更新日期：2019-03-01 00:00:00

abstract：:Little is known about the specificities and neutralization breadth of the H7-reactive antibody repertoire induced by natural H7N9 infection in humans. We have isolated and characterized 73 H7-reactive monoclonal antibodies from peripheral B cells from four donors infected in 2013 and 2014. Of these, 45 antibodies were...

journal_title：Nature microbiology

authors： Huang KA,Rijal P,Jiang H,Wang B,Schimanski L,Dong T,Liu YM,Chang P,Iqbal M,Wang MC,Chen Z,Song R,Huang CC,Yang JH,Qi J,Lin TY,Li A,Powell TJ,Jan JT,Ma C,Gao GF,Shi Y,Townsend AR

更新日期：2019-02-01 00:00:00

abstract：:Toxoplasma gondii establishes a lifelong chronic infection in humans and animals1. Host cell entry and egress are key steps in the lytic cycle of this obligate intracellular parasite, ensuring its survival and dissemination. Egress is temporally orchestrated, underpinned by the exocytosis of secretory organelles calle...

journal_title：Nature microbiology

authors： Bisio H,Lunghi M,Brochet M,Soldati-Favre D

更新日期：2019-03-01 00:00:00

abstract：:Human onchocerciasis is a serious neglected tropical disease caused by the filarial nematode Onchocerca volvulus that can lead to blindness and chronic disability. Control of the disease relies largely on mass administration of a single drug, and the development of new drugs and vaccines depends on a better knowledge ...

journal_title：Nature microbiology

authors： Cotton JA,Bennuru S,Grote A,Harsha B,Tracey A,Beech R,Doyle SR,Dunn M,Hotopp JC,Holroyd N,Kikuchi T,Lambert O,Mhashilkar A,Mutowo P,Nursimulu N,Ribeiro JM,Rogers MB,Stanley E,Swapna LS,Tsai IJ,Unnasch TR,Voronin

更新日期：2016-11-21 00:00:00

abstract：:How does environmental complexity affect the evolution of single genes? Here, we measured the effects of a set of Bacillus subtilis glutamate dehydrogenase mutants across 19 different environments-from phenotypically homogeneous single-cell populations in liquid media to heterogeneous biofilms, plant roots and soil po...

journal_title：Nature microbiology

authors： Noda-García L,Davidi D,Korenblum E,Elazar A,Putintseva E,Aharoni A,Tawfik DS

更新日期：2019-07-01 00:00:00

abstract：:How does knowing the evolutionary history of microorganisms affect our analysis of microbiological datasets? Depending on the research question, the common ancestry of microorganisms can be a source of confounding variation, or a scaffolding used for inference. For example, when performing regression on traits, common...

journal_title：Nature microbiology

authors： Washburne AD,Morton JT,Sanders J,McDonald D,Zhu Q,Oliverio AM,Knight R

更新日期：2018-06-01 00:00:00

abstract：:Cancer arises from the acquisition of multiple genetic and epigenetic changes in host cells over the span of many years, promoting oncogenic traits and carcinogenesis. Most cancers develop following random somatic alterations of key oncogenic genes, which are favoured by a number of risk factors, including lifestyle, ...

journal_title：Nature microbiology

authors： Tsilimigras MC,Fodor A,Jobin C

更新日期：2017-02-22 00:00:00

abstract：:The evolution of virulence traits is central for the emergence or re-emergence of microbial pathogens and for their adaptation to a specific host 1-5 . Typhoid toxin is an essential virulence factor of the human-adapted bacterial pathogen Salmonella Typhi 6,7 , the cause of typhoid fever in humans 8-12 . Typhoid toxin...

journal_title：Nature microbiology

authors： Gao X,Deng L,Stack G,Yu H,Chen X,Naito-Matsui Y,Varki A,Galán JE

更新日期：2017-12-01 00:00:00

abstract：:In structured environments, antibiotic-producing microorganisms can gain a selective advantage by inhibiting nearby competing species1. However, despite their genetic potential2,3, natural isolates often make only small amounts of antibiotics, and laboratory evolution can lead to loss rather than enhancement of antibi...

journal_title：Nature microbiology

authors： Gerardin Y,Springer M,Kishony R

更新日期：2016-09-26 00:00:00

abstract：:Aichi virus (AiV), an unusual and poorly characterized picornavirus, classified in the genus Kobuvirus, can cause severe gastroenteritis and deaths in children below the age of five years, especially in developing countries1,2. The seroprevalence of AiV is approximately 60% in children under the age of ten years and r...

journal_title：Nature microbiology

authors： Zhu L,Wang X,Ren J,Kotecha A,Walter TS,Yuan S,Yamashita T,Tuthill TJ,Fry EE,Rao Z,Stuart DI

更新日期：2016-09-05 00:00:00

abstract：:The development of new drug regimens that allow rapid, sterilizing treatment of tuberculosis has been limited by the complexity and time required for genetic manipulations in Mycobacterium tuberculosis. CRISPR interference (CRISPRi) promises to be a robust, easily engineered and scalable platform for regulated gene si...

journal_title：Nature microbiology

authors： Rock JM,Hopkins FF,Chavez A,Diallo M,Chase MR,Gerrick ER,Pritchard JR,Church GM,Rubin EJ,Sassetti CM,Schnappinger D,Fortune SM

更新日期：2017-02-06 00:00:00

abstract：:Glycans are major nutrients for the human gut microbiota (HGM). Arabinogalactan proteins (AGPs) comprise a heterogenous group of plant glycans in which a β1,3-galactan backbone and β1,6-galactan side chains are conserved. Diversity is provided by the variable nature of the sugars that decorate the galactans. The mecha...

journal_title：Nature microbiology

authors： Cartmell A,Muñoz-Muñoz J,Briggs JA,Ndeh DA,Lowe EC,Baslé A,Terrapon N,Stott K,Heunis T,Gray J,Yu L,Dupree P,Fernandes PZ,Shah S,Williams SJ,Labourel A,Trost M,Henrissat B,Gilbert HJ

更新日期：2018-11-01 00:00:00

abstract：:The original version of this Letter has been modified in the abstract and main text to better reflect the distribution of Neu5Ac sialoglycans in humans. Additionally, co-author Lingquan Deng's present address has been further clarified. ...

journal_title：Nature microbiology

authors： Gao X,Deng L,Stack G,Yu H,Chen X,Naito-Matsui Y,Varki A,Galán JE

更新日期：2017-12-01 00:00:00

abstract：:The Epstein-Barr virus M81 strain, isolated from a nasopharyngeal carcinoma, induces potent spontaneous virus production in infected B cells. We found that the M81 non-coding Epstein-Barr-encoded RNA EBER2, which carries polymorphisms that are mainly restricted to viruses found in endemic nasopharyngeal carcinomas, ma...

journal_title：Nature microbiology

authors： Li Z,Tsai MH,Shumilov A,Baccianti F,Tsao SW,Poirey R,Delecluse HJ

更新日期：2019-12-01 00:00:00

abstract：:Competition among microorganisms is a key determinant of successful host colonization and persistence. For Streptococcus pneumoniae, lower than predicted rates of co-colonizing strains suggest a competitive advantage for resident bacteria over newcomers. In light of evolutionary theory, we hypothesized that S. pneumon...

journal_title：Nature microbiology

authors： Shen P,Lees JA,Bee GCW,Brown SP,Weiser JN

更新日期：2019-01-01 00:00:00

abstract：:Monkeypox is a viral zoonotic disease on the rise across endemic habitats. Despite the growing importance of monkeypox virus, our knowledge on its host spectrum and sylvatic maintenance is limited. Here, we describe the recent repeated emergence of monkeypox virus in a wild, human-habituated western chimpanzee (Pan tr...

journal_title：Nature microbiology

authors： Patrono LV,Pléh K,Samuni L,Ulrich M,Röthemeier C,Sachse A,Muschter S,Nitsche A,Couacy-Hymann E,Boesch C,Wittig RM,Calvignac-Spencer S,Leendertz FH

更新日期：2020-07-01 00:00:00

abstract：:Bacterial toxin-antitoxin systems (TASs) are thought to respond to various stresses, often inducing growth-arrested (persistent) sub-populations of cells whose housekeeping functions are inhibited. Many such TASs induce this effect through the translation-dependent RNA cleavage (RNase) activity of their toxins, which ...

journal_title：Nature microbiology

authors： Kirkpatrick CL,Martins D,Redder P,Frandi A,Mignolet J,Chapalay JB,Chambon M,Turcatti G,Viollier PH

更新日期：2016-02-22 00:00:00

abstract：:Most microorganisms live in environments where nutrients are limited and fluctuate over time. Cells respond to nutrient fluctuations by sensing and adapting their physiological state. Recent studies suggest phenotypic heterogeneity(1) in isogenic populations as an alternative strategy in fluctuating environments, wher...

journal_title：Nature microbiology

authors： Schreiber F,Littmann S,Lavik G,Escrig S,Meibom A,Kuypers MM,Ackermann M

更新日期：2016-05-09 00:00:00

abstract：:Virus taxonomy emerged as a discipline in the middle of the twentieth century. Traditionally, classification by virus taxonomists has been focussed on the grouping of relatively closely related viruses. However, during the past few years, the International Committee on Taxonomy of Viruses (ICTV) has recognized that th...

journal_title：Nature microbiology

authors： International Committee on Taxonomy of Viruses Executive Committee.

更新日期：2020-05-01 00:00:00

abstract：:CRISPR-Cas adaptive immune systems protect bacteria and archaea against their invading genetic parasites, including bacteriophages/viruses and plasmids. In response to this immunity, many phages have anti-CRISPR (Acr) proteins that inhibit CRISPR-Cas targeting. To date, anti-CRISPR genes have primarily been discovered...

journal_title：Nature microbiology

authors： Mahendra C,Christie KA,Osuna BA,Pinilla-Redondo R,Kleinstiver BP,Bondy-Denomy J

更新日期：2020-04-01 00:00:00

abstract：:Understanding metabolism in live microalgae is crucial for efficient biomaterial engineering, but conventional methods fail to evaluate heterogeneous populations of motile microalgae due to the labelling requirements and limited imaging speeds. Here, we demonstrate label-free video-rate metabolite imaging of live Eugl...

journal_title：Nature microbiology

authors： Wakisaka Y,Suzuki Y,Iwata O,Nakashima A,Ito T,Hirose M,Domon R,Sugawara M,Tsumura N,Watarai H,Shimobaba T,Suzuki K,Goda K,Ozeki Y

更新日期：2016-08-01 00:00:00

abstract：:Autophagy and interferon (IFN)-mediated innate immunity are critical antiviral defence mechanisms, and recent evidence indicated that tripartite motif (TRIM) proteins are important regulators of both processes. Although the role of TRIM proteins in modulating antiviral cytokine responses has been well established, muc...

journal_title：Nature microbiology

authors： Sparrer KMJ,Gableske S,Zurenski MA,Parker ZM,Full F,Baumgart GJ,Kato J,Pacheco-Rodriguez G,Liang C,Pornillos O,Moss J,Vaughan M,Gack MU

更新日期：2017-11-01 00:00:00

abstract：:Single-cell RNA sequencing has revealed extensive cellular heterogeneity within many organisms, but few methods have been developed for microbial clonal populations. The yeast genome displays unusually dense transcript spacing, with interleaved and overlapping transcription from both strands, resulting in a minuscule ...

journal_title：Nature microbiology

authors： Nadal-Ribelles M,Islam S,Wei W,Latorre P,Nguyen M,de Nadal E,Posas F,Steinmetz LM

更新日期：2019-04-01 00:00:00

abstract：:Viral discovery is accelerating at an unprecedented rate due to continuing advances in culture-independent sequence-based analyses. One important facet of this discovery is identification of the hosts of these recently characterized uncultured viruses. To this end, we have adapted the viral tagging approach, which byp...

journal_title：Nature microbiology

authors： Džunková M,Low SJ,Daly JN,Deng L,Rinke C,Hugenholtz P

更新日期：2019-12-01 00:00:00

abstract：:Clostridium difficile infection is the leading cause of hospital-acquired diarrhoea and pseudomembranous colitis. Disease is mediated by the actions of two toxins, TcdA and TcdB, which cause the diarrhoea, as well as inflammation and necrosis within the colon. The toxins are large (308 and 270 kDa, respectively), homo...

journal_title：Nature microbiology

authors： Chumbler NM,Rutherford SA,Zhang Z,Farrow MA,Lisher JP,Farquhar E,Giedroc DP,Spiller BW,Melnyk RA,Lacy DB

更新日期：2016-01-11 00:00:00

abstract：:Staphylococcus epidermidis is a conspicuous member of the human microbiome, widely present on healthy skin. Here we show that S. epidermidis has also evolved to become a formidable nosocomial pathogen. Using genomics, we reveal that three multidrug-resistant, hospital-adapted lineages of S. epidermidis (two ST2 and on...

journal_title：Nature microbiology

authors： Lee JYH,Monk IR,Gonçalves da Silva A,Seemann T,Chua KYL,Kearns A,Hill R,Woodford N,Bartels MD,Strommenger B,Laurent F,Dodémont M,Deplano A,Patel R,Larsen AR,Korman TM,Stinear TP,Howden BP

更新日期：2018-10-01 00:00:00