Exaggerated headline shock.

abstract：:Zika virus is a mosquito-borne pathogen that is rapidly spreading across the Americas. Due to associations between Zika virus infection and a range of fetal maladies(1,2), the epidemic trajectory of this viral infection poses a significant concern for the nearly 15 million children born in the Americas each year. Asce...

journal_title：Nature microbiology

authors： Perkins TA,Siraj AS,Ruktanonchai CW,Kraemer MU,Tatem AJ

更新日期：2016-07-25 00:00:00

abstract：:Bacterial toxin-antitoxin systems (TASs) are thought to respond to various stresses, often inducing growth-arrested (persistent) sub-populations of cells whose housekeeping functions are inhibited. Many such TASs induce this effect through the translation-dependent RNA cleavage (RNase) activity of their toxins, which ...

journal_title：Nature microbiology

authors： Kirkpatrick CL,Martins D,Redder P,Frandi A,Mignolet J,Chapalay JB,Chambon M,Turcatti G,Viollier PH

更新日期：2016-02-22 00:00:00

abstract：:Little is known about the specificities and neutralization breadth of the H7-reactive antibody repertoire induced by natural H7N9 infection in humans. We have isolated and characterized 73 H7-reactive monoclonal antibodies from peripheral B cells from four donors infected in 2013 and 2014. Of these, 45 antibodies were...

journal_title：Nature microbiology

authors： Huang KA,Rijal P,Jiang H,Wang B,Schimanski L,Dong T,Liu YM,Chang P,Iqbal M,Wang MC,Chen Z,Song R,Huang CC,Yang JH,Qi J,Lin TY,Li A,Powell TJ,Jan JT,Ma C,Gao GF,Shi Y,Townsend AR

更新日期：2019-02-01 00:00:00

abstract：:In the version of this Article originally published, author Carolina Falcón Garcia's name was coded wrongly, resulting in it being incorrect when exported to citation databases. This has now been corrected, though no visible changes will be apparent. ...

journal_title：Nature microbiology

authors： Dragoš A,Martin M,Garcia CF,Kricks L,Pausch P,Heimerl T,Bálint B,Maróti G,Bange G,López D,Lieleg O,Kovács ÁT

更新日期：2019-02-01 00:00:00

abstract：:The sexually transmitted pathogen Neisseria gonorrhoeae is regarded as being on the way to becoming an untreatable superbug. Despite its clinical importance, little is known about its emergence and evolution, and how this corresponds with the introduction of antimicrobials. We present a genome-based phylogeographical ...

journal_title：Nature microbiology

authors： Sánchez-Busó L,Golparian D,Corander J,Grad YH,Ohnishi M,Flemming R,Parkhill J,Bentley SD,Unemo M,Harris SR

更新日期：2019-11-01 00:00:00

abstract：:Many animal viruses are enveloped in a lipid bilayer taken up from cellular membranes. Because viral surface proteins bind to these membranes to initiate infection, we hypothesized that free virions may also be capable of interacting with the envelopes of other virions extracellularly. Here, we demonstrate this hypoth...

journal_title：Nature microbiology

authors： Cuevas JM,Durán-Moreno M,Sanjuán R

更新日期：2017-05-22 00:00:00

abstract：:Single-cell RNA sequencing has revealed extensive cellular heterogeneity within many organisms, but few methods have been developed for microbial clonal populations. The yeast genome displays unusually dense transcript spacing, with interleaved and overlapping transcription from both strands, resulting in a minuscule ...

journal_title：Nature microbiology

authors： Nadal-Ribelles M,Islam S,Wei W,Latorre P,Nguyen M,de Nadal E,Posas F,Steinmetz LM

更新日期：2019-04-01 00:00:00

abstract：:Glycans are major nutrients for the human gut microbiota (HGM). Arabinogalactan proteins (AGPs) comprise a heterogenous group of plant glycans in which a β1,3-galactan backbone and β1,6-galactan side chains are conserved. Diversity is provided by the variable nature of the sugars that decorate the galactans. The mecha...

journal_title：Nature microbiology

authors： Cartmell A,Muñoz-Muñoz J,Briggs JA,Ndeh DA,Lowe EC,Baslé A,Terrapon N,Stott K,Heunis T,Gray J,Yu L,Dupree P,Fernandes PZ,Shah S,Williams SJ,Labourel A,Trost M,Henrissat B,Gilbert HJ

更新日期：2018-11-01 00:00:00

abstract：:Outbreaks of viral infections are a global health burden. Although type I interferon (IFN-I) exerts broad-spectrum antiviral effects, its antiviral efficacy in host cells is largely restricted by viruses. How the antiviral efficacy of IFN-I can be improved remains to be explored. Here, we identified the ADP-ribosyltra...

journal_title：Nature microbiology

authors： Guo T,Zuo Y,Qian L,Liu J,Yuan Y,Xu K,Miao Y,Feng Q,Chen X,Jin L,Zhang L,Dong C,Xiong S,Zheng H

更新日期：2019-11-01 00:00:00

abstract：:Marine microeukaryotes play a fundamental role in biogeochemical cycling through the transfer of energy to higher trophic levels and vertical carbon transport. Despite their global importance, microeukaryote physiology, nutrient metabolism and contributions to carbon cycling across offshore ecosystems are poorly chara...

journal_title：Nature microbiology

authors： Cohen NR,McIlvin MR,Moran DM,Held NA,Saunders JK,Hawco NJ,Brosnahan M,DiTullio GR,Lamborg C,McCrow JP,Dupont CL,Allen AE,Saito MA

更新日期：2021-02-01 00:00:00

abstract：:In the version of this Perspective originally published, the first and last name of co-author Manimozhiyan Arumugam were switched. This has now been corrected in all versions of the Perspective. ...

journal_title：Nature microbiology

authors： Costea PI,Hildebrand F,Arumugam M,Bäckhed F,Blaser MJ,Bushman FD,de Vos WM,Ehrlich SD,Fraser CM,Hattori M,Huttenhower C,Jeffery IB,Knights D,Lewis JD,Ley RE,Ochman H,O'Toole PW,Quince C,Relman DA,Shanahan F,Sunaga

更新日期：2018-03-01 00:00:00

abstract：:Immune responses in insects are differentially triggered depending on the infection route used by the pathogen. In most studies involving Drosophila melanogaster and viruses, infection is done by injection, while oral infection, which is probably the most common route of viral entry in nature, remains unexplored. Here...

journal_title：Nature microbiology

authors： Mondotte JA,Gausson V,Frangeul L,Blanc H,Lambrechts L,Saleh MC

更新日期：2018-12-01 00:00:00

abstract：:Viral discovery is accelerating at an unprecedented rate due to continuing advances in culture-independent sequence-based analyses. One important facet of this discovery is identification of the hosts of these recently characterized uncultured viruses. To this end, we have adapted the viral tagging approach, which byp...

journal_title：Nature microbiology

authors： Džunková M,Low SJ,Daly JN,Deng L,Rinke C,Hugenholtz P

更新日期：2019-12-01 00:00:00

abstract：:Toxoplasma gondii establishes a lifelong chronic infection in humans and animals1. Host cell entry and egress are key steps in the lytic cycle of this obligate intracellular parasite, ensuring its survival and dissemination. Egress is temporally orchestrated, underpinned by the exocytosis of secretory organelles calle...

journal_title：Nature microbiology

authors： Bisio H,Lunghi M,Brochet M,Soldati-Favre D

更新日期：2019-03-01 00:00:00

abstract：:The molecular processes that determine the outcome of influenza virus infection in humans are multifactorial and involve a complex interplay between host, viral and bacterial factors1. However, it is generally accepted that a strong innate immune dysregulation known as 'cytokine storm' contributes to the pathology of ...

journal_title：Nature microbiology

authors： Te Velthuis AJW,Long JC,Bauer DLV,Fan RLY,Yen HL,Sharps J,Siegers JY,Killip MJ,French H,Oliva-Martín MJ,Randall RE,de Wit E,van Riel D,Poon LLM,Fodor E

更新日期：2018-11-01 00:00:00

abstract：:Mesalamine serves as the gold standard in treating ulcerative colitis. However, its precise mechanism(s) of action remains unclear. Here, we show that mesalamine treatment rapidly decreases polyphosphate levels in diverse bacteria, including members of the human gut microbiome. This decrease sensitizes bacteria toward...

journal_title：Nature microbiology

authors： Dahl JU,Gray MJ,Bazopoulou D,Beaufay F,Lempart J,Koenigsknecht MJ,Wang Y,Baker JR,Hasler WL,Young VB,Sun D,Jakob U

更新日期：2017-01-23 00:00:00

abstract：:Clostridium difficile infection is the leading cause of hospital-acquired diarrhoea and pseudomembranous colitis. Disease is mediated by the actions of two toxins, TcdA and TcdB, which cause the diarrhoea, as well as inflammation and necrosis within the colon. The toxins are large (308 and 270 kDa, respectively), homo...

journal_title：Nature microbiology

authors： Chumbler NM,Rutherford SA,Zhang Z,Farrow MA,Lisher JP,Farquhar E,Giedroc DP,Spiller BW,Melnyk RA,Lacy DB

更新日期：2016-01-11 00:00:00

abstract：:Coenzymes are vital for cellular metabolism and act on the full spectrum of enzymatic reactions. Intrinsic chemical reactivity, enzyme promiscuity and high flux through their catalytic cycles make coenzymes prone to damage. To counteract such compromising factors and ensure stable levels of functional coenzymes, cells...

journal_title：Nature microbiology

authors： Hartl J,Kiefer P,Meyer F,Vorholt JA

更新日期：2017-05-15 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature microbiology

authors： Deme JC,Johnson S,Vickery O,Aron A,Monkhouse H,Griffiths T,James RH,Berks BC,Coulton JW,Stansfeld PJ,Lea SM

更新日期：2020-12-01 00:00:00

abstract：:It is generally believed that exchange of secondary metabolite biosynthetic gene clusters (BGCs) among closely related bacteria is an important driver of BGC evolution and diversification. Applying this idea may help researchers efficiently connect many BGCs to their products and characterize the products' roles in va...

journal_title：Nature microbiology

authors： Wang G,Zhao Z,Ke J,Engel Y,Shi YM,Robinson D,Bingol K,Zhang Z,Bowen B,Louie K,Wang B,Evans R,Miyamoto Y,Cheng K,Kosina S,De Raad M,Silva L,Luhrs A,Lubbe A,Hoyt DW,Francavilla C,Otani H,Deutsch S,Washton NM,

更新日期：2019-12-01 00:00:00

abstract：:How does knowing the evolutionary history of microorganisms affect our analysis of microbiological datasets? Depending on the research question, the common ancestry of microorganisms can be a source of confounding variation, or a scaffolding used for inference. For example, when performing regression on traits, common...

journal_title：Nature microbiology

authors： Washburne AD,Morton JT,Sanders J,McDonald D,Zhu Q,Oliverio AM,Knight R

更新日期：2018-06-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature microbiology

authors： Petrovic Fabijan A,Lin RCY,Ho J,Maddocks S,Ben Zakour NL,Iredell JR,Westmead Bacteriophage Therapy Team.

更新日期：2020-04-01 00:00:00

abstract：:A major form of transcriptional regulation in bacteria occurs through the exchange of the primary σ factor of RNA polymerase (RNAP) with an alternative extracytoplasmic function (ECF) σ factor1. ECF σ factors are generally intrinsically active and are retained in an inactive state via the sequestration into σ factor-a...

journal_title：Nature microbiology

authors： Iyer SC,Casas-Pastor D,Kraus D,Mann P,Schirner K,Glatter T,Fritz G,Ringgaard S

更新日期：2020-03-01 00:00:00

abstract：:Many insects, including mosquitoes, planthoppers, aphids and leafhoppers, are the hosts of bacterial symbionts and the vectors for transmitting viral pathogens1-3. In general, symbiotic bacteria can indirectly affect viral transmission by enhancing immunity and resistance to viruses in insects3-5. Whether symbiotic ba...

journal_title：Nature microbiology

authors： Jia D,Mao Q,Chen Y,Liu Y,Chen Q,Wu W,Zhang X,Chen H,Li Y,Wei T

更新日期：2017-03-06 00:00:00

abstract：:Viruses and plasmids (invasive mobile genetic elements (iMGEs)) have important roles in shaping microbial communities, but their dynamic interactions with CRISPR-based immunity remain unresolved. We analysed generation-resolved iMGE-host dynamics spanning one and a half years in a microbial consortium from a biologica...

journal_title：Nature microbiology

authors： Martínez Arbas S,Narayanasamy S,Herold M,Lebrun LA,Hoopmann MR,Li S,Lam TJ,Kunath BJ,Hicks ND,Liu CM,Price LB,Laczny CC,Gillece JD,Schupp JM,Keim PS,Moritz RL,Faust K,Tang H,Ye Y,Skupin A,May P,Muller EEL,Wilm

更新日期：2021-01-01 00:00:00

abstract：: ...

journal_title：Nature microbiology

authors： Francetic O

更新日期：2018-11-01 00:00:00

abstract：:Primary sclerosing cholangitis (PSC) is a chronic inflammatory liver disease and its frequent complication with ulcerative colitis highlights the pathogenic role of epithelial barrier dysfunction. Intestinal barrier dysfunction has been implicated in the pathogenesis of PSC, yet its underlying mechanism remains unknow...

journal_title：Nature microbiology

authors： Nakamoto N,Sasaki N,Aoki R,Miyamoto K,Suda W,Teratani T,Suzuki T,Koda Y,Chu PS,Taniki N,Yamaguchi A,Kanamori M,Kamada N,Hattori M,Ashida H,Sakamoto M,Atarashi K,Narushima S,Yoshimura A,Honda K,Sato T,Kanai T

更新日期：2019-03-01 00:00:00

abstract：:Phylogenetic and geological evidence supports the hypothesis that life on Earth originated in thermal environments and conserved energy through methanogenesis or sulfur reduction. Here we describe two populations of the deeply rooted archaeal phylum Korarchaeota, which were retrieved from the metagenome of a circumneu...

journal_title：Nature microbiology

authors： McKay LJ,Dlakić M,Fields MW,Delmont TO,Eren AM,Jay ZJ,Klingelsmith KB,Rusch DB,Inskeep WP

更新日期：2019-04-01 00:00:00

abstract：:Tigecycline is one of the last-resort antibiotics to treat complicated infections caused by both multidrug-resistant Gram-negative and Gram-positive bacteria1. Tigecycline resistance has sporadically occurred in recent years, primarily due to chromosome-encoding mechanisms, such as overexpression of efflux pumps and r...

journal_title：Nature microbiology

authors： Sun J,Chen C,Cui CY,Zhang Y,Liu X,Cui ZH,Ma XY,Feng Y,Fang LX,Lian XL,Zhang RM,Tang YZ,Zhang KX,Liu HM,Zhuang ZH,Zhou SD,Lv JN,Du H,Huang B,Yu FY,Mathema B,Kreiswirth BN,Liao XP,Chen L,Liu YH

更新日期：2019-09-01 00:00:00

abstract：:Leishmania are ancient eukaryotes that have retained the exosome pathway through evolution. Leishmania RNA virus 1 (LRV1)-infected Leishmania species are associated with a particularly aggressive mucocutaneous disease triggered in response to the double-stranded RNA (dsRNA) virus. However, it is unclear how LRV1 is ex...

journal_title：Nature microbiology

authors： Atayde VD,da Silva Lira Filho A,Chaparro V,Zimmermann A,Martel C,Jaramillo M,Olivier M

更新日期：2019-04-01 00:00:00